These things have been found to be different in acne prone skin.
This is specifically about what's going on in our skin, not about the various other factors going on elsewhere in our bodies that worsen the acne condition. For the most part, other people have those things happening too, they just don't get the symptom of acne. These are the differences between us and all your friends that can eat all the junk they want and make whatever other unhealthy lifestyle choices and even have other hormonal or other health problems, yet still have clear skin while you get acne.
-A tendency towards follicular hyperkeratosis or abnormal follicular keratosis (genetic tendency affected by many things such as high glycemic diet, IGF1 in diary, etc More about hyperkeratinization/hyperproliferation of cells & what to do about it. http://www.acne.org/...acne/?p=2580171
-A deficiency in linoleic acid (applies to skin prone to all kinds of problems and all mammals) Linoleic acid is an important part of normal sebum and all of it's many functions in mammalian skin. This Affects almost all of the other things on this list. It's the root. Acne Prone Skin/sebum Deficient In Linoleic Acid, Possible Topical Solution: http://www.acne.org/...pical-solution/ which contains links to studies and papers that show that at least 3 genes/enzyme mutations are involved in the linoleic acid deficiency found in mammalian skin prone to skin irritations. But there are also many ways diet affects fat metabolism and fatty acid composition of sebum. What to do about the linoleic acid deficiency: http://www.acne.org/...20#entry3303681 Diet & lifestyle habits to improve metabolism of fats and improve sebum quality: http://www.acne.org/...acne/?p=2637530
-Patients prone to cystic/nodular acne has been found to be deficient in HDL cholesterol. Accutane improves HDL synthesis. But so can many other diet & lfestyle habits. See lipid metabolism above.
Lipoprotein metabolism and lipoprotein lipase in severe cystic acne. http://www.ncbi.nlm..../pubmed/2934279
Isotretinoin versus minocycline in cystic acne: a study of lipid metabolism. http://www.epistemon...b1706465b0ea71d
-Fewer llamelar granulars that contain the desquammation enzymes and lipids (the things that make cells exfoliate normally without clogging pores. Affected by linoleic acid deficiency more info & research in the above link)
-More permeable around sebaceous glands and follicles. (affected by linoleic acid deficiency)
-There are more estrogen/androgen receptors in skin of the acne prone, especially in males per the research. http://www.ncbi.nlm....pt=AbstractPlus And http://www.ncbi.nlm..../pubmed/6448587
-Higher levels of dehydroepiandrosterone (DHEA) are found in the sebaceous glands. This in turn is converted by 5-alpha reductase into DHT (possibly due to the deficiency in linoleic acid in sebum which inhibits the conversion) 5-alpha reductase can be inhibited by some nutrients, i.e. beta sito sterol, obtained in food, supplements, and can be topically applied)
-More of the enzymes that convert androgens and estrogens - (promoted by dairy, high GI diets, inhibited by linoleic acid)
-Deficient in retinoids, possible due to mutations in CYP26AI gene that causes it to be metabolized too fast to be used. These have a huge impact on hyperkeratinization and exfoliation, which would be why they are prescribed for acne treatments. http://www.acne.org/...n/#entry3229786 (may be boosted with beta carotene consumption & UVB exposure. This mutation may also impair ability to make vitamin D, an important factor in normal cell proliferation/desquammation)
-A subspecies of P. Acnes bacteria that may be more problematic that the species inhabiting normal skin. http://www.acne.org/...-2#entry3257204
There's also chronic inflammation, various hormones, stress, function of various organs such as liver, thyroid, adrenals, digestive tract and more. All affected by diet and lifestyle habits.
I.E. Some foods are anti-inflammatory such as omega 3 fats and just about any plant food, herb, tea or spice that isn't a seed and that you don't have an intolerance for. Other foods are pro-inflammatory such as sugars, trans fats & hydrogenated oils, omega 6 from seeds, seed oils, products from grain fed animals and anything you have an intolerance for.
Even Melatonin affects cell proliferation. And your melatonin levels are affected by your diet and your daily exposure to light and dark. You should be in bright light in the daytime. And darkness at night. Avoid artificial light as much as possible. This also affects hormones, and carb/glucose metabolism and is just about as big a factor in developing diabetes as diet. http://www.acne.org/...tion/?p=3216466
Edited by alternativista, 18 August 2014 - 01:05 PM.