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Epigenetics--What You Do To Yourself Changes Your Gene Expression

genes genetics acne diet phenotype epigenetics methylation accutane epigenetics changes

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#61 alternativista

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Posted 20 January 2014 - 08:42 AM

New Google search term:  'epigenetic mechanism'

 

There are several mechanisms that make it happen.  DNA Methylation is merely the first mechanism discovered. Way back In the '70s!

 

http://epigenie.com/...tic-regulation/


Edited by alternativista, 29 January 2014 - 10:20 AM.


#62 alternativista

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Posted 14 February 2014 - 05:48 PM

From an article about cancer fighting abilities of propolis:

Epigenetic changes refer to alterations of the DNA expression without changing its sequence, and therefore in the absence of mutations. Modifying enzymes (histone deacetylases) can switch off entire DNA regions and block expression of the genes there. This has been shown to be a powerful way to interrupt normal cellular metabolism and lead to uncontrolled replication, which is certainly involved in cancer growth and metastasis. To prevent these problems, all cells have in their DNA specialized genes, called tumour suppressor genes, which are expected to be activated if a cell becomes cancerous and either promote healing or induce programmed cell death, if the genetic damages are beyond repair. Conveniently, these protective genes are usually deactivated in cancer cells, allowing them to bypass the security mechanisms built in the DNA. This is exactly where propolis acts; by restoring the functions of DNA, it re-activates the ability of the cell to fight off the malignancy and regulate its replication, therefore blocking tumour growth. According to the authors, this study proves that...

 

Histone deacetylase inhibitors are a class of drugs designated as epigenetic agents that modulate the activities of tumour suppressor genes, among others.

 

http://www.greenmedi...propolis?page=2

 

And this article is on how disrupted sleep (jet lat, night shifts, etc) alter gene expression

http://articles.merc...t_rid=426299157

 

For instance, one study found that the circadian clocks of mice control an essential immune system gene that helps their bodies sense and ward off bacteria and viruses. When levels of that particular gene, called toll-like receptor 9 (TLR9), were at their highest, the mice were better able to withstand infections.3

Interestingly, when the researchers induced sepsis, the severity of the disease was dependent on the timing of the induction. According to the authors, this may help explain why septic patients are known to be at higher risk of dying between the hours of 2 a.m. and 6 a.m.

Separate research also found that when participants cut their sleep from 7.5 to 6.5 hours a night, there were increases in activity in genes associated with inflammation, immune excitability, diabetes, cancer risk, and stress.4

Mistimed sleep disrupts circadian regulation of the human transcriptome

http://www.pnas.org/...c4-3b809898e94c


Edited by alternativista, 21 February 2014 - 11:41 AM.


#63 alternativista

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Posted 21 February 2014 - 11:33 AM

Meditation Alters Your Genetic Expression

http://articles.merc...t_rid=432792765

 

Genetic study2 of eight-week and long-term meditators demonstrated evidence of changes to gene expression – specifically antioxidant production, telomerase activity, and oxidative stress – as a result of the relaxation response. They theorize that NF-kappa B gene sets may be the messenger between psychological and physical stress wherein the body translates worry into inflammation.

One of the studies cited that studied effects of various Relaxation Response techniques, in addition to meditaion, like Yoga, Tai Chi, deep breathing. 

 

Relaxation Response Induces Temporal Transcriptome Changes in Energy Metabolism, Insulin Secretion and Inflammatory Pathways

 

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0062817 

 

Also
5

According to neuroscientist, Dr. Lazar,4 long-term meditation practice appears to be associated with preferential cortical thickening:

"…brain regions associated with attention, interoception and sensory processing were thicker in meditation participants than matched controls, including the prefrontal cortex and right anterior insula" and that these findings were further validated by an eight-week intervention trial.


Edited by alternativista, 21 February 2014 - 11:39 AM.


#64 alternativista

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Posted 21 February 2014 - 11:50 AM

Vocabulary:

 

The genome is made up of deoxyribonucleic acid (DNA), a long, winding molecule that contains the instructions needed to build and maintain cells.

 

For these instructions to be carried out, DNA must be transcribed into corresponding molecules of ribonucleic acid (RNA), referred to as transcripts.

 

Transcription is the first step of gene expression, in which a particular segment of DNA is copied into RNA by the enzyme RNA polymerase. Both RNA and DNA are nucleic acids, which use base pairs of nucleotides as a complementary language that can be converted back and forth from DNA to RNA by the action of the correct enzymes.

