Repairing the long-term damage from Accutane

10,342 posts in this topic

http://gradworks.umi.com/14/99/1499815.html

''Riboflavin (RF) is an important biological molecule. It is a photolabile, water-soluble vitamin (B2) necessary for the healthy function of the human body. In enzymatic systems, riboflavin often binds metals in order to aid in catalytic activity. The role of bound metals, especially molybdenum (Mo) is not well understood. We propose the use of the RF-Mo complex as a model to envisage an in vitro interaction where Mo(V), necessary for the function of some important enzymes in the human body bound to the isoalloxazine moiety of RF.

Here we are exploring the binding characteristics'' ...

maybe the molybdenum fanctionality is hurt when reboflavin is absent.

there was somone here who was teste low on molybdenum. so maybe b2 is not enough.

http://pubs.acs.org/doi/abs/10.1021/ja01641a090

from the right bottom of the page-''THE ROLE OF MOLYBDENUM AND FLAVIN IN HYDROGENASE''

its about some bacteria. i dno't realy understand. but maybe it worth somthing

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671166/

''and aldehyde oxidase (AO, EC 1.2.3.1). All these proteins are characterized by an equatorial sulfur ligand at the Moco essential for the enzymatic activity [2], and belong to the class of complex molybdo-flavoenzymes (MFEs) containing two nonidentical [2Fe-2S] clusters and FAD as additional cofactors [3], [4].''

EDIT: i'm concern about taking molybdenum.if it is radioavtive isotope or somthing, i found it can be made from radio active waste(dont know if this in supps) or from some stone, both case i understood that that moly is radioactive in it nutare or som't like that, but maybe it is not much differ from radioactive from regular foods?l since reading the next i start to look about it more

http://forums.phoenixrising.me/index.php?threads/the-resistant-starch-challenge-is-it-the-key-weve-been-looking-for.26976/page-48

''did take molybdenum for a while but it ended up in my thyroid for some strange reason.

Asklipia said:

How do you know that, Violeta? A thyroid biopsy ? clear.png

A biological dentist that does a type of kinesiology testing told me that. I had taken less than a bottle of molybdenum a few years earlier.

Then later I found articles like this one http://www.ncbi.nlm.nih.gov/pubmed/10616042 and read some old books about uric acid (readit here: https://archive.org/details/uricacidasafact02haiggoog )and decided to get minerals except potassium and magnesium from food.

I had also had a C scan done for a heart problem and wonder if the molybdenum was from the radioisotopes but don't know anyone that can help with that question.''

Edited by Modeaa

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http://www.landesbioscience.com/supplement/NelsonDE1-3-Sup1.pdf

''Complete list: Significantly Changed genes after 8 weeks isotretinoin treatment''

i suppose that the positive numbers mean upregulation and the minus mean downregulation

this is a good catch.

maybe try to cross reference the biggest ++ and biggest -- on that list.... and find influences with different enzymes and what minerals are used up by those being used up faster or slower.


If you have a majority of the following: Joint pain,Brain fog,lethargy,high bilirubin,dry skin, night-blindness, sweat easily, thin easily damaged skin, poor wound healing, dry brittle hair..... Please get a RBC copper, ceruloplasmin, plasma copper,  RBC zinc and a Vitamin D test ASAP


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http://www.landesbioscience.com/supplement/NelsonDE1-3-Sup1.pdf

''Complete list: Significantly Changed genes after 8 weeks isotretinoin treatment''

i suppose that the positive numbers mean upregulation and the minus mean downregulation

this is a good catch.

maybe try to cross reference the biggest ++ and biggest -- on that list.... and find influences with different enzymes and what minerals are used up by those being used up faster or slower.

if we can put a list of nutrients and substances to each gene on that list it can realy help. i wonder if it is scientificly correct to assume that the -- could have been first ++. -- mean it dont want to work?... -- means it want to work but out of nutrients(because of other gene on that list demand for the same nutrients,substence)?

maybe if this list was made after 5 days of treatment you could see the -- being in the ++ and vise versa?

getting sicence people to decipher that list could be helpfull alot.http://www.landesbio...nDE1-3-Sup1.pdf

Edited by Modeaa

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ZINC

http://en.wikipedia.org/wiki/Metallothionein

''Metallothionein (MT) is a family of cysteine-rich,''...

