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Topiramate for Scars

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#1 zupelman

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Posted 05 January 2006 - 09:29 AM

I found this link that says that a drug can eliminate even dissapear acne scars! cool.gif
Here is the link http://dermatology.c...ate/rakesh.html

Abstract

Topiramate may be a safe and effective treatment for scars. Shapira et al. reported an open label study on ten adult subjects with discolored or raised scars at least 2 years old who were given topiramate in an oral dosage of 15 mg per day for 1 month. The dosage was then increased to 30 mg per day if there was minimal or no improvement [1]. Based on that study, BDC Research Centre treated 91 patients with various scarring conditions including post acne, varicella, dermatitis scars, melasma, hypertrophic scars, and keloids. Excellent to good results were observed in post-acne and post-varicella scars.



#2 zxc

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Posted 05 January 2006 - 09:51 AM

I am not going to take that drug before it is 100 % sure that it eliminates scars. And since it says "may be a safe..." it is not 100 % sure. Sorry to disappoint, but this seems like another company trying to earn money.

#3 Baravykas

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Posted 05 January 2006 - 09:54 AM

This is bullshit man! Don't fall for such crap. There are many pages which advertise drugs that they say 'eliminates' scars. Just look at those pictures of the girl. The lighting angle is absolutely diferent + tones of makeup added and scars are still visible. So as I said don't fall for that crap.

#4 zxc

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Posted 05 January 2006 - 10:04 AM

Try Tretinoin-ionophoresis. Opposing to this drug it has been DOCUMENTED to work.

#5 Colonel Angus

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Posted 05 January 2006 - 10:12 AM

First of all this drug has been mentioned already a while back on this forum. Secondly it was originally manufactured and approved by the FDA as a prescription drug for epileptic seizures. This drug isn't from some BS con artist website that claims a scar cure all. Studies were done and the drug showed marked improvement in peoples scars so believe what you will.

#6 zxc

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Posted 05 January 2006 - 10:29 AM

QUOTE(IDBNVS2 @ Jan 5 2006, 05:12 PM) View Post

First of all this drug has been mentioned already a while back on this forum. Secondly it was originally manufactured and approved by the FDA as a prescription drug for epileptic seizures. This drug isn't from some BS con artist website that claims a scar cure all. Studies were done and the drug showed marked improvement in peoples scars so believe what you will.


So you're indicating that it SHOULD work? eusa_doh.gif eusa_eh.gif

Why would it work? Was does the drug actually do?

#7 Baravykas

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Posted 05 January 2006 - 10:32 AM

QUOTE(IDBNVS2 @ Jan 5 2006, 10:12 AM) View Post

First of all this drug has been mentioned already a while back on this forum. Secondly it was originally manufactured and approved by the FDA as a prescription drug for epileptic seizures. This drug isn't from some BS con artist website that claims a scar cure all. Studies were done and the drug showed marked improvement in peoples scars so believe what you will.



Ok ok. I get the point eusa_angel.gif But still, I always do conlclusions about the drug when looking at before/after pics. If the lighting angle, intensity isnt changed and no makeup is added then its ok. I dont know is it just me or that girl has no makeup in the first pic and tons of makeup in the second one. I just dont understand why a serious organisation would do such a thing.

#8 Colonel Angus

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Posted 05 January 2006 - 11:04 AM

QUOTE(zxc @ Jan 5 2006, 10:29 AM) View Post

QUOTE(IDBNVS2 @ Jan 5 2006, 05:12 PM) View Post

First of all this drug has been mentioned already a while back on this forum. Secondly it was originally manufactured and approved by the FDA as a prescription drug for epileptic seizures. This drug isn't from some BS con artist website that claims a scar cure all. Studies were done and the drug showed marked improvement in peoples scars so believe what you will.


So you're indicating that it SHOULD work? eusa_doh.gif eusa_eh.gif

Why would it work? Was does the drug actually do?


