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Genes Involved In Acne

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#21 radikal

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Posted 09 April 2012 - 12:02 PM

@tritonxiv:
My take on the range of severities:

a) mild acne, acne vulgaris: may or may not be genetical, more likely not. It wouldn't make sense otherwise as upwards to 90% of teens are affected, it must be hormonal (DHT, etc)
b) adult acne (> 25y/o), cystic acne at any age - definitely genetic.
c) over-production of sebum - definitely genetic (just like with seborheea in Parkinson's).

#22 alternativista

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Posted 20 April 2012 - 01:36 PM

How is it worse in winter? Melatonin affects cell proliferation so perhaps the altered melatonin cycle in winter is a factor.

Have you tried applying a linoleic acid source topically?


Also there's a change in ceramide production that affects skin permeability and makes skin more sensitive in winter. There's more on that in the linoleic acid thread.

Also, there's links to abstracts of articles/studies that say at least 3 genes/enzyme mutations are involved in the linoleic acid deficiency found in mammalian skin prone to skin irritations of all sorts. http://www.acne.org/...pical-solution/

Edited by alternativista, 11 June 2012 - 10:39 AM.

Status: Clear after 30 years. Wow, I guess it's been 6 years, now.

[ Story: Severe Acne since I was 10. 10+ years of Dermatologists, Antibiotics, topicals and ACCUTANE did nothing. Discovered oranges triggered the worst of my cystic acne = about 70% improvement. Tried some nutrient supplements like B-complex with zinc and C, saw palmetto and a BHA like the aspirin mask = more improvement, a lot less oily. Then, Diet changes = Clear.

Regimen: Anti-inflammatory, nutrient dense, blood sugar stabilizing diet and supplements (for hormones, inflammation, aging, health). No soap or other cleanser except for hand washing! Water only or Oil cleanse. Aloe Vera mixed with niacinimide and a high linoleic acid oil for moisturizer and reduce pigmentation.

Diet effects acne in so many ways: hormone balance, inflammation, Insulin levels, digestion, allergies and intolerances, liver function, adrenal function, SHBG levels, sebum quality, cell function and turnover, nutrient deficiencies, body fat, etc. Basic advice: Eat, sleep, supplement and exercise like you are a diabetic. And eat real food!

For more information, see my Good Things for Acne thread *Moderator edit - Please refer to the board rules (see “Advertising/soliciting”, “Linking” and “Signatures”)*

When you eat stuff, Stuff Happens!


#23 Sum1killme

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Posted 05 July 2012 - 05:57 PM

It has to do something with genetics not every single teen gets acne actually i remember in my high school very little people had acne maby 3%. I of course was in that 3 percent so i know who had it or not.

#24 Kin92

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Posted 11 July 2012 - 01:15 AM

My mom has oily skin, very mild hormonal acne, and my dad had only mild acne on his back, and I got the unlucky combo Posted Image But everything is getting better

#25 Jc08

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Posted 11 July 2012 - 06:01 AM

Mother's side of the family is plagued with acne. Unfortunately, she passed down her terrible, terrible genetics to my three brothers and I. Ironic how I had the most severe acne and accutane failed to work for me, sigh.....

#26 alternativista

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Posted 16 July 2012 - 09:02 AM

Of course they exist. They just have no bearing on acne.


Yes they do. 1) allergy and other intolerances promote inflammation which is at the root of acne formation. and 2) some get pimple formation as a direct response to the allergen within a day of exposure, although I think this is not necessarily true acne. I also wonder about women who breakout along with their cycle. How does it happen that fast?

I think the symptom of acne can be produced by many pathways and they don't all follow the several week process they tell us.

Mother's side of the family is plagued with acne. Unfortunately, she passed down her terrible, terrible genetics to my three brothers and I. Ironic how I had the most severe acne and accutane failed to work for me, sigh.....


Have you tried improving your diet and lifestyle habits? Keep blood sugar stable? Fill up on nutrient dense foods rather than processed empty and nearly empty calorie crap? Sleep well?

Accutane did nothing for me as well. Nor did anything else any dermatologist ever prescribed. But many years later, diet changes cleared me.

Status: Clear after 30 years. Wow, I guess it's been 6 years, now.

[ Story: Severe Acne since I was 10. 10+ years of Dermatologists, Antibiotics, topicals and ACCUTANE did nothing. Discovered oranges triggered the worst of my cystic acne = about 70% improvement. Tried some nutrient supplements like B-complex with zinc and C, saw palmetto and a BHA like the aspirin mask = more improvement, a lot less oily. Then, Diet changes = Clear.