 

A transcriptome is a collection of all the transcripts present in a given cell. The transcriptome is the set of all RNA molecules produced in one or a population of cells. It differs from the exome in that it includes only those RNA molecules found in a specified cell population, and usually includes the amount or concentration of each RNA molecule in addition to the molecular identities.

 

Places to learn:

http://www.nature.co...opic/genetics-5

http://www.genome.gov/10000002



#65 alternativista

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Posted 07 March 2014 - 02:30 PM

http://www.greenmedi...c17316-86969685

 

Article about a doctor who claimed to fix a boys fatal genetic disorder that tends to lead to leukemia.  I skimmed through most of it to get to the nutrition part.  But here's an explanation & below the diet supplements.

each time a cell divides it will either produce the same mutation or it will fix the mutation. I told her that mutation was a normal thing that the body has to contend with each and every day. It isn't until the exposures to chemical toxicities overwhelms our nutritional ability that we end up with such chronic mutations or disease. This process is called epigenetics.Epigenetics is a fascinating process by which the body turns on and off genes through one carbon metabolism. By understanding how to help the body with its epigenetic gene manipulation, a physician can help recover mutations and unfavorable gene sequencing. [3] This whole process is why my identical twin daughters are slightly different as they get older. Their DNA is 100% identical but through environmental factors, diet, and lifestyle, their DNA sequencing has evolved to allow these slight variations.

 

My dietary goal is to balance out the methylation process to improve the gene signaling while improving the body's ability to repair and edit the mutated DNA. This was accomplished by switching the patient to a low glycemic, nutrient dense diet with lots of fruits, vegetables, nuts, seeds, berries, and legumes; real actual food with the least processing. Next we supplemented with methylcobalamin (methyl B12 lozenges), folate, and B6 supplements. Each of these helps regulate the homocysteine pathway which regulates gene sequencing. This one carbon metabolism of methylation normally is fed by a rich diet of beans, greens and fermented foods. [8]

 

Funny, ever since I first heard of methylation, the definition always included something about methyl donors. And methyl donors are your sulfur containing amino acids.  So I'd been under the impression that it was 'all about sulfur'. But B vitamins seem to be what most are concerned about due to the homocysteine pathway.

 

Also, I'd think you'd want to promote the recycling of tissues, in which the body would hopefully break down bad or damaged tissues.  And intermittent fasting is the way.  We aren't supposed to have plenty to eat all the time & it's when we go hungry, that this happens.

 

Paper about Genetics researchers from Taiwan's National Central University findings that over a third of herbal medicines used in Traditional Chinese Medicine  - and nearly all leading therapeutic herbs - alter our genes or alter enzymes that alter our genetic material. http://www.greenmedinfo.com/blog/herbal-medicine-alters-genes-cell-mitosis-and-epigenome.  
 

[50%] of them promote what is called chromatin condensation. Chromatin is the complex of DNA and protein material that our cells' nucleus is made of. Through the histone enzymes, chromatin will bind up and prepare for cell division, allowing a copy of our DNA to be made during mitosis.

Chromatin condensation occurs during the cell's reproductive cycle – as cells divide. During the interphase step the chromatin is loosely mixed, and then during the prophase step the chromatin will condense and the chromosomes will become visible to microscopic observation. This condensed state continues one through the next stages of mitosis until the cell successfully divides. The histones organize the DNA during this chromatin condensation process. The relates directly to DNA repair.

 

the researchers found a correlation between traditional Chinese medicine hot or cold characteristics as they processed the analysis of the herbs. They also found that some of the alteration occurred through a process called methylation, which occurs as methyl groups are displaced and replaced in order to neutralize radicals.

The fact that so many herbal medicines interact with the histones of the body's cells is critical to understanding the importance of the herbal medicine from both a macro and microscopic view. 

This research confirms a study published in 2011 that found nearly 30% of those herbal medicines tested alter the miRNA of cells, and modify our genetic epigenome.

 

Also' "an enzyme called MTHFR (5,10-methylenetetrahydrofolate reductase) to convert folic acid and food folate into 5-methylenetetrahydrofolate."  Which is the the form involved in epigenetic changes/DNA Repair &/or whatnot.  and 'active thyroid hormone is needed to support MTHFR function'

http://www.greenmedi...hylation?page=2

"

"It hopefully goes without saying that oxidative stress from environmental pollutants, food allergens, poor sleep, and limited relaxation all increase the demand to the corrective efforts of methylation.  A clean diet, home, body, and mind are a part of this package.  There is rarely a one pill solution, pharmaceutical or nutriceutical."

 






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