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#41 onefatalgoose

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Posted 21 February 2013 - 10:19 AM

And this forum is filled with people for whom it didn't work. And with people who chose not to use medicines that cause harm.

 

This forum is also filled with people who haven't made much progress with their acne in years. So not much of an argument.

 

 

I believe the argument here is still that benzoyl peroxide works for some, and doesn't for others.  And for the people it does work for, they are still subjecting their skin to extremely high levels of oxidative stress, which causes the redness, dryness, itchiness, and long term skin damage from free radicals.  So...while it may be effective at treating acne for many people, it comes with a price.  

 

The same can be said for most if not all modern medicines.  They may serve the purpose they are prescribed for, but they come with a whole host of side-effects that interfere with other important metabolic processes.  They are band-aid fixes, and most illness/disease can be prevented and even reversed via proper nutrition and avoidance of toxic foods so commonly found in the western diet.  

 

Also, what about green tea cream?  Apparently there was a study conducted by a Dr. Jennifer Gan-Wong from the Memorial Medical Center in the Philippines that showed a 3% concentration of green tea cream was as effective at treating acne as a 4% concentration of benzoyl peroxide.  I wish i could find the actual study itself.  It is cited repeatedly, but i'd still love to see the study.  I think you have to pay a monthly fee to get access to some of these studies, which is unfortunate.  


                                                      80%-20% Alkaline forming vs Acid forming Diet

                                                                                `Organic~
                                                                            I don't consume:
                                                                                     *Dairy
                                                                               *Whole grains
                                                                             *Refined sugars
                                                                                 *Table salt
                                                                              *Vegetable oils
                                                                        *Processed/Fast foods
                                           *Genetically Modified Foods (GMOs)
                                                                      As well as the pesticides/herbicides that come with them

                                                      My philosophy: Less externally, more internally

                 Even taking long hot showers in chemically treated tap water is too harsh for acne prone skin

                                                                 (And that's without a face wash)

                         

                                     This site is absolutely loaded with info on curing acne internally

 


#42 sepsi

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Posted 21 February 2013 - 09:38 PM

I believe the argument here is still that benzoyl peroxide works for some, and doesn't for others.  And for the people it does work for, they are still subjecting their skin to extremely high levels of oxidative stress, which causes the redness, dryness, itchiness, and long term skin damage from free radicals.  So...while it may be effective at treating acne for many people, it comes with a price.  

 

The same can be said for most if not all modern medicines.  They may serve the purpose they are prescribed for, but they come with a whole host of side-effects that interfere with other important metabolic processes.  They are band-aid fixes, and most illness/disease can be prevented and even reversed via proper nutrition and avoidance of toxic foods so commonly found in the western diet.  

 

Also, what about green tea cream?  Apparently there was a study conducted by a Dr. Jennifer Gan-Wong from the Memorial Medical Center in the Philippines that showed a 3% concentration of green tea cream was as effective at treating acne as a 4% concentration of benzoyl peroxide.  I wish i could find the actual study itself.  It is cited repeatedly, but i'd still love to see the study.  I think you have to pay a monthly fee to get access to some of these studies, which is unfortunate.  

 

 

I'm not arguing against the statement that BP has side-effects, or that it's an oxidizing agent and causes oxidative damage in the skin. I argue against black and white thinking that's so prevalent here. I argue against statements like 'BP causes oxidative damage, therefore it's automatically bad and should be shunned'.
 
Here's the point that argument misses. ACNE itself causes a lot of oxidative damage on the skin. So if something reduces acne it most likely reduces inflammation in the skin.
 
The way I see it is that BP causes little oxidative damage to prevent bigger damage from occuring. This is evident from the fact that for many people, but not for everybody, acne goes away and skin becomes less red and irritated when they use BP.
 
I'm the first person to admit that BP can also make your skin worse. If you use too much of it or the concentration is too strong. And with moisturizers or antioxidant creams you can mitigate the damage even further.
 
If you can find a natural cream that gets the same results, then fantastic. So far there has been done, and I'm pretty up to date with research on acne. As I said, there are some promising candidates, like niacin and vitamin C derivates. Green tea catechins might also work, but so far the studies have been way too small and inconclusive to say for sure.
 
I'm not aware of the study you are referring to. This is the latest green tea related acne study in the PubMed index:
 


#43 alternativista

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Posted 22 February 2013 - 08:03 AM



And this forum is filled with people for whom it didn't work. And with people who chose not to use medicines that cause harm.

 
This forum is also filled with people who haven't made much progress with their acne in years. So not much of an argument.
It has a few people that haven't made much progress, including some who have real health issues. Most people who clear their skin stop posting regularly. But the forum is filled with how I cleared my skin threads.

Edited by alternativista, 22 February 2013 - 08:43 AM.

Status: Clear after 30 years. Wow, I guess it's been 6 years, now.

[ Story: Severe Acne since I was 10. 10+ years of Dermatologists, Antibiotics, topicals and ACCUTANE did nothing. Discovered oranges triggered the worst of my cystic acne = about 70% improvement. Tried some nutrient supplements like B-complex with zinc and C, saw palmetto and a BHA like the aspirin mask = more improvement, a lot less oily. Then, Diet changes = Clear.

