I for one don't have acne anymore since I reduced my sebum production to an extent and got rid of my p bacteria. Oily skin is still a big problem for me.
Accutane reduces oil production and this manages to help solve the acne problem. But it doesn't solve the root of the problem: the cause of sebum overproduction during and after production.
It seems that androgens like testosterone and DHT stimulate the growth of sebaceous glands and oil production, and it won't be a good idea to go on Androgen Inhibitors. However, topical anti-androgens are proven to reduce sebaceous activity - studies done on mice.
That's one way of solving the problems.
What to do?
Get some Topical Anti-Androgens
More specifically, sebaceous glands are not directly affected by DHT, but rather testosterone. Studies have shown that testosterone exerts it's effects on the sebaceous glands through 5ar - 5 Alpha Reductase which converts the testosterone to DHT at the immediate site. Inhibiton of 5ar should theoretically inhibit the production of sebum, and thereby prevent acne.
Inhibition of 5 alpha-reductase activity in human skin by zinc and azelaic acid.
The effects of zinc sulphate and azelaic acid on 5 alpha-reductase activity in human skin were studied using an in vitro assay with 1,2[3H]-testosterone as substrate. When added at concentrations of 3 or 9 mmol/l, zinc was a potent inhibitor of 5 alpha-reductase activity. At high concentrations, zinc could completely inhibit the enzyme activity. Azelaic acid was also a potent inhibitor of 5 alpha-reductase; inhibition was detectable at concentrations as low as 0.2 mmol/l and was complete at 3 mmol/l. An additive effect of the two inhibitors was observed. Vitamin B6 potentiated the inhibitory effect of zinc, but not of azelaic acid, suggesting that two different mechanisms are involved. When the three substances were added together at very low concentrations which had been shown to be ineffective alone, 90% inhibition of 5 alpha-reductase activity was obtained. If this inhibition is confirmed in vivo, zinc sulphate combined with azelaic acid could be an effective agent in the treatment of androgen related pathology of human skin.
Perhaps the use of oral zinc and B6 supplementation in conjunction with topical Zinc Pyrithione and Oxide as wells as Azeleic Acid, could lessen the production of sebum.
Zinc, azelaic acid, β-sitosterol, certain unsaturated aliphatic fatty acids such as gamma-linolenic acid, alpha-linolenic acid, linoleic acid, and oleic acid, and a variety of polyphenols have been found to inhibit 5α-reductase activity to varying degrees.
What to do?
Get yourself a 5ar inhibitor. Preferrably topical.
The sebaceous gland
The development and function of the sebaceous gland in the fetal and neonatal periods appear to be regulated by maternal androgens and by endogenous steroid synthesis, as well as by other morphogens. The most apparent function of the glands is to excrete sebum. A strong increase in sebum excretion occurs a few hours after birth; this peaks during the first week and slowly subsides thereafter. A new rise takes place at about age 9 years with adrenarche and continues up to age 17 years, when the adult level is reached. The sebaceous gland is a target organ but also an important formation site of hormones, and especially of active androgens. Hormonal activity is based on an hormone (ligand)-receptor interaction, whereas sebocytes express a wide spectrum of hormone receptors. Androgens are well known for their effects on sebum excretion, whereas terminal sebocyte differentiation is assisted by peroxisome proliferator-activated receptor ligands. Estrogens, glucocorticoids, and prolactin also influence sebaceous gland function. In addition, stress-sensing cutaneous signals lead to the production and release of corticotrophin-releasing hormone from dermal nerves and sebocytes with subsequent dose-dependent regulation of sebaceous nonpolar lipids. Among other lipid fractions, sebaceous glands have been shown to synthesize considerable amounts of free fatty acids without exogenous influence. Atopic dermatitis, seborrheic dermatitis, psoriasis and acne vulgaris are some of the disease on which pathogenesis and severity sebaceous lipids may or are surely involved.
See, some of you guys like to masturbate. Do you know what happens when you masturbate? You release prolactin and cortisol. Testosterone is also elevated for some time afterwards. Testosterone converts to estrogen as well. IGF1 is also increased by testosterone, which plays a big role in acne.
What to do?
Don't masturbate. Simple as.
Free fatty acids are used by the bacteria in order to grow. You have to inhibit free fatty acids in the bloodstream to prevent new acne formation at night when the hormones peak and sebaceous activity increases.
What to do?
Use 500mg Niacin (Flush Version) before bed
Bacteria causes inflammation of the clogged pore. Get rid of the bacteria using an antibacterial and strengthen the immune system.
What to do?
Take lactoferrin 250mg x 3-4 per day
Take colostrum - up to you.
Stop when your acne is gone.
There is a slight problem, you might not want to overdo this and get rid of all the bacteria because yeast competes with bacteria. Rather have bacteria than yeast because it's frickin hard to cure yeast acne. I should know... Been there done that.
Another problem is that certain dietary foods can increase and decrease SHBG levels. Sexual Hormone Binding Globin regulates androgenic and estrogenic binding. Free testsoterone and oestrogen are able to bind effectively to the receptors and carry out their functions, such as converting to local DHT and stimulating Sebum production. Increasing SHBG results in more bound up testosterone thereby lowering the androgenic/sebaceous activity of testosterone overral.
SHBG levels appear to be controlled by a delicate balance of enhancing and inhibiting factors. Its level is decreased by high levels of insulin and insulin-like growth factor 1 (IGF-1) (see:milk). Also, high androgen and transcortin levels decrease SHBG, whereas high growth hormone, estrogen, and thyroxine levels increase it.
However, recent evidence suggests that it is the liver's production of fats that reduces SHBG levels, not any direct effect of insulin and specific genetic mechanisms that do this have been found.
Now, testosterone decreases SHBG, and oestrogens increase SHBG. The older you get, the more Testosterone you produce - until your 30s I think, which is when you go through Andropause.
I took some testosterone boosters and some steroids a while back, most importantly oxandrolone which inhibits SHBG potently. Even after stopping oxandrolone, SHBG will remain inhibited for a very long time - 8+ months. Boy, I regret taking oxandrolone now.
What to do?
Green Tea Extract! Drink the stuff or supplement it.
Hmmm, now that we have the sebum issue covered, we should focus on preventing the pores from getting clogged. We can always kill the acne with benzoyl peroxide and our own defense system, but we can't prevent pores from getting clogged.
If the pores don't get clogged in the first place, the sebum that we need to keep our skin naturally healthy, will flow freely onto the skin - just like it should.
WIll update later.
Edited by RedPatrick, 19 February 2012 - 01:47 PM.