IndigoRush

Repairing the long-term damage from Accutane

12,302 posts in this topic

1 hour ago, Kynarr said:

Should I try Letrozole or Anastrozole? I'll request for either on Jan 30th. I'll give the benefit of the doubt to this theory based on reports by Ehohel and the propreciahelp forum. Legendary's hormones before treatment are just about exactly the same as mine, and he reported gym+ living healthy before hand too. I'm trying it.

I'd maybe just question.. why did Calcium D Glucarate and DIM not help me as much as I'd thought then? Maybe not strong enough..?

edit: Apparently DIM lowers DHT now? Didn't know that! Certainly would explain while I didn't at all feel better on it..

"Why did calcium d glucarate not work as well as hoped"??

well perhaps like me ( I hoped for more on CDG although I'm still currently taking it ) your gut health is poor!!?

Your thoughts on gut health?

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49 minutes ago, TrueJustice said:

Pariot works for reflux ✔️

Rifaximin & Vancomycin don't work ✖️

Pribiotics although good arent a cure ✖️

Eliminating sugar although good is no cure ✖️

Eating fermented foods good ✔️

Where to next??

I have a few thoughts. some conflicting. first is the acid reflux.excess bloating can be  a sign of a few different things ibs, gastritis, sibo. if bloating is causing food to build up and stagnate this would eventually cause a buildup of gas that is going out one way or the other, like burping. the bloating is prob putting alot of pressure on the les valve and that's what could be causing the reflux. if this is happening constantly and severe enough you prob need to be on a ppi to prevent damage to the esophagus. But ppis are a double edged sword because they can contribute to sibo and further slow down digestion.  i've mentioned this a few times about that teenage girl that had surgery and lost most of her pancreas  due to a high dose of accutane. I wonder if there was any sort of minor pancreatic insufficiency caused by accutane that became chronic in us. pancreatic enzymes along with gastric acid , and motility and  are the main things that keep sibo in check. from everything i read, if there was a bacterial overgrowth, probiotics are generally not recommended(more fuel for the fire).

Rifaximin is more for sibo that feature chronic watery stools. i Think most of us have the opposite problem. there is another antibiotic used mainly for constipation. starts with a N. there is sibo that could be resistant to both of these antibiotics btw. and alot of times they say sibo can come back shortly after a course of antibiotics. 

Me personally im looking at allicin from garlic, a sweetener called stevia, eccentric coded pancreatic enzymes .this supplement called dysbiocide.
what some of these  here have in common is they work where antibiotics have failed. stevia has been compared to triple antibiotic therapy. Allicin has worked on some MRSA resistant supper bugs, and is very broad spectrum and gets into the blood stream.

the reflux though. this could be big as well. hard to tell when its happening. might even happen in your sleep and you not know it. this could put your body in a constant stress/anxiety state. and if its reaching your throat nose and sinuses, this could effect your quality of sleep and energy level the following day. and all that inflammation could def mess with your concentration/brain fog. how they treat that is a daily ppi and  150 zantac or pepcid complete at night. sometimes even a ppi twice daily. have to wait up to 6 months for results. healing takes much longer past the esophagus. ramble ramble ramble. I should have been a doctor. i mEAN IN MY DO OVER LIFE.

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41 minutes ago, guitarman01 said:
I have a few thoughts. some conflicting. first is the acid reflux.excess bloating can be  a sign of a few different things ibs, gastritis, sibo. if bloating is causing food to build up and stagnate this would eventually cause a buildup of gas that is going out one way or the other, like burping. the bloating is prob putting alot of pressure on the les valve and that's what could be causing the reflux. if this is happening constantly and severe enough you prob need to be on a ppi to prevent damage to the esophagus. But ppis are a double edged sword because they can contribute to sibo and further slow down digestion.  i've mentioned this a few times about that teenage girl that had surgery and lost most of her pancreas  due to a high dose of accutane. I wonder if there was any sort of minor pancreatic insufficiency caused by accutane that became chronic in us. pancreatic enzymes along with gastric acid , and motility and  are the main things that keep sibo in check. from everything i read, if there was a bacterial overgrowth, probiotics are generally not recommended(more fuel for the fire).

Rifaximin is more for sibo that feature chronic watery stools. i Think most of us have the opposite problem. there is another antibiotic used mainly for constipation. starts with a N. there is sibo that could be resistant to both of these antibiotics btw. and alot of times they say sibo can come back shortly after a course of antibiotics. 

Me personally im looking at allicin from garlic, a sweetener called stevia, eccentric coded pancreatic enzymes .this supplement called dysbiocide.
what some of these  here have in common is they work where antibiotics have failed. stevia has been compared to triple antibiotic therapy. Allicin has worked on some MRSA resistant supper bugs, and is very broad spectrum and gets into the blood stream.

the reflux though. this could be big as well. hard to tell when its happening. might even happen in your sleep and you not know it. this could put your body in a constant stress/anxiety state. and if its reaching your throat nose and sinuses, this could effect your quality of sleep and energy level the following day. and all that inflammation could def mess with your concentration/brain fog. how they treat that is a daily ppi and  150 zantac or pepcid complete at night. sometimes even a ppi twice daily. have to wait up to 6 months for results. healing takes much longer past the esophagus. ramble ramble ramble. I should have been a doctor. i mEAN IN MY DO OVER LIFE.


