IndigoRush

Repairing the long-term damage from Accutane

11,034 posts in this topic

To the guy who used homeopathy,did you have any luck?

I have set up a group of facebook called roaccutane action uk-all please join where we can discuss maybe more easily:)

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Don't know if you are talking to me but, isotherapy was very effective yes. I don't think it is an absolute necessity but it's useful to force the body to react and do the process he need to heal itself and expell a specific drug, otherwise the body will do his natural job and do what he can from what is the current priority, as accutane created indirect problems, damage and global toxicity and acidity he won't act mainly against accutane (theory). When we start eating a physiological diet and stimulating the body detox system naturally the body start to detoxify itself layer by layer and its common to see the release of drug took 10 or even 20 years ago.
But don't do the isotherapy if your body is too toxic and congestioned, it will do more arm than good.

Edited by anonyy

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Hey guys,

I am trying to get your opinions on anti-oxidants. I am looking into taking reservatol-derived from red grapes. I have read many conflicting articles about this anti-oxidant. Some articles claim that it blocks the positive affects of exercise and many others provide proof of the positives. I know this is not a new supplement, and I have done a fair amount of research on it's affects and potential upsides. I do however have a link to a website showing studies that pill based forms might be bad because it does not force the body to up-regulate it's own enzyme to fight oxidative stress. What do you guys think? Waste of money and possibly bad for health, or something worth supplementing? I know natural foods are the best way to get anti-oxidants, but at this time, my diet is not where I would like it, and I don't see it being that way for a little while. I would drink red wine, but I don't alcohol and I don't know how I would fair being that I took tane.(not saying I haven't drank, just not in a long time. http://gettingstronger.org/2011/03/the-case-against-antioxidants/. Sorry for not hyperlinking-couldn't figure it out. I'm looking for peoples' interpretations of this article. Thanks guys! Hope all is well.

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Alcohol and Tan don't mix well I wouldn't recommend it , a lot of people report they are hung over for three days after drinking myself included , ironic because it has been shown that moderate alcohol consumption is beneficial to the body example would be a glass of wine per day like the Mediterranean diet . It just shows you how toxic this stuff is and what gene expression alterations can do to the body.

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alcohol is poison, at any dose, wine same even if there is little "beneficial" tanin. gene expression alteration is normal (everything that get in contact to the cells "alter" it), its temporary and only a side effect, not a cause.

Edited by anonyy

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Not true alcohol in moderation is beneficial under normal circumstances . Red wine is turning out to be a super food , although many health conscious people have opted to get isolated grape compounds in capsule form . Recent research however is showing that the best way is to drink red wine.That's because red wine contains the entire grape polyphenol group of of nutrients a group that has been shown to work much better

synergistically .

In fact newly releases research has shown that breast tumor growth and metastasis to bone and liver are inhibited by the complete

grape polyphenol complex.

I recommend reading some articles at Natural News. com and type red wine in the search bar.

Edited by Gladiatoro

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Sadly it's 100% false, alcohol is poison at any dose. If you want benefit from grapes, eat them or juice them.
ps: Polyphenol = tanin.

Edited by anonyy

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Many studies have shown that moderate alcohol consumption improves HDL cholesterol (good cholesterol), improves insulin sensitivity etc. Other studies have shown that moderate and even heavy consumers of alcohol live longer than those who abstain. However, I'm not going to run out and buy several bottles of vodka under that pretence just yet.

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Do your part to raise awareness:

For new individuals PM'ing me, I will reply IF you report all your side effects to the links below and screenshot each one once you have completed it. PM me with your email and I will message you and you can send the screenshots over with whatever questions you like.

Report side effects to organisations here:

Rxisk
https://www.rxisk.org/Explore-Side-Effects/About.aspx
FDA
https://www.accessdata.fda.gov/scripts/medwatch/index.cfm?action=consumer.reporting1
NHS
http://yellowcard.mhra.gov.uk/
Roche
http://www.roche.co.uk/portal/uk/xxxcontactxxx

Report side effects to accutane sympathetic MP's here (UK):

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vaizeye@parliament.uk

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There is no good and bad cholesterol, this myth has to end. You can search what you want, alcohol will always be a poison to the body no matter the dosage. People searching excuses for their bad habits...

