How much iodine are you taking?
6.25mg (half an Iodoral). Tried higher, up to 100mg, got Wolff–Chaikoff effect which is a decrease in sodium-iodine symporter (NIS) expression for a few days.
NIS may be thought of as a kind of I− metabolism master molecule, participating in the anion's translocation from its intestinal absorption to its uptake in the thyroid, lactating breast, salivary glands, and gastric mucosa. In these last two tissues, NIS activity causes I− to return to the gastrointestinal lumen, from which the anion, as part of an I− conservation system, is again absorbed via NIS in the small intestine.
NIS is expressed in the thyroid, the salivary glands, gastric mucosa, and the lactating mammary gland. TSH and iodide regulate iodide accumulation by modulating NIS activity via transcriptional and posttranscriptional mechanisms.
hNIS transcripts of approximately 4 kb were detected in thyroid gland and parotid gland but not in a broad range of endocrine and nonendocrine tissues. RT-PCR and Southern hybridization revealed hNIS gene expression in thyroid gland, salivary gland, parotid gland, submandibular gland, pituitary gland, pancreas, testis, mammary gland, gastric mucosa, prostate and ovary, adrenal gland, heart, thymus, and lung. By contrast, hNIS transcripts were not detected in normal orbital fibroblasts, colon, and nasopharyngeal mucosa.
TSH, however, does not influence NIS expression in extrathyroidal tissues such as mammary gland, salivary gland, and gastric mucosa. [...] The thyroid gland expresses several iodide transporters in addition to NIS, including pendrin, apical iodide transporter, and a predicted iodide-permeable chloride channel (9). Those transporters are expressed on the apical membrane of thyrocytes and are responsible for transport of iodide from thyrocytes into the follicular lumen. Recent in vitro studies, however, revealed that excess expression of those transporters and/or excess concentration of iodide outside of the cells give these transporters the ability to promote iodide influx in monolayer cells.
Treatment of FRTL-5 rat thyroid cells with tRA [all-trans retinoic acid], however, downregulates NIS mRNA. These findings suggest differential regulation of NIS expression by RA in normal and malignant thyroid tissues.
In contrast, in nontransformed rat FRTL-5 cells, 1 microM RA downregulated NIS mRNA levels, inhibited the TSH- or forskolin-triggered induction of NIS message after TSH-depletion, and reduced iodide uptake to 38% after 5 d. This divergent RA-responsivity of NIS may provide the means to target radioiodide to thyroid carcinomas by upregulating iodide transport into tumor tissue while simultaneously inhibiting iodide accumulation in normal thyrocytes and may thus re-establish the potential for radioiodide therapy.
Refresher: Accutane (isotretinoin aka 13-cis retinoic acid) metabolizes to 4-oxo-isotretinoin, retinoic acid, and 4-oxo-retinoic acid. It's used over all-trans retinoic acid because it's more stable, less toxic and has a longer half-life. It's a cancer drug first and foremost.
These studies show RA increases NIS expression in some cancers initially then it decreases. In normal tissue it decreases. I wonder if the length of accutane treatment periods makes epigenetic changes to NIS or RAR/RXR receptor expression. Maybe the high DNA methylation activity causes depletion of it's co-factors (way beyond me). B-12, folate, sam-e, choline support methylation. Vitamin C can repair NIS according to iodine experts. Selenium protects the thyroid from autoimmunity. Magnesium cos everything needs it (mg oxide is useless btw). Water distribution needs iodine and chloride (link).
It only contains EPA and DHA, these are two essential fatty acids that the body can synthesize from ALA and plant based omega 3's. It's like for example vitamin A, it comes in the form of carotene and retinol. [...] For people with no sebum post accutane, the basic building blocks of sebum are omega 3 and omega 6, the over use of oleic acid as found in olive oil can mess up the ratio's and acne can result.
The first thing i'd take if i had acne would be udo's choice oil and i'd make sure that i avoided fatty meats in favour of chicken
ALA doesn't convert well to DHA (link). Same with beta-carotene to retinol (even less in hypothyroidism) (link).
Chicken has a lot of omega 6. Flax oxidizes easily.
In my case all foods with retinol cause problems with me
I found out taking cod liver oil (4000iu retinol palmitate) with vit d3 (say, 5000iu) greatly reduces any reaction. Vit A/D/K2 taken together prevent toxicity (link). Since upping iodine I've tried clo by itself with no problem but I'm still avoiding it for now. Retinoic acid is inflammatory in IBD (link).
just an updated. 2 weeks on iodine and i feel amazing...i'm over the hump of draining mucus from my head, and now i can breathe all of a sudden...i smelled nature the other day and it brought me to tears. I have next to no joint pain and I don't need to drink as much water. fucking loving life. no negative side effects, but i need to be careful not to overdo it. also, moisture in my skin and eyes! still have scalp issues though. apple cider vinegar has calmed the burning and inflammation though. seeing a derm next month to get a scalp biopsy. i'll give up my hair for no joint pain. not that vain, but it'd be nice to have hair too.
Awesome We're 2 for 2!
The easy answer to hair loss is hypothyroidism (eyebrows thinning?), but it's also a symptom of other potentially related conditions like malabsorption, impaired protein and iron metabolism. Could be bacterial/fungal, in which case apply coconut oil.
Incredible lecture for anybody who wants to try ALA
Didn't watch thing but make sure it's R-Alpha Lipoic Acid and cycle it.