Regimen: Anti-inflammatory, nutrient dense, blood sugar stabilizing diet and supplements (for hormones, inflammation, aging, health). No soap or other cleanser except for hand washing! Water only or Oil cleanse. Aloe Vera mixed with niacinimide and a high linoleic acid oil for moisturizer and reduce pigmentation.

Diet effects acne in so many ways: hormone balance, inflammation, Insulin levels, digestion, allergies and intolerances, liver function, adrenal function, SHBG levels, sebum quality, cell function and turnover, nutrient deficiencies, body fat, etc. Basic advice: Eat, sleep, supplement and exercise like you are a diabetic. And eat real food!

For more information, see my Good Things for Acne thread *Moderator edit - Please refer to the board rules (see “Advertising/soliciting”, “Linking” and “Signatures”)*

When you eat stuff, Stuff Happens!

#44 alternativista

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Posted 22 February 2013 - 12:48 PM

The value of green tea/EGCG has been known for a while, but this study identifies several factors affected by topical EGCG

Epigallocatechin-3-Gallate Improves Acne in Humans by Modulating Intracellular Molecular Targets and Inhibiting P. acnes.
[url=http://www.ncbi.nlm....ubmed?term=Yoon JY[Author]&cauthor=true&cauthor_uid=23096708]Yoon JY


Source
Acne Research Laboratory, Seoul National University Hospital, Seoul, South Korea.



Abstract

Acne vulgaris is a highly prevalent skin disorder characterized by hyperseborrhea, inflammation, and Propionibacterium acnes overgrowth. Only isotretinoin and hormonal therapy reduce sebum production. To identify a new drug candidate that modulates sebum, we examined the effects of EGCG, the major polyphenol in green tea, on human SEB-1 sebocytes and in patients with acne. In SEB-1 sebocytes, we found that EGCG reduced sebum by modulating the AMPK-SREBP-1 signaling pathway. EGCG also reduces inflammation by suppressing the NF-κB and AP-1 pathways. EGCG also induces cytotoxicity of SEB-1 sebocytes via apoptosis and decreases the viability of P. acnes, thus targeting almost all the pathogenic features of acne. Finally, and most importantly, EGCG significantly improved acne in an 8-week randomized, split-face, clinical trial, and was well tolerated. Our data provide a therapeutic rationale for the use of EGCG in acne.


 


Status: Clear after 30 years. Wow, I guess it's been 6 years, now.

[ Story: Severe Acne since I was 10. 10+ years of Dermatologists, Antibiotics, topicals and ACCUTANE did nothing. Discovered oranges triggered the worst of my cystic acne = about 70% improvement. Tried some nutrient supplements like B-complex with zinc and C, saw palmetto and a BHA like the aspirin mask = more improvement, a lot less oily. Then, Diet changes = Clear.

Regimen: Anti-inflammatory, nutrient dense, blood sugar stabilizing diet and supplements (for hormones, inflammation, aging, health). No soap or other cleanser except for hand washing! Water only or Oil cleanse. Aloe Vera mixed with niacinimide and a high linoleic acid oil for moisturizer and reduce pigmentation.

Diet effects acne in so many ways: hormone balance, inflammation, Insulin levels, digestion, allergies and intolerances, liver function, adrenal function, SHBG levels, sebum quality, cell function and turnover, nutrient deficiencies, body fat, etc. Basic advice: Eat, sleep, supplement and exercise like you are a diabetic. And eat real food!

For more information, see my Good Things for Acne thread *Moderator edit - Please refer to the board rules (see “Advertising/soliciting”, “Linking” and “Signatures”)*

When you eat stuff, Stuff Happens!

#45 sepsi

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Posted 25 February 2013 - 08:39 AM

The value of green tea/EGCG has been known for a while, but this study identifies several factors affected by topical EGCG

 

There are also a few other green tea studies. The problem is that none of them are definitive. The study you referred was mostly in vitro, though it also had an in vivo part. These studies are interesting and provide some evidence for green tea and EGCG but the problem is that they don't have proper controls. Once we see a few studies with 100 or so participants that compare EGCG cream to BP head to head then I can say that there's reasonably good evidence for it. Such studies exists for vitamin B3 and vitamin C derivates.



#46 Binga

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Posted 25 February 2013 - 08:46 AM

I would also add topical vitamin b5 to the list. It was greatly reduced the oiliness in my face if not acne. If there is a moisturizer with high amounts of B5, B3, C, E, zinc, EGCC, Thyme and hyalauronic acid then there should not be any chance of acne at all.


Edited by Binga, 25 February 2013 - 08:55 AM.


#47 alternativista

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Posted 28 February 2013 - 08:34 PM

This article about a study involving the mapping of the genomes and identifying several different strains od P. Acnes finds a strain predominant in clear skin. Theorizes that it provides protection against harmful microbes in the skin similar to the way beneficial flora do in your intestines.

http://news.sciencem...er-.html?ref=hp
Status: Clear after 30 years. Wow, I guess it's been 6 years, now.

[ Story: Severe Acne since I was 10. 10+ years of Dermatologists, Antibiotics, topicals and ACCUTANE did nothing. Discovered oranges triggered the worst of my cystic acne = about 70% improvement. Tried some nutrient supplements like B-complex with zinc and C, saw palmetto and a BHA like the aspirin mask = more improvement, a lot less oily. Then, Diet changes = Clear.