Edited by anonyy

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Not true moderate again key word moderate alcohol consumption IS beneficial , binge drinking on the other had is not , and yes cholesterol is a scam

in fact having higher cholersterol is actually beneficial , cholesterol isn't the problem it's inflammation . Most of my relatives and ancestors drank not hard

liquor but beer which is very low in alcohol typically 5% and has vitamins , antioxidants and hops and they all lived to an old age that being said alcohol and isotretinoin don't mix too well but that is only because the drug does strange things to the body as I and all of you have found out , isotretionin in reality is a controlled poisoning , FACT.

Honest derms will actually tell you that and some derms even refuse to prescribe it what does that say about this drug.... Wine would be the same thing in moderation it is healthy just ask people who live in the Italy , Greece , Portugal etc.. most drink wine moderately and heart disease is very low in that part of the world.

Edited by Gladiatoro

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It has nothing to do with wine... You can't say the contrary, alcohol is poison, even at low dosage, it has no positive function in the body, even if there is some good tanin who come with it in wine. Of course if you drink one glass per week its fine..

Edited by anonyy

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None of the remedies in this thread will work. Diet will ASSIST some of the damage. It depends on what was damaged. Accutane has clearly damaged something, likely in those who are already genetically vulnerable. You all keep saying it yourselves: Accutane is a cancer drug. There are MANY organs it can affect. But one thing it usually seems to affect is calcium levels in the body in cancer patients. Which means it can damage your parathyroid glands first and foremost. But no one ever bothers getting this tested. Test it if you haven't.

It could have enlarged them ( which causes brain fog, difficulty concentrating) and all kinds of the crap that everyone keeps complaining about with the drug, from headaches to horrendous joint aches because once you get parathyroid disease, it starts stealing calcium from your bones. Hyperactive parathyroid glands will raise the calcium in your blood, which means it's being leeched from your bones. You will feel like shyt. Parathyroid hormone is one of the most powerful hormones in the body. It is used to control calcium levels, after all. Get your parathyroid hormone level assays checked ALONGSIDE your calcium levels. It's not related to your thyroid whatsoever.

Interesting blog: http://accutanecountdown.tripod.com/ <--she talks about her calcium levels being HIGH and the doctor ignoring them, which is a common problem. Parathyroid disease kills slowwwwly over time. It is caused by either a tumor on the parathyroid gland or enlargement--meaning they will still have to be removed or the overactive glands will keep doing what they should not.

http://www.medscape.com/viewarticle/434461_3 <---here you go thank me later

tl;dr test your parathyroid/calcium levels first. If they're slightly elevated even, then they have been affected ( because calcium should never even be mildly elevated, do the research I've done and you'll see).

I took the time out of my day to write this for a reason. Now get to testing.

Love,

Person

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Again accutane as nothing to do with genetic (or epigenetic), this is scam & bs. But people with a body in an already bad state (before accutane), toxic & demineralized, yes, 100%
It's true about thyroid, accutane affect all glands, directly and indirectly.
Diet doesnt assist, diet = do no more arm & give your body what he's made to eat and what he need specially when sick, fruits & vegetables, this is the base of physiology. If you give your body food he's not physiologicaly supposed to eat, don't be surprise to not be in good health.
The body need to be re-mineralized (raw/juiced fruits vegs), accutane cause big mineral loss (directly and by inducing acidity/toxicity). Also he need to be assisted to eliminate all of his toxins/acids & natural waste (acne is an elimination) with flushs or herbs, accutane damage the emunctories (skin is the third kidney), and specially the intestine & liver (liver isn't a "true" emunctory).
You can tell your friend to stop dairy + acidic foods & drink (meat, soda, etc.) to fix a big part of the calcium problem. Anything that contain soy too, the worst thyroid poison.

Edited by anonyy

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Elkhoundgold,

This is based on research, or based on experience ?

Anonyy,

You are pretty much cured right..

What happens when you eat "normal" again. Will symptons get back to you ?

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"normal" isn't normal but yes the symptoms come back (differently) and far less powerful than when it was my main diet. i can only say that about grains (specially wheat), i never eated back meat & dairy since a long time ago and i did the mistake of taking back wheat only 2-3 times past 8 month.

Edited by anonyy

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Ok so if I understad correctly

Lets say wheat was the cause of the acne.

Accutane changed what wheat does to us.