''MTs function is not clear, but experimental data suggest MTs may provide protection against metal toxicity, be involved in regulation of physiological metals (Zn and Cu) and provide protection against oxidative stress. There are four main isoforms expressed in humans (family 1, see chart below): MT1 (subtypes A, B, E, F, G, H, L, M, X), MT2, MT3, MT4. In the human body, large quantities are synthesised primarily in the liver and kidneys. Their production is dependent on availability of the dietary minerals, as zinc, copper and selenium, and the amino acids histidine and cysteine.''

http://digitool.library.mcgill.ca/R/?func=dbin-jump-full&object_id=23988

''Metallothionein pre-induction by zinc and isotretinoin teratogenicity in CD-1 mice''

''This investigation evaluated the potential protective role of Zn, through modulation of MT, against the teratogenic effects of isotretinoin (ITR),''

''Significant induction of MT by Zn supplementation was observed in mouse embryos both in vivo and in vitro.''

''There was a six-fold increase in MT expression in the Zn treatment group, resulting in MT concentration of 688 $ mu$g/g protein. Pre-induction of MT by Zn exposure was found to offer protection against subsequent exposure to ITR in vivo and in vitro.''

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dont know if this is about what might be going on in the body..and dont understnad a thing here but thought i will put it here anyway

http://www.chemicalbook.com/ChemicalProductProperty_EN_CB6222631.htm

''Isotretinoin Chemical Properties,Usage,Production''

Reactivity Profile
An organic acid and unsaturated aliphatic hydrocarbon. Carboxylic acids donate hydrogen ions if a base is present to accept them. They react in this way with all bases, both organic (for example, the amines) and inorganic. Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat. Neutralization between an acid and a base produces water plus a salt. Insoluble carboxylic acids react with solutions of cyanides to cause the release of gaseous hydrogen cyanide. Flammable and/or toxic gases and heat are generated by the reaction of carboxylic acids with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides. Carboxylic acids, especially in aqueous solution, also react with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat. Their reaction with carbonates and bicarbonates generates a harmless gas (carbon dioxide) but still heat. Like other organic compounds, carboxylic acids can be oxidized by strong oxidizing agents and reduced by strong reducing agents. These reactions generate heat. A wide variety of products is possible. Like other acids, carboxylic acids may initiate polymerization reactions; like other acids, they often catalyze (increase the rate of) chemical reactions.

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molybdenum anacdote:

''timatronI also had a $400 organic acids test done. Most things there were good. Methylation, neurotransmitters all that were good. I was extremely low in sulfate though''

DuulTested MicroNutrient deficiencies. Which said I was low in Vitamin C, Alpha Lipoic Acid, Molybdenum. For vitamin A it said I had normal levels.''

wonder if in the second case the molybdenum was mesured directly or that the deficiency was inferred from mesuring sulfite sulfate. this is importent becuse http://www.livestrong.com/article/371139-molybdenum-deficiency-symptoms/''According to the Merck Manuals Online Medical Library, in 1967, a child with a genetic disorder that inhibited the utilization of molybdenum''

utilization is not the same as deficiency,it might be only fanctional deficiency due to utilization defect which it source could be other deficency which might be b2.EDIT: OR deficency on what is needed to activate the gene for it http://www.uniprot.org/uniprot/Q3ATJ0''Putative molybdenum utilization protein ModD''

http://www.livestrong.com/article/371139-molybdenum-deficiency-symptoms/

''. Another documented deficiency, published in a November 1981 report in the "American Journal of Clinical Nutrition," concerned a man who received intravenous nutrition for 18 months and developed an intolerance to certain amino acids -- structural components of protein -- as a result of inadequate molybdenum.''

so if there is a molybdenum deficiency from accutane the above might explain the reports on improvment from fasting.

if theres others who tested there molybdenum or sulfite sulfate please share

Edited by Modeaa

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Trying to find this study... help:

A Polish study found that certain cancer-fighting drugs that impair collagen synthesis and delay wound healing work by immobilizing manganese, so that it can’t activate the collagen-building enzyme.


