Have you tried Digestive Enzymes as an alternative?
I currently take Enzymedica's Digest formula; I've not noticed a difference in terms of my constipation but figure it may help my body to assimilate nutrients a bit better.
I've not tried Digest + Probiotics; I don't think the CFU (400 million) is enough to do anything, especially if one's gut is overrun by bad bacteria. I suspect that that low of a CFU may be a case of Enzymedica getting something (from paying customers) for nothing.
So I suppose I'm looking for a product with a CFU in the lower billions. (Again, a product with 15 billion CFU--which has both Lactobacillus and Bifidobacterium--caused me both gut and skin issues, so maybe a lower CFU is better. Or maybe it was just the wrong probiotics cocktail for my particular issues.