I take DIM in the morning and before sleep, splitting the dose — I don't think it matters though. I took the recommended dose from the beginning (100mg or two capsules), and saw even faster improvement in my skin when I took 150mg (3 capsules) for a while. Once I was clear I went back down to 50-100mg. I don't see any harm in taking a lower dose to start... it might just take longer to see results. It is a hormonal supplement so it may take a few months (it did for me), even though I read reviews and anecdotes of it working for some much sooner.
It says on my bottle of DIM to take it with food. I did have some mild stomach cramping the first week of taking it, which I read is normal in a review. It went away for me and the reviewer. I'm not sure why that can happen (veggies = gas?), but someone said taking it with enough food (full meal) helps prevent that. After that first week I haven't had problems either way, food or not.
Good luck with it! (: If it doesn't work for what you want you can always just stop. I hope it helps you though... your melasma / skin clears and food intolerances improve!
Thanks & happy new year! I'm hoping to start low and work up to the dose you recommended But for now, I can't find DIM where I am in Europe. Last week, I had to take a decongestant & antihistamine due to a bad cold and allergic reactions (my mom practically forced me to take it because I was in bed for days and didn't want to waste my vacation in bed). Anyway, after I got off it, I got some rebound acne, which I should have expected because it always happens after I stop antihistamines/ decongestants. I went to see an herbalist I always see when I'm home to see if he could help me. He said DIM isn't that popular in Europe and couldn't find any, so he put me back on vitex to see if it would help. I was so desperate, I started taking it again at a low dose and within a couple of days my skin is now calm again and I have been able to eat more freely without any major issues. Ugh!!! Not sure if I should switch to DIM when I'm back in the US, or stick with what I know works for me for now (vitex & inositol)? The herbalist recommended I get my prolactin tested in 3 months and then lower vitex and keep taking inositol. He said if I keep taking inositol consistently, it will make it easier to come off vitex this time.
EDIT: I forgot to add that, since starting DCI along with regular inositol, my hair seems to be fuller and I noticed new hair growth. I hope vitex doesn't mess up this progress. How is inositol working for you?
Edited by WishClean, 02 January 2014 - 04:31 PM.