But Sebum viscosity is affected by temperature. Sebum reduces water loss in the skin. At temperatures below 30c sebum is either solid or in liquid form.
It seems plausible that perturbation of the balance of solid and liquid components of sebum, such as by P. acnes action, may lead to blockage of the follicle. Future research will investigate strategies to dissolve and/or liquify the solid phase of sebum.
SUMMARY – The effect of a local increase or decrease in skin temperature on the rate of sebum excretion from forehead skin was studied in 9 subjects. The relationship between skin temperature and sebum excretion rate was highly significant, and heating and cooling produced changes of the orders of 10% per 1°C. These changes occurred within 90 min., which suggests that the sebum excretion rate measured by the present technique may not always accurately reflect the rate of sebum production deep in the glands. Variations in temperature affect the rate at which sebum is absorbed by the collecting papers, probably due to changes in sebum viscosity, and this could explain the observed changes in sebum excretion.
investigators have noted that accutane has
- resulted in a reduction of facial skin temperature by up to 1 degree C within 3 days of treatment,
- led to a 40 percent reduction in blood flow through the cheeks (as measured by laser doppler)
- eliminated facial burning in 18 patients within several weeks of taking accutane.
Wikipedia: Human Body Temperature
Edited by RedPatrick, 27 February 2012 - 02:37 PM.