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Retinoids Prevent Post-Accutane Relapse

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Something I wish I had known after taking Accutane.

[url=""]Actas Dermosifiliogr.[/url] 2012 Dec 26. pii: S1578-2190(12)00358-7. doi: 10.1016/j.adengl.2012.05.021. [Epub ahead of print]
[b] Acne Relapse Rate and Predictors of Relapse Following Treatment with Oral Isotretinoin.[/b]

[url=""]Morales-Cardona CA[/url], [url=""]Sánchez-Vanegas G[/url].

[b] Source[/b]

Oficina de Docencia e Investigación, Centro Dermatológico Federico Lleras Acosta Empresa Social del Estado Bogotá D.C., Colombia. Electronic address: [email protected]
[b] Abstract[/b]


Relapse rates in patients with acne after treatment with oral isotretinoin vary between 10% and 60% depending on the dosage regimen used, the length of follow-up, and the characteristics of the study population. The aim of this study was to determine the acne relapse rate within 2 years of completion of isotretinoin therapy and to identify the prognostic factors associated with relapse.

We studied a series of patients with cystic acne who had received a cumulative therapeutic dose of at least 120mg/kg of oral isotretinoin. Data were analyzed using descriptive and analytical statistical methods. The relapse rate was expressed as the number of events divided by the amount of person-time. Factors predicting relapse were identified using multivariate Cox regression analysis.
[b] RESULTS:[/b]

A total of 142 patients were followed up for 24 months or until relapse occurred. The relapse rate was 15 events per 100 person-years of follow-up. The risk of relapse was twice as high among men. [b]The protective effect of maintenance treatment with topical retinoids was 32% for each month of use. The risk of relapse was 3.5 times higher among women not receiving antiandrogen therapy.[/b]

The relapse rate in our study was high and similar to that reported in the literature, [b]Maintenance treatment with topical retinoids in men and women and androgen treatment in women helped to prevent relapse.[/b]

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