Regimen: Anti-inflammatory, nutrient dense, blood sugar stabilizing diet and supplements (for hormones, inflammation, aging, health). No soap or other cleanser except for hand washing! Water only or Oil cleanse. Aloe Vera mixed with niacinimide and a high linoleic acid oil for moisturizer and reduce pigmentation.

Diet effects acne in so many ways: hormone balance, inflammation, Insulin levels, digestion, allergies and intolerances, liver function, adrenal function, SHBG levels, sebum quality, cell function and turnover, nutrient deficiencies, body fat, etc. Basic advice: Eat, sleep, supplement and exercise like you are a diabetic. And eat real food!

For more information, see my Good Things for Acne thread *Moderator edit - Please refer to the board rules (see “Advertising/soliciting”, “Linking” and “Signatures”)*

When you eat stuff, Stuff Happens!


#27 Jc08

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Posted 16 July 2012 - 11:33 AM


Of course they exist. They just have no bearing on acne.


Yes they do. 1) allergy and other intolerances promote inflammation which is at the root of acne formation. and 2) some get pimple formation as a direct response to the allergen within a day of exposure, although I think this is not necessarily true acne. I also wonder about women who breakout along with their cycle. How does it happen that fast?

I think the symptom of acne can be produced by many pathways and they don't all follow the several week process they tell us.

Mother's side of the family is plagued with acne. Unfortunately, she passed down her terrible, terrible genetics to my three brothers and I. Ironic how I had the most severe acne and accutane failed to work for me, sigh.....


Have you tried improving your diet and lifestyle habits? Keep blood sugar stable? Fill up on nutrient dense foods rather than processed empty and nearly empty calorie crap? Sleep well?

Accutane did nothing for me as well. Nor did anything else any dermatologist ever prescribed. But many years later, diet changes cleared me.


Hey,

I've actually been reading all your posts regarding dieting and everything. However, I have an extremely fast metabolism and every time I attempt to diet, it leaves me starving and feeling weak. The only foods that I have totally eliminated from my diet are dairy, refined sugars, and pork. I'm also taking a daily multivitamin, vitamin e+c. Before I actually got acne I use to have refined sugars, dairy, and pork on a daily basis, now not anymore. I also have an oil problem, which I know is the culprit for my acne. Do you have any idea how chromium supplements might help me?

#28 alternativista

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Posted 16 July 2012 - 12:13 PM

Hey,

I've actually been reading all your posts regarding dieting and everything. However, I have an extremely fast metabolism and every time I attempt to diet, it leaves me starving and feeling weak. The only foods that I have totally eliminated from my diet are dairy, refined sugars, and pork. I'm also taking a daily multivitamin, vitamin e+c. Before I actually got acne I use to have refined sugars, dairy, and pork on a daily basis, now not anymore. I also have an oil problem, which I know is the culprit for my acne. Do you have any idea how chromium supplements might help me?

Chromium helps with stable blood sugar.

What do you mean by diet? Because this doesn't necessarily involve calorie reduction. Do you have trouble finding substitutes for grains and refined carbs? I used to feel weak when I was hungry. Often just before lunchtime. And it was a big problem when traveling since I used to eat breakfast nearly first thing and when you travel, you usually get ready and head out somewhere before eating. I nearly passed out once but usually got nauseous. I don't have that problem anymore since improving my diet. Now I walk the dog first and often other exercise and chores before breakfast to deliberately prolong the fast.

Also a once a day multi vitamin is usually useless. It does no good to take water soluble vitamins once and there are many nutrients for which your body can only take in so much at a time, and that amount is not the RDA, most of which are too low. And to get enough magnesium, it would make a really, really big pill. I take nature's way alive twice a day. It's meant to be taken 3 times, but I eat well, especially at lunch, so I stretch my dollars a bit by not taking it then.

Edited by alternativista, 12 November 2012 - 04:46 PM.

Status: Clear after 30 years. Wow, I guess it's been 6 years, now.

[ Story: Severe Acne since I was 10. 10+ years of Dermatologists, Antibiotics, topicals and ACCUTANE did nothing. Discovered oranges triggered the worst of my cystic acne = about 70% improvement. Tried some nutrient supplements like B-complex with zinc and C, saw palmetto and a BHA like the aspirin mask = more improvement, a lot less oily. Then, Diet changes = Clear.

