Repairing the long-term damage from Accutane

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Simple, just listen to what your body is telling you (not anyone else). If it works for you and makes you feel better, continue to take it. And if it makes you feel worst, come off it. Everyone is different. What works for Mikkael may not works for Heinrich, and may in fact causes Heinrich even more problems. And when that happens to Heinrich, who should he blame?

Edited by Max-
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A quick temper will make a fool of you soon enough


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P.s. this is why I don't hang around these boards anymore....I and others who have experienced side effects post tane have learn't how our bodies respond to particular supplements, I was advising you that MANY people in the same boat as 'us' experience a worsening or completely new side affects when taking omega 3's.

I took the shit 5 years ago so I know how my body reacts to many substances since I ingested it. Others have had over 20 years so you can either listen to studies based on the general population or take the advice of people who are in the same boat as you.

Knock yourselves out if you don't want to listen and there will always be people who think they know better.

I agree with Lamarr on this as Omega 3 supplementation was just making things worse for me. I know that you wanted scientific evidence to back that up, but unfortunately you will find very little scientific evidence on the post accutane side effects overall so I can't provide any. The dermatologist that gave me tane straight up denied that accutane could cause my flushing when i came back complaining about it despite the fact that six months prior I had never flushed in my life. Trust me man. If I didn't have to do all of my own research on trying to heal the damage that accutane caused I wouldn't. I would much prefer going to a doctor and getting a standard treatment, but there aren't any and the vast majority of doctors don't have any idea how to treat post accutane sufferers. If you strongly believe that it will help you then go ahead and give it a go. Who knows. Maybe your side effects are caused by a different reason than mine. I really can't say. I would just say to be careful and to stop if things get worse.

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Yo dude, I'm doing ok man, yourself?

L-carnitine I presume you mean? I try it every now and again because the science is there but long term it doesn't seem to do alot?

I'm taking 480 mg of GLA a day from borage oil. It seems to help my eye and dryness, but i've read it can take several months for full affects so i'm giving it longer this time! Dr Chu really advocates GLA.

No sides from the mepa, I'm on half the dose I used to be on, and no, no signs whatsoever of flushing. My main problems (now that I'm working full time) is cognitive function and my ocular rosacea, i'm going at both full on at the moment and seem to be making progress...

Meh I'm OK I guess haha. Still have the flushing and joint/muscle issues. Within the last year or so I have developed daily headaches too which sucks, but overall I'm surviving. Glad to hear that mepacrine is still working out for you. Do you plan on staying at that dose long term or continue to ween yourself off it?

I'm going to start either L-Car or GLA soon and I was just wondering what dosage you were using for L-Car when you take it? Also, what brand is that borage oil that you take?

Thanks again

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Obviously the thread starter only hear what he wants to hear. So if he has decide what he wants to take or do then just let him be. It is his life and body anyway. Engaging in an arguement regarding someone else's life is a waste of time. And being angry during the confrontation make you look haggard because of the unnecessary stress involved.


A quick temper will make a fool of you soon enough


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One of the reason for No OMEGA 3 is the fact that Omega-3 fats and other moulecules bind to Vitamin A receptors. Same as Vitamin D is also the most important partnership with Vit A and Omega's.

Retinoids, Vit A, Vit D, Thyroid hormones is in a group called the steroid family. This family is known for developing partnerships w/other hormones (such as growth hormones) They all bind to nuclear receptors, meaning they have acess to the nucleus, where they influence gene expression.

When you have either Vit A or Vit D it almost always does so in partnership with Vit A receptor, which binds vitamin A or the omega-3 fatty acid DHA. In the nucleus of the cell, it sits as judge and jury, deciding which genes are turned on and which are turned off. Vit D and its partners Vit A and DHA (omega 3) are conducting the orchestra.

(book written by James E. Dowd, M.D. from Mi Arthritis Institute)

So in a normal person who hasn't been damaged by accutane, receptors haven't been damaged or genes haven't been altered it would be okay, but for thoose like me it is not.