Regimen: Anti-inflammatory, nutrient dense, blood sugar stabilizing diet and supplements (for hormones, inflammation, aging, health). No soap or other cleanser except for hand washing! Water only or Oil cleanse. Aloe Vera mixed with niacinimide and a high linoleic acid oil for moisturizer and reduce pigmentation.

Diet effects acne in so many ways: hormone balance, inflammation, Insulin levels, digestion, allergies and intolerances, liver function, adrenal function, SHBG levels, sebum quality, cell function and turnover, nutrient deficiencies, body fat, etc. Basic advice: Eat, sleep, supplement and exercise like you are a diabetic. And eat real food!

For more information, see my Good Things for Acne thread *Moderator edit - Please refer to the board rules (see “Advertising/soliciting”, “Linking” and “Signatures”)*

When you eat stuff, Stuff Happens!

#48 alternativista

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Posted 01 July 2013 - 04:56 PM

In addition to the many ways diet and lifestyle affects your acne by affecting the function of the various organs involved in managing hormones and inflammation: liver, gut, adrenals, thyroid, brain, etc.  There are some pathways and systems involved.  Both of the below are studies looking into how isotretinoin tends to clear acne.  Because they've been prescribing it to children for a couple of decades without really know what it does.
 
mTORC1 signaling:
Dietary intervention in acne: Attenuation of increased mTORC1 signaling promoted by Western diet
http://www.landesbioscience.com/journals/dermatoendocrinology/article/19828/?show_full_text=true  full text avialable.
The western diet habits that promote the mTORC1 signaling include high glycemic meal habits and dairy.
 

The purpose of this paper is to highlight the endocrine signaling of Western diet, a fundamental environmental factor involved in the pathogenesis of epidemic acne. Western nutrition is characterized by high calorie uptake, high glycemic load, high fat and meat intake, as well as increased consumption of insulin- and IGF-1-level elevating dairy proteins. Metabolic signals of Western diet are sensed by the nutrient-sensitive kinase, mammalian target of rapamycin complex 1 (mTORC1), which integrates signals of cellular energy, growth factors (insulin, IGF-1) and protein-derived signals, predominantly leucine, provided in high amounts by milk proteins and meat.......
 
It is conceivable that isotretinoin may downregulate mTORC1 in sebocytes by upregulation of nuclear levels of FoxO1.

 
Fox01 deficiency
 
The role of transcription factor FoxO1 in the pathogenesis of acne vulgaris and the mode of isotretinoin action. http://www.ncbi.nlm....pubmed/20930691

Nuclear FoxO1 deficiency is the result of increased growth factor signaling with activated phosphoinositol-3-kinase (PI3K) and Akt kinase during growth hormone signaling of puberty and increased insulin/IGF-1 signaling due to consumption of insulinotropic milk/dairy products as well as hyperglycemic carbohydrates of Western diet.



J Dtsch Dermatol Ges. 2010 Feb;8(2):105-14. doi: 10.1111/j.1610-0387.2010.07344.x.
FoxO1 - the key for the pathogenesis and therapy of acne?
[Article in English, German]
Melnik BC.
Source
Department of Dermatology, Enviromental Medicine and Health Theory, University of Osnabrück, Germany. melnik@t-online.de
Abstract
Five main factors play a pivotal role in the pathogenesis of acne: androgen dependence, follicular retention hyperkeratosis, increased sebaceous lipogenesis, increased colonization with P. acnes, and inflammatory events. This paper offers a solution for the pathogenesis of acne and explains all major pathogenic factors at the genomic level by a relative deficiency of the nuclear transcription factor FoxO1. Nuclear FoxO1 suppresses androgen receptor, other important nuclear receptors and key genes of cell proliferation, lipid biosynthesis and inflammatory cytokines. Elevated growth factors during puberty and persistent growth factor signals due to Western life style stimulate the export of FoxO1 out of the nucleus into the cytoplasm via activation of the phos-phoinositide-3-kinase (PI3K)/Akt pathway. By this mechanism, genes and nuclear receptors involved in acne are derepressed leading to increased androgen receptor-mediated signal transduction, increased cell proliferation of androgen-dependent cells, induction of sebaceous lipogenesis and upregulation of Toll-like-receptor-2-dependent inflammatory cytokines. All known acne-inducing factors exert their action by reduction of nuclear FoxO1 levels. In contrast, retinoids, antibiotics and dietary intervention will increase the nuclear content of FoxO1, thereby normalizing increased transcription of genes involved in acne. Various receptor-mediated growth factor signals are integrated at the level of PI3K/Akt activation which finally results in nuclear FoxO1 deficiency.


Edited by alternativista, 02 July 2013 - 01:28 PM.

Status: Clear after 30 years. Wow, I guess it's been 6 years, now.

[ Story: Severe Acne since I was 10. 10+ years of Dermatologists, Antibiotics, topicals and ACCUTANE did nothing. Discovered oranges triggered the worst of my cystic acne = about 70% improvement. Tried some nutrient supplements like B-complex with zinc and C, saw palmetto and a BHA like the aspirin mask = more improvement, a lot less oily. Then, Diet changes = Clear.

Regimen: Anti-inflammatory, nutrient dense, blood sugar stabilizing diet and supplements (for hormones, inflammation, aging, health). No soap or other cleanser except for hand washing! Water only or Oil cleanse. Aloe Vera mixed with niacinimide and a high linoleic acid oil for moisturizer and reduce pigmentation.

