Spironolactone slightly raises cortisol as well, though sometimes cortisol is a double-edged sword, too much cortisol can cause midsection weight gain and other problems.
Also remember that progesterone is a precursor to cortisol. It's also a precursor to estrogen and testosterone. Technically it CAN morph into any of those substances as your body sees fit. So it is much more powerful and versatile than an anti-androgen drug because it can regulate hormones but also create more of them!
It is hard to say if weight gain on spiro occurs because of estrogen dominance or because of raised cortisol levels. Spiro definitely can give some people insomnia if taken too late in the day because of the cortisol spike (cortisol has to lower as the day wears on so you can fall asleep at night).
Interesting! I knew about progesterone being a precursor to many hormones, but I thought I would just bring it up in this thread because cortisol was mentioned earlier in relation to progesterone.
I didn't know spiro affected cortisol too, however. It's weird, I gained SO much weight and had insomnia on spiro, and absolutely none on progesterone. In fact, progesterone keeps the bloat away and makes me sleep like a baby! Maybe it had to do more with the estrogen in spiro, at least in my case.
I have the same issues with anti-androgens...they make me so lethargic and bloated, even when I tried spearmint tea.
I have a question and I need some feedback. So, I think that inositol is mainly helping with facial/body hair reduction, but isn't addressing estrogen imbalances. I read that it can actually be a bit estrogenic, even with the progesterone boost. So what I'm wondering is whether I would benefit from using it with DIM to filter out excess estrogens. I'm staring to think that my increased body hair is caused by androgens, but my acne is caused by high estrogens low progesterone...why else would vitex clear my skin yet cause more facial hair & some shedding on my head? So would DIM work in similar ways as vitex without being as strong? I have a love-hate relationship with vitex but I always resort to it because acne > hirsutism for me lol. But I would like to fix both!
So here are my concerns about DIM, hopefully you can reassure me since you know more about it than I do.
- Does DIM increase GOOD estrogen in addition to filtering out the bad estrogens? And could having too much good estrogen also cause estrogen dominance? I'm worried bc I developed melasma and having more estrogen of any kind will be bad for this.
- Does DIM indirectly boost testosterone ??? I'm worried about this because this is basically what vitex did to me by adjusting my estrogen :progesterone ratio. If so, would the anti-androgenic effects of inositol be enough to counter this?
-Given that vitex has managed to clear my skin in the past while anti-androgens alone (saw palmetto, androcur, spearmint tea) haven't, does that mean that DIM is more likely to work for me since it's almost similar to vitex?
Please let me know what you think! I am seriously considering it. I'm also finally picking up a saliva hormone kit from my doctor to see if that will shed some light. Although she wanted me to complete a detox diet first, so I'm a bit embarrassed to tell her I don't have that much self-restraint to only drink liquids for a week! haha