Definitely need to split it up, I take 50mg morning and 50mg at night WITH food and plenty of water. I'm talking a full meal, not just a granola bar or a bowl of cereal. Make sure whatever you are eating includes some protein and fat for absorption, not just carbs.
I actually eat my whole meal and then take the spiro, so there is plenty in my stomach before the pill goes down.
Something you should know is that spironolactone, as an antimineralcorticosteroid, will inhibit the healing of ulcers. It will not cause ulcers, but if you have an existing ulcer problem (that maybe you didn't know about it), it will make them heal slower because it inhibits fibrous tissue growth in that area (because of its action on aldosterone).
If taking spiro with plenty of food and water doesn't resolve your problems, please read this page on Achlorhydria. I have found that ulcer problems are commonly from too LITTLE stomach acid, not too much as many traditional doctors believe. Especially if you have been on antibiotics, it is likely that the antibiotics disrupted your GI tract and you no longer produce enough stomach acid. I had an Achlorhydria problem for many years...because of all the stupid antibiotics I was on for acne. I developed very painful ulcers. I was on Prevacid, Prilosec, Tums, and other antiacid meds and it only made it worse. I then went the natural route and took Betaine HCL, which is an acid stimulator, and after a few months all my symptoms went away.
Edited by Green Gables, 12 September 2013 - 12:04 PM.