Diet effects acne in so many ways: hormone balance, inflammation, Insulin levels, digestion, allergies and intolerances, liver function, adrenal function, SHBG levels, sebum quality, cell function and turnover, nutrient deficiencies, body fat, etc. Basic advice: Eat, sleep, supplement and exercise like you are a diabetic. And eat real food!

For more information, see my Good Things for Acne thread *Moderator edit - Please refer to the board rules (see “Advertising/soliciting”, “Linking” and “Signatures”)*

When you eat stuff, Stuff Happens!

#49 alternativista

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Posted 02 July 2013 - 01:39 PM

Let's look at this, as I've never really explored the role of Fox01 before.

 

J Dtsch Dermatol Ges. 2010 Feb;8(2):105-14. doi: 10.1111/j.1610-0387.2010.07344.x.
FoxO1 - the key for the pathogenesis and therapy of acne?
[Article in English, German]
Melnik BC.
Source
Department of Dermatology, Enviromental Medicine and Health Theory, University of Osnabrück, Germany. melnik@t-online.de
Abstract
Five main factors play a pivotal role in the pathogenesis of acne: androgen dependence, follicular retention hyperkeratosis, increased sebaceous lipogenesis, increased colonization with P. acnes, and inflammatory events. This paper offers a solution for the pathogenesis of acne and explains all major pathogenic factors at the genomic level by a relative deficiency of the nuclear transcription factor FoxO1. Nuclear FoxO1 suppresses androgen receptor, other important nuclear receptors and key genes of cell proliferation, lipid biosynthesis and inflammatory cytokines. Elevated growth factors during puberty and persistent growth factor signals due to Western life style stimulate the export of FoxO1 out of the nucleus into the cytoplasm via activation of the phos-phoinositide-3-kinase (PI3K)/Akt pathway. By this mechanism, genes and nuclear receptors involved in acne are derepressed leading to increased androgen receptor-mediated signal transduction, increased cell proliferation of androgen-dependent cells, induction of sebaceous lipogenesis and upregulation of Toll-like-receptor-2-dependent inflammatory cytokines. All known acne-inducing factors exert their action by reduction of nuclear FoxO1 levels. In contrast, retinoids, antibiotics and dietary intervention will increase the nuclear content of FoxO1, thereby normalizing increased transcription of genes involved in acne. Various receptor-mediated growth factor signals are integrated at the level of PI3K/Akt activation which finally results in nuclear FoxO1 deficiency.

 

So, they name 5 major factors in the pathogenesis of acne:
androgen dependence, follicular retention hyperkeratosis, increased sebaceous lipogenesis, increased colonization with P. acnes, and inflammatory events.

 

All those factors are related to  a relative deficiency of the nuclear transcription factor FoxO1.

 

Nuclear FoxO1 suppresses androgen receptors,  genes involved in cell proliferation and lipid biosynthesis. and inflammatory cytokines.  

 

Elevated growth factors due to puberty OR  Western diet and lifestyle decrease Fox01 

 

This leads to increased androgen receptor sensitivity, increased cell proliferation,  and increase in inflammatory cytokines.   I have to look into what 'induction of sebaceous lipogenesis' means, exactly.

 

Retinoids, antibiotics work by increasing FoxO1 and so will dietary interventions.  I.e. avoiding high glycemic and insulinotropic diet habits.

 

'thereby normalizing increased transcription of genes involved in acne'  - in other words, it flips some genetic switches.


Status: Clear after 30 years. Wow, I guess it's been 6 years, now.

[ Story: Severe Acne since I was 10. 10+ years of Dermatologists, Antibiotics, topicals and ACCUTANE did nothing. Discovered oranges triggered the worst of my cystic acne = about 70% improvement. Tried some nutrient supplements like B-complex with zinc and C, saw palmetto and a BHA like the aspirin mask = more improvement, a lot less oily. Then, Diet changes = Clear.

Regimen: Anti-inflammatory, nutrient dense, blood sugar stabilizing diet and supplements (for hormones, inflammation, aging, health). No soap or other cleanser except for hand washing! Water only or Oil cleanse. Aloe Vera mixed with niacinimide and a high linoleic acid oil for moisturizer and reduce pigmentation.

Diet effects acne in so many ways: hormone balance, inflammation, Insulin levels, digestion, allergies and intolerances, liver function, adrenal function, SHBG levels, sebum quality, cell function and turnover, nutrient deficiencies, body fat, etc. Basic advice: Eat, sleep, supplement and exercise like you are a diabetic. And eat real food!

For more information, see my Good Things for Acne thread *Moderator edit - Please refer to the board rules (see “Advertising/soliciting”, “Linking” and “Signatures”)*

When you eat stuff, Stuff Happens!

#50 alternativista

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Posted 31 July 2013 - 11:21 AM

Bioactive Dietary Factors and Plant Extracts in Dermatology

Book excerpt on discussing mTorC1,Fox01, and the phos-phoinositide-3-kinase (PI3K)/Akt pathways

 

http://books.google....ng acne&f=false

 

I wish I could copy and paste. 

 

Further down it mentions the role of  a high intake of Branched Chain Amino Acids from dairy and meat (especially leucine, especially in young body builders and athletes) May also increase mTorc1 signaling. 

 

And then, after the skip, it starts talking about resveraterol inhibits mTorc1.