Numerous Post Accutane Suffers Do Not React Well to Omega 3's! I myself eat salmon and am okay, but other foods high in omega 3 make my symptoms worse, just like many Vit A enriched foods.

As for Omega 6 my Rhuem acutally told me that I could take either GLA (omega 6) in a high dose or a anti malaria, or mix of both.....High dose of GLA is very benifical in people with Rhuematoid Arthritis and has shown to decrease inflamation.

If you are looking for help we can try and give you the knowledge that from our research, studies and knowledge from our own experince. Not trying to be rude, but you come asking for help, If your taking Omega 3 right now and not doing any better, it won't hurt to stop!

I myself was on death's bed from accutane and acutally almost died (not from depression or suicide reasons either)...Thanks to other suffers including that of Lamarr I am in a much better place then almost 3 yrs ago!

Oh and thanks Lamarr on the tip for the supplement on memory! Will try you bet and having a teenager doesn't help with having lack memory she tends to get away with too much lol :lol:

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The secret of health for both mind & body

is not to mourn for the past, not to worry about the future, or not anticipate troubles, but to live the present moment wisely and earnestly.

The Buddha


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I'm also looking into bowel/liver cleasing.

It's a good idea.

I know to do it properly you should withdraw from bad foods (like milk, bread, sugar, alcohol) for about a week... But I'm not sure I can go a week without cakes and what-not.

If I knew you had to do it just the once, obviously I'd do it.

For now though, I think I'm doing my liver some good with the milk thistle and dandelion root extract. I ordered the supplement you said about... 'Calcium D-Glucarate', though I'm not sure it'll really work as surely within 5 years my body would've elminated the toxins... But we'll see. You started with it yet?

No, I can't find it in stores. I'll have to order it.

Some people say they have high vitamin A even years after Accutane, so perhaps some of it stays in your liver. Your liver does store excess vitamin A when it can. Maybe this is why some get the long term side effects, their liver absorbs it, for some reason it can't get rid of it fast enough so it just continues to be deactivated and reactivated through the process of glucuronidation and beta-glucoronidase.

I've noticed something. When I take a tablespoon of olive oil, the next few days are hell and it's like I'm reliving Accutane. My bones begin to ache more, hair falls out more, and my skin begins to shed like crazy. I think it's because, when you consume a good amount of fat you gallblader will release your bile which contains all the toxins into your bowels, and then some of it is excreted while some is reabsorbed causing the side effects to reoccur.

Interesting. Why would you take a tablespoon of olive oil? I've heard you can do that as part of a detox. I feel terrible at the moment :(

Hi there i'm in UK but it was my son son whom recently was taking Isotretinoin. he has had lots of real bad side effects to the drug also.

Having just read about the drink with the cabbage , broccoli etc, which may not be as good as you think as dark green Veg has Vitamin A in them

My son is 17 and his life has changed dramatically ...

It Pi**es me off that they have the balls to tell us you can't prove its the drug.

Just wondered if you people have asked about or looked into Nerve damage or Chemical Neurotoxicity. check out the link below and read what we know to be the truth. It makes sense that it could be the brain that is the problem when the doctors cannot find any problems with bloods, MRI scans etc,...

the link was missing.. but you can find it on Neurotox.com A Dr Raymond Singer

Mitch UK

Edited by mitch UK

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Hi Indigo, Ganoderma lucidum extract may be something worth considering - it is a medicinal mushroom that is supposed to have incredible healing and detoxifcation abilities due to the high anti oxidant and glyconutrient content. Also, come over to the nutrition board - there are loads of very experienced and knowledgeable people there who don't generally hang around the medications section who would definately be able to help you.

:)

I've just heard of ganoderma in the form of soap. Supposedly it will help fade away pigmentation. Have you used the soap or now anyone who has? Do you think it helps scars?