My specialist put me on Paroit for my reflux- definitely does the trick but I must now watch magnesium lvls.

Still it's not the cure for great gut health, it only prevents my reflux. What about Metronizadole & Parmomycin??

Let me work backwards here and ask "why shouldn't we be taking these antibiotics"?

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4 hours ago, Kynarr said:

Should I try Letrozole or Anastrozole? I'll request for either on Jan 30th. I'll give the benefit of the doubt to this theory based on reports by Ehohel and the propreciahelp forum. Legendary's hormones before treatment are just about exactly the same as mine, and he reported gym+ living healthy before hand too. I'm trying it.

I'd maybe just question.. why did Calcium D Glucarate and DIM not help me as much as I'd thought then? Maybe not strong enough..?

edit: Apparently DIM lowers DHT now? Didn't know that! Certainly would explain while I didn't at all feel better on it..
Hi Kynarr - did you read the transcript re endocrinologist - there are at least , 2n one on pg 9. Shame most doctors are only interested in what they think they know. They don't listen to their patients and they make sweeping comments. I was told by endo that the lower the E in men the better.
I would say that this is quite basic knowledge - men need E. What are we up against if endos don't know what healthy T and E is?

I received this email from an Andrologist - I have posted before.
A study by Finkelstein et al New England Journal of Medicine (2013;369:1011-1022) suggested that low oestradiol affected sexual function and fat distribution in younger men and many accept 95-170 pmol/l as the normal range. 
The issue is how we deal with a probable drug induced side effect, similar to what we see with antidepressants and finasteride where effects can last for years afterwards. Do we wait for the body to recover with time or do we give more medication to reverse these changes (given that these problems are rare)?
Giving Sildenafil (daily Cialis better) is quite reasonable , as the penis needs regular oxygenation and deterioration occurs if morning erections are lost. There are no risks with this.
Low Oestradiol increases the risk of osteoporosis in the long term and should not be ignored.
 
Treating him would involve "unlicensed" medication. Clomid would increase both T and Oestradiol and potentiate recovery of the pituitary, but opinions would differ as there are no trials or guidelines to help us here. Some doctors today feel totally restrained by guidelines.
 
Hope this helps,
4 hours ago, Kynarr said:

Should I try Letrozole or Anastrozole? I'll request for either on Jan 30th. I'll give the benefit of the doubt to this theory based on reports by Ehohel and the propreciahelp forum. Legendary's hormones before treatment are just about exactly the same as mine, and he reported gym+ living healthy before hand too. I'm trying it.

I'd maybe just question.. why did Calcium D Glucarate and DIM not help me as much as I'd thought then? Maybe not strong enough..?

edit: Apparently DIM lowers DHT now? Didn't know that! Certainly would explain while I didn't at all feel better on it..
Hi Kynarr - did you read the transcript re endocrinologist - there are at least , 2n one on pg 9. Shame most doctors are only interested in what they think they know. They don't listen to their patients and they make sweeping comments. I was told by endo that the lower the E in men the better.
I would say that this is quite basic knowledge - men need E. What are we up against if endos don't know what healthy T and E is?

I received this email from an Andrologist - I have posted before.
A study by Finkelstein et al New England Journal of Medicine (2013;369:1011-1022) suggested that low oestradiol affected sexual function and fat distribution in younger men and many accept 95-170 pmol/l as the normal range. 
The issue is how we deal with a probable drug induced side effect, similar to what we see with antidepressants and finasteride where effects can last for years afterwards. Do we wait for the body to recover with time or do we give more medication to reverse these changes (given that these problems are rare)?
Giving Sildenafil (daily Cialis better) is quite reasonable , as the penis needs regular oxygenation and deterioration occurs if morning erections are lost. There are no risks with this.
Low Oestradiol increases the risk of osteoporosis in the long term and should not be ignored.
 
Treating him would involve "unlicensed" medication. Clomid would increase both T and Oestradiol and potentiate recovery of the pituitary, but opinions would differ as there are no trials or guidelines to help us here. Some doctors today feel totally restrained by guidelines.
 
Hope this helps,
4 hours ago, Kynarr said:

Should I try Letrozole or Anastrozole? I'll request for either on Jan 30th. I'll give the benefit of the doubt to this theory based on reports by Ehohel and the propreciahelp forum. Legendary's hormones before treatment are just about exactly the same as mine, and he reported gym+ living healthy before hand too. I'm trying it.

