I agree with above poster, not only that it can disrupt cholesterol which you can get deposits of yellow in the eyes. Jaundice, gallbladder issues. Drug Induced Hemolytic Anemia, high bilirubin (found in people with gilberts syndrome and other diseases of the liver etc...) pancreatic issues.
What are the rare but possible severe side effects of taking Accutane?
If you experience any of these severe side effects while taking Isotretinoin, stop taking the medication and seek medical attention. Some of the rare but possible severe side effects of Isotretinoin include depression, thoughts of ending your life, vision problems, seizures, yellow eyes, yellow skin, dark stools, hives, an all over rash, vomiting, numbness of the arms or legs, impaired hearing, persistent diarrhea, high fever, loss of appetite, abdominal (stomach) pains, bleeding from the rectum, and chills.
We are not doctors and yellow eyes can be serious, seek medical attention and If your derm doesn't help see a regular physician! 13 yrs. off and on Accutane, that's extremely a long time, not even cancer pts take it that long off and on.