IndigoRush

Repairing the long-term damage from Accutane

11,053 posts in this topic

Anonyy, you cited homocysteine levels being elevated during Iso treatment. This should be easy to find out if we continue to have elevated homocysteine by simply asking for a test from a doctor. Not sure why they would have much objection to writing out a prescription for this test since it's commonly used to test for health.

I would say this is unlikely but I actually have been wondering if just having depleted serotonin can the be the cause (serotonin has tons of receptors in the frontal lobe). Apparently serotonin is needed to regulate the hypothalamic pituitary axis which regulates the neuroendocrine system. So if the HPA is screwed up you will have messed up pituitary hormones like some of us have which can lead to sexual dysfunction.

SSRI's can cause similar problems to ours and I just read an article stating that in order to compensate for decreased serotonin reuptake the brain begins producing less serotonin (60% less serotonin in certain parts of the brain they found in this study they did on rats). Also when I took 5-HTP i woke up with more frequent erections than normal (normal for me now is 0).

The issue is how would finasteride cause this? Possibly by depleting progesterone which is known to boost serotonin levels. Maybe there is a relationship between allopregnanolone and serotonin. I'm not sure. I would say this is probably an unlikely cause but just something I've been thinking about the last couple days.

In the unlikely event that this IS the cause, CBD has been shown to repair brain damage and normalize serotonin levels.

Allopregnanolone does have an effect on seratonergic activity, although it binds to GABA receptors:

Modulation of the firing activity of female dorsal raphe nucleus serotonergic neurons by neuroactive steroids

http://joe.endocrinology-journals.org/content/182/1/11

Gender and gonadal status modulation of dorsal raphe nucleus serotonergic neurons. Part II. Regulatory mechanisms

http://www.sciencedirect.com/science/article/pii/S0028390802002186

Isotretinoin does have a "negative" effect on the function on these seratogenic raphe cells, which communicate with the hippocampus. I doubt the effect is much different between humans and the mice used in these studies:

Chronic 13-cis-retinoic acid administration disrupts network interactions between the raphe nuclei and the hippocampal system in young adult mice

http://www.sciencedirect.com/science/article/pii/S0014299909000156

Chronic administration of 13-cis-retinoic acid does not alter the number of serotoninergic neurons in the mouse raphe nuclei

"The potential pro-depressant behavioural and molecular effects associated with chronic administration of 13-cis-RA may result from changes in serotoninergic activity rather than changes in the number of serotoninergic neurons." (functional alterations, but not apoptic effects)

http://www.sciencedirect.com/science/article/pii/S0306452210014053

SSRIs may elicit much of their effect by increasing allopregnanolone at the expense of decreasing 5-alpha reduced progesterone (DHP). Also, what happens to the levels of allopregnanolone when one stops an SSRI? Does it fall below what it was initially before treatment?

Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes.

http://www.pnas.org/content/96/23/13512.full.pdf

Fluoxetine and norfluoxetine stereospecifically and selectively increase brain neurosteroid content at doses that are inactive on 5-HT reuptake

http://link.springer.com/article/10.1007/s00213-005-0213-2

And finally, finasteride has been shown to decrease levels of DHP and therefore, allopregnaolone (a 5-alpha AND 3-alpha reduced progesterone metabolite):

Some pretty interesting connections I think.

I really do believe lowered allopregnanolone can explain the depressive symptoms, brain fog, decreased hippocampal neurogenesis, and even lowered libido to an extent, since localized allo concentrations in certain parts of the brain have been shown to influence sexual behavior in rats.

Unfortunately this doesn't seem to fully explain changes to penile tissue or gynecomastia in the presence of adequate hormone levels.

Depression itself doesn't really explain the lack of morning wood either.

CBD has some affinity for estrogen receptors too. I have to wonder if it shares enough chemical similarity to allopregnanolone to bind to GABA receptors also. This might explain some of the mild sedative and anxiolytic effects if true.

Study showing CBD bind to estrogen receptor at higher concentration.

http://www.ncbi.nlm.nih.gov/pubmed/6296360

Anonyy, you cited homocysteine levels being elevated during Iso treatment. This should be easy to find out if we continue to have elevated homocysteine by simply asking for a test from a doctor. Not sure why they would have much objection to writing out a prescription for this test since it's commonly used to test for health.

