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Unusual Spironolactone Issues

spironolactone doxycycline cystic acne severe acne hormonal acne

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#1 Emsy


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Posted 17 February 2014 - 12:01 AM

I'm having some issues on Spironolactone. 


Today is my 30th day taking it. I started on 25mg and went up to 50mg about 2 1/2 weeks ago. My initial breakout was not going away, so my doctor added 200mg Doxycycline. 


My skin was looking a LOT better......smoother, less cysts. Then, about last Wednesday, BAM. Cysts. I have 7 of them right now. They're not going away, and I'm getting a couple new ones. I haven't changed anything major, so I don't understand what's happening. 


Has anyone else experienced this? Should I just wait it out (I know it's early in the treatment)? Or should I go up a dose? This is really freaking me out.......... 


(I'm calling my dermatologist tomorrow, but I just thought I'd ask for opinions first). 

#2 paigems


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Posted 17 February 2014 - 12:43 AM

You really just have to wait longer. I cleared on only 25 mg, but it wasn't until the 6th month.

#3 CarpeMomentum


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Posted 17 February 2014 - 08:29 AM

I experienced an initial breakout out 2-3 weeks into starting Spiro.  I also started Doxy during the IB.  Doxy took about 2+ weeks to calm the inflammation.  I haven't had a cyst since the IB.  However, you did up your dose, so think of this last round of cysts potentially your IB from the dosage change.  Where are you in your cycle?  Do you have any food sensitivities, dairy, caffeine, gluten, etc?  Hang in there 30 days was definitely a tough time for me.  I'm 50 days on 50 mg and have to say I 

m glad I hung in there even when I felt it wasn't working. 

Current- Clear skin, light oil production, no inflammation on Spiro 100 mg
Started 12/30/2013-50mg
Stopped Yasmin 2/2015 due to Aphasia/Migraines, while taking Spiro 75mg
Upped Spiro to 100mg 2/2015


Current skin care -Makeup Artists Choice


MUAC Mandelic Acid Cleanser

MUAC Mandelic Acid Toner
Neutrogena 2.5% as prevention

Cerave PM  


Sometimes I exfoliate.  I did swear by facial peels by MUAC earlier this year and would absolutely pick them up again.


#4 megtree



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Posted 17 February 2014 - 06:12 PM

It takes a very long time for spiro to build up in your system and begin working. Some people see success very early in treatment, but this is definitely the exception to the rule. When I was prescribed spiro, I was told not to expect significant improvement for at least 4-6 months. Unfortunately, after about 8 months of beign on 125mg of spiro, I was showing no impovement. Now I am on isotretinoin and I am finally improving. I think my situation reflects a small minority of people who take spiro though, so waiting it out is the best bet. It is very unlikely that spiro is worsening the situation more than doing nothing at all. It could however, be a resistance to the doxy, especially if you've taken it in the past.

My Accutane log (with pictures): Holy Isotretinoin Batman It's another Accutane Log!
26 y/o female- approx. 54kg
Absorica -40 mg, 1 daily, December 26, 2013 - February, 25, 2014
Absorica - 60 mg, 1 daily. February 26, 2014 - July 6th 
Probiotic - 1 daily
Fish oil supplement w/ vit D - 1 daily
Cetaphil cleanser
Food Grade Rose water - Toner
La Roche Posay Mineral Water Spray
Vichy 50+ Capital Soleil Cream for Sensitive Skin
Cetaphil Cleanser
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