I am vegan as well, and recently I noticed comments about this issue from reading the literature. Bioavailability of accutane is much higher when taken with a high-fat meal. There's some info and references for this is the accutane FAQ as well.
But I was also wondering what exactly is a high-fat meal. Interestingly, for the purposes of clinical trials it's specified by the FDA. I found the following document that discusses this issue
and the relevant bit of text is (bottom of page 5)
"A high-fat (approximately 50 percent of total caloric content of the meal) and high-calorie (approximately 800 to 1000 calories) meal is recommended as a test meal for food-effect BA and fed BE studies. This test meal should derive approximately 150, 250, and 500-600 calories from protein, carbohydrate, and fat, respectively."
I don't know about you, but that's probably more fat in one go than I eat in a whole day! I eat a lot of avocados, but not that many...
Edited by steve0asdf, 22 January 2014 - 04:11 AM.