I would say this is unlikely but I actually have been wondering if just having depleted serotonin can the be the cause (serotonin has tons of receptors in the frontal lobe). Apparently serotonin is needed to regulate the hypothalamic pituitary axis which regulates the neuroendocrine system. So if the HPA is screwed up you will have messed up pituitary hormones like some of us have which can lead to sexual dysfunction.

SSRI's can cause similar problems to ours and I just read an article stating that in order to compensate for decreased serotonin reuptake the brain begins producing less serotonin (60% less serotonin in certain parts of the brain they found in this study they did on rats). Also when I took 5-HTP i woke up with more frequent erections than normal (normal for me now is 0).

The issue is how would finasteride cause this? Possibly by depleting progesterone which is known to boost serotonin levels. Maybe there is a relationship between allopregnanolone and serotonin. I'm not sure. I would say this is probably an unlikely cause but just something I've been thinking about the last couple days.

In the unlikely event that this IS the cause, CBD has been shown to repair brain damage and normalize serotonin levels.

Allopregnanolone does have an effect on seratonergic activity, although it binds to GABA receptors:

Modulation of the firing activity of female dorsal raphe nucleus serotonergic neurons by neuroactive steroids

http://joe.endocrinology-journals.org/content/182/1/11

Gender and gonadal status modulation of dorsal raphe nucleus serotonergic neurons. Part II. Regulatory mechanisms

http://www.sciencedirect.com/science/article/pii/S0028390802002186

Isotretinoin does have a "negative" effect on the function on these seratogenic raphe cells, which communicate with the hippocampus. I doubt the effect is much different between humans and the mice used in these studies:

Chronic 13-cis-retinoic acid administration disrupts network interactions between the raphe nuclei and the hippocampal system in young adult mice

http://www.sciencedirect.com/science/article/pii/S0014299909000156

Chronic administration of 13-cis-retinoic acid does not alter the number of serotoninergic neurons in the mouse raphe nuclei

"The potential pro-depressant behavioural and molecular effects associated with chronic administration of 13-cis-RA may result from changes in serotoninergic activity rather than changes in the number of serotoninergic neurons." (functional alterations, but not apoptic effects)

http://www.sciencedirect.com/science/article/pii/S0306452210014053

SSRIs may elicit much of their effect by increasing allopregnanolone at the expense of decreasing 5-alpha reduced progesterone (DHP). Also, what happens to the levels of allopregnanolone when one stops an SSRI? Does it fall below what it was initially before treatment?

Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes.

http://www.pnas.org/content/96/23/13512.full.pdf

Fluoxetine and norfluoxetine stereospecifically and selectively increase brain neurosteroid content at doses that are inactive on 5-HT reuptake

http://link.springer.com/article/10.1007/s00213-005-0213-2

And finally, finasteride has been shown to decrease levels of DHP and therefore, allopregnaolone (a 5-alpha AND 3-alpha reduced progesterone metabolite):

Some pretty interesting connections I think.

I really do believe lowered allopregnanolone can explain the depressive symptoms, brain fog, decreased hippocampal neurogenesis, and even lowered libido to an extent, since localized allo concentrations in certain parts of the brain have been shown to influence sexual behavior in rats.

Unfortunately this doesn't seem to fully explain changes to penile tissue or gynecomastia in the presence of adequate hormone levels.

Depression itself doesn't really explain the lack of morning wood either.

CBD has some affinity for estrogen receptors too. I have to wonder if it shares enough chemical similarity to allopregnanolone to bind to GABA receptors also. This might explain some of the mild sedative and anxiolytic effects if true.

Study showing CBD bind to estrogen receptor at higher concentration.

http://www.ncbi.nlm.nih.gov/pubmed/6296360

What are these penile tissue changes and gynecomastia symptoms you speak of? Has anyone else experienced this post-accutane?

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There are guys in the ATM forum, ragforum, and this thread who have mentioned penile shrinkage and gyno.

Mine went from being plump to being shriveled-up as if I'm freezing cold after Accutane. Tree1 openly said he developed gyno, and IndigoRush mentioned shrinkage too. Additionally, I spoke with 2 men over Skype who had gnarled-up dicks after tane.

Seems to on the rare side, even among guys with sexual dysfunction, but it happens. There are also case studies about gyno after isotretinoin.

Thanks for calling the maker of Epuris. I hope you "officially" reported your side-effects to Health Canada or the manufacturer too.