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I have extremely severe sebborheic dermatitis of the face as a result of taking Accutane when i was 17 years old. The seb derm was so bad, that i didn't go out the house for years, it covered the entire length of my face and scalp in thick diffuse plaques similar to psoriasis. I have to use vaseline every night to stop my lips from cracking and bleeding. Likewise I've developed scarring of the face as a result of the skin condition. I'd suffer from very bad joint cracking and hair loss as well. All in all pretty brutal stuff.

Anyway i'm not here to scare people into not taking Accutane, i understand what happened to me was an extremely rare thing, although unfortunate it should not deter people from taking the drug. I am only here to help people suffering from the long term side effects of the drug. I've had this for 8 years now and as you can imagine i've tried everything under the sun to cure it. I'm getting better now, alot better infact and it's down to the things i'll share with you now. Bare in mind everyone is different, what works for one might not work for another, but there are certain things all people suffering from Accutane side effects have in common and can benefit from.

Firstly as i say, all these symptoms are based around retinoic acid (accutane) and it's effect in the body. Retinoic acid cannot be stored in the liver like normal vitamin A. It only works in the skin cells. All these people thinking Accutane is still stored in their livers are wrong, it's not. The reason in my mind why Accutane causes side effects is because it is a glucuronidated drug. Ie as it comes into the body, the liver binds the retinoic acid to glucuronic acid molecule which makes it more water soluble. The only problem is over time these glucurides build up and slow down bile flow, or bile acid transport to be precise. Just like anabolic steroid's Accutane causes a similar Liver toxicity. If your suffering from accutane side effects, check your stools....i know i sounds gross but how dark are your stools? if they are a light brown / clay colour you ain't got enough bile flow, chances are your bile has slowed to a snails pace.

Heres an analogy....imagine a bathtub, now look at the hole in the bottom of the tub, it's filled with clumps of hair, the taps are on full blast, eventually it's going to overflow right?

Well the hole is your bile flow (or lack thereof) and the water is the toxins that you accumulate from living ie processed food, air, shampoos, cleansers, soda's, trans fats.

First port of call is to clean up your diet, eat a high percentage raw food diet, organic fruits, vegetables, lots of green juices, spring water, small amounts of soaked nuts, natural personal care items, throw out your perfumes, cleansers, synthetic chemicals, if it's not natural don't put it in your body or on your body (everything you put on your skin is absorbed into the bloodstream in 15 minutes)

Now if you do have low bile acid transport as a result of Accutane toxicity their are certain things that help.....Firstly if you got very low bile flow you cant digest fat or fat soluble vitamins

1. Virgin Coconut oil - is a MCT, it's a medium chain fat.....which means it doesn't need pancreatic enzymes or bile to be absorbed. Without bile it's almost certain you wont absorb any fat so Coconut oil will be one of the few you can absorb very easily. Coconut cream, young coconuts, coconut meat anything coconut related it fine, as long as it's raw.

2. You wanna avoid eating lots of high retinol foods they'll make you more ill....ie milk, cheese, eggs, liver etc. Retinoic acid is a derivative of vitamin A (retinol), so taking large amounts exasperates hair loss, skin conditions, joint cracking, impotence, chellitis etc.

3. Drinking lots of alcohol is very bad for those with long term accutane side effects as retinoic acid react's with alcohol, especially those with liver problems related to accutane.

3. Organic raw food diet is the best tactic to bring about healing, as it stops the chemical load coming in which takes the strain off the liver, kidneys etc. Plus its just the natural way to live. You can eat some steamed chicked occasionally, but at least 70% of your food should be organic raw food, with some green juices, ginger, lemons etc

Accutane basically shuts down the bile acid transport in people with severe accutane side effects, joint cracking, hair loss, seb derm, psoriasis, impotence. All these side effects are caused by the accutane still being in your body, because once the bile has stopped, how is the retinoic acid going to be removed? it isn't? the bodys going to go into hibernation mode and it'll try and protect the organs by storing the accutane in the fat cells. A lack of bile means a lack of fat absorption hence inability to gain weight.