I'd maybe just question.. why did Calcium D Glucarate and DIM not help me as much as I'd thought then? Maybe not strong enough..?

edit: Apparently DIM lowers DHT now? Didn't know that! Certainly would explain while I didn't at all feel better on it..
Hi Kynarr - did you read the transcript re endocrinologist - there are at least , 2n one on pg 9. Shame most doctors are only interested in what they think they know. They don't listen to their patients and they make sweeping comments. I was told by endo that the lower the E in men the better.
I would say that this is quite basic knowledge - men need E. What are we up against if endos don't know what healthy T and E is?

I received this email from an Andrologist - I have posted before.
A study by Finkelstein et al New England Journal of Medicine (2013;369:1011-1022) suggested that low oestradiol affected sexual function and fat distribution in younger men and many accept 95-170 pmol/l as the normal range. 
The issue is how we deal with a probable drug induced side effect, similar to what we see with antidepressants and finasteride where effects can last for years afterwards. Do we wait for the body to recover with time or do we give more medication to reverse these changes (given that these problems are rare)?
Giving Sildenafil (daily Cialis better) is quite reasonable , as the penis needs regular oxygenation and deterioration occurs if morning erections are lost. There are no risks with this.
Low Oestradiol increases the risk of osteoporosis in the long term and should not be ignored.
 
Treating him would involve "unlicensed" medication. Clomid would increase both T and Oestradiol and potentiate recovery of the pituitary, but opinions would differ as there are no trials or guidelines to help us here. Some doctors today feel totally restrained by guidelines.
 
Hope this helps,
4 hours ago, Kynarr said:

Should I try Letrozole or Anastrozole? I'll request for either on Jan 30th. I'll give the benefit of the doubt to this theory based on reports by Ehohel and the propreciahelp forum. Legendary's hormones before treatment are just about exactly the same as mine, and he reported gym+ living healthy before hand too. I'm trying it.

I'd maybe just question.. why did Calcium D Glucarate and DIM not help me as much as I'd thought then? Maybe not strong enough..?

edit: Apparently DIM lowers DHT now? Didn't know that! Certainly would explain while I didn't at all feel better on it..
Hi Kynarr - did you read the transcript re endocrinologist - there are at least , 2n one on pg 9. Shame most doctors are only interested in what they think they know. They don't listen to their patients and they make sweeping comments. I was told by endo that the lower the E in men the better.
I would say that this is quite basic knowledge - men need E. What are we up against if endos don't know what healthy T and E is?

I received this email from an Andrologist - I have posted before.
A study by Finkelstein et al New England Journal of Medicine (2013;369:1011-1022) suggested that low oestradiol affected sexual function and fat distribution in younger men and many accept 95-170 pmol/l as the normal range. 
The issue is how we deal with a probable drug induced side effect, similar to what we see with antidepressants and finasteride where effects can last for years afterwards. Do we wait for the body to recover with time or do we give more medication to reverse these changes (given that these problems are rare)?
Giving Sildenafil (daily Cialis better) is quite reasonable , as the penis needs regular oxygenation and deterioration occurs if morning erections are lost. There are no risks with this.
Low Oestradiol increases the risk of osteoporosis in the long term and should not be ignored.
 
Treating him would involve "unlicensed" medication. Clomid would increase both T and Oestradiol and potentiate recovery of the pituitary, but opinions would differ as there are no trials or guidelines to help us here. Some doctors today feel totally restrained by guidelines.
 
Hope this helps,
4 hours ago, Kynarr said:

Should I try Letrozole or Anastrozole? I'll request for either on Jan 30th. I'll give the benefit of the doubt to this theory based on reports by Ehohel and the propreciahelp forum. Legendary's hormones before treatment are just about exactly the same as mine, and he reported gym+ living healthy before hand too. I'm trying it.

I'd maybe just question.. why did Calcium D Glucarate and DIM not help me as much as I'd thought then? Maybe not strong enough..?

edit: Apparently DIM lowers DHT now? Didn't know that! Certainly would explain while I didn't at all feel better on it..
Hi Kynarr - did you read the transcript re endocrinologist - there are at least , 2n one on pg 9. Shame most doctors are only interested in what they think they know. They don't listen to their patients and they make sweeping comments. I was told by endo that the lower the E in men the better.
I would say that this is quite basic knowledge - men need E. What are we up against if endos don't know what healthy T and E is?

I received this email from an Andrologist - I have posted before.
A study by Finkelstein et al New England Journal of Medicine (2013;369:1011-1022) suggested that low oestradiol affected sexual function and fat distribution in younger men and many accept 95-170 pmol/l as the normal range. 
The issue is how we deal with a probable drug induced side effect, similar to what we see with antidepressants and finasteride where effects can last for years afterwards. Do we wait for the body to recover with time or do we give more medication to reverse these changes (given that these problems are rare)?
Giving Sildenafil (daily Cialis better) is quite reasonable , as the penis needs regular oxygenation and deterioration occurs if morning erections are lost. There are no risks with this.
Low Oestradiol increases the risk of osteoporosis in the long term and should not be ignored.
 