Instead of wheat causing acne, it now causes dry skin etc

So when someone is cured, wheat should cause Acne again.

That is the goal right ? Get acne again

So anonyy I understand you are sympton free, but it is sympton curing, because when you fall back into bad habits it comes back.

What are our thoughts about this?

Edited by Ottovisual

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It's not only wheat, it's dairy, meat, every grains, etc.. anything that's acidifying, contain toxins and cause mineral depletion & congestion.
Accutane destroy the intestine as hard as the skin, that's why a physiological diet is an absolute necessity to get health back, in normal circonstance the body can "handle" those toxic food but after accutane, it's impossible. And even physiological food is a problem after accutane, fibers in raw vegetables are too irritating for us, we need to juice them (bonus chlorophyll in green leafy vegs heal the intestine).

About acne it can came back but not as much as before accutane, to repair the skin it takes time and it require the same thing as to heal the whole body, whole diet change, great elimination of toxins&acids and a good re-alkalinization to permit the body to do his job, so after that there is no reason to have acne. My acne came back but like 3-4 pimple some times, not something really disturbing.

Edited by anonyy

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Elkhoundgold,

This is based on research, or based on experience ?

Anonyy,

You are pretty much cured right..

What happens when you eat "normal" again. Will symptons get back to you ?

Both research and experience.

http://www.medscape....rticle/434461_3

^relinked article, let me know if it gives you problems.

Edited by elkhoundgold

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"Retinoids, which are vitamin A derivatives, are known to cause hypercalcemia. [7] The precise mechanism for each vitamin A compound has not been clearly defined. Retinoic acid may regulate bone cell proliferation and differentiation by suppressing alkaline phosphatase activity, osteocalcin production, and prostaglandin-induced interleukin-6 synthesis in osteoblast cells. [8] Retinoic acid also can inhibit parathyroid hormone, suggesting that increased bone resorption may account for hypercalcemia. [7]

The synthetic retinoid 13- cis-retinoic acid, or isotretinoin, regulates cell proliferation and differentiation and decreases N-myc expression. [9] In addition, 13- cis-retinoic acid enhances normal hematopoietic differentiation by increasing the responsiveness of myeloid and erythroid progenitor cells to myeloid colony-stimulating activity and erythropoietin, respectively. [10] It is highly protein bound, primarily to albumin, and is hepatically metabolized to 4-oxoisotretinoin, which is excreted in urine and feces. Whether 4-oxoisotretinoin is biologically active is unknown. [11]

Hypercalcemia has been reported in patients with neuroblastoma receiving 13- cis-retinoic acid. [12] A phase I trial of the agent in children with neuroblastoma after bone marrow transplantation examined the toxicities, pharmacokinetics, and maximum tolerated dosage. [13] Of the 51 patients between 2 and 12 years of age who received 13- cis-retinoic acid, three developed severe hypercalcemia (serum calcium levels 12.6-18.7 mg/dl) prompting discontinuation of the drug. Nine other patients had elevations in serum calcium levels that did not require drug discontinuation. The investigators concluded that hypercalcemia may be a dosage-limiting adverse effect of 13- cis-retinoic acid. Accordingly, they advised that serum calcium levels should be monitored in patients receiving high dosages of the drug.

A subsequent study reviewed the three patients who developed severe hypercalcemia requiring discontinuation of 13- cis-retinoic acid therapy. [12] Only one patient experienced arthralgias and myalgias; this occurred during the fifth cycle of therapy. The patient, who had been receiving 13- cis-retinoic acid 200 mg/m 2/day, also had an elevated uric acid level of 8.3 mg/dl and an increase in aspartate aminotransferase. Temporary discontinuation and a dosage reduction to 160 mg/m 2/day for subsequent cycles resolved the hypercalcemia. The second patient developed severe hypercalcemia during the second cycle of 13- cis-retinoic acid. This patient complained of tinnitus and had an elevated uric acid level of 13 mg/dl. The patient had renal insufficiency, with a reported creatinine clearance of 81 ml/minute/1.73m 2. The patient's 13- cis-retinoic acid dosage was 160 mg/m 2/day; discontinuation followed by a dosage reduction to 125 mg/m 2/day for subsequent cycles prevented further episodes of hypercalcemia. The third patient who experienced hypercalcemia (serum calcium 11.3 mg/dl) was asymptomatic and had been receiving 13- cis-retinoic acid 200 mg/m 2/day. Decreasing the dosage to 160 mg/m 2/day for future cycles resolved the hypercalcemia.