Regimen: Anti-inflammatory, nutrient dense, blood sugar stabilizing diet and supplements (for hormones, inflammation, aging, health). No soap or other cleanser except for hand washing! Water only or Oil cleanse. Aloe Vera mixed with niacinimide and a high linoleic acid oil for moisturizer and reduce pigmentation.

Diet effects acne in so many ways: hormone balance, inflammation, Insulin levels, digestion, allergies and intolerances, liver function, adrenal function, SHBG levels, sebum quality, cell function and turnover, nutrient deficiencies, body fat, etc. Basic advice: Eat, sleep, supplement and exercise like you are a diabetic. And eat real food!

For more information, see my Good Things for Acne thread *Moderator edit - Please refer to the board rules (see “Advertising/soliciting”, “Linking” and “Signatures”)*

When you eat stuff, Stuff Happens!


#29 Jc08

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Posted 16 July 2012 - 12:59 PM



Of course they exist. They just have no bearing on acne.


Yes they do. 1) allergy and other intolerances promote inflammation which is at the root of acne formation. and 2) some get pimple formation as a direct response to the allergen within a day of exposure, although I think this is not necessarily true acne. I also wonder about women who breakout along with their cycle. How does it happen that fast?

I think the symptom of acne can be produced by many pathways and they don't all follow the several week process they tell us.

Mother's side of the family is plagued with acne. Unfortunately, she passed down her terrible, terrible genetics to my three brothers and I. Ironic how I had the most severe acne and accutane failed to work for me, sigh.....


Have you tried improving your diet and lifestyle habits? Keep blood sugar stable? Fill up on nutrient dense foods rather than processed empty and nearly empty calorie crap? Sleep well?

Accutane did nothing for me as well. Nor did anything else any dermatologist ever prescribed. But many years later, diet changes cleared me.


Hey,

I've actually been reading all your posts regarding dieting and everything. However, I have an extremely fast metabolism and every time I attempt to diet, it leaves me starving and feeling weak. The only foods that I have totally eliminated from my diet are dairy, refined sugars, and pork. I'm also taking a daily multivitamin, vitamin e+c. Before I actually got acne I use to have refined sugars, dairy, and pork on a daily basis, now not anymore. I also have an oil problem, which I know is the culprit for my acne. Do you have any idea how chromium supplements might help me?


^^

Yes, I'm actually having a hard time finding substitutes for grains and refined carbs, again I'm very new to this and changing diets is very difficult for me because of my previous eating habits before I broke out. I'm also confused on what you meant by taking once a day multivitamins being useless? Is nature's way alive a better multivitamin alternative? I know for a fact my acne is 100% hormonal considering 1. dairy breaks me out horribly, and 2. masturbation causes me to breakout
.

#30 Binga

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Posted 22 July 2012 - 01:07 AM

Gene therapy for acne in the future could be the solution:

http://www.bbc.co.uk...health-18926892

#31 radikal

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Posted 26 July 2012 - 05:57 AM

Gene therapy for acne in the future could be the solution:

http://www.bbc.co.uk...health-18926892


This is probably the first news item that makes me see some sort of light down the road.

I have an unshaken belief the root cause of genetic acne is some sort of lipase metabolism disorder COMBINED with a hyper-keratinization disorder.
If they're considering approval of gene therapy then they must have worked out a less dangerous viral vector.

I'll look into getting tested for fat metabolism disorders (which are not that uncommon).

#32 alternativista

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Posted 12 February 2013 - 11:27 AM

Genetic control of sebum excretion and acne--a twin study.
[url=http://www.ncbi.nlm....med?term=Walton S[Author]&cauthor=true&cauthor_uid=2965597]Walton S

 [url=http://www.ncbi.nlm....bmed?term=Wyatt EH[Author]&cauthor=true&cauthor_uid=2965597]Wyatt EH, [url=http://www.ncbi.nlm....d?term=Cunliffe WJ[Author]&cauthor=true&cauthor_uid=2965597]Cunliffe WJ.


Source
Department of Dermatology, Hull Royal Infirmary, U.K.

Abstract

Sebum excretion and acne grades were measured in 20 pairs each of identical and non-identical like-sex twins. The identical twins had virtually identical rates of sebum excretion (P greater than 0.05), but they had a significantly different degree of acne severity (P less than 0.01). The non-identical twins had significantly different sebum excretion rates (P less than 0.01) and acne grades (P less than 0.01). These findings suggest that sebum excretion is under genetic control and the development of clinical lesions is modified by environmental factors.

