is there anyway for the body to normalize sebum quality by itself? anyway to correct this linoleic deficiency from the inside through some calculated diet/supplements?
Well, since one theory is that the relative deficiency is due to the linoleic acid being diluted by excess sebum, anything that reduces excess sebum would help:
Foods that improve the PPAR receptor balance (which is what accutane does) such as resveraterol, sesamin (as in sesame seed), chlorophyll, fish oil/omega 3s, and linoleic acid. Also stable blood sugar/insulin.http://www.acne.org/...n/#entry3234944
Anything that supports thyroid function helps as thyroid hormone affects the composition of lipids:http://www.acne.org/...n/#entry3235072
Avoiding trans fats as studies have found that it accelerates the break down of linoleic and alpha linoleic acidshttp://www.acne.org/...n/#entry3235308
Gut flora also apparently affect lipid metabolism/profile in tissues. I don't know how, but I have an abstract to a study/report that says so:http://www.acne.org/...20#entry3242187
(The next topics about enzymes and possible mutations are harder to understand and simplify, and the points at which I start feeling to tired to continue and quit trying to get to the bottom of it all. But I suspect the root cause of our deficiency is here. Enzymes are how your genes do their jobs, btw.
Retinoids also affect lipids in sebum:
A phenotype mutation in the enzyme stearoyl-CoA desaturase 1 (SCD1
has been found in problem skin.http://www.acne.org/...n/#entry3235335
Coenzyme A/B5 are supplements that may improve this function.Beta carotene
and UV rays (sunlight) might stimulate retinoid production in the skin. I started gathering info on that here: http://www.acne.org/...00#entry3233046
And in the next post. The CYP26AI enzyme is involved in retinoic acid in the skin. I think it breaks it down, therefore we want to inhibit it. also affects vitamin D synthesis.Melatonin
- So cancer studies have found that 'high levels of melatonin released by the pineal gland block the ability of tumors to take up linoleic acid and convert it to 13-HODE (a molecule called 13-hydroxyoctadecadienoic acid). While exposed to light, however, melatonin levels are extremely low, and tumors are no longer protected by melatonin from the tumor-stimulating action of linoleic acid'
Yeah, so that's about cancer cells. But I'd say that as natural as possible circadian cycle
will improve your lipid profile and linoleic acid deficiency in sebaceous glands. Maybe the ability of your sebacious glands to take up linoleic acid.Avoid Aspirin and other NSAIDS. And steroids like cortisone:
the non-steroidal anti-inflammatory drugs (NSAIDs; antirheumatic drugs) like aspirin interfere with the complicated fatty acid metabolism via enzyme inhibition it is recommended to take into account any possible side effects of medication.
By means of the enzyme phospholipase A2, arachidonic acid is released from phospholipids. Prescriptions containing cortisone act as enzyme inhibitors and thus will prevent the formation of arachidonic acid metabolites which support inflammations. Any inflammatory processes in the skin can thus be treated immediately and also very effectively. The other side of the coin is, however, that the skin will develop deficiencies in the supply of other important fatty acids, a fact that will consequently result in atrophic skin.
(And see, I've decided that my dog scratches and chews himself to occupy himself whenever I leave him home alone. Like the dog version of cutting. So I'd nearly decided to take him to the vet for a cortisone shot to stop all the itching and hopefully by the time it wears off, the habit will be broken. But doing so will make his deficiency worse at the same time. )
Also note that peroxidated squalene has been implicated as a cause of the inflammation that is at the root of malformed cells that don't differentiate properly. http://www.acne.org/...0#entry3242146
And olive oil is high in squalene. http://www.acne.org/...20#entry3242176
Apparently 3 genes have been identified that affect the lipid profile in skin:Changes in at least 3 groups of genes encoding structural proteins, epidermal proteases and protease inhibitors predispose to a defective epidermal barrier and increase the risk of developing atopic dermatitis. http://www.acne.org/...20#entry3238844
And if we do have mutations in our genes/enzymes that govern these processes, then I'd say a topical application of linoleic acid is important.
Edited by alternativista, 12 June 2012 - 09:38 AM.
Status: Clear after 30 years. Wow, I guess it's been 6 years, now.
[ Story: Severe Acne since I was 10. 10+ years of Dermatologists, Antibiotics, topicals and ACCUTANE did nothing. Discovered oranges triggered the worst of my cystic acne = about 70% improvement. Tried some nutrient supplements like B-complex with zinc and C, saw palmetto and a BHA like the aspirin mask = more improvement, a lot less oily. Then, Diet changes = Clear.
Regimen: Anti-inflammatory, nutrient dense, blood sugar stabilizing diet and supplements (for hormones, inflammation, aging, health). No soap or other cleanser except for hand washing! Water only or Oil cleanse. Aloe Vera mixed with niacinimide and a high linoleic acid oil for moisturizer and reduce pigmentation.
Diet effects acne in so many ways: hormone balance, inflammation, Insulin levels, digestion, allergies and intolerances, liver function, adrenal function, SHBG levels, sebum quality, cell function and turnover, nutrient deficiencies, body fat, etc. Basic advice: Eat, sleep, supplement and exercise like you are a diabetic. And eat real food!
For more information, see my Good Things for Acne thread *Moderator edit - Please refer to the board rules (see “Advertising/soliciting”, “Linking” and “Signatures”)*
When you eat stuff, Stuff Happens!