Status: Clear after 30 years. Wow, I guess it's been 6 years, now.

[ Story: Severe Acne since I was 10. 10+ years of Dermatologists, Antibiotics, topicals and ACCUTANE did nothing. Discovered oranges triggered the worst of my cystic acne = about 70% improvement. Tried some nutrient supplements like B-complex with zinc and C, saw palmetto and a BHA like the aspirin mask = more improvement, a lot less oily. Then, Diet changes = Clear.

Regimen: Anti-inflammatory, nutrient dense, blood sugar stabilizing diet and supplements (for hormones, inflammation, aging, health). No soap or other cleanser except for hand washing! Water only or Oil cleanse. Aloe Vera mixed with niacinimide and a high linoleic acid oil for moisturizer and reduce pigmentation.

Diet effects acne in so many ways: hormone balance, inflammation, Insulin levels, digestion, allergies and intolerances, liver function, adrenal function, SHBG levels, sebum quality, cell function and turnover, nutrient deficiencies, body fat, etc. Basic advice: Eat, sleep, supplement and exercise like you are a diabetic. And eat real food!

For more information, see my Good Things for Acne thread *Moderator edit - Please refer to the board rules (see “Advertising/soliciting”, “Linking” and “Signatures”)*

When you eat stuff, Stuff Happens!

#51 alternativista

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Posted 28 June 2014 - 03:53 PM

Page needing exploring about how accutane works and what else it's doing to you.

http://max001.proboards.com

 

 

I wish I could copy and paste the higher level board topics and their summaries. Topics like: " Significant Irriversible Hormone Antagonism" and "Affected neurotransmitters and parts of the brain".  Unfortunately, in addition to some good content, there's a lot of placeholders and a hell of a lot of spam.


Edited by alternativista, 14 July 2014 - 11:47 AM.

Status: Clear after 30 years. Wow, I guess it's been 6 years, now.

[ Story: Severe Acne since I was 10. 10+ years of Dermatologists, Antibiotics, topicals and ACCUTANE did nothing. Discovered oranges triggered the worst of my cystic acne = about 70% improvement. Tried some nutrient supplements like B-complex with zinc and C, saw palmetto and a BHA like the aspirin mask = more improvement, a lot less oily. Then, Diet changes = Clear.

Regimen: Anti-inflammatory, nutrient dense, blood sugar stabilizing diet and supplements (for hormones, inflammation, aging, health). No soap or other cleanser except for hand washing! Water only or Oil cleanse. Aloe Vera mixed with niacinimide and a high linoleic acid oil for moisturizer and reduce pigmentation.

Diet effects acne in so many ways: hormone balance, inflammation, Insulin levels, digestion, allergies and intolerances, liver function, adrenal function, SHBG levels, sebum quality, cell function and turnover, nutrient deficiencies, body fat, etc. Basic advice: Eat, sleep, supplement and exercise like you are a diabetic. And eat real food!

For more information, see my Good Things for Acne thread *Moderator edit - Please refer to the board rules (see “Advertising/soliciting”, “Linking” and “Signatures”)*

When you eat stuff, Stuff Happens!

#52 alternativista

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Posted 18 August 2014 - 01:11 PM

What accutane does.  Not light reading.

 

Isotretinoin and FOX01

http://www.ncbi.nlm....ctid984712title

 

about FOX01 obviously, but also  PPARy, IGF-1, Innate & aquired immune response, and many more mechanisms. including those that least to adverse affects like causing muscle pain, bone density, dry mucosa, hair loss, etc. ( I have the dry eyes/nasal passages (and mouth but it didn't mention mouth) and maybe the muscle ache. ) )


Status: Clear after 30 years. Wow, I guess it's been 6 years, now.

[ Story: Severe Acne since I was 10. 10+ years of Dermatologists, Antibiotics, topicals and ACCUTANE did nothing. Discovered oranges triggered the worst of my cystic acne = about 70% improvement. Tried some nutrient supplements like B-complex with zinc and C, saw palmetto and a BHA like the aspirin mask = more improvement, a lot less oily. Then, Diet changes = Clear.

Regimen: Anti-inflammatory, nutrient dense, blood sugar stabilizing diet and supplements (for hormones, inflammation, aging, health). No soap or other cleanser except for hand washing! Water only or Oil cleanse. Aloe Vera mixed with niacinimide and a high linoleic acid oil for moisturizer and reduce pigmentation.

Diet effects acne in so many ways: hormone balance, inflammation, Insulin levels, digestion, allergies and intolerances, liver function, adrenal function, SHBG levels, sebum quality, cell function and turnover, nutrient deficiencies, body fat, etc. Basic advice: Eat, sleep, supplement and exercise like you are a diabetic. And eat real food!

For more information, see my Good Things for Acne thread *Moderator edit - Please refer to the board rules (see “Advertising/soliciting”, “Linking” and “Signatures”)*

When you eat stuff, Stuff Happens!

#53 alternativista

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Posted 18 August 2014 - 01:35 PM

Here's one people should like.  Marijuana for acne.

 

Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes

 

Cannabidiol is one of the compounds most studied for medicinal use. http://www.leafscien...annabidiol-cbd/

 

The thing to look into is the content in Hemp or Hemp seed/oil. 


Status: Clear after 30 years. Wow, I guess it's been 6 years, now.