Treating him would involve "unlicensed" medication. Clomid would increase both T and Oestradiol and potentiate recovery of the pituitary, but opinions would differ as there are no trials or guidelines to help us here. Some doctors today feel totally restrained by guidelines.
 
Hope this helps,
4 hours ago, Kynarr said:

Should I try Letrozole or Anastrozole? I'll request for either on Jan 30th. I'll give the benefit of the doubt to this theory based on reports by Ehohel and the propreciahelp forum. Legendary's hormones before treatment are just about exactly the same as mine, and he reported gym+ living healthy before hand too. I'm trying it.

I'd maybe just question.. why did Calcium D Glucarate and DIM not help me as much as I'd thought then? Maybe not strong enough..?

edit: Apparently DIM lowers DHT now? Didn't know that! Certainly would explain while I didn't at all feel better on it..
Hi Kynarr - did you read the transcript re endocrinologist - there are at least , 2n one on pg 9. Shame most doctors are only interested in what they think they know. They don't listen to their patients and they make sweeping comments. I was told by endo that the lower the E in men the better.
I would say that this is quite basic knowledge - men need E. What are we up against if endos don't know what healthy T and E is?

I received this email from an Andrologist - I have posted before.
A study by Finkelstein et al New England Journal of Medicine (2013;369:1011-1022) suggested that low oestradiol affected sexual function and fat distribution in younger men and many accept 95-170 pmol/l as the normal range. 
The issue is how we deal with a probable drug induced side effect, similar to what we see with antidepressants and finasteride where effects can last for years afterwards. Do we wait for the body to recover with time or do we give more medication to reverse these changes (given that these problems are rare)?
Giving Sildenafil (daily Cialis better) is quite reasonable , as the penis needs regular oxygenation and deterioration occurs if morning erections are lost. There are no risks with this.
Low Oestradiol increases the risk of osteoporosis in the long term and should not be ignored.
 
Treating him would involve "unlicensed" medication. Clomid would increase both T and Oestradiol and potentiate recovery of the pituitary, but opinions would differ as there are no trials or guidelines to help us here. Some doctors today feel totally restrained by guidelines.
 
Hope this helps,
4 hours ago, Kynarr said:

Should I try Letrozole or Anastrozole? I'll request for either on Jan 30th. I'll give the benefit of the doubt to this theory based on reports by Ehohel and the propreciahelp forum. Legendary's hormones before treatment are just about exactly the same as mine, and he reported gym+ living healthy before hand too. I'm trying it.

I'd maybe just question.. why did Calcium D Glucarate and DIM not help me as much as I'd thought then? Maybe not strong enough..?

edit: Apparently DIM lowers DHT now? Didn't know that! Certainly would explain while I didn't at all feel better on it..
Hi Kynarr - did you read the transcript re endocrinologist - there are at least , 2n one on pg 9. Shame most doctors are only interested in what they think they know. They don't listen to their patients and they make sweeping comments. I was told by endo that the lower the E in men the better.
I would say that this is quite basic knowledge - men need E. What are we up against if endos don't know what healthy T and E is?


 
4 hours ago, Kynarr said:

Should I try Letrozole or Anastrozole? I'll request for either on Jan 30th. I'll give the benefit of the doubt to this theory based on reports by Ehohel and the propreciahelp forum. Legendary's hormones before treatment are just about exactly the same as mine, and he reported gym+ living healthy before hand too. I'm trying it.

I'd maybe just question.. why did Calcium D Glucarate and DIM not help me as much as I'd thought then? Maybe not strong enough..?

edit: Apparently DIM lowers DHT now? Didn't know that! Certainly would explain while I didn't at all feel better on it..
Hi Kynarr - did you read the transcript re endocrinologist - there are at least , 2n one on pg 9. Shame most doctors are only interested in what they think they know. They don't listen to their patients and they make sweeping comments. I was told by endo that the lower the E in men the better.
I would say that this is quite basic knowledge - men need E. What are we up against if endos don't know what healthy T and E is?


 

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For most Endos , it seems any discussion of the latest research on sexual hormones is 'complex' and foreign to them.   Diabetes is their ticket.     We would have little to zero luck going to them.      We need to seek out  'Andrologists'   or  'Anti ageing'  general practitioners.     Even with these, it can be frustrating as to the gross lack of some basic knowledge. 

Edited by mikez
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21 hours ago, mikez said:

I had my hopes on the DHT theory...all the science/reasoning was there,  but my DHT came back smack in the middle of the range.   Sometimes knowing where not to invest time can be just as helpful I guess.  


I'm the same, my DHT is high. How do you respond to DHT inhibitors like zinc? I'm better for eating loads of pumpkin seeds which are a natural DHT inhibitor. 

I've recently tried to lower E2 by using sustain alpha, but it doesn't help me at all. I just got progressively weaker morning glory, and started to feel low e2 sides like increasing anxiety, I was getting bad fatigue and was generally starting to feel pretty shit. I've stopped using it, and now those things are improving again. Others however are seeing good benefits from this stuff. 