You are probably right about them leaving ED on the list of side-effects in an attempt to protect themselves from litigation. I also doubt only one guy in a study of over 400 had ED from this drug. Why bother going through the embarrassment of mentioning ED if you think it's going to go away once you're finished with treatment. It took me over 2 years to come up with the courage to tell anyone.

Edited by Dubya_B
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In the flaccid or erect state? I feel 100% certain I have lost girth...what a hell this drug has made of my life

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There is actually a study that accutaneresearch posted on the ragfourm regarding Isotretintoin - dna methylation and mental disorder. I need to pm a mod as for some reason acne.org wont let me copy and paste bleh!

Edited by oli girl
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The secret of health for both mind & body

is not to mourn for the past, not to worry about the future, or not anticipate troubles, but to live the present moment wisely and earnestly.

The Buddha


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Oligirl, Check your PM box. I'm pretty certain there's an easy way for you to work around not being able to copy and paste with right click on this forum.

Was this the same thread you were talking about?

EDIT: I guess it was this one:

http://ragforum.freeforums.org/research-isotretinoin-dna-methylation-mental-health-disorder-t160.html

In the flaccid or erect state? I feel 100% certain I have lost girth...what a hell this drug has made of my life

For me it's mostly noticeable in the flaccid state. It used to be sort of "full and squishy" even when it was flaccid before tane. Since crashing it's more shriveled-up and smaller when flaccid. The first several years I was dealing with this it didn't seem to effect size in the rare event that I got a full erection, but I think being like this for so long has begun to effect even that too.

Some guys mention it taking on an "hourglass" shape after they took the drug, and couple have even mentioned peyronies disease after tane, where it actually gets mis-shapen and gnarled. The loss of girth is a common complaint too.

That's what sort of pisses me off is that people think our sexual dysfunction is strictly a result of depression caused by Accutane. Even some doctors who know that Accutane can cause severe and long-lasting side effects.

No way in hell is depression all there is to it. Just a part of the big picture.

Edited by Dubya_B

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Your right Dubya there is a much larger picture of damage from this drug including , brain damage as clearly shown on MRI's , sexual dysfunction , penis shrinkage (that's a new one I never knew about) , pseudo tumor , joint / bone damage , hair loss , obvious skin damage , cardio vascular damage ( extent of which is unknown at this time ) , vision damage , ear damage , then we have intestinal damage the list goes on and on diabetes for some like oli girl this is one ^&(( of a drug , allopathic medicine at it's best ha.... I truly don't understand how this POISON is legal ..... as time goes on Isotretinoin will be exposed and has been exposed for what it truly is a CHEMO drug first designed to treat CANCER then cross marketed for something as simple and minor as pimples ( which by the way can be easily corrected with diet and trigger foods ) to maim and poison teenagers and adults and maybe improve the state of your pimples while causing massive collateral damage at the same time , and in reality a life time of collateral damage , not a good deal.

And one wonders why there are so many law suits against the makers of this drug ROCHE they are great at making toxic and deadly drugs it is there specialty they also make the date rape drug called Rohypnol a wonderful DRUG company .... just like the rest of the DRUG dealers and there co's. but I think they are one of the worst out there heck they even make synthetic vitamins , evil suckers....

On a positive note Hemp Oil looks promising as a viable treatment ........

Edited by Gladiatoro
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It is useless to look for any symptomatic treatment, they will never fix anything. CBD can be good as it help natural body mechanism, only the body can fix itself.

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@Gladiatoro: Hah, Roche couldn't even pull-off selling vitamins without getting busted for price fixing. Billions and billions of dollars.

And they sent the government after the whistleblower too, causing another suicide in the process:

http://en.wikipedia.org/wiki/Hoffmann-La_Roche#Vitamin_price_fixing

"Vitamin price fixing

Stanley Adams, Roche's World Product Manager in Basel, contacted the European Economic Community in 1973 with evidence that Roche had been breaking antitrust laws, engaging in price fixing and market sharing for vitamins with its competitors. Roche was fined accordingly, but a bungle on the part of the EEC allowed the company to discover that it was Adams who had blown the whistle. He was arrested for unauthorised disclosure — an offence under Swiss law — and imprisoned. His wife, having learnt that he might face decades in jail, committed suicide.[12] Adams was released soon after but arrested again more than once before eventually fleeing to Britain, where he wrote a book about the affair, Roche Versus Adams (London, 1984, ISBN 0-224-02180-X).