[ Story: Severe Acne since I was 10. 10+ years of Dermatologists, Antibiotics, topicals and ACCUTANE did nothing. Discovered oranges triggered the worst of my cystic acne = about 70% improvement. Tried some nutrient supplements like B-complex with zinc and C, saw palmetto and a BHA like the aspirin mask = more improvement, a lot less oily. Then, Diet changes = Clear.

Regimen: Anti-inflammatory, nutrient dense, blood sugar stabilizing diet and supplements (for hormones, inflammation, aging, health). No soap or other cleanser except for hand washing! Water only or Oil cleanse. Aloe Vera mixed with niacinimide and a high linoleic acid oil for moisturizer and reduce pigmentation.

Diet effects acne in so many ways: hormone balance, inflammation, Insulin levels, digestion, allergies and intolerances, liver function, adrenal function, SHBG levels, sebum quality, cell function and turnover, nutrient deficiencies, body fat, etc. Basic advice: Eat, sleep, supplement and exercise like you are a diabetic. And eat real food!

For more information, see my Good Things for Acne thread *Moderator edit - Please refer to the board rules (see “Advertising/soliciting”, “Linking” and “Signatures”)*

When you eat stuff, Stuff Happens!

#54 righthandman

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Posted 21 October 2014 - 08:20 AM

Beta carotene, UV exposure and Retinoic Acid

Trying to follow up on a theory by autonomousone

acne may be a genetic defect in vitamin a metabolism particularly with the pathway that creates retinoic acid in the skin. iv</strong>e read studies that suggest retinoic acid could be rendered inactive in our bodies so we may have ultra low levels of it, sending our skin and sebum cells into chaos.

BETA CAROTENE is derived from plants only and enters the body as ~60% beta carotene and 40 % retinal . the body can then turn retinal into retinol as needed and the body can store large amounts of beta carotene with no known overdose. So the true source of retinol is beta carotene ...
one other interesting fact to consider is that our skin stores a lot of our beta carotene intake thats why eating too many carrots can turn your skin orange. i also find it interesting that acne mainly occurs on the face and the back and these are places that are otherwise exposed to the sun when walking outside, <strong>and ive read a study that proves uv rays cause beta carotene to stimulate retinoic acid production</strong>. Interestng thoughts hey!!


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We are lacking/have too much of/have a mutation in the CYP26AI enzyme/gene in involved in the metabolism of retinoic acid in our skin?? And UV involvement in stimulating retinoic acid production could be one way many people's skin clears when they get more sun exposure
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Polymorphisms in the human cytochrome P-450 1A1 gene (CYP1A1) as a factor for developing acne.
Paraskevaidis A, Drakoulis N, Roots I, Orfanos CE, Zouboulis CC.
Department of Dermatology, University Medical Center Benjamin Franklin, Free University of Berlin, Germany.

Cytochromes P-450 are a supergene family of enzymes involved in the metabolism of a wide range of endogenous and foreign compounds. The existing genetic variations of the distinct isozymes lead to interindividually different metabolic capacity. Since vitamin A, endogenous retinoids and their natural metabolites are morphogenic for the sebaceous gland, we investigated the polymorphisms of cytochrome P-450 1A1, as being one of the most active isozymes involved in their interconversion. From the known mutations, two were investigated; an additional cleavage site for MspI in the 3'-flanking region identified as a thymine-to-cytosine transition 1,194 bp downstream of exon 7 (m1) and an adenine-to-guanine transition at position 4889 in exon 7 (m2). We studied 96 acne patients for m1 and m2 mutations by restriction fragment length polymorphism and allele-specific polymerase chain reaction, respectively, and compared the results with 408 reference individuals. No statistically significant difference was found in the distribution of m2 alleles; the frequency was 3.13 and 3.06% of the alleles, respectively (odds ratio = 1.02, confidence limits 0.41-2.52, p = 0.96). In contrast,a trend to an overrepresentation of m1 alleles in acne patients was observed; allele frequency was 8.33 in the patients and 6.99% in the control subjects, respectively (odds ratio 1.21, 95% confidence limits 0.68-2.16, p = 0.52). As the m1 mutation might define a marker for alterations on regulatory sites, the biological efficacy of natural retinoids could be greatly impaired by their rapid metabolism to inactive compounds. The resulting deficit of active natural retinoids may lead to abnormal sebocyte differentiation and hyperkeratinization of the follicular canal implicating the development of acne in some patients.

http://www.ncbi.nlm....st_uids=9557256




Dermatology. 1998;196(1):171-5. Related Articles, Links

Promotes keratinocyte differentiation and apoptosis:
"Combination of betaC-promoted keratinocyte differentiation with the cellular "UV response" caused synergistic induction of cell cycle arrest and apoptosis." <a href="http://www.ncbi.nlm....?dopt=Abstract" class="bbc_url" title="External link" rel="nofollow external">http://www.ncbi.nlm....pt=Abstract</a>


"UV-induced cell death by apoptosis is considered to be a natural protective mechanism that removes damaged keratinocytes and circumvents the risk of malignant transformation." <a href="http://www.ncbi.nlm....ubmed/15964692" class="bbc_url" title="External link" rel="nofollow external">http://www.ncbi.nlm....ed/15964692</a>


About the skin's ability to metabolize retinoic acid from beta carotene:

Skin retinoid concentrations are modulated by CYP26AI expression restricted to basal keratinocytes in normal human skin and differentiated 3D skin models.
<a href="http://www.ncbi.nlm....?dopt=Abstract" class="bbc_url" title="External link" rel="nofollow external">http://www.ncbi.nlm....des<em><strong> '

strong constitutive expression of CYP26AI in vivo and in organotypic culture was found to be restricted to basal epidermal keratinocytes, as well as eccrine sweat glands and sebaceous glands. These studies verify the capacity of human skin to metabolize RA, although substantial differences exist in CYP expression between normal skin and 3D skin models compared to monolayer cultures. Complex metabolic processes that maintain retinoid homeostasis may therefore be better studied in model systems more closely resembling in vivo skin. In light of our prior studies documenting the functional activity of RA metabolites, expression of CYP26 in the sebaceous gland epithelium supports the suggestion that <strong>altered RA metabolism may be involved in the pathogenesis of acne

Biogenesis of retinoic acid from beta-carotene. Differences between the metabolism of beta-carotene and retinal.
<a href="http://www.ncbi.nlm....?dopt=Abstract" class="bbc_url" title="External link" rel="nofollow external">http://www.ncbi.nlm....pt=Abstract</a>

Expression and function of cytochrome p450-dependent enzymes in human skin cells.
<a href="http://www.ncbi.nlm....ubmed/18781947" class="bbc_url" title="External link" rel="nofollow external">http://www.ncbi.nlm....47</a></strong>

"human skin cells express various CYP enzymes, including </span></span></p><strong>CYP26AI which is responsible for the metabolism of retinoic acid in skin cells"

Good report with sources for research:
Cytochrome P450: A Target for Drug Development for Skin Diseases
;<a href="http://www.nature.co.../5602457a.html" class="bbc_url" title="External link" rel="nofollow external">http://www.nature.co...02457a.html</a>

The special interest for CYP enzymes in skin is evident by the fact that most, if not all, drugs used by the practicing dermatologist are either substrate or inducer, or inhibitor of this enzyme family (<a href="http://www.nature.co...457a.html#tbl1" class="bbc_url" title="External link" rel="nofollow external">Table I</a>. It is important to mention here that CYP enzymes act on many endogenous substrates including vitamin D and vitamin A, which are widely used in clinical practice for treating a variety of dermatological disorders....
 

Liarozole, which is an imidazole-containing compound, is known to inhibit the CYP-mediated metabolism of t-RA resulting in an increase of the retinoid in skin and plasma ( <a href="http://www.nature.co...57a.html#bib81" class="bbc_url" title="External link" rel="nofollow external">VanWauwe and Janssen, 1989</a>; <a href="http://www.nature.co...57a.html#bib21" class="bbc_url" title="External link" rel="nofollow external">Dockx <em>et al</em>, 1995</a></sup>

Cyp enzymes also affect vitamin D production:

Based on several studies, it is now clear that the active form of vitamin D and its analogs suppress growth and stimulate the terminal differentiation of keratinocytes ( <a href="http://www.nature.co...57a.html#bib39" class="bbc_url" title="External link" rel="nofollow external">Kira <em>et al</em>, 2003</a>
It is also known that in psoriatic lesions, epidermal keratinocytes exhibit hyper-proliferation and impaired differentiation triggered by inflammation. Therefore, it is quite reasonable to assume that vitamin D is effective on psoriasis.


From this on hirsutism and PCOS <a href="http://www.fastbleep...aeds/17/39/251" class="bbc_url" title="External link" rel="nofollow external">http://www.fastbleep...s/17/39/251</a>

Spironolactone: An aldosterone antagonist. Reduces Hitsutism through competitive inhibition of DHT, reduces CYP enzyme and increases peripheral aromatisation of testosterone and inhibition of skin 5 alpha reductase.


Vitamin A and its natural and synthetic metabolites ( retinoids) affect growth and differentiation of human skin and among the genes affected by retinoids in epidermis are keratin genes. <a href="http://www.ncbi.nlm....ubmed/22110773" class="bbc_url" title="External link" rel="nofollow external">http://www.ncbi.nlm....ed/22110773</a>


"Vitamin A and its natural and synthetic metabolites (retinoids) affect growth and differentiation of human skin and among the genes affected by retinoids in epidermis are keratin genes."</p>

Retinoids might also help by being anti-inflammatory: Inflammation resolved by retinoid X receptor-mediated inactivation of leukotriene signaling pathways (Such as by acting PPARs.)