If you have a majority of the following: Joint pain,Brain fog,lethargy,high bilirubin,dry skin, night-blindness, sweat easily, thin easily damaged skin, poor wound healing, dry brittle hair..... Please get a RBC copper, ceruloplasmin, plasma copper,  RBC zinc and a Vitamin D test ASAP


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Hi, so do you believe taking manganese is majorly important for us accutane sufferers? I've tried almost everything. My next step is to do some major detoxing through liver flushing and colon hydrotherapy. Also, this is my first post. Hello everyone... 20 year old who took accutane when I was 17. Severely messed me up. Would love to have some input from others about what has worked. - Alan

Trying to find this study... help:

A Polish study found that certain cancer-fighting drugs that impair collagen synthesis and delay wound healing work by immobilizing manganese, so that it can’t activate the collagen-building enzyme.


Resources for people looking to heal: http://bit.ly/fixingaccutanedamage
Some of the tests I've had over the years of being ill: http://bit.ly/testingresults
My symptoms I've suffered from (includes accutane dosage): http://goo.gl/ZmNCHN
Email I can be contacted at: optimumpremonition2 at gmail dot com


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Trying to find this study... help:

A Polish study found that certain cancer-fighting drugs that impair collagen synthesis and delay wound healing work by immobilizing manganese, so that it can’t activate the collagen-building enzyme.

So, supplementing with Manganese would not help. Because there is a mechanism inside of us that handles it differently after accutane.

Or because you have to take accutane for some months it has made a habit out of the mechanism after we stopped accutane. Supplementing with an "overdose" manganese will return the balance?

Also, people are reporting brain fog. Is there any link with manganese ?

Edited by Walden Rev

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TO MEMBER DUUL.

if you see this, PLEASE tell me if you know whether the test that found you are deficient in molybdenum mesured molybdenum directly or that it was some kind of analyzing of data of other thinhgs that where mesured which led to this conclusion by the lab analyst. thank you

http://ghr.nlm.nih.gov/gene/SUOX

''Sulfite oxidase is a homodimeric protein localized to the intermembrane space of mitochondria. Each subunit contains a heme domain and a molybdopterin-binding domain.''

iron problem from accutane been broth up . the iron might be deficient acording to some science reported cases, or another option (according to internet forum info which might be wrong. messege 32- http://forums.phoenixrising.me/index.php?threads/b2-i-love-you.15209/page-2 ) iron can be unusable because of an manganese deficency ,this manganese is needed for iron to be relase from the liver,and the manganese deficincy can be beucase of b2 deficency.

so is it the manganese and b2 that being more needed, or the molybdenum itself is deficient also?

TO MEMBER DUUL.

if you see this, PLEASE tell me if you know whether the test that found you are deficient in molybdenum mesured molybdenum directly or that it was some kind of analyzing of data of other thinhgs that where mesured which led to this conclusion by the lab analyst. thank you

Edited by Modeaa

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TO MEMBER DUUL.

if you see this, PLEASE tell me if you know whether the test that found you are deficient in molybdenum mesured molybdenum directly or that it was some kind of analyzing of data of other thinhgs that where mesured which led to this conclusion by the lab analyst. thank you

http://ghr.nlm.nih.gov/gene/SUOX

''Sulfite oxidase is a homodimeric protein localized to the intermembrane space of mitochondria. Each subunit contains a heme domain and a molybdopterin-binding domain.''

iron problem from accutane been broth up . the iron might be deficient acording to some science reported cases, or another option (according to internet forum info which might be wrong. messege 32- http://forums.phoenixrising.me/index.php?threads/b2-i-love-you.15209/page-2 ) iron can be unusable because of an manganese deficency ,this manganese is needed for iron to be relase from the liver,and the manganese deficincy can be beucase of b2 deficency.

so is it the manganese and b2 that being more needed, or the molybdenum itself is deficient also?

