After trying different routes to treat my acne, I started, by advice of my naturopath, looking into my high homocysteine level as a possible culprit. I took a B12 shot (I'm vegan, so it's most likely my B12, not my folic acid is the bottleneck when degrading homocysteine) and have been taking sublingual B12 too. I still haven't had a new blood test to see if it's reduced, but I will soon.
Reading about the subject, I stumbled upon this http://www.lef.org/p...eduction_01.htm, which describes the dangers of high homocysteine and how to reduce it. I also found an old thread from this forums http://www.acne.org/...at-your-greens/. It doesn't have any sources to back its claims, but it's interesting nonetheless.
To sum it up, homocysteine is an amino-acid formed from methionine that is quite dangerous in many ways, and is better marker for heart disease than cholesterol. "It is metabolized through two pathways: remethylation and transsulfuration. Remethylation requires folate and B12 coenzymes; transsulfuration requires pyridoxal-5’-phosphate, the B6 coenzyme." (Lef.org)
Then, trying understand methylation, I found this page www.healthboards.com/boards/acne/296667-acne-new-theory.html which has some very interesting information that seems to put together many "culprits" under one coherent (or almost) theory. This somewhat more scientific page seems to give that "new theory" some credibility http://www.custommed...er-methylation/
I didn't go very deep into the thread, but basically it claims that some people are genetically predisposed to have what is "biochemically but not yet medically recognized" as "histadelic metabolism". "Histadelics have super-fact metabolism, at a cellular level (rather than a glandular one). Super-fast metabolisms burn food much faster and less cleanly and so produce much more toxins than the cellular (and liver) anti-oxidant systems can cope with." (kkpb7825, page 1) The characteristics of this condition may also explain why fasting and insulin helps acne. According to this user, "during fasting, insulin levels fall to almost nothing, so it cannot be the insulin itself that is helping acne it must be something it is doing! When fasting there is no food to 'give off' toxins and in the second case, giving Insulin causes a switch in metabolism from catabolism (burning food) to anabolism (storing food), a histadelic metabolism is a catabolic one." See also these posts http://www.healthboa...875-post62.html http://www.healthboa...901-post88.html
"High-histamine levels are due to a metabolic imbalance known as under-methylation, a biochemical process responsible for the elimination of histamine as well as other functions." (Custommedicine.au)
Again, according to that same user, "Thus, because histadelics have chronically raised histamine they 'run out' of SAMe (amino-acid that gives the methyl group in the methylation process), which can have bad consequences for the body, they become under-methylators. So It seems that from all angles histadelia seems to set up the appropriate conditions for acne-genesis...toxins, low nutrients, low zinc, high copper, immune imbalance, delayed-type hypersensitivity and now low-methylation."
It seems this route of treatment and research may be interesting for those who fit the profile of under-methylators/histadelics, as not only could this condition be in the core of one's acne issues, it could also increase the chances of heart diseases and other serious diseases.
What do you think about it? Has anyone tried something similar to what's prescribed in page 2 of that Lef.org site?