Thats my two cents.

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Hi Chico,

What you've said is interesting. I'm going to get some coconut oil, as I didn't know this differed from other fats in terms of digestion.

I have no reason not to believe that bile flow is adverseley effected during/after accutane. I'm not convinced though that this could be the only cause for accutane's side effects, as I think this is just too simple, as there are ways to increase bile flow through certain herbs (chinese herb coptis) and via liver flushing. So are you saying that by simply getting a good bile flow back, in simple terms, "accutane", or "retinoic acid" as you say, can be removed from our system?

I've been on another forum (via searching google) and someone posted something similar to what you have posted, about glucuronic acid binding with the retinoic acid. Maybe this was also you... maybe you could confirm this? The post said there's an enzyme called beta-glucosidase that will un-bind the two and thus reactivate Accutane causing a viscous cycle, and that there's a supplement called Calcium D-Glucarate that inhibits this process, thus allowing your body to eliminate more Accutane. Is this something you wrote on another froum (i pretty much have copied the exact wording, so you should know if this was you).

If this was you, why didn't you mention Calcium D-Glucarate in your post? Do you know if anyone has had any positive results using this supplement? I've briefly googled but can't find anything really.... maybe this is a relatively new theory therefor know ones really tried it????? Could it work?

Your thoughts on these would be good.

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Hi Chico,

What you've said is interesting. I'm going to get some coconut oil, as I didn't know this differed from other fats in terms of digestion.

I have no reason not to believe that bile flow is adverseley effected during/after accutane. I'm not convinced though that this could be the only cause for accutane's side effects, as I think this is just too simple, as there are ways to increase bile flow through certain herbs (chinese herb coptis) and via liver flushing. So are you saying that by simply getting a good bile flow back, in simple terms, "accutane", or "retinoic acid" as you say, can be removed from our system?

I've been on another forum (via searching google) and someone posted something similar to what you have posted, about glucuronic acid binding with the retinoic acid. Maybe this was also you... maybe you could confirm this? The post said there's an enzyme called beta-glucosidase that will un-bind the two and thus reactivate Accutane causing a viscous cycle, and that there's a supplement called Calcium D-Glucarate that inhibits this process, thus allowing your body to eliminate more Accutane. Is this something you wrote on another froum (i pretty much have copied the exact wording, so you should know if this was you).

If this was you, why didn't you mention Calcium D-Glucarate in your post? Do you know if anyone has had any positive results using this supplement? I've briefly googled but can't find anything really.... maybe this is a relatively new theory therefor know ones really tried it????? Could it work?

Your thoughts on these would be good.

Hey. Sorry to disappoint, but after being recommended Calcium D-Glucarate myself, I bought it and took consistently for 2 months. Nothing happened.

I'm currently trying some chinese herbs (Reishi, Ho Shou Wu and Cordyceps along with Astragalus). As soon as I have help to offer, I will write here.

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Indigo - No problem.. I didn't expect much from it. Out of interest, what was the strength you were taking?

Those chinese herbs you are taking, are they specific liver herbs, or more for general wellbeing, or energy etc?? Tincture form with alcohol?

Have you tried liver flushing?

Edited by jmsil

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Indigo - No problem.. I didn't expect much from it. Out of interest, what was the strength you were taking?

Those chinese herbs you are taking, are they specific liver herbs, or more for general wellbeing, or energy etc?? Tincture form with alcohol?

Have you tried liver flushing?

Hi.. It was Swansons, 250mg x 1 a day.

I recently discovered the herbs through YouTube. A guy called 'herbgardner00'.

I've only been taking them a week or so, in tea form. Bear in mind they're expensive, but if I've not noticed anything after I've run out, I won't re-buy. They're meant to be good in general for your immune system, and they were once only available to emperors (apparantly) thousands of years ago. Ho Shou Wu for example is meant to be good for sexual function (libido) and has been said to regain hair growth and even return grey hairs to their original colour. Sounds too good to be true but it's been proven in studies to work on most users.