TO MEMBER DUUL.

if you see this, PLEASE tell me if you know whether the test that found you are deficient in molybdenum mesured molybdenum directly or that it was some kind of analyzing of data of other thinhgs that where mesured which led to this conclusion by the lab analyst. thank you

some of DUULs sides were interesting... all to me indicate collagen/Mn thyroid/Mn deficiency:

-Minor Tintinitus (slight ringing of ears) Ears tested: Hearing is fine.

- TMJ / Jaw clicking (hurts to yawn sometimes)

- Cracking joints such as Knees and thumbs. (loud knee cracks, thumbs always want to crack)

- Low Libido

-Eye floaters (happened 3 years after accutane)

-Dry Eyes (sometimes they are in the way, my eyes are never white - always some pinkness or eye irritation)

-Changes in Body Temperature, Sometimes feet are ice cold, other parts of my body are warm.

Modeaa:

Taurine.....

Some studies suggest humans are dependent upon dietary taurine to maintain "adequate" taurine reserves. Females tend toward lower taurine levels than males as their production pathways don't work as efficiently.

Taurine is closely bound to zinc & manganese so deficiencies of either of these can interfere with its' utilization. Likewise, zinc & manganese enhance the effects of taurine.

Eye floaters and taurine hmmm.

http://www.earthclinic.com/cures/eye-floaters_questions.html

and of course the taurine conjugates:

DETOXIFICATION: Taurine conjugates & detoxifies various internal & external toxic compounds & may help chemical sensitivities.

cross referencing brain fog and manganese i got two blogs i havent seen before

http://www.socialanxietysupport.com/forum/f11/is-manganese-the-solution-70691/

https://aaronjreid.wordpress.com/tag/manganese/

Edited by tryingtohelp2014
1 person likes this

If you have a majority of the following: Joint pain,Brain fog,lethargy,high bilirubin,dry skin, night-blindness, sweat easily, thin easily damaged skin, poor wound healing, dry brittle hair..... Please get a RBC copper, ceruloplasmin, plasma copper,  RBC zinc and a Vitamin D test ASAP


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Trying to find this study... help:

A Polish study found that certain cancer-fighting drugs that impair collagen synthesis and delay wound healing work by immobilizing manganese, so that it can’t activate the collagen-building enzyme.

So, supplementing with Manganese would not help. Because there is a mechanism inside of us that handles it differently after accutane.

Or because you have to take accutane for some months it has made a habit out of the mechanism after we stopped accutane. Supplementing with an "overdose" manganese will return the balance?

Also, people are reporting brain fog. Is there any link with manganese ?

read first review

http://www.amazon.com/Source-Naturals-Manganese-Chelate-elemental/product-reviews/B000EQ2S28


If you have a majority of the following: Joint pain,Brain fog,lethargy,high bilirubin,dry skin, night-blindness, sweat easily, thin easily damaged skin, poor wound healing, dry brittle hair..... Please get a RBC copper, ceruloplasmin, plasma copper,  RBC zinc and a Vitamin D test ASAP


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http://en.wikipedia.org/wiki/Retinol_dehydrogenase