Think about it. Alot of prescription drugs have side effects. Maybe this drug's side effect is it causes the immune system to repair damage like it should. Not all side effects have to be bad but most typically are. Most drug companies and scientists don't truly understand what alot of drugs do in the body, just that they cause certain reactions to occur. These reactions are also different from person to person which is why you get allergic reactions in some people with some drugs. But the goal of any drug is to induce a targeted 'good' reaction in a high percentage of the population with little to no side effects. The higher the percentage the 'safer' the drug.

#9 zxc

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Posted 05 January 2006 - 12:38 PM

Then it would be VERY interesting for the ones, who have large disfiguring scars! Definitely!

#10 Colonel Angus

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Posted 05 January 2006 - 12:39 PM

Look at the acne scar improvement on the first two pictures. http://dermatology.c...rs/shapira.html

#11 zxc

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Posted 05 January 2006 - 12:44 PM

A drug doing that from the inside shock.gif

what are the possible side-effects?

Why has it not been more discussed/used?

#12 sick_skin

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Posted 05 January 2006 - 12:46 PM

it says all the patients had discoloured or raised scars. Most people who have acne scars have indented scars. Maybe it would help people with red scars but i wouldn`t take an anti seizure medicine for something taht will heal on is own anyway

#13 Colonel Angus

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Posted 05 January 2006 - 12:54 PM

QUOTE(sick_skin @ Jan 5 2006, 12:46 PM) View Post

it says all the patients had discoloured or raised scars. Most people who have acne scars have indented scars. Maybe it would help people with red scars but i wouldn`t take an anti seizure medicine for something taht will heal on is own anyway


Look at my link above it shows acne scars on a 41 year old woman. In the original study all the scars were 2 years or older so they don't just start healing again after 2 years or more by themselves. If you look at the link that was posted by zupelman Rakesh did a separate experiment similar to Shapira and found that acne scarring had good to excellent results, better than surgical or keloidal scars.

#14 zxc

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Posted 05 January 2006 - 01:02 PM

No the important effect of this drug is not that the wound healing is fastened, but that the scar itself is beginning to heal....

If I had big disfiguring scars - I had certainly taken this drug if there are not any major side-effects.

Maybe it would be possible to find out exactly what in this drug causes it to have a positive effect on scars. If we could find that - we could take only that part of the drug and have a very much better effect.

100 times better! Unless it's all the drug's ingredients that together make the effect. BUT I HIGHLY DOUBT THAT!



The medicine "regulates the activity of nerves". Anybody see why that would be good for scars?


Damn those side-effects look dangerous!

#15 zxc

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Posted 05 January 2006 - 01:38 PM

Where can one buy "Topical Topiramate"? Does it exist?


What exactly does Topiramate contain?

#16 NEC2234

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Posted 05 January 2006 - 02:58 PM

QUOTE
Eight out of the ten patients enrolled in the study reported a total of 19 adverse events. Most were mild and transient. The most common side effects were language problems (n = 3), sleep disturbances (n = 3), anorexia (n = 2), and dizziness (n = 2) followed by one of each of the following: anhedonia, confusion, congestion, headache, muscle pain, nervousness, numbness, paresthesia, and pruritus. No side effects resulted in discontinuation of a subject. Only one subject (language problems) lowered the topiramate dose (from 30 mg/day to 15 mg/day).


Side effects exerted from the article. While the language problems indicates a neurological side effect--certaintly not dismissable--others aren't outrageous. Although I find it odd anorexia is included. This isn't exactly an effect I'd blame entirely on the medicine.

These test need to be conducted on more people specifically suffereing from Acne scars. Even if minimal results are shown, I wouldn't mind trying topiramate. Three months for a pill taken once a day is little inconvenience.

Browsing Google, I'm surprised not to see any follow up studies done. The original experiment was conducted over two years ago. You would have thought with a drug so promosing, someone would have bothered to write about it since summer of 03'.

ZXC--Goggle (google.com) topiramte. It's expensive. I hope you wouldn't consider buying it without atleast consulting a doctor.

#17 Colonel Angus

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Posted 05 January 2006 - 03:02 PM

QUOTE(zxc @ Jan 5 2006, 01:38 PM) View Post

Where can one buy "Topical Topiramate"? Does it exist?


What exactly does Topiramate contain?


Topiramate only comes in oral form and you need a prescription here in the US anyways.

