Here is the research that I have been doing regarding Prolactin and it's association with acne.
Zinc decreases prolactin:
“Zn2+ can inhibit PRL secretion within a range of physiologically and pharmacologically relevant concentrations”
More proof that zinc decreases prolactin:
“We studied the in vitro influence of physiologically relevant zinc concentrations on the pituitary synthesis and secretion of prolactin (Prl). Zinc in concentrations between 1 and 10 μM reduced Prl secretion and, to a milder extent, synthesis, but not basal or stimulated growth hormone (GH) or LH release. At a supraphysiological concentration of 100 μM, zinc markedly decreased Prl synthesis and secretion, but increased LH secretion. The ability of a physiological zinc concentration to influence Prl secretion suggests that this trace element may have a role in the in vivo regulation of Prl release.”
Prolactin increases 5-alpha-reductase:
“Treatment of intact immature (25-day-old) rats with bromoergocryptine (BR), which suppressed prolactin (Prl) secretion, decreased testicular 5 alpha-reductase activity”
More proof that a decrease in prolactin decreases androgens:
“Hypophysectomy caused significant decreases in testicular enzyme activities per gram of tissue, androgen production, and testicular LH receptors”
Masturbation/sex produces high levels of Prolactin:
“masturbation-induced orgasm produces pronounced, long-lasting increases in plasma prolactin concentrations in both males and females”
More proof that masturbation/sex creates prolactin:
“This series of studies clearly demonstrated that plasma prolactin (PRL) concentrations are substantially increased for over 1h following orgasm (masturbation and coitus conditions) in both men and women”
Spironolactone, a DHT inhibitor, improves acne:
“Our study demonstrates that 5% topical spironolactone cream acts as an antiandrogen in human sebaceous glands, competing with DHT receptors and producing a decrease of labelled DHT”
Bromocriptine, which lowers prolactin, is associated with decreasing acne:
All patients had a fall of basal prolactin levels to normal and a great improvement in or even disappearance of their acne."
Study about Bromocriptine and Sebum:
Bromocriptine (10mg/day) was the second dopaminergic therapy employed in the present work. Similarly to L-dopa, this dopaminergic agonist was able to significantly reduce sebum secretion (both CL and SER) of male patients"
Prolactin and Acne association:"t
here was a significant correlation between serum prolactin level and severity of acne"
Thoughts: Decreasing prolactin in the body will stop acne. There are many ways to do this. Cut out your pituitary gland (not advised). Supplement with zinc and vitamin b6 and other things that lower prolactin naturally. But there are complications with vitamin b6. Abstain from masturbation/sex/orgasm. Take a dopamine agonist or prolactin inhibitor such as Bromocriptine (Other names: Parlodel, Cycloset) or Cabergoline (Other name: Dostinex). I am currently trying to get a prescription for Bromocriptine. It is important to note that in one study they found that the difference in Prolactin levels between acne patients and 'healthy' patients was not very significant BUT the levels of prolactin in an acne patients body were directly correlated to the severity of ones acne. This study was only done on women though. It is unclear why men produce Prolactin at all. I just want to clarify that this is all just a theory and I would love input. Thank you!
Here is acne.org user who experienced relief from Bromocriptine:http://www.acne.org/...h/page__st__180
"...but anyways, I have personally tried the bromocriptine and it has worked amazingly on my acne. I think others should try it and I cant say it will work for you but it did for me. I am taking 5 mg ever night which is a moderate dose. you can get it from 2.5 mg-i think like 10? mg..."
Random elitefitness.com user who experienced body acne relief from Bromocriptine when Accutane didn't work:
"I've been on accutane for about 2-3 months now. It has worked wonders on my face acne, but my back, chest and shoulders haven't been much better. That's until I started using bromocriptine for weightloss (and cause I, now and then, use GBL) two weeks ago. I haven't got a new one on my body since, and it's clearing up very good."
Edited by Joner, 09 December 2012 - 03:04 PM.