Some retinol dehydrogenases are in extra-ocular tissues, such as human retinol dehydrogenase-4 (RoDH-4), which converts retinol and 1-cis-retinol to different aldehydes in liver and skin. It was also found that 13-cis-retinoic acid (isotretinoin), 3,4-didehydroretinoic acid, and 3,4-didehydroretinol can act as competitive inhibitor of the 3α-hydroxysteroid dehydrogenase oxidative activity of the enzyme. This can potentially explain how isotretinoin, the active ingredient is Roaccutane (Accutane), can suppress sebaceous glands and be used for severe acne treatment.

i have not read yet but i will put it here

https://www.deepdyve.com/lp/elsevier/13-cis-retinoic-acid-competitively-inhibits-3-hydroxysteroid-oxidation-obmA1pG8e3

''13-cis-Retinoic acid competitively inhibits 3α-hydroxysteroid oxidation by retinol dehydrogenase RoDH-4: a mechanism for its anti-androgenic effects in sebaceous glands?''

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some here have also theorized that intrahepatic cholestasis is a reason for the continued side effects years after stopping this drug....

"Intrahepatic cholestasis is defined as a disturbance of bile secretion without anatomic obstruction (Feur and Difonzo, 1992). This situation results most often as an adverse consequence of drug therapy **** think accutane here ****(Chan et al., 1998; Plaa and Priestly, 1976; Stieger et al., 2000)"

http://toxsci.oxfordjournals.org/content/73/2/378.full

"An interesting feature of the present study is that only the Mn-BR combination induces cholestasis. Injection of Mn alone leads to significant increase in the activities of cholesterol metabolism key enzymes, HMG-CoA reductase, and cholesterol 7α-hydroxylase."

"These findings may help to further elucidate the biochemical mechanisms of drug-induced cholestasis in human and lead to possible therapeutic maneuvers to prevent or treat the cholestasis induced by drug interactions."

when Mn is taken alone, it showed to increase the bile flow?!

Edited by tryingtohelp2014

If you have a majority of the following: Joint pain,Brain fog,lethargy,high bilirubin,dry skin, night-blindness, sweat easily, thin easily damaged skin, poor wound healing, dry brittle hair..... Please get a RBC copper, ceruloplasmin, plasma copper,  RBC zinc and a Vitamin D test ASAP


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You're very good at finding interesting studies. I wonder what the mechanism is that Mn plays in resolving the cholestasis. Also this video comes to mind:

(he believes liver flushing cured him. related to intrahepatic cholestasis perhaps...)

Also, here is an article about accutane and Vit A: http://www.westonaprice.org/health-topics/the-pursuit-of-happiness/

I can confirm that I was indeed very deficient in Vitamin A 1 year post accutane (according to Spectracell Labs Micronutrient Testing). I took the accutane for 5 months. During the entire treatment and after, I ate incredibly high amounts of beta carotene through sweet potatoes each and every day. My actual Vit A intake was not high however. Just some more thoughts..

some here have also theorized that intrahepatic cholestasis is a reason for the continued side effects years after stopping this drug....

"Intrahepatic cholestasis is defined as a disturbance of bile secretion without anatomic obstruction (Feur and Difonzo, 1992). This situation results most often as an adverse consequence of drug therapy **** think accutane here ****(Chan et al., 1998; Plaa and Priestly, 1976; Stieger et al., 2000)"

http://toxsci.oxfordjournals.org/content/73/2/378.full

"An interesting feature of the present study is that only the Mn-BR combination induces cholestasis. Injection of Mn alone leads to significant increase in the activities of cholesterol metabolism key enzymes, HMG-CoA reductase, and cholesterol 7α-hydroxylase."

"These findings may help to further elucidate the biochemical mechanisms of drug-induced cholestasis in human and lead to possible therapeutic maneuvers to prevent or treat the cholestasis induced by drug interactions."

when Mn is taken alone, it showed to increase the bile flow?!