,

Although many of us, myself included, have found that diet and other habits can improve sebum output. And quality.  So I doubt this study isof any validity.

 

This study on the genetics of P acnes finds that there we might have a subspecies of the bacteria that causes acne as opposed to the bacteria present in normal skin:
 

Population genetic analysis of Propionibacterium acnes identifies a subpopulation and epidemic clones associated with acne.

The involvement of Propionibacterium acnes in the pathogenesis of acne is controversial, mainly owing to its dominance as an inhabitant of healthy skin. This study tested the hypothesis that specific evolutionary lineages of the species are associated with acne while others are compatible with health. Phylogenetic reconstruction based on nine housekeeping genes was performed on 210 isolates of P. acnes from well-characterized patients with acne, various opportunistic infections, and from healthy carriers. Although evidence of recombination was observed, the results showed a basically clonal population structure correlated with allelic variation in the virulence genes tlyand camp5, with pulsed field gel electrophoresis (PFGE)- and biotype, and with expressed putative virulence factors. An unexpected geographically and temporal widespread dissemination of some clones was demonstrated. The population comprised three major divisions, one of which, including an epidemic clone, was strongly associated with moderate to severe acne while others were associated with health and opportunistic infections. This dichotomy correlated with previously observed differences in in vitro inflammation-inducing properties. Comparison of five genomes representing acne- and health-associated clones revealed multiple both cluster- and strain-specific genes that suggest major differences in ecological preferences and redefines the spectrum of disease-associated virulence factors. The results of the study indicate that particular clones of P. acnes play an etiologic role in acne while others are associated with health.

 

 


Full article: http://www.ncbi.nlm....82/?tool=pubmed


Edited by alternativista, 10 October 2013 - 01:31 PM.

Status: Clear after 30 years. Wow, I guess it's been 6 years, now.

[ Story: Severe Acne since I was 10. 10+ years of Dermatologists, Antibiotics, topicals and ACCUTANE did nothing. Discovered oranges triggered the worst of my cystic acne = about 70% improvement. Tried some nutrient supplements like B-complex with zinc and C, saw palmetto and a BHA like the aspirin mask = more improvement, a lot less oily. Then, Diet changes = Clear.

Regimen: Anti-inflammatory, nutrient dense, blood sugar stabilizing diet and supplements (for hormones, inflammation, aging, health). No soap or other cleanser except for hand washing! Water only or Oil cleanse. Aloe Vera mixed with niacinimide and a high linoleic acid oil for moisturizer and reduce pigmentation.

Diet effects acne in so many ways: hormone balance, inflammation, Insulin levels, digestion, allergies and intolerances, liver function, adrenal function, SHBG levels, sebum quality, cell function and turnover, nutrient deficiencies, body fat, etc. Basic advice: Eat, sleep, supplement and exercise like you are a diabetic. And eat real food!

For more information, see my Good Things for Acne thread *Moderator edit - Please refer to the board rules (see “Advertising/soliciting”, “Linking” and “Signatures”)*

When you eat stuff, Stuff Happens!


#33 alternativista

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Posted 14 March 2013 - 12:43 PM

I just noticed the wikipedia article has a couple more genes to look into:

 

The predisposition for specific individuals to acne is likely explained by a genetic component, which has been supported by twin studies as well as studies that have looked at rates of acne among first degree relatives. The genetics of acne susceptibility is likely polygenic, as the disease does not follow classic Mendelian inheritance pattern. There are multiple candidates for genes which are possibly related to acne, including polymorphisms in TNF-alphaIL-1 alphaCYP1A1 among others.[19]


Edited by alternativista, 10 October 2013 - 01:32 PM.

Status: Clear after 30 years. Wow, I guess it's been 6 years, now.

[ Story: Severe Acne since I was 10. 10+ years of Dermatologists, Antibiotics, topicals and ACCUTANE did nothing. Discovered oranges triggered the worst of my cystic acne = about 70% improvement. Tried some nutrient supplements like B-complex with zinc and C, saw palmetto and a BHA like the aspirin mask = more improvement, a lot less oily. Then, Diet changes = Clear.

Regimen: Anti-inflammatory, nutrient dense, blood sugar stabilizing diet and supplements (for hormones, inflammation, aging, health). No soap or other cleanser except for hand washing! Water only or Oil cleanse. Aloe Vera mixed with niacinimide and a high linoleic acid oil for moisturizer and reduce pigmentation.

