Are you sure your dose is 0.25 mg? I don't think spiro is manufactured at that low of a dose. Likely 25 mg. In any case, I take 50 mg twice a day and have for 2 years now. It took a while (~3 months) to see a difference, but the number of days I woke up without new pimples was the first thing I noticed. I used to get a few new cysts a week, and that also began to slow. It made me slightly less oily after that, but this was a less noticeable effect.
Are you taking the spiro with food? Unlike a lot of meds that recommend this, spiro won't make you nauseous if you take it on an empty stomach, BUT it is significantly better absorbed if taken with food. I usually take a spiro after breakfast and after dinner. You don't want to take it too close to bedtime, as it is a diuretic and disrupted sleep is the enemy of healing skin.
Are you taking anything other than spiro?
Edited by hughesan91, 30 August 2014 - 11:11 AM.