Our findings demonstrate that hypercalcemia may be a dosage-limiting adverse effect of 13- cis-retinoic acid in children receiving an initial dosage of 160 mg/m 2/day. To our knowledge, the only other patient reported to have severe hypercalcemia at this initial dosage had renal insufficiency. [12] Our patient had a baseline serum creatinine of 0.7 mg/dl and had no signs of renal insufficiency. A 50% dosage reduction did not prevent recurrence of severe hypercalcemia during the second cycle. We did not find any other cases in the literature of symptomatic hypercalcemia with 13- cis-retinoic acid 80 mg/m 2/day. According to the Naranjo rating scale, it is probable that 13- cis-retinoic acid caused severe hypercalcemia in our patient. [14]

Before each hospitalization, our patient reported a decrease in appetite and caloric intake. However, her daily dietary calcium intake was never accurately recorded. Knowledge of her calcium intake would have allowed us to exclude exogenous intake as a possible cause of her hypercalcemia. Our patient tolerated her remaining cycles of 13- cis-retinoic acid after the duration of each cycle was shortened to 7 days. Unfortunately, the efficacy of this therapy against high-risk neuroblastoma is unknown, given that the patient received a lower 13- cis-retinoic acid dosage and a shorter duration of treatment than the recommended protocol. [5]

Our findings support previous evidence that hypercalcemia is a dosage-limiting adverse effect of 13- cis-retinoic acid therapy in patients with neuroblastoma. Serum calcium levels therefore should be monitored closely in these patients. Resolution of hypercalcemia can occur with a temporary discontinuation of 13- cis-retinoic acid, followed by a 25-50% dosage reduction. Our patient required a decrease in both dosage (to 80 mg/m 2/day) and duration of each treatment cycle (to 7 days) to prevent recurrence of hypercalcemia."

This is what the article said.

Source http://www.medscape.com/viewarticle/434461_4

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Mother of God, 200mg twice per day to a child!?!?!? WTF is this study!?


Anyway some more good news. I wrote a list of people who recovered a couple of pages back. 'donteat16' was last on that list. Dubya & I weren't sure on how he recovered at the time, so just presumed it was a 'natural' recovery with time. However, Dubya messaged me last night saying how he remembered that 'donteat16' had told him a while back that he 'smoked so much weed that his parents thought that was the cause of his health problems'. So that makes another individual who recovered who also consumed a lot of ganja!


Do your part to raise awareness:

For new individuals PM'ing me, I will reply IF you report all your side effects to the links below and screenshot each one once you have completed it. PM me with your email and I will message you and you can send the screenshots over with whatever questions you like.

Report side effects to organisations here:

Rxisk
https://www.rxisk.org/Explore-Side-Effects/About.aspx
FDA
https://www.accessdata.fda.gov/scripts/medwatch/index.cfm?action=consumer.reporting1
NHS
http://yellowcard.mhra.gov.uk/
Roche
http://www.roche.co.uk/portal/uk/xxxcontactxxx

Report side effects to accutane sympathetic MP's here (UK):

mail@nickharveymp.com

vaizeye@parliament.uk

I encourage people to copy this signature into their own.


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Also, anyone suffering from sexual dysfunction - PM either myself or Dubya with your email. I've finished collating research into a single word document and would recommend printing it out and taking it to the doctors.

Edited by Crank92
2 people like this

Do your part to raise awareness:

For new individuals PM'ing me, I will reply IF you report all your side effects to the links below and screenshot each one once you have completed it. PM me with your email and I will message you and you can send the screenshots over with whatever questions you like.

Report side effects to organisations here:

Rxisk
https://www.rxisk.org/Explore-Side-Effects/About.aspx
FDA
https://www.accessdata.fda.gov/scripts/medwatch/index.cfm?action=consumer.reporting1
NHS
http://yellowcard.mhra.gov.uk/
Roche
http://www.roche.co.uk/portal/uk/xxxcontactxxx

Report side effects to accutane sympathetic MP's here (UK):

mail@nickharveymp.com

vaizeye@parliament.uk

I encourage people to copy this signature into their own.


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