Low Methylation As A Cause For Acne?

6 posts in this topic

After trying different routes to treat my acne, I started, by advice of my naturopath, looking into my high homocysteine level as a possible culprit. I took a B12 shot (I'm vegan, so it's most likely my B12, not my folic acid is the bottleneck when degrading homocysteine) and have been taking sublingual B12 too. I still haven't had a new blood test to see if it's reduced, but I will soon.

Reading about the subject, I stumbled upon this, which describes the dangers of high homocysteine and how to reduce it. I also found an old thread from this forums It doesn't have any sources to back its claims, but it's interesting nonetheless.

To sum it up, homocysteine is an amino-acid formed from methionine that is quite dangerous in many ways, and is better marker for heart disease than cholesterol. "It is metabolized through two pathways: remethylation and transsulfuration. Remethylation requires folate and B12 coenzymes; transsulfuration requires pyridoxal-5’-phosphate, the B6 coenzyme." (

Then, trying understand methylation, I found this page which has some very interesting information that seems to put together many "culprits" under one coherent (or almost) theory. This somewhat more scientific page seems to give that "new theory" some credibility

I didn't go very deep into the thread, but basically it claims that some people are genetically predisposed to have what is "biochemically but not yet medically recognized" as "histadelic metabolism". "Histadelics have super-fact metabolism, at a cellular level (rather than a glandular one). Super-fast metabolisms burn food much faster and less cleanly and so produce much more toxins than the cellular (and liver) anti-oxidant systems can cope with." (kkpb7825, page 1) The characteristics of this condition may also explain why fasting and insulin helps acne. According to this user, "during fasting, insulin levels fall to almost nothing, so it cannot be the insulin itself that is helping acne it must be something it is doing! When fasting there is no food to 'give off' toxins and in the second case, giving Insulin causes a switch in metabolism from catabolism (burning food) to anabolism (storing food), a histadelic metabolism is a catabolic one." See also these posts

"High-histamine levels are due to a metabolic imbalance known as under-methylation, a biochemical process responsible for the elimination of histamine as well as other functions." (

Again, according to that same user, "Thus, because histadelics have chronically raised histamine they 'run out' of SAMe (amino-acid that gives the methyl group in the methylation process), which can have bad consequences for the body, they become under-methylators. So It seems that from all angles histadelia seems to set up the appropriate conditions for acne-genesis...toxins, low nutrients, low zinc, high copper, immune imbalance, delayed-type hypersensitivity and now low-methylation."

It seems this route of treatment and research may be interesting for those who fit the profile of under-methylators/histadelics, as not only could this condition be in the core of one's acne issues, it could also increase the chances of heart diseases and other serious diseases.

What do you think about it? Has anyone tried something similar to what's prescribed in page 2 of that site?

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Another interesting piece of information: Homocysteine, free-radicals, elevated blood sugar, uric acid and oxidized lipoproteins, are the main inducers of chronic inflammation.

Here on the forums most people only seem to worry about sugar levels and somewhat about eating the right kinds of fats, but rarely about the others, maybe that's why most don't see results despite a very strict "healthy" diet: there's much more to it than just sugar and fats, the underlying cause of acne-inducing chronic inflammation may be something that requires a more "scientific" intervention.

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Yeah, we do have a few threads on over and under methylators. And histadelics?? I'd love to read all you found, but don't think I can right now.

Methylation is how epigenetic changes occur - how you change your genes. It's an important topic.

However, from the info in our prior threads, I concluded that it didn't sound like it was my issue. I certainly do not burn calories at a high rate.

Status: Clear after 30 years. Wow, I guess it's been 6 years, now.

[ Story: Severe Acne since I was 10. 10+ years of Dermatologists, Antibiotics, topicals and ACCUTANE did nothing. Discovered oranges triggered the worst of my cystic acne = about 70% improvement. Tried some nutrient supplements like B-complex with zinc and C, saw palmetto and a BHA like the aspirin mask = more improvement, a lot less oily. Then, Diet changes = Clear.

Regimen: Anti-inflammatory, nutrient dense, blood sugar stabilizing diet and supplements (for hormones, inflammation, aging, health). No soap or other cleanser except for hand washing! Water only or Oil cleanse. Aloe Vera mixed with niacinimide and a high linoleic acid oil for moisturizer and reduce pigmentation.

Diet effects acne in so many ways: hormone balance, inflammation, Insulin levels, digestion, allergies and intolerances, liver function, adrenal function, SHBG levels, sebum quality, cell function and turnover, nutrient deficiencies, body fat, etc. Basic advice: Eat, sleep, supplement and exercise like you are a diabetic. And eat real food!

For more information, see my Good Things for Acne thread *Moderator edit - Please refer to the board rules (see “Advertising/soliciting”, “Linking” and “Signatures”)*

When you eat stuff, Stuff Happens!

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Bump....great post!

Current regimen: garlic supplements  & turmeric [as needed, for antioxidants, both are AMAZING for skin], Enzymedica gluten blocker/ digestive enzymes [as needed], nicadan [the only vitamin presciption I take -1/2 per day works well], DIM (needed), inositol (very rarely nowadays - no longer needed as my PCOS is balanced). Also trying herbs for adrenal fatigue. I try to simplify as much as I can. Don't take more supplements than you need....try one at a time and be patient.

The supplements that really helped me when my acne was at its worst: inositol, DIM [not as frequently now!] digestive enzymes [don't need them every day anymore, only on cheat days], herpanacine & vitamin C with rose hips/ low acid [not every day], regular sun exposure for vitamin D3, superoxide dismutase (SOD) enzyme supplements. NOTE: I do not recommend DIM for long term use, and I do not recommend hormonal creams without doctor supervision.

Lifestyle & Skin Care: acupuncture, regular exercise/ yoga, low histamine diet, avoiding unnecessary stress, balancing skin's PH (using BioClin and other products), using distilled/ filtered water to wash face, occasional high frequency & lactic acid peel facials...


Grocery list:



** Find the cause, find the cure **

** If you have a question for me, please ask it publicly so that others can benefit from the discussion**



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bump once again as histamines seem to be up on the boards these days.

Any hints as to how to improve under methylation?

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I am currectnly looking into the methalaytion cycle also. Have you looked up pyroluria? I have more of the symtoms of pyroluria but if I come up negative under the simple urine screening I plan to move on to inspecting my methalaytion system somehow. I like to come on because there is always a new idea on what could be causing these skin problems. If the tests come back saying otherwise I move on to the next thing and start experimenting with that theory. Although I have probably tried over 500+ different things to help my skin conditiions I still have not found all the answers. BUT i have seemed to get my seb derm under control after years and years so although the acne/cyst problem is still occuring I have beat one skin disease that my derm said I would have the rest of my life.

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