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Green Gables

Igf Levels Decrease, Cholesterol Increases, After Accutane

2 posts in this topic


  • acne;

  • insulin-like growth factor-1;

  • insulin-like growth factor binding protein-3;

  • isotretinoin

Summary Background  Isotretinoin is an effective treatment for acne vulgaris. However, it has numerous side-effects. It was previously reported that serum growth hormone (GH) levels decreased with isotretinoin treament.

Objectives  To analyse whether isotretinoin has any effects on insulin-like growth factor-1 (IGF-1), insulin-like growth factor binding protein-3 (IGFBP3) and GH levels.

Methods  Forty-seven patients aged 21·5 ± 5·1 years (mean ± SD) with acne vulgaris were included in this study. Isotretinoin therapy was initiated at a dose of 0·5–0·75 mg kg−1 daily and then adjusted to 0·88 mg kg−1 daily as maintenance dosage after 1 month. Screening for biochemical and hormonal parameters was performed just before initiation and after 3 months of isotretinoin treatment.

Results  IGF-1 and IGFBP3 levels decreased significantly after treatment (P <0·01), while GH levels did not change. Post-treatment, significant increases were seen in aspartate aminotransferase, total cholesterol, low-density lipoprotein cholesterol, triglycerides and low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio (P <0·0001) while high-density lipoprotein cholesterol levels were significantly decreased (P <0·0001).;jsessionid=ABABA7E8B3DD37412651CFC74757F097.d04t01?userIsAuthenticated=false&deniedAccessCustomisedMessage=




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The detrimental affects to the lipid profile is news to me. I wonder for how long this life threatening affect lasts.

I'll have to get mine checked. Although I know my total cholesterol level is good but that doesn't mean much. Kit was a free test to promote the services of one of those clinics opening up supermarkets and drugstores to supplement our ridiculously expensive sickcare system.

Status: Clear after 30 years. Wow, I guess it's been 6 years, now.

[ Story: Severe Acne since I was 10. 10+ years of Dermatologists, Antibiotics, topicals and ACCUTANE did nothing. Discovered oranges triggered the worst of my cystic acne = about 70% improvement. Tried some nutrient supplements like B-complex with zinc and C, saw palmetto and a BHA like the aspirin mask = more improvement, a lot less oily. Then, Diet changes = Clear.

Regimen: Anti-inflammatory, nutrient dense, blood sugar stabilizing diet and supplements (for hormones, inflammation, aging, health). No soap or other cleanser except for hand washing! Water only or Oil cleanse. Aloe Vera mixed with niacinimide and a high linoleic acid oil for moisturizer and reduce pigmentation.

Diet effects acne in so many ways: hormone balance, inflammation, Insulin levels, digestion, allergies and intolerances, liver function, adrenal function, SHBG levels, sebum quality, cell function and turnover, nutrient deficiencies, body fat, etc. Basic advice: Eat, sleep, supplement and exercise like you are a diabetic. And eat real food!

For more information, see my Good Things for Acne thread *Moderator edit - Please refer to the board rules (see “Advertising/soliciting”, “Linking” and “Signatures”)*

When you eat stuff, Stuff Happens!

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