Resources for people looking to heal: http://bit.ly/fixingaccutanedamage
Some of the tests I've had over the years of being ill: http://bit.ly/testingresults
My symptoms I've suffered from (includes accutane dosage): http://goo.gl/ZmNCHN
Email I can be contacted at: optimumpremonition2 at gmail dot com


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Hello everone. First let me start out by saying i am extremely appreciative of everyone in here who contributes and has a general concern for overcoming all of these accutane induced symptoms.

From what I understand, the dry eyes, ED's, joint pain and digestion issues seem to be the stand outs of long term side effects. I was hoping someone could point me in the right direction for my symptoms which like all of you i am sure that accutane has caused.

- IBD/Chrons I haven't had a normal poo since the week before I started accutane. (2 years)

- Incredibly dry irritated skin.

- lots of hairloss and extremely dry hair!

I have tried oodles and oodles of supplements, fasting etc and have had no success. From my skimming of the 292 pages (which took almost 2 weeks :D) it seems like a maganese supplement would be a good idea?

Im just wondering if maganese is now the best approach for my symptoms, or maybe I missed something while reading.

Id be happy to report back as I try new things.

Kind Regards,

Aaron

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You're very good at finding interesting studies. I wonder what the mechanism is that Mn plays in resolving the cholestasis. Also this video comes to mind:

(he believes liver flushing cured him. related to intrahepatic cholestasis perhaps...)

Also, here is an article about accutane and Vit A: http://www.westonaprice.org/health-topics/the-pursuit-of-happiness/

I can confirm that I was indeed very deficient in Vitamin A 1 year post accutane (according to Spectracell Labs Micronutrient Testing). I took the accutane for 5 months. During the entire treatment and after, I ate incredibly high amounts of beta carotene through sweet potatoes each and every day. My actual Vit A intake was not high however. Just some more thoughts..

some here have also theorized that intrahepatic cholestasis is a reason for the continued side effects years after stopping this drug....

"Intrahepatic cholestasis is defined as a disturbance of bile secretion without anatomic obstruction (Feur and Difonzo, 1992). This situation results most often as an adverse consequence of drug therapy **** think accutane here ****(Chan et al., 1998; Plaa and Priestly, 1976; Stieger et al., 2000)"

http://toxsci.oxfordjournals.org/content/73/2/378.full

"An interesting feature of the present study is that only the Mn-BR combination induces cholestasis. Injection of Mn alone leads to significant increase in the activities of cholesterol metabolism key enzymes, HMG-CoA reductase, and cholesterol 7α-hydroxylase."

"These findings may help to further elucidate the biochemical mechanisms of drug-induced cholestasis in human and lead to possible therapeutic maneuvers to prevent or treat the cholestasis induced by drug interactions."

when Mn is taken alone, it showed to increase the bile flow?!

i saw this....

I think its the utilization of choline by way of Mn that helps with the cholestasis problem. Trimethylglycine will help with this as well. Mn also helps to produce stomach acid...and if you watch that video...his digestion was all messed up. he was low on iron...again this is an indirect symptom. starts with stomach acid, then goes onto the intestines and your gut...thats where probiotics will come into play. liver and gall bladder flushes... i really dont know about that. its very vague, and most studies ive seen say they dont do a thing. we basically took a highly potent acid for an extended period of time...and our body robbed our stores of mineral (s) to combat this.

im a 2300 rated chess player. im good at connecting dots. now that im committed to this, i WILL figure it out.

Edited by tryingtohelp2014
2 people like this

If you have a majority of the following: Joint pain,Brain fog,lethargy,high bilirubin,dry skin, night-blindness, sweat easily, thin easily damaged skin, poor wound healing, dry brittle hair..... Please get a RBC copper, ceruloplasmin, plasma copper,  RBC zinc and a Vitamin D test ASAP


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im a 2300 rated chess player. im good at connecting dots. now that im committed to this, i WILL figure it out.