What were your other results from your hormone panel? 

  Edited by tanedout

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On 1/5/2017 at 9:45 PM, TrueJustice said:
All good info that I agree with but it's the long way of working on a cure via diet when we could possibly benefit from taking the correct antibiotic yeah??

 I'm of the opinion that the gut still needs to be cleaned up for lasting quality of health!!!

My final point on the gut issue is this: We know antibiotics destroy microbiome diversity. All of us here were on Accutane from the start, and likely preceded that medication with an antibiotic(s). Therefore, throwing a third or fourth microbiome-destroying agent in the mix seems like a high-risk idea. It's one thing if you are doing so under the supervision of a medical professional who knows of some protocol for building gut flora back up, but as far as I know, we know of no ironclad methods in humans. Antibiotics are associated with all sorts of issues, so unless something substantial is in place following the antibiotics, I wouldn't take any (assuming no apparent infection or other proven gut issue). We can't reverse autoimmune/mental/degenerative conditions by manipulating bacteria like we can in animals.  Fecal transplants are a great step, but they aren't even a guarantee. The best we can do is eat fermented foods, probiotics, avoid grains, limit carbs, and eat a balanced diet. I'm not saying it will cure you, but it's the best we got. Feel free to prove me wrong on the risk of antibiotics.

@Kynarr, I certainly wouldn't be surprised if it took more than diet to recover from this mess, even if you were strict 100% of the time. But if one wanted to focus on gut health, I think that diet is a great start. Edited by ACCUiTy_drANE

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All good info ACCUiTy - you always provide good info.

I know antibiotics can destroy gut flora - the very thing we're trying to fix. I would hate to find out though one day that Accutane smashed our gut flora and led to some type of infection and all we had to do was take the right antibiotic to fix it, that's my concern!!

I will say this in regard to diet, to those who've worked hard at eliminating this and that only to feel little improvement, when diet is really poor ie too much sugar and crap food I feel like absolute hell so I would say that a good diet would at the very least boost ones self esteem and psychologically give you a lift, that's a lot when you're trying work and compete in this world so don't beat yourself up too much with trying to work on diet.

A good diet, exercise and reasonable amount of sleep can sustain one for a long time while we chip away at all these other problems!!

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Does anyone here have anything to say about anhedonia because if you keep ignoring posts about this from different people, then you're brushing probably the most serious issue under the rug. I nearly committed suicide over this in September and was in a psych ward for 5 weeks (I might have mentioned that here) and things have only gotten worse. I probably would have killed myself if it wasn't for the high dose of Effexor I am on now, but that only lessens suicidal urges by making you feel good and probably messes with my head even more. I've tried nsi 189 but I doubt that's done anything at all.

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5 hours ago, cnb30 said:

Does anyone here have anything to say about anhedonia because if you keep ignoring posts about this from different people, then you're brushing probably the most serious issue under the rug.

Anhedonia and emotional blunting have been my worse symptoms. Even if I take a compound that has mood-boosting effects, it feels as if it occurs behind a thick wall. Everything feels watered-down. This is something I have been researching obsessively, so here we go.
 
The biggest break-through in anhedonia treatment seems to be Ketamine, but few clinics prescribe it in the U.S. It is thought that mTOR transmission and activation of AMPA receptors are responsible for these potent anti-depressant effects. The amino acids Sarcosine and Agmatine (technically a metabolite of Arginine) share these mechanisms of action with Ketamine. Better yet, they lack the hallucinogenic/recreational effects. Personally, I've been having great success by taking two grams of Agmatine per day.
 
That aside, you can always get creative with conventional treatments. Personally, I stay far away from SSRIs, as sustained use can limit burst activity and overall firing rate of dopamine. In my experience, SSRIs can make emotional blunting worse. You can combine an SSRI with another drug (5HT2c antagonist/inverse agonist) to diminish the anti-dopaminergic effect of the SSRIs (e.g., Sertraline/Zoloft + Nortriptyline), but it's obviously a risk. Consult a doctor.

I spoke to highly respected psychiatrist on this matter, named Dr. Gillman. I like him because he is blatantly honest that 1) many doctors have no ****ing idea how to treat depression 2) the market is littered with ineffective drugs due to corporate games 3) the measures studies use to determine the so-called "anti-depressant" potency of a compound are inherently flawed, because are largely based on irrelevant properties like the anti-anxiety or hypnotic properties of a drug! WHAT?! Point number 3 explains why many mainstream antidepressants SUCK at treating anhedonia. Many antidepressants are actually sleep-aids, anti-anxiety meds, or even antihistamines, lol. A faulty model breeds faulty medications, never mind the issue of feigned/concealed clinical trials. That being said, Dr. Gillman is a big proponent of irreversible MAOIs (e.g., Parnate, Nardil). They simply work well. If you want a fresh perspective on treating depression (in the context of pharmaceuticals), feel free to read his articles on Psychotropical.com.
 