"Leukotrienes are implicated in the pathogenesis of diverse, inflammation-driven diseases.... Retinoids affect numerous signaling pathways in human skin (36) <a href="http://www.fasebj.or...2/538.full#B36" class="bbc_url" title="External link" rel="nofollow external"><img src="http://www.fasebj.or.../ref-arrow.gif" alt="Posted Image" class="bbc_img"></a><span style="color: #403838"> .
Their antiinflammatory, prodifferentiating, and chemopreventative properties are efficacious toward diverse disorders including psoriasis, acne, ichthyosis, photoaging, cancer, emphysema, and bronchopulmonary dysplasia in newborns (38</span><a href="http://www.fasebj.or...2/538.full#B38" class="bbc_url" title="External link" rel="nofollow external"><img src="http://www.fasebj.or.../ref-arrow.gif" alt="Posted Image" class="bbc_img"></a><span style="color: #403838"> 39</span><a href="http://www.fasebj.or...2/538.full#B39" class="bbc_url" title="External link" rel="nofollow external"><img src="http://www.fasebj.or.../ref-arrow.gif" alt="Posted Image" class="bbc_img"></a><span style="color: #403838"> 40</span><a href="http://www.fasebj.or...2/538.full#B40" class="bbc_url" title="External link" rel="nofollow external"><img src="http://www.fasebj.or.../ref-arrow.gif" alt="Posted Image" class="bbc_img"></a><span style="color: #403838"> 41)</span><a href="http://www.fasebj.or...2/538.full#B41" class="bbc_url" title="External link" rel="nofollow external"><img src="http://www.fasebj.or.../ref-arrow.gif" alt="Posted Image" class="bbc_img"></a><span style="color: #403838"> . We present evidence that retinoids up-regulate a proresolving pathway in human epidermal keratinocytes by mechanisms involving RXR-mediated </span><em>CYP4F</em><span style="color: #403838">transcriptional activation (</span><strong>Fig. 6</strong><a href="http://www.fasebj.or.../2/538.full#F6" class="bbc_url" title="External link" rel="nofollow external"><img src="http://www.fasebj.or.../ref-arrow.gif" alt="Posted Image" class="bbc_img"></a><span style="color: #403838"> ). One result is increased epithelial capacity to metabolically inactivate leukotrienes produced by infiltrating neutrophils, thereby antagonizing LTB4 signaling and further neutrophil recruitment. This CYP4F-dependent pathway functions as a physiological stop signal for epithelial inflammation, facilitating the switch to tissue repair and wound healing. </span><span style="color: #403838">"&nbsp;&nbsp; There's talk of celiac disease near the end of the full text..</span>
<a href="http://www.fasebj.or.../22/2/538.full" class="bbc_url" title="External link" rel="nofollow external">http://www.fasebj.or.../2/538.full</a>


Caratenoids and how they protect us from UVA damage with a comparison of beta carotene, Astaxanthin, and canthaxanthin
<a href="http://www.ncbi.nlm....ubmed/18803658" class="bbc_url" title="External link" rel="nofollow external">http://www.ncbi.nlm....ed/18803658</a>

Carotenoids and other phytonutrients protect from photodamage
<a href="http://www.ncbi.nlm....ubmed/22254062" class="bbc_url" title="External link" rel="nofollow external">http://www.ncbi.nlm....4062</a><p></p>

1: Biochem Biophys Res Commun. 1987 Aug 31;147(1):25-30. Links
Interference of retinoic acid binding to its binding protein by omega-6 fatty acids.Sani BP, Allen RD, Moorer CM, McGee BW.
Cellular retinoic acid-binding protein (CRABP) is the putative mediator of the biological effects of retinoic acid in the control of epithelial differentiation and tumorigenesis. Omega-6 fatty acids such as linoleic acid and arachidonic acid, precursors of prostaglandin synthesis, caused inhibition of retinoic acid binding to CRABP. These fatty acids, however, possessed lower affinity than retinoic acid for the binding protein. Omega-3 fatty acids, such as eicosapentaenoic acid and docosohexaenoic acid, did not cause such inhibition in the binding of retinoic acid. Whereas retinoic acid was a potent modulator of differentiation of F9 embryonal carcinoma cells, neither omega-3 nor omega-6 fatty acids showed any significant differentiation potential. Competition by omega-6 fatty acids with retinoic acid for CRABP may neutralize the binding protein-mediated biological functions of retinoic acid, and could thereby enhance tumor production.

Cordain may have said something about insulin surges can also lowering retinoic acid binding protien. (along with other factors like sex hormone binding globulin.

 

 

It's has been awhile since I posted on this site but I wanted to report a partial success I had with Vitamin A. This theory about UV light definetly holds some truth. I noticed that after taking Vitamin A in the form of 10,000 IU of retinol (the animal source, not beta carotene) and exposing my face and body to the sun every other day for an adequate amount of time, I could manage my acne to an extent. Now this didn't "cure" or completely cure my condition but it helped tremendously. I must note that during this time I was eating very healthy and also consumed many sources of plant sourced Beta-carotene from spinach, carrots, sweet potatoes, butternut squash, etc. Although I suggest only using retinol at first (since it is already converted to the active Vitamin A form whereas the conversion rate of beta-carotene is very low) beta-carotene could have still played a factor since I know that beta carotene is deposited in the surface skin and acts as an fat soluble antioxidant, and an electron acceptor from the sun.

 

This further supports the evolutionary biology approach to acne. At my worst points, I experienced severe acne on my face, and tops of my back and chest, the areas on the body that would be exposed most to the sun when we lived primitively. I believe we evolved a higher density of retinoic acid receptors in these areas of the skin so that more sun light was needed to produce a normal amount of retinoic acid. Now, our traditional american diets are low in Vitamin A, and antioxidants/pigments (zeaxanthin, astaxanthin, lutein, beta-carotene, lycopene) and we are being told to avoid the sun at all cost. My theory is that the sun and its "harmful" UV's do NOT cause skin cancer, but our lack of internal protection allow us to be susceptible to cancer. Please don't quote me saying that vitamin a cures skin cancer, this is just a theory on acne and the skin. And again I must stress that acne is multifactorial and this is just on of the ways it can "get" you, not including omega 3:6 ratio, hormone imbalace, etc...






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