I'm very happy you are determined and extremely grateful to have you here. I will definitely be sharing what ends up helping me.

little video on epigenetics. She mentions accutane at 36:45:

So you don't think the drug is still in our system? I've heard another person say they got over symptoms just from doing simple oxygen based colon cleansers. Seems too good to be true haha. And as for the liver/gallbladder flush, I don't think it would hurt. I will be attempting it this month along with many colonics, colemas, and enemas (After I get tested for small intestinal bacterial overgrowth)

Edit: Going to be getting NOW Foods TMG 1000mg along with the manganese you recommend

Edited by yetanotheraccutanevictim

Resources for people looking to heal: http://bit.ly/fixingaccutanedamage
Some of the tests I've had over the years of being ill: http://bit.ly/testingresults
My symptoms I've suffered from (includes accutane dosage): http://goo.gl/ZmNCHN
Email I can be contacted at: optimumpremonition2 at gmail dot com


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im a 2300 rated chess player. im good at connecting dots. now that im committed to this, i WILL figure it out.

I'm very happy you are determined and extremely grateful to have you here. I will definitely be sharing what ends up helping me.

little video on epigenetics. She mentions accutane at 36:45:

So you don't think the drug is still in our system? I've heard another person say they got over symptoms just from doing simple oxygen based colon cleansers. Seems too good to be true haha. And as for the liver/gallbladder flush, I don't think it would hurt. I will be attempting it this month along with many colonics, colemas, and enemas (After I get tested for small intestinal bacterial overgrowth)

Edit: Going to be getting NOW Foods TMG 1000mg along with the manganese you recommend

i am 1000% certain there is still a residue or metabolite still residing in us. something is causing a constant epigenetic change. something is suppressing. everyone can say what they will, but of this im certain... albeit purely anecdotal. 4 or 5 years after stopping the course of accutane, i went on a massive weight loss program in order to flush this stuff out. while i wasnt overweight to begin with, i lost about 30 lbs...and towards the end i was just racked with the same side effects x100, as when i was on the drug, to the point where my joints were screaming in pain with the palms and soles of my feet literally peeling from dryness! i had to stop. but while this was happening...i would get a day where my oil glands would turn on 100% again...just like before taking the drug, only to shut off when i started to eat normally. I definitely think i stirred it up, but i didnt have the cofactors/enzymes to take it out.

you have to take more than the TMG.... TMG was just a part of the methylation protocol. the methylation is an attempt to epigenetically repair ourselves.

im sure accutane metabolites replace/mimic natural vitamin A, but also prevents normal vitamin A status.

Edited by tryingtohelp2014

If you have a majority of the following: Joint pain,Brain fog,lethargy,high bilirubin,dry skin, night-blindness, sweat easily, thin easily damaged skin, poor wound healing, dry brittle hair..... Please get a RBC copper, ceruloplasmin, plasma copper,  RBC zinc and a Vitamin D test ASAP


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you have to take more than the TMG.... TMG was just a part of the methylation protocol. the methylation is an attempt to epigenetically repair ourselves.

im sure accutane metabolites replace/mimic natural vitamin A, but also prevents normal vitamin A status.

I spent $1500 in the past 2 months. I only have about $400 left. I'm just trying to get a couple things that I think might help without being too expensive. I'm pretty sure I am taking most of the required methyl donors in my current supp regimen. If you could provide some requirements that need to go along with TMG and manganese that'd be much appreciated. I may already be taking them.


Resources for people looking to heal: http://bit.ly/fixingaccutanedamage
Some of the tests I've had over the years of being ill: http://bit.ly/testingresults
My symptoms I've suffered from (includes accutane dosage): http://goo.gl/ZmNCHN
Email I can be contacted at: optimumpremonition2 at gmail dot com


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you have to take more than the TMG.... TMG was just a part of the methylation protocol. the methylation is an attempt to epigenetically repair ourselves.

im sure accutane metabolites replace/mimic natural vitamin A, but also prevents normal vitamin A status.

