More manganese , probiotic and accutane connections
Pathway......Accutane ---> increased ROS levels> increased need for mnSOD > increased need for MnSOD meanwhile depletes the small Mn stores > L. plantarum 299 needs Mn to grow and survive > loss of L.plantarum > increased inflammatory response > IBD
Sufficient Manganese and mnSOD + lots of viable L Plantarum 299 (introduced by a probiotic )= lots of propionic acid to reduce immune response and reduce inflammation response
mnSOD and SOD= manganese zinc copper iron
again... i think accutane depletes our bodies of certain minerals/cofactors/enzymes. We can eat healthy, do liver flushes or kidney cleanses, drain the lymph, look at your eyeballs??! etc etc. thats all well and good, but logically, if it was that easy, everyone wouldve been fixed of these long term side effects in short order. Cleanses DO NOT correct deficiencies. Like fasting, they might make it easier for your body to absorb nutrients in the future...but I believe a more drastic approach is needed with supplementation in the right combination and dosage. This includes active B vitamins, certain minerals and probiotics.
the manganese > probiotic > propanoic acid chain....
The making of propanoic acid gives acne bacteria their scientific name, Propionibacterium acnes.
3) L. plantarum has a high growth requirement for manganese and can accumulate high
intercellular levels of manganese (Archibald and Fridovich 1981b). Manganese provides a
defence for L. plantarum against oxygen toxicity by the reduction of oxygen radicals (ROS) to
H2O2 (Archibald and Fridovich 1981a). The produced H2O2 can then be converted to and water by manganese cofactored pseudocatalase (Kono and Fridovich 1983a, 1983b). O2Göran Molin, 2008-01-25
Lactobacillus plantarum 299 2
Catalase= major detoxification pathway
Because ibuprofen is a derivative of propionic acid and L. plantarum can generate large quantities of this acid from dietary fiber, we are inclined to suggest that propionic acid exerts a specific antiinflammatory action through a hitherto unknown mechanism, perhaps related to the activation by ibuprofen of peroxisome proliferator-activated receptor α, which modulates the nuclear transcription factor κB and reduces the production of inflammatory cytokines by monocytes-macrophages (30).
Lactobacillus plantarum = sauerkraut,kimche,pickles etc
more on L. Plantarum:
and i found this reading the comment section...somebody else made the connection in supplementing this as well:
Another thing i have been interested in is co-factors of the various bacteria. For example L.Plantarum has manganese dependent process that help it scavenge oxygen radicals.http://microbewiki.k...al_implications
Therefore supplementing with manganese alongside the L.Plantarum may be very beneficial.
Since taking manganese and a probiotic containing L plantarum (NOW 25 billion 10 strain) for two weeks, I have lessened my gastritis problems i have had for years by 90% ! im now going to add the 299v strain as well. I'm now convinced that this is how Accutane causes IBD/Crohns. My hope now is that manganese along with other cofactors will help my tendons and joints by being a major co-factor for collagen and hyaluronic acid. I think the activated Bs will open up detoxification pathways, minerals will correct enzyme problems and Choline ( as Alpha GPC) and TMG will in the long term, to rid the body of any residue and reestablish a correct bile flow.
Edited by tryingtohelp2014, Today, 11:36 AM.