I live in the UK and bought a small amount on eBay. The guy who was selling them to me recently opened a store online: www.hybridherbs.co.uk, and I'm buying them from there now. After contacting him through email (his name is Keiran) and asking him if he thought it'd help with roaccutane side effects, I discovered he took the drug too, which seemed to be the reason he'd come across them. He said they'd definitely helped, though he was honest and said he's not 100% better. I'm more optimistic about my hair now though, as he said Ho Shou Wu has helped his.

During the vast research I've done online, I also came across this site: http://www.canceractive.com/cancer-active-...link.aspx?n=536

If you scroll to the bottom it lists four herbs that are known to help chemo side effects. Accutane was initially used for cancer, and the side effects match chemo drugs, so I think it's worth a shot.

Like I said though, I'll report back as soon as I have good news (IF I ever do!)

Meanwhile, you can subscribe to me on YouTube if you'd like: www.youtube.com/FireYourDoctor

I've done a video about Acne in which I state people shouldn't take Accutane.

Once the herbs have kicked in (which they should) I will make videos about them.

I think we need to give our immune systems a boost though, as they've definitely been hurt.

As far as a liver flush, I haven't tried yet.

I'm 21, so live at home. My mum cooks good food!

I'm currently unemployed as I decided I couldn't cope with a full-time job while I had these worries. I didn't enjoy the job so really felt life wasn't worth living.

I have a couple of books on liver flushing so I guess now is the best time for me to try it out.

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Trust me it's all about getting the bile flow back, something like Livotox by Dr Khoshbin will help it's an excellent natural product. Milk thistle does not work. Biotin and fish oil do not work at all. Liver flushes are notoriously hard post accutane, it's rare to get any stones out. If it's hairloss, cut down on fat soluble vitamin A foods like cheese, butter, milk. Cut down slightly on high beta carotene foods like carrots, your hair will stop falling out. Livotox is a good supp to take.

Your hair is falling out because you still have accutane in your body, Accutane slowed your bile flow down to a stand still and your body is unable to remove it. Taking high retinol / beta carotene foods only exasperates it, hence more hairloss. Sort out the liver and your hair will 100% stop falling out. Lots of people post accutane have problems with fat, they dont have the bile needed to absorb fat or fat soluble vitamins. Natural is the best way to go by far. Your wasting your money on those antifungal / hair growth shampoos they are for people that have hairloss due to DHT, thats not you, accutane hairloss is like hypervitaminosis A hairloss.

Edited by Chico Esposito
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Trust me it's all about getting the bile flow back, something like Livotox by Dr Khoshbin will help it's an excellent natural product. Milk thistle does not work. Biotin and fish oil do not work at all. Liver flushes are notoriously hard post accutane, it's rare to get any stones out. If it's hairloss, cut down on fat soluble vitamin A foods like cheese, butter, milk. Cut down slightly on high beta carotene foods like carrots, your hair will stop falling out. Livotox is a good supp to take.

Your hair is falling out because you still have accutane in your body, Accutane slowed your bile flow down to a stand still and your body is unable to remove it. Taking high retinol / beta carotene foods only exasperates it, hence more hairloss. Sort out the liver and your hair will 100% stop falling out. Lots of people post accutane have problems with fat, they dont have the bile needed to absorb fat or fat soluble vitamins. Natural is the best way to go by far. Your wasting your money on those antifungal / hair growth shampoos they are for people that have hairloss due to DHT, thats not you, accutane hairloss is like hypervitaminosis A hairloss.