5 hours ago, cnb30 said:

I probably would have killed myself if it wasn't for the high dose of Effexor I am on now,


I am happy to hear it has done you any good at all. :) According to Dr. Gillman, Clomipramine is a significantly more potent SNRI. He says many of his patients who have tried both Clomipramine and Effexor (Venlafaxine) prefer Clomipramine . Unfortunately, it isn't prescribed as much anymore because it is off-patent. Money rules.

These are just thoughts I'm sharing since you asked. This is not medical advice. Edited by ACCUiTy_drANE
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So correct me if I'm wrong but the biggest side effect to look out for when taking Roaccutane is Depression right?? emotional blunting, lack of drive ect  etc - It's all depression. So my question is, how does it cause this depression???

Is it due to wreaking havoc on the gut? thus interfering with serotonin production? Or does it disrupt receptors in brain that control dopamine & serotonin and have nothing to do with the gut?

No one has ever explained how accutane causes depression?? the jury's still out as far as I'm concerned as to whether it's a gut problem or brain receptor problem, I just don't know....


Similarly - how did I get all these eye floaters that I've now had for nearly 20 years? What the hell caused them?

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On 26.8.2016 at 4:25 PM, john86 said:
The most obvious and intrusive physical sensations in my case are:  
1) This constant feeling of muscular tension all over my body, and especially in my head, face, mouth, and throat...Overall, it feels like my muscles are always "locked up" and my body is never relaxed like it could be before Accutane.

[...]

Does anyone else have anything like this?

Hi to all.

My muscles are feeling tensed all the time too, especially my calfs hurt. I developed Plantar Fasciitis and my archilles tendons hurt, I can't walk without ache anymore.
I have been trying now for 4 years to fix the problem with lots of therapies and visited doctors but nobody could give me an answer why I have this problem. Then I found this post and made the possible connection to Roaccutan.

I took Roaccutan 15 years ago for about 11 months (30 mg/60 kg), together with cortison (5 months).

- what did Roa damage in my body? The muscles, tendons, nerves or something in my brain?
- is it reversible?
- which possibilities do I have to fix it?
- @john86 did you find something that helped you?

Thanks a lot for every reply.


Mat

 

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Hello,

I finish a long consolidation within the framework of an acute promyelocytic leukemia , blood disease in which the retinoic acid plays a fundamental role with regard to not only remission but also cure (in conjunction with arsenic trioxide). Did I want simply to know if somebody in this forum could explain me if there exist differences between  isotretinoin (molecule of the accutane) and tretinoin (molecule of the vesanoid)? Being given the scarcity of my leukemia one almost does not speak about this drug. I recognized myself in certain side-effects quoted here and others not. It is true that in my case, it is initially more urgent to fight to remain in life than to trouble about side-effects. Lastly, if somebody can provide me explanations or a link towards a particular site Thank you!

PS : sorry for my bad English :-(

 

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2 hours ago, belgianboy1830 said:

Hello,

I finish a long consolidation within the framework of an acute promyelocytic leukemia , blood disease in which the retinoic acid plays a fundamental role with regard to not only remission but also cure (in conjunction with arsenic trioxide). Did I want simply to know if somebody in this forum could explain me if there exist differences between  isotretinoin (molecule of the accutane) and tretinoin (molecule of the vesanoid)? Being given the scarcity of my leukemia one almost does not speak about this drug. I recognized myself in certain side-effects quoted here and others not. It is true that in my case, it is initially more urgent to fight to remain in life than to trouble about side-effects. Lastly, if somebody can provide me explanations or a link towards a particular site Thank you!

PS : sorry for my bad English :-(

 
Sorry, unable to advise but good luck.
 



Increase T:

https://www.spectracell.com/media/uploaded/3/0e2064997_392testosteronewheel.pdfhttps://www.spectracell.com/media/uploaded/3/0e2064997_392testosteronewheel.pdf

An interesting test.
https://www.gdx.net/core/sample-reports/NutrEval_FMV-Sample-Report.pdf

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On 1/8/2017 at 6:29 PM, cnb30 said:

Does anyone here have anything to say about anhedonia because if you keep ignoring posts about this from different people, then you're brushing probably the most serious issue under the rug. I nearly committed suicide over this in September and was in a psych ward for 5 weeks (I might have mentioned that here) and things have only gotten worse. I probably would have killed myself if it wasn't for the high dose of Effexor I am on now, but that only lessens suicidal urges by making you feel good and probably messes with my head even more. I've tried nsi 189 but I doubt that's done anything at all.

hey man, effexor is many many times more likely to cause suicidal tendencies than accutane. and if you're worried about anhedonia, why are you taking something that causes it?

are you sure accutane caused your issues?

no disrespect intended, i genuinely would like an explanation

i was on cymbalta a few years ago, which is almost exactly like effexor, and i would almost rather take a very low dose of accutane again than go on cymbalta/effexor. makes u depressed, apathetic, suicidal, and has horrible withdrawal. i wouldnt touch that stuff if i were u

https://www.suicideforum.com/community/threads/effexor-highest-suicide-rate-medication-fda-says.28133/

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19 hours ago, hatetane said:

Just posting this again as so many Vit D defficient.
 