#18 Colonel Angus

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Posted 05 January 2006 - 05:07 PM

NEC,

I dont think you read both links. There were two studies done, one by Shapira and one by Rakesh. Shapira's was more traumatic and surgical type scars but Rakesh's did include acne scars and the result were good to excellent.
I have a prescription for Topamax which is the brand name for topiramate.


Colin

#19 Ty189

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Posted 05 January 2006 - 05:09 PM

QUOTE(IDBNVS2 @ Jan 5 2006, 11:07 PM) View Post

QUOTE(NEC2234 @ Jan 5 2006, 02:58 PM) View Post

QUOTE
Eight out of the ten patients enrolled in the study reported a total of 19 adverse events. Most were mild and transient. The most common side effects were language problems (n = 3), sleep disturbances (n = 3), anorexia (n = 2), and dizziness (n = 2) followed by one of each of the following: anhedonia, confusion, congestion, headache, muscle pain, nervousness, numbness, paresthesia, and pruritus. No side effects resulted in discontinuation of a subject. Only one subject (language problems) lowered the topiramate dose (from 30 mg/day to 15 mg/day).


Side effects exerted from the article. While the language problems indicates a neurological side effect--certaintly not dismissable--others aren't outrageous. Although I find it odd anorexia is included. This isn't exactly an effect I'd blame entirely on the medicine.

These test need to be conducted on more people specifically suffereing from Acne scars. Even if minimal results are shown, I wouldn't mind trying topiramate. Three months for a pill taken once a day is little inconvenience.

Browsing Google, I'm surprised not to see any follow up studies done. The original experiment was conducted over two years ago. You would have thought with a drug so promosing, someone would have bothered to write about it since summer of 03'.

ZXC--Goggle (google.com) topiramte. It's expensive. I hope you wouldn't consider buying it without atleast consulting a doctor.


NEC,

I dont think you read both links. There were two studies done, one by Shapira and one by Rakesh. Shapira's was more traumatic and surgical type scars but Rakesh's did include acne scars and the result were good to excellent.
I have a prescription for Topamax which is the brand name for topiramate.


Colin


Colin- i would be really interested to know your results with this.

#20 Sassy_Svengali

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Posted 05 January 2006 - 07:23 PM

This is so weird! I was going to post how my sleeping tablets may be making my scars look better. It is lunesta, a new drug for sleeping. I wonder if it could be possible... eusa_think.gif

Anyone else take it?

QUOTE(IDBNVS2 @ Jan 5 2006, 04:07 PM) View Post

QUOTE(NEC2234 @ Jan 5 2006, 02:58 PM) View Post

QUOTE
Eight out of the ten patients enrolled in the study reported a total of 19 adverse events. Most were mild and transient. The most common side effects were language problems (n = 3), sleep disturbances (n = 3), anorexia (n = 2), and dizziness (n = 2) followed by one of each of the following: anhedonia, confusion, congestion, headache, muscle pain, nervousness, numbness, paresthesia, and pruritus. No side effects resulted in discontinuation of a subject. Only one subject (language problems) lowered the topiramate dose (from 30 mg/day to 15 mg/day).


Side effects exerted from the article. While the language problems indicates a neurological side effect--certaintly not dismissable--others aren't outrageous. Although I find it odd anorexia is included. This isn't exactly an effect I'd blame entirely on the medicine.

These test need to be conducted on more people specifically suffereing from Acne scars. Even if minimal results are shown, I wouldn't mind trying topiramate. Three months for a pill taken once a day is little inconvenience.

Browsing Google, I'm surprised not to see any follow up studies done. The original experiment was conducted over two years ago. You would have thought with a drug so promosing, someone would have bothered to write about it since summer of 03'.

ZXC--Goggle (google.com) topiramte. It's expensive. I hope you wouldn't consider buying it without atleast consulting a doctor.


NEC,

I dont think you read both links. There were two studies done, one by Shapira and one by Rakesh. Shapira's was more traumatic and surgical type scars but Rakesh's did include acne scars and the result were good to excellent.
I have a prescription for Topamax which is the brand name for topiramate.


Colin

Great! Let us know how it goes.