Hi. My hair doesn't fall out too bad now, just sometimes from my eyebrows. Milk thistle is said to be great for the liver, so I'll keep taking it. I know Accutane interferes with the liver. I was told my a Doc that I'm prone to going jaundice. Milk thistle just may be subtle - You can't see it working. If anything, it should protect against further damage. But I can agree about bile flow. Over more recent months, my digestion has become (pardon the pun) shit. Digestion is very important. I've not tried shampoos and don't intend to, I know that's not going to correct anything. So livotox is something you have to take forever? Did this correct your bowel movements? It's like I'm constipated but need to go when I do. I started taking Natural (herbal) laxatives to try and compensate.

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Trust me it's all about getting the bile flow back, something like Livotox by Dr Khoshbin will help it's an excellent natural product. Milk thistle does not work. Biotin and fish oil do not work at all. Liver flushes are notoriously hard post accutane, it's rare to get any stones out. If it's hairloss, cut down on fat soluble vitamin A foods like cheese, butter, milk. Cut down slightly on high beta carotene foods like carrots, your hair will stop falling out. Livotox is a good supp to take.

Your hair is falling out because you still have accutane in your body, Accutane slowed your bile flow down to a stand still and your body is unable to remove it. Taking high retinol / beta carotene foods only exasperates it, hence more hairloss. Sort out the liver and your hair will 100% stop falling out. Lots of people post accutane have problems with fat, they dont have the bile needed to absorb fat or fat soluble vitamins. Natural is the best way to go by far. Your wasting your money on those antifungal / hair growth shampoos they are for people that have hairloss due to DHT, thats not you, accutane hairloss is like hypervitaminosis A hairloss.

Livotox sounds great, but they don't post outside the US and Canada :(

(I live in the UK).

Any suggestions?

It's funny you say Milk Thistle doesn't work though - It's one of the key ingredients in Livotox.

I cut milk, butter, bread etc a while back. Just sugar/meat I find hard to avoid.

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Thanks for letting me know Indigo. Chico - thanks again for the information.

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Trust me it's all about getting the bile flow back, something like Livotox by Dr Khoshbin will help it's an excellent natural product. Milk thistle does not work. Biotin and fish oil do not work at all. Liver flushes are notoriously hard post accutane, it's rare to get any stones out. If it's hairloss, cut down on fat soluble vitamin A foods like cheese, butter, milk. Cut down slightly on high beta carotene foods like carrots, your hair will stop falling out. Livotox is a good supp to take.

Your hair is falling out because you still have accutane in your body, Accutane slowed your bile flow down to a stand still and your body is unable to remove it. Taking high retinol / beta carotene foods only exasperates it, hence more hairloss. Sort out the liver and your hair will 100% stop falling out. Lots of people post accutane have problems with fat, they dont have the bile needed to absorb fat or fat soluble vitamins. Natural is the best way to go by far. Your wasting your money on those antifungal / hair growth shampoos they are for people that have hairloss due to DHT, thats not you, accutane hairloss is like hypervitaminosis A hairloss.

Hi. My hair doesn't fall out too bad now, just sometimes from my eyebrows. Milk thistle is said to be great for the liver, so I'll keep taking it. I know Accutane interferes with the liver. I was told my a Doc that I'm prone to going jaundice. Milk thistle just may be subtle - You can't see it working. If anything, it should protect against further damage. But I can agree about bile flow. Over more recent months, my digestion has become (pardon the pun) shit. Digestion is very important. I've not tried shampoos and don't intend to, I know that's not going to correct anything. So livotox is something you have to take forever? Did this correct your bowel movements? It's like I'm constipated but need to go when I do. I started taking Natural (herbal) laxatives to try and compensate.

I've found from my experience milk thistle does nothing for accutane side effects, but your welcome to carry on taking it. Accutane causes intrahepatic cholastasis, thats were the side effects stem from. Once the bile transport is stopped or dramatically slowed, the body is unable to remove the drug. Digestion is bad because bile is needed to absorb fat, bile emulisifys fat and without it, fat cannot be absorbed. Likewise fat soluble vitamins will not be absorbed either. Your constipated because a lack of bile causes you to go the toilet once every 2-3 days, sometimes longer. Livotox increased my bowel movements but you'd get the same effect from taking ox bile with every meal. (it's what they give people that have had their gallbladders removed due to gallstones) Next time you go the toilet look at your stools if they are not a very dark brown it's bile related. Don't bother with the laxatives.

