This is specifically about what's going on in our skin, not about the various other factors going on elsewhere in our bodies that worsen the acne condition. For the most part, other people have those things happening too, they just don't get the symptom of acne. These are the differences between us and all your friends that can eat all the junk they want and make whatever other unhealthy lifestyle choices and even have other hormonal or other health problems, yet still have clear skin while you get acne.
-A tendency towards follicular hyperkeratosis or abnormal follicular keratosis (affected by many things such as high glycemic diet, IGF1 in diary, etc http://www.acne.org/...dpost&p=2581754)
-A deficiency in linoleic acid (applies to skin prone to all kinds of problems and all mammals) Linoleic acid is an important part of normal sebum and all of it's many functions in mammalian skin. Affects most of the other things on this list.
Acne Prone Skin/sebum Deficient In Linoleic Acid, Possible Topical Solution: http://www.acne.org/...pical-solution/ which contains links to studies and papers that show that at least 3 genes/enzyme mutations are involved in the linoleic acid deficiency found in mammalian skin prone to skin irritations.
-Fewer llamelar granulars that contain the desquammation enzymes and lipids (the things that make cells exfoliate normally without clogging pores. Affected by linoleic acid)
-More permeable around sebaceous glands and follicles (affected by linoleic acid deficiency)
-There are more estrogen/androgen receptors in skin of the acne prone, especially in males. http://www.ncbi.nlm....pt=AbstractPlus And http://www.ncbi.nlm..../pubmed/6448587
-Higher levels of dehydroepiandrosterone (DHEA) are found in the sebaceous glands. This in turn is converted by 5-alpha reductase into DHT
(possibly due to the deficiency in linoleic acid in sebum which inhibits the conversion)
-More of the enzymes that convert androgens and estrogens - (promoted by/in dairy, high GI diets, inhibited by linoleic acid)
-Deficient in retinoids, possible due to mutations in CYP26AI gene that causes it to be metabolized too fast to be used. These have a huge impact on hyperkeratinization and exfoliation, which would be why they are prescribed for acne treatments. http://www.acne.org/...n/#entry3229786 (may be boosted with beta carotene consumption)
-A subspecies of P. Acnes bacteria that may be more problematic that the species inhabiting normal skin. http://www.acne.org/...-2#entry3257204
Edited by alternativista, 28 February 2013 - 02:56 PM.