I spent $1500 in the past 2 months. I only have about $400 left. I'm just trying to get a couple things that I think might help without being too expensive. I'm pretty sure I am taking most of the required methyl donors in my current supp regimen. If you could provide some requirements that need to go along with TMG and manganese that'd be much appreciated. I may already be taking them.

with manganese... you need to add B1 B2 and Choline ... but these are taken at different times. manganese is taken by itself, away from food.

the three supplements that ive noticed actually doing something, besides the initial energy rush of the B12.....

TMG ... noticed in my eye whites....and skin changes. i thnik this will take many months to have a greater effect.

probiotics NOW 25 bil 10 strain.... vast improvement in all stomach issues within days. ive been on other probiotics before... nothing compared to this though

Manganese .... noticeable joint pain relief, especially in my shoulders after a few weeks of supplementation at 10 mg a day. dosages will need to be played with. eat foods high in Mn. dont take everyday. skip a day or 3 and then come back with a 20 mg dose and see if that helps or produces something different. we're all different.

start slow....watch for any signs/side effects. dont get out of balance.

Edited by tryingtohelp2014
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If you have a majority of the following: Joint pain,Brain fog,lethargy,high bilirubin,dry skin, night-blindness, sweat easily, thin easily damaged skin, poor wound healing, dry brittle hair..... Please get a RBC copper, ceruloplasmin, plasma copper,  RBC zinc and a Vitamin D test ASAP


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TMG ... noticed in my eye whites....and skin changes. i thnik this will take many months to have a greater effect.

Sorry, but could you elaborate on skin changes.

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Sorry one more comment...slightly off topic I guess. I kind of squeaked my way into this thread. Hi I am Aaron btw.

I am aware this is likely a huge stretch, but if anyone waned to connect the dots... feel free. I've been off accutane for 2 years now. Several occasions over the past 2 years have resulted in large amounts of liquor being consumed.

In every occasion, the following morning has resulted in clear and hydrated skin... ( the red "scars" all over my temples would be 90% faded). The terrible dry irritated red disgusting skin would be no more. This would usually last for 1 day and then things would go back to normal. Is it too much of a stretch to say that the alcohol put some sort of stress on my liver that resulted in beautiful skin the next day? Or is probably blood sugar related? Oh god do I have diabetes? hehe.

Has anyone else noticed a vast improvement in their skin health the morning after drinking?

Thanks for any insights.

Edited by Accutazed

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Sorry one more comment...slightly off topic I guess. I kind of squeaked my way into this thread. Hi I am Aaron btw.

I am aware this is likely a huge stretch, but if anyone waned to connect the dots... feel free. I've been off accutane for 2 years now. Several occasions over the past 2 years have resulted in large amounts of liquor being consumed.

In every occasion, the following morning has resulted in clear and hydrated skin... ( the red "scars" all over my temples would be 90% faded). The terrible dry irritated red disgusting skin would be no more. This would usually last for 1 day and then things would go back to normal. Is it too much of a stretch to say that the alcohol put some sort of stress on my liver that resulted in beautiful skin the next day? Or is probably blood sugar related? Oh god do I have diabetes? hehe.

Has anyone else noticed a vast improvement in their skin health the morning after drinking?

Thanks for any insights.

WE CAN DRINK IT OUT OF US! :)

Reduced efficacy has been noted when isotretinoin is taken with heavy alcohol intake.66 Isotretinoin is metabolized by cytochrome P450 enzymes, these are inducible by ethanol and inhibited by some drugs

66. Soria C, Allegue F, Galiana J, Ledo A. Decreased isotretinoin efficacy during acute alcohol intake. Dermatologia. 1991;182:203.[PubMed]

1 person likes this

If you have a majority of the following: Joint pain,Brain fog,lethargy,high bilirubin,dry skin, night-blindness, sweat easily, thin easily damaged skin, poor wound healing, dry brittle hair..... Please get a RBC copper, ceruloplasmin, plasma copper,  RBC zinc and a Vitamin D test ASAP


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