If it is bile related, clean up your diet as well because your body cant remove fat soluble toxins without bile. Avoid synthetic chemicals in everything. I'm from the uk too, Livotox in my mind was very good at helping my bile flow, it's not the full cure but it is addressing the main cause.

Accutane's side effects can be brought back to two things....hypervitaminosis A and intrahepatic cholastasis. Both go hand in hand with each other. Accutane causes hypervitaminosis A as your essentially taking massive amounts of Vitamin A. The only reason you can take that level of vitamin A is because retinoic acid is not stored in the liver, if you tried to take the equivalent of 80mg of retinoic acid in standard retinol it would be 266,640 IU per day. The RDA is 3000 IU per day. It's safe to say taking that amount of retinol could kill a man in 6 months. Accutane is different cos it's not stored in the liver, but it still causes hypervitaminosis A and is a very liver toxic drug. Hypervitaminosis A leads to intrahepatic cholastasis once this happens the body cant remove the drug, hence long term accutane side effects.

Hope this helps, i would look into chinese bitters....livotox is my favourite.

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Hi Chico, thanks again for the detailed explanations.

One thing I don't understand which hopefull yyou ill be able to answer. You say accutane is not stored in the liver, yet you also say because the bile flow is slowed or stopped, the body is unable to remove the drug. It sounds contradicting. Can you clear this up?

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QUOTE (jmsil @ Aug 7 2011, 10:28 AM)

Hi Chico, thanks again for the detailed explanations.

One thing I don't understand which hopefull yyou ill be able to answer. You say accutane is not stored in the liver, yet you also say because the bile flow is slowed or stopped, the body is unable to remove the drug. It sounds contradicting. Can you clear this up?

Sure, Accutane is Retinoic Acid, retinoic acid can only be used in the skin cells, when the body eats a retinol containing food... milk for example, the body takes the retinol and decides whether it needs to be used right away. If it doesn't need to be used it will store the retinol in the liver. Beta carotene is absorbed through plant foods, the body converts that into retinol, it then converts that retinol into retinoic acid so it can be used in the skin cells. The point is once it's converted to retinoic acid, it cannot be converted back to retinol. Retinol can be stored in the liver but retinoic acid cannot. It's only purpose is in the skin cells.

Unlike retinol, retinoic acid and its analogues are not stored in the liver, but are rapidly metabolized (Moore, 1967)

In a natural world the body knows exactly how much retinol to convert into retinoic acid at all times. As soon as you start taking Accutane suddenly there's massive... toxic amounts of Retinoic acid flooding the body and because it's a fat soluble compound the liver has to remove it in the bile. It uses the glucuronidation pathway to do this. Which means it binds the retinoic acid to a Glucuronic acid molecule, which in theory makes it more water soluble. The only problem is these glucurides build up and slow down bile acid transport (bile flow) over time. When the bile is slowed to a halt, then the removal of accutane becomes nearly impossible, hence people suffering with hypervitaminosis A side effects for many years.

Hope this helps

Edited by Chico Esposito
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thanks chico, that's really well explained. you make it almost seem straightfowward. if only it was that easy to get rid of accutane from one's system! do you beleive you can really become completely accutane free eventually chico, by taking things that will strengthen the liver/bile? I know you said you still have problems (i think) but had improved. are you still improving all th time.. or has it stopped? are you still taking herbs to increase bile flow?

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my question is simple, is thier anyone out thier who has come off accutane had had no problems since ?>

*there :P

Thanks Chico.

Where do you buy your Ox Bile and how many do you take a day?

When I first googled Ox Bile, it bought up Taurine which seems to be along the same lines (?)

Does it have to be Ox Bile, as that's more expensive?

Cheers

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