In 1999 Roche was the worldwide market leader in vitamins, with a market share of 40%. Between 1990 and 1999, the company continued to participate in an illegal price fixing cartel for vitamins, which also included BASF and Rhone-Poulenc SA. In 1999, Roche pleaded guilty in the United States and paid a US$500 million fine, then the largest fine ever secured in the U.S.[13] The European Commission fined Roche 462 million for the same infraction in 2001, also a record fine at the time.[12]

Roche sold its vitamin business in late 2002 to the Dutch group DSM.

Controversies

In 1999 the firm plead guilty to participation in a worldwide conspiracy to raise and fix prices for vitamins sold in the USA and globally. Hoffmann-La Roche paid $500 million in criminal fines [14] to the United States."

Ethics!

http://www.roche.com/responsibility/business_ethics.htm

Edited by Dubya_B
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Well the latest thing they are being investigated in are the some of the recent studies on IBD & Crohn's that have come out. Looks like they tried to use them in the New jersey court cases only to find out they were funded by yours truly.....that's right Roche!

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The secret of health for both mind & body

is not to mourn for the past, not to worry about the future, or not anticipate troubles, but to live the present moment wisely and earnestly.

The Buddha


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Indeed! Yet another fine example of the ethics employed by Roche Pharmaceuticals . Their executives and legal team are unarguably due for corporate sainthood.

I truly feel for Roche for being bullied by the legal system. If only that pesky judge in the recent IBD and Crohn's Accutane cases just would have been dismissed like they lobbied for.

Roche Loses Bid To Appeal Accutane Judge's Recusal Ruling

http://www.law360.com/articles/461301/roche-loses-bid-to-appeal-accutane-judge-s-recusal-ruling

They must be too preoccupied with bending their European consumers over and stuffing their mouths full of chemotherapy to properly rig the system this round.

Defense Lawyer Earns A Well-Deserved Benchslap For Misguided Recusal Motion

http://www.litigationandtrial.com/2013/02/articles/attorney/consumer-protection/recusal-benchslap/

Faced with serious claims, Roche and its lawyers came up with a couple of, shall we say, aggressive strategies, including getting plaintiffs — many of whom have suffered horrific injuries, requiring multiple surgeries and ruining the functioning of their excretory system — under oath at depositions and asking them about Paraphrase: "backdoor friendships" and whether or not they’re good Catholics who regularly attend mass. Opinion, p. 12. (In case you’re wondering, no, there’s no connection between Paraphrase: "backdoor friendships" and IBD, and Roche never produced a medical expert arguing otherwise.) The plaintiffs’ lawyers brought this misconduct to the attention of Judge Higbee, who was “disturbed” by the questions, and disturbed that the same questions were being asked at depositions across the country. A defense lawyer even told the Judge during an ex parte break (which the plaintiffs’ lawyer permitted) that she felt the questions were inappropriate and that she was following a script.

It seems Roche may have been to blame for "violating" the plaintiffs in several ways.


This isn’t some sort of trial lawyer fantasy: in 2006, researchers at the University of Chicago found a link between Accutane use and inflammatory bowel disease. Following up on the 2006 study, a study published in the September 2010 edition of the American Journal of Gastroenterology found that Accutane users had over four times the rate of ulcerative colitis as non-users.

Notice this lawyer mentions that the studies NOT funded by Roche found a high correlation between isotretinon and IBD?

Really, in light of this failed attempt to expose their own version of the truth, what difference will it make to us if their self-funded clinical studies become public knowledge? More colored-in statistics?

How do they keep getting away with it Oli? A deal with Satan?

Edited by Dubya_B
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All rightey people I'm back from holiday,

I'm going to tentatively put forth that I have good news. I actually think this cannabis stuff is really really legit, I've tried to control for all other confounding factors e.g placebo effect (I had a smashing hangover, generally not a feel good thing) amongst others.

I'm going to do a full write up once the girl friend is off home (tomorrow or Monday). But I think AccutaneIsPoison really was onto something.

Muchos Love

Crank

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Do your part to raise awareness:

For new individuals PM'ing me, I will reply IF you report all your side effects to the links below and screenshot each one once you have completed it. PM me with your email and I will message you and you can send the screenshots over with whatever questions you like.

Report side effects to organisations here:

Rxisk
https://www.rxisk.org/Explore-Side-Effects/About.aspx
FDA
https://www.accessdata.fda.gov/scripts/medwatch/index.cfm?action=consumer.reporting1
NHS
http://yellowcard.mhