I am also interested in this post. I have also the same problem, I am 43 years old, suffering with cystic acne since I was teen. And every time I get my blood tested, the doctor says to me that my hormonal levels are normal. And I have been also taking diane35 for 5 years. I still have acne, but not so severe.
But the last time I had my blood tested, my doctor said that my estrogen levels were very low, the levels for estrogen were <5 (I don´t know if the levels in your country are the same) because of the menopause. I would like to ask michi31 that said at her posts that her estrogen levels were low, how did you manage with the problem of low estrogen levels? Because I am currently taking Diane35, and I think this medication should provide enough estrogen. And do you think my low estrogen levels can cause my cystic acne ?
Well as of now I am on Spiro 100mg for 7 months and minocycline 50mg and I'm clear - but I'm so scared I will break out when I go off the mino as I am still oily. Anyway, it's interesting that you say you are on Diane and estrogen levels still low. I specifically asked my doctor if I go on birth control, will the estrogen in the pill be measurable in the blood and he said yes. So not sure if this is untrue or if your levels are STILL that low including the estrogen from the pill. I am planning to go on hormone replacement therapy - such as people do after menopause. I'll let you know how that goes. I do think low estrogen is connected - when I was in my third trimester and had sky high estrogen levels I was completely clear and not oily at all.
I would be careful before supplementing estrogen. You could have had high estrogen levels in your third trimester but your progesterone levels are also insanely higher during the third trimester too, which might have actually been enough to counter the estrogen and was what actually cleared your skin. The increase in progesterone is what some say gives people that pregnancy "glow".
It is interesting - I have always thought progesterone was the culprit of my horrendous first trimester breakouts as I was supplementing heavily with progesterone at that time. But as they go up together throughout pregnancy, I suppose I'll never know. Also estrogen is the anti-androgen where progesterone has androgenic effects - which is why women breakout right before their period and why you get a pregnancy "glow" aka oily skin.
Mikito - My estrogen has fluctuated between 11 and 30. I'm sorry I don't have the units in front of me, but this is well below normal. It is consistent with post-menopause and I could never ovulate at these levels. The weird thing is my FSH is not elevated, so I am not technically in menopause. My endo wants me to supplement with estrogen because as you know, low estrogen leads to bone deterioration and osteoporosis already runs in my family. He thinks it's a major problem especially since I have such low estrogen at such a young age (I'm 32). why is your doc against it? It does have to be counterbalanced with progesterone to avoid the cancerous side effects, so it is much like the pill.
Mitchi31, It,s very interesting as you said in your post that my estrogen levels are so low, considering that I have been taking Diane35 for 5 years. I had my blood tested 1 month ago, and yesterday, my doctor gave me the results: 6.1 estradiol and he says its very low for a person at my age ( 43 years). The blood test was done the first day of my period. The last time I had my blood tested the results of estradiol was <5 estradiol ( I don`t know if in your country it´s the same ).
It,s also very interesting that you are going to start hormone therapy replacement. How old are you? Have you decided to do this on your own? What,s your level of estrogen?. Please let me know how it,s going. I thought of taking soya isoflavones. Have you ever taking them?
But I think you should be very careful as hearts says.
My doctor says that hormone therapy replacement is a mistake but he can´t explain why I have my estradiol so low if I am currently taking 2 mg of estradiol every day.
Why i think estrogen is good from the link that was just posted:
While testosterone and DHT have clear roles in acne
pathogenesis, research continues on the role of estrogen.
Estrogen is known to suppress sebum production when
given in sufficient amounts. Other mechanisms for
estrogen’s effect include direct opposition effect on
testosterone and inhibition of testosterone secretion.6,15 In
addition, through the metabolization of estrogen in the
liver, estrogen increases sex hormone-binding globulin
(SHBG).16 SHBG has a high affinity for testosterone and
will bind to it preferentially over estrogen. Since
testosterone and its conversion to DHT are the primary
androgens in acne, increased SHBG leads to improvement