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Why Not Try This? 40 Mg Doxycycline Per Day For Long-Term Use, No Side Effect, Approved By Fda. Sounds Perfect?

doxycycline

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#1 bobowang

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Posted 12 March 2014 - 08:40 PM

I found this from the pinned thread.
Quoted from American Academy of Dermatology(AAD)
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Rosacea Treatment-Bumps and Pus-filled Lesions -from AAD

Non-antibiotic Dosage Doxycycline
Weighing in at only 40 milligrams of doxycycline per capsule, this dosage of doxycycline is not potent enough to kill bacteria. Since it cannot kill bacteria, it does not act as an antibiotic.

Effectiveness: Research shows that 40 milligrams can effectively stop inflammation. When inflammation decreases, patients tend to see fewer bumps and pus-filled lesions.

In clinical trials, this medication has proven safe and effective for treating the bumps, pus-filled lesions, and redness of rosacea. This led the U.S. Food and Drug Administration (FDA) to approve non-antibiotic dosage doxycycline for the treatment of the bumps and pus-filled lesions of rosacea in adults. The medication is meant for once daily use and can be taken long term.

Side Effects: While the antibiotic dosage of doxycycline can cause side effects, these side effects were not observed in the clinical trials for non-antibiotic dosage. Patients did not say they had an upset stomach or sun sensitivity. None of the women treated with the non-antibiotic dosage, also called the anti-inflammatory dosage, experienced a yeast infection. Since the anti-inflammatory dosage cannot kill bacteria, a patient would not be expected to develop antibiotic resistance. When a patient develops antibiotic resistance, the antibiotic becomes ineffective in killing or weakening the targeted bacteria. Antibiotic resistance is a global health concern.


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Advances Changing Face of Rosacea Treatment -from AAD

Non-antibiotic Doxycycline Treats Bumps and Pus-Filled Lesions
Weighing in at only 40 milligrams of doxycycline per capsule, this dosage of doxycycline is not potent enough to kill bacteria. Since it cannot kill bacteria, it does not act as an antibiotic. But research shows that 40 milligrams can effectively stop inflammation. When inflammation decreases, patients see fewer bumps and pus-filled lesions.

This result was seen again and again during clinical trials. In the phase III clinical trials the final trials needed to determine whether or not a drug will receive approval from the U.S. Food and Drug Administration (FDA) adults with moderate to severe rosacea were asked to take one capsule per day for 16 weeks. The capsule contained either 40 milligrams of doxycycline or a placebo (no active ingredient).

The adults who received the 40 milligrams of doxycycline saw significantly greater improvement. On average, each person in the study had about 20 bumps and/or pus-filled lesions and 2 or fewer nodules. The adults who received the 40 milligrams of doxycycline saw between 11.8 and 9.5 fewer lesions by week 16. This translates to a mean reduction of 61% and 46%, respectively. Adults who received the 40 milligrams of doxycycline also saw a significant decrease in facial redness.

When the patients were also given 1% metronidazole gel, a medication approved by the FDA for treating the papules and pustules of rosacea, the lesions decreased more quickly. The gel was to be used daily for 12 weeks and then stopped. The patients continued taking the 40 milligrams of doxycycline for 16 weeks.

While the antibiotic dosage of doxycycline can cause significant side effects, such side effects were not reported in these clinical trials. Patients did not say they had an upset stomach or sun sensitivity. None of the women treated with the non-antibiotic dosage, also called the anti-inflammatory dosage, experienced a yeast infection. Since the anti-inflammatory dosage cannot kill bacteria, a patient would not be expected to develop antibiotic resistance. When a patient develops antibiotic resistance, the antibiotic becomes ineffective in killing the targeted bacteria. Antibiotic resistance is a global health concern.

The results of these studies led the FDA to approve the 40-milligram capsule of doxycycline for the treatment of the papules (bumps) and pustules (pus-filled lesions) of rosacea in patients who are 18 years of age and older. This 40-milligram capsule is approved for once daily use.

The medication is meant for once daily use and can be taken long term! oops!

#2 Mohsin Khan

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Posted 13 March 2014 - 07:22 AM

I have Rosacea+Psoriasis. I took doxycycline for about 2 months and it worked wonders. But after that, It had counter effect on me. Everytime i took doxy, my face redness was more apparent. Doc switched me over to minocycline but too many side effects for me to handle.



#3 cvd

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Posted 05 April 2014 - 11:09 AM

I have taken 40 mg of doxy for over two years now without a problem.  I had taken Oracea before but it was too expensive.  When I took Oracea it really didn't do much of anything and I'm not sure the doxy has either.  I'm on a complex tx regime (see below) so who knows for sure what is doing what.  I am slowly weaning off the doxy to see what happens.  I've been clear for a long time except for sometimes when I get really tiny flat lesions, only a couple at a time...that sometimes have pus, sometimes not.  They seem to come up after eating rosacea triggers so I think they must be rosacea (I also have been diagnosed with acne).



#4 bobowang

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Posted 10 April 2014 - 01:16 AM

Doxycycline 40 mg (anti-inflammatory dose - not antibiotic) --- currently weaning off doxy

Spironolactone 100 mg

 

Why weaning off doxy?

I think you need weaning off Spironolactone. It has a lot of side effects, and it's female only?


Edited by bobowang, 10 April 2014 - 01:19 AM.


#5 cvd

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Posted 11 April 2014 - 04:35 PM

No need to stay on a med that most likely isn't doing anything anyway.  As I mentioned above oracea never kept me clear and I don't think low dose doxy was doing anything.  I had cystic acne + rosacea.  Low dose doxy was for rosacea inflammation....but I made diet changes that helped that.  Perhaps when my rosacea was really bad it helped but I don't need it now.  Spiro is for cystic acne and sensitivity to androgens (effectively blocks androgen receptors) and I've taken that for over 10 years with no problem ---- whenever it was stopped cystic acne returned so I think I will stay on that...altho my derm may lower the dose.  Could be that the fairly recent addition of BP cleanser + topical antibiotic (Cleocin-T)+ monthly microdermabrasions two years ago may address the cystic acne.  If so then I may be able to maintain clear skin on just those 3 things plus the diet changes.  However that's a big "if" since I've had chronic cystic acne since teens and I'm much older now.  Most likely I'll have to stay on spiro if I want clearer skin.



#6 bobowang

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Posted 15 April 2014 - 06:31 AM

and I've taken that for over 10 years with no problem

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thanks for your information!!!  But I am male, I don't know if I can take Spiro for long term use without any side effect.



#7 cvd

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Posted 16 April 2014 - 08:15 AM

Nope - guys can't take spiro unless they want boobs (sorry).  But the trio of BP cleanser (Panoxyl 4%) + Cleocin-T (topical antibiotic) + monthly microdermabrasions is a method recommended by my derm who specializes in chronic adult acne and has very good results...and it is something that anyone can do.  I was a bit hesitant about the cost for regular microdermabrasions but they are essential for priming the skin for the topical meds.  And they reduce scarring.  Also try avoiding processed oils.  I found this key to helping pores stay clearer and less inflammed.  And eat as fresh and whole as possible (no junk).  Doing these things attack acne on all fronts --- killing acne bacteria, opening pores, reducing inflammation throughout the body.






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