Because my T levels are to high. Putting b5 aside, high T causes hairloss which is why when bodytbuilders run a cycle, many of them take s5 cream or propecia. Progesterone also suppressed T levels as you just posted.
It's much more complicated than that. In fact, the hormonal profile found in premature balding men, is actually LOW testosterone not high testosterone. http://www.ncbi.nlm....pubmed/14758568
Also, I never said progesterone suppresses testosterone in men. It controls estrogen dominance though and will lower estrogen, thus improving T/E ratios (testosterone/estrogen ratio's). It will also reduce DHT levels.
Total testosterone may be low, but free testosterone isn't (which is all we really care about).
http://www.ncbi.nlm....les/PMC3877475/ Also insulin resistance would play a role as well, more insulin would mean less binding of igf-1 and DHT down regulated igf-1 in the follicle to cause hair loss in the first place (gross simplification).
Also of course progesterone would suppress natural testosterone production, that coupled with estradiol are how you chemically castrate a male.
I tried topical nanosomal progesterone at some point because I'm on testosterone replacement anyway (either b5 or propecia resulted in my secondary hypogonadism, likely the latter), and it shut my libido down hard. I wouldn't mess around with progesterone personally. If you want actual anecdotal reports on what it does, check out transgendered forums and see why male to female users love it. Progesterone also down regulates some estrogen receptors in the body and upregulates others, and hair needs estrogen, so who knows which it does at the follicle level. Not to mention some females hair loss is triggered by progesterone. Is there even one study linking progesterone to hair loss directly?
Spiro is probably the safest anti-androgen to use IMO. RU is has more potential for systemic effects, same with duta, and finasteride. OC would be great it there was a known way to apply it that worked.
I'm also not sure what role MPB plays in B5 hairloss given it's diffuse pattern. Only thing that makes sense is the follicles local IGF-1 system is borked, reduces local aromatase (testing this theory now), or upregulation/sensitivity to DHT on all scalp follicles.
Edited by liquidfirex, 22 July 2014 - 02:38 PM.