Uh, thank you for sharing. What an epiphany. I just starting focusing on diet this week, and so far I've learned I've been doing literally everything wrong. Thanks to that video and Rhonda's genetic tool, I learned that I am "slow metabolizer of heterocyclic amine carcinogens formed when meat is cooked at high temperatures." In fact, I have the dead-worse mutation so I have been exposed to lots of carcinogens by simply eating meat. I've been eating fried, grass-fed beef for a couple years now. It looks as though I will be boiling ALL meats, fish, and eggs (soft-boiled is amazing anyway) now, since that will keep the food below the 300 degree Fahrenheit danger threshold. It also turns out I have a gene (rs17817449(G;T)) that causes saturated fats to negatively impact my blood glucose and insulin levels. Perhaps I will be trading my usual ground beef for chicken or fish. (Unfortunately, the mercury controversy scares me from fish.)  Lastly, it seems I have multiple genes that impact my vitamin D synthesis, to the point the usual 1,000 IUs is probably not enough. I will be upping my dosage to 10,000 IUs per day.

I type this out so others are aware of how wrong their diets may be. Just a few days ago I learned that replacing my excessive grain consumption with nuts/seeds may actually PROMOTE inflammation if I don't supplement with Omega 3s (fish oil, fish, chia seeds, flaxseeds). However, chia seeds and flaxseeds only provide ALA, which is only then converted into EPA and DHA by the body. According to my genes, my body cannot do much to convert ALA to EPA, so that may explain why I felt like crap when I was vegan.

So in summary, I would be well-served trading in my fried beef for BOILED chicken/eggs and supplementing with 10,000 IUs of Vitamin D and some fish oil. I encourage everyone to give 23andMe + Rhonda's genetic tool a go. Hopefully your body is more efficient at doing stuff than mine is.

  Edited by ACCUiTy_drANE

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On ‎1‎/‎6‎/‎2017 at 4:28 PM, MrErdem said:

After checking my testicles by other urologist and everything seems fine, my endocrinologist said I dont need hormone replacement therapy. After I insisted that I had the all side effects of high estrogen, she gave me Nebido Testo Injection (single injection for 3 months). Anybody has any experience with Nebido? I doubt that this will help, as Testo will be aromatised to estrogen. 
I found it interesting your TSH is .75 which here in the U.S. the standard from the American College of Endo would consider you either hyper or borderline hyper thyroid. There standard for a normal thyroid is between 2.0-3.0. However, labs are not mandated to update their values here. Go figure. It wouldn't surprise me though I can't remember all your symptoms if this might be the reason too for high Estrogen, Low T and a few other issues. I developed Graves/Hyper shortly after my course. My values were in the .52 and I was recently at .75 and they did some adjustments.

The secret of health for both mind & body

is not to mourn for the past, not to worry about the future, or not anticipate troubles, but to live the present moment wisely and earnestly.

The Buddha


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3 hours ago, ACCUiTy_drANE said:

Uh, thank you for sharing. What an epiphany. I just starting focusing on diet this week, and so far I've learned I've been doing literally everything wrong. Thanks to that video and Rhonda's genetic tool, I learned that I am "slow metabolizer of heterocyclic amine carcinogens formed when meat is cooked at high temperatures." In fact, I have the dead-worse mutation so I have been exposed to lots of carcinogens by simply eating meat. I've been eating fried, grass-fed beef for a couple years now. It looks as though I will be boiling ALL meats, fish, and eggs (soft-boiled is amazing anyway) now, since that will keep the food below the 300 degree Fahrenheit danger threshold. It also turns out I have a gene (rs17817449(G;T)) that causes saturated fats to negatively impact my blood glucose and insulin levels. Perhaps I will be trading my usual ground beef for chicken or fish. (Unfortunately, the mercury controversy scares me from fish.)  Lastly, it seems I have multiple genes that impact my vitamin D synthesis, to the point the usual 1,000 IUs is probably not enough. I will be upping my dosage to 10,000 IUs per day.

I type this out so others are aware of how wrong their diets may be. Just a few days ago I learned that replacing my excessive grain consumption with nuts/seeds may actually PROMOTE inflammation if I don't supplement with Omega 3s (fish oil, fish, chia seeds, flaxseeds). However, chia seeds and flaxseeds only provide ALA, which is only then converted into EPA and DHA by the body. According to my genes, my body cannot do much to convert ALA to EPA, so that may explain why I felt like crap when I was vegan.

So in summary, I would be well-served trading in my fried beef for BOILED chicken/eggs and supplementing with 10,000 IUs of Vitamin D and some fish oil. I encourage everyone to give 23andMe + Rhonda's genetic tool a go. Hopefully your body is more efficient at doing stuff than mine is.