Diet effects acne in so many ways: hormone balance, inflammation, Insulin levels, digestion, allergies and intolerances, liver function, adrenal function, SHBG levels, sebum quality, cell function and turnover, nutrient deficiencies, body fat, etc. Basic advice: Eat, sleep, supplement and exercise like you are a diabetic. And eat real food!

For more information, see my Good Things for Acne thread *Moderator edit - Please refer to the board rules (see “Advertising/soliciting”, “Linking” and “Signatures”)*

When you eat stuff, Stuff Happens!


#34 alternativista

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Posted 08 January 2014 - 03:43 PM

I made a limited effort to substantiate my statements and also learned something new in the process.
Older research from 2002 (which I read back then but did not keep an index to):
http://www.nature.co...l/5603340a.html

And newer (2009) and very interesting finding:
http://www.nature.co...jid200947a.html
the take-away being: "A genetic background is suggested, with mother's acne history being the most important prognostic factor".

which is entirely aligned with my family's experience, with acne transmitted along maternal line for the three generations I have data on.
So it's a chromosome X linked defect then, hmmm...it follows that if I conceive a BOY with an unaffected female it should result in unaffected offspring if my cursory understanding of genetics is correct.
XY (me) + XX (unaffected female) --> X(clear female)Y(clear me) = clear BOY or X(clear female)X(affected me) = acne GIRL
XY (me) + XX (affected female) --> X(affected female)Y(clear me) = acne BOY or X(affected female)X(affected me) = double-acne GIRL

Looks like acne girls should not conceive, and acne guys should only have boys with clear girls; don't hate, I'm just a messenger....

 

My acne prone father conceived boys & girls with clear skinned girl.  All acne prone.


Status: Clear after 30 years. Wow, I guess it's been 6 years, now.

[ Story: Severe Acne since I was 10. 10+ years of Dermatologists, Antibiotics, topicals and ACCUTANE did nothing. Discovered oranges triggered the worst of my cystic acne = about 70% improvement. Tried some nutrient supplements like B-complex with zinc and C, saw palmetto and a BHA like the aspirin mask = more improvement, a lot less oily. Then, Diet changes = Clear.

Regimen: Anti-inflammatory, nutrient dense, blood sugar stabilizing diet and supplements (for hormones, inflammation, aging, health). No soap or other cleanser except for hand washing! Water only or Oil cleanse. Aloe Vera mixed with niacinimide and a high linoleic acid oil for moisturizer and reduce pigmentation.

Diet effects acne in so many ways: hormone balance, inflammation, Insulin levels, digestion, allergies and intolerances, liver function, adrenal function, SHBG levels, sebum quality, cell function and turnover, nutrient deficiencies, body fat, etc. Basic advice: Eat, sleep, supplement and exercise like you are a diabetic. And eat real food!

For more information, see my Good Things for Acne thread *Moderator edit - Please refer to the board rules (see “Advertising/soliciting”, “Linking” and “Signatures”)*

When you eat stuff, Stuff Happens!


#35 alternativista

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Posted 27 June 2014 - 09:14 AM

If only some one was looking into how we might flip the epigenetic switches on the genes/enzyme mutations that have been identified in acne prone skin. And I don't mean with drugs. There are several mechanisms.

Methylation is one and that means diet- several sulfur containing amino acids an b vitamins.

Status: Clear after 30 years. Wow, I guess it's been 6 years, now.

[ Story: Severe Acne since I was 10. 10+ years of Dermatologists, Antibiotics, topicals and ACCUTANE did nothing. Discovered oranges triggered the worst of my cystic acne = about 70% improvement. Tried some nutrient supplements like B-complex with zinc and C, saw palmetto and a BHA like the aspirin mask = more improvement, a lot less oily. Then, Diet changes = Clear.

Regimen: Anti-inflammatory, nutrient dense, blood sugar stabilizing diet and supplements (for hormones, inflammation, aging, health). No soap or other cleanser except for hand washing! Water only or Oil cleanse. Aloe Vera mixed with niacinimide and a high linoleic acid oil for moisturizer and reduce pigmentation.

Diet effects acne in so many ways: hormone balance, inflammation, Insulin levels, digestion, allergies and intolerances, liver function, adrenal function, SHBG levels, sebum quality, cell function and turnover, nutrient deficiencies, body fat, etc. Basic advice: Eat, sleep, supplement and exercise like you are a diabetic. And eat real food!

For more information, see my Good Things for Acne thread *Moderator edit - Please refer to the board rules (see “Advertising/soliciting”, “Linking” and “Signatures”)*

When you eat stuff, Stuff Happens!



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