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Omnivium

Oily Skin Research

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Great info, I've been looking into this too and it explains many things about chronic excessively-oily skin.

The big reason why it's so hard to control is the fact that for most people, it's caused by hormones. Specifically, it has to do with either us having large amounts of Testosterone (and its derivatives) OR that our sebaceous glands in the skin are over-sensitive to the average levels of Test we have.

A good majority of the few success stories we have based on this. Green Tea, Saw Palmetto, and Birth Control work mainly because they regulate hormones. Green Tea and Saw Palmetto have compounds that inhibit the conversion of Test to DHT, and birth control works a little differently but has the same net effects.

The problem though, is for men, messing around with our most important hormones is entirely a roll of the dice. It might work, or you could have disastrous consequences. Using this approach systemically I'd only recommend for women.

BUT a topical DHT conversion inhibitor shows lots of promise. I saw a study that showed a 2% green tea cream reduced oil production by 60% over 8 weeks in 20 men. Unfortunately things like this are still in the testing phase.

I think ultimately this is how we will treat oily skin in the future, it's just a matter of clearing the pharmacuetical red tape.

I look forward to reading your next posts. Thanks

I don't think hormones are automatically the reason most people have oily skin. The sebaceous gland has so many different receptors it's insane! Have a look at pubmed paper PMC2835895.

I've seen papers that relate to many of the receptors on the sebaceous gland. While most of the experiments I read about were performed in the lab - so you can't automatically assume they work on a person - there has been success in reduce sebaceous oil production in many different ways.

Unfortunately very few effective products have made it to market, and I have not found any that are safe for me.

Interesting about green tea and androgen: I hadn't come across that link before you mentioned it! I thought that with green tea EGCG being a polyphenol - like nobiletin, tangeritin, quercetin, etc - it was an antiproliferative effect.

I think it's great that you guys are doing some experimentation (though I hope you do it safely)! What get's me excited these days is activated photo dynamic therapy to reduce the size of the sebaceous gland (see PMC3283851).

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also ran into some interesting but hard to believe posts about something called Nobiletin. Jofo you may have some experience with this one. Didn't have much time to look into it in terms of effectiveness and practicality.

Both niacinamide and nobiletin (along with EGCg) are contained in the T-Zone Serum that I'm experimenting with right now. I've been using it twice a day for 20 days so far. I'll post an update if I notice any improvements.

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Okay, so here's a quick update. I have seen quite a few things about niacinamide (Vitamin B3) applied topically to reduce oil. I must say this is one that I looked at awhile ago but never followed through with some trials, and I have to thank moderator AKL for reminding me of it.

It is very easy and actually pretty cheap to just buy some niacinamide powder in Bulk Form on amazon, and then just add it to a moisturizer or solution. I haven't had much time to look up the mechanism behind how it works, but I have seen studies confirming it's oily production reducing ability.

I also ran into some interesting but hard to believe posts about something called Nobiletin. Jofo you may have some experience with this one. Didn't have much time to look into it in terms of effectiveness and practicality.

My last midterms and finals are coming up, so I may be MIA for awhile. Physics III is threatening to absolutely destroy my GPA right now, so that is my number one priority LOL. But come summer time the niacinamide experiments will begin.

I look forward to your results. Have you ever considered trying something like b5 or vitamin a topically?

And I totally understand about school. I've pretty much been gone for weeks already. I'm in PHYS 182, and the class average is an F.


How I Stay Clear:

  • Accutane 5mg/day
  • Probiotics 25 billion organisms/day
  • Cetaphil gentle skin cleanser 2x/day

Low Dose Accutane Log


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Okay, so here's a quick update. I have seen quite a few things about niacinamide (Vitamin B3) applied topically to reduce oil. I must say this is one that I looked at awhile ago but never followed through with some trials, and I have to thank moderator AKL for reminding me of it.

It is very easy and actually pretty cheap to just buy some niacinamide powder in Bulk Form on amazon, and then just add it to a moisturizer or solution. I haven't had much time to look up the mechanism behind how it works, but I have seen studies confirming it's oily production reducing ability.

I also ran into some interesting but hard to believe posts about something called Nobiletin. Jofo you may have some experience with this one. Didn't have much time to look into it in terms of effectiveness and practicality.

My last midterms and finals are coming up, so I may be MIA for awhile. Physics III is threatening to absolutely destroy my GPA right now, so that is my number one priority LOL. But come summer time the niacinamide experiments will begin.

I look forward to your results. Have you ever considered trying something like b5 or vitamin a topically?

And I totally understand about school. I've pretty much been gone for weeks already. I'm in PHYS 182, and the class average is an F.

Yea that's what I'm going to be looking into next. I see so much about various B-vitamins affecting oily skin, so I may try them in some form.

And yea for our last exam on Special Relativity the class average was a 54% :)

Our next exam is on Quantum Theories, so that's going to be fun lol


People never cease to amaze me. Some with their brilliance, others with their ignorance. eusa_think.gif

Here's A Few Acne.org Threads Of Mine You May Find Useful/Interesting (updated 7/25/13)

-- DIY Apple Cider Vinegar Toner

-- How to Ice Inflammed or Picked at Cysts

-- Milk of Magnesia Uses

Other Threads Worth Looking At

-- Oily Skin Research Thread: This shows some of our previous efforts and explains the mechanisms behind oily skin.

-- My failed but enlightening experiment going the "less is more" route, aka "The Caveman Routine"


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4. Vitamin D Suppresses Sebocyte Cell Proliferation

From this article we see that a metabolite of vitamin D "resulted in a dose-dependent suppression of [sebocyte] cell proliferation, modulation of cell cycle regulation and of apoptosis" in vitro. To get this metabolite called calcitriol, vitamin D needs to be metabolized by the liver and then the kidneys. The article goes on to say that vitamin D is likely important for regulation of sebum production.

This article also says that vitamin D3 "induces time- and dose-dependent modulation of cell proliferation, cell cycle regulation, lipid content and IL6 and IL8 secretion by cultured sebocytes."

I am having difficulty finding actual clinical trials, but I did find this. It said that in mice, removing the vitamin D receptors[in sebocytes] resulted in a number of problems including enlargement of the sebaceous glands and development of epidermal cysts. It says their data imply that vitamin D receptors control collagen production, hair development and growth, and proliferation of sebaceous glands.

I think in our modern way of life, most of us are deficient in vitamin D. I know I am. If you have oily skin, I think getting some sunlight or taking some vitamin D3 is worth a try. I didn't find any clinical trials about its effectiveness at regulating sebum production, but you can easily find plenty of testimonials online.


How I Stay Clear:

  • Accutane 5mg/day
  • Probiotics 25 billion organisms/day
  • Cetaphil gentle skin cleanser 2x/day

Low Dose Accutane Log


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