 

Do you attribute low Vit D due to Accutane or are you just someone who genetically has issues with D levels?

I know no one knows but why are we potentially deficient in Vit D post tane??

Too much Vit A in liver/body correct??

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4 hours ago, TrueJustice said:

Do you attribute low Vit D due to Accutane or are you just someone who genetically has issues with D levels?

I know no one knows but why are we potentially deficient in Vit D post tane??

Too much Vit A in liver/body correct??
5AR inhibition is linked with low VD3 very often.

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11 hours ago, ACCUiTy_drANE said:

Uh, thank you for sharing. What an epiphany. I just starting focusing on diet this week, and so far I've learned I've been doing literally everything wrong. Thanks to that video and Rhonda's genetic tool, I learned that I am "slow metabolizer of heterocyclic amine carcinogens formed when meat is cooked at high temperatures." In fact, I have the dead-worse mutation so I have been exposed to lots of carcinogens by simply eating meat. I've been eating fried, grass-fed beef for a couple years now. It looks as though I will be boiling ALL meats, fish, and eggs (soft-boiled is amazing anyway) now, since that will keep the food below the 300 degree Fahrenheit danger threshold. It also turns out I have a gene (rs17817449(G;T)) that causes saturated fats to negatively impact my blood glucose and insulin levels. Perhaps I will be trading my usual ground beef for chicken or fish. (Unfortunately, the mercury controversy scares me from fish.)  Lastly, it seems I have multiple genes that impact my vitamin D synthesis, to the point the usual 1,000 IUs is probably not enough. I will be upping my dosage to 10,000 IUs per day.

I type this out so others are aware of how wrong their diets may be. Just a few days ago I learned that replacing my excessive grain consumption with nuts/seeds may actually PROMOTE inflammation if I don't supplement with Omega 3s (fish oil, fish, chia seeds, flaxseeds). However, chia seeds and flaxseeds only provide ALA, which is only then converted into EPA and DHA by the body. According to my genes, my body cannot do much to convert ALA to EPA, so that may explain why I felt like crap when I was vegan.

So in summary, I would be well-served trading in my fried beef for BOILED chicken/eggs and supplementing with 10,000 IUs of Vitamin D and some fish oil. I encourage everyone to give 23andMe + Rhonda's genetic tool a go. Hopefully your body is more efficient at doing stuff than mine is.

 


All you just wrote is absolutely correct. For the best diet to control inflammation, my best suggestion is to buy the Bulletproof Diet book. Dave Asprey is absolutely anal on avoiding inflammation at all cost. Alternatively, most content is available in posts on his website for free. If you seek the perfect diet for inflammation, that would be it. It discusses vit D, how to properly cook meat and veggies to avoid inflammation, cancerous components and degradation of nutrients, and adresses mercury in fish (and fish oil). Take Krill oil. For ALA, don't even look at it. Non-animal o3 is poorly converted and likely rancid by the time you eat it.

I wouldn't worry about genes affecting your diet this much. I've looked it all up and maybe you deal with fats a little bit less well than some people, but the benefits from eating fat beat the cons, no matter your genes. In my case, I supposedly handle sulfur and ammonia poorly, but if I try to avoid that.. I'll eat nothing healthy. 

If you do take 10k IU vit D a day, which is fine temporarily, just make sure you get your levels tested after ~3 months to see where you're at. You don't want to overdo it.

https://blog.bulletproof.com/bulletproof-cooking-kitchen-prep-guidelines/
http://paleomagazine.com/mercury-tuna-fish
https://blog.bulletproof.com/bulletproof-your-sleep-with-vitamin-d/
http://www.marksdailyapple.com/is-it-primal-chia-seeds-black-rice-refined-avocado-oil-and-other-foods-scrutinized/

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On 1/9/2017 at 8:28 PM, Weltschmerz47 said:
hey man, effexor is many many times more likely to cause suicidal tendencies than accutane. and if you're worried about anhedonia, why are you taking something that causes it?

are you sure accutane caused your issues?

no disrespect intended, i genuinely would like an explanation

i was on cymbalta a few years ago, which is almost exactly like effexor, and i would almost rather take a very low dose of accutane again than go on cymbalta/effexor. makes u depressed, apathetic, suicidal, and has horrible withdrawal. i wouldnt touch that stuff if i were u

https://www.suicideforum.com/community/threads/effexor-highest-suicide-rate-medication-fda-says.28133/

how the hell do I get off of it then? I'm stuck in a spot where I'm kinda forced on it right now. Do I lie my way out? BTW, I feel more suicidal OFF the medicine than on.  Edited by cnb30

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12 minutes ago, mikez said:

Has anyone tried Clomid?   

Good question. Given my previous posts, email from a top PFS doctor and an andrologist suggesting clomid as a treatment, any experiences
would be extremely helpful.
 

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2 hours ago, mikez said:

Has anyone tried Clomid?   

I'm taking an AI which is a lot more powerful PCT treatment to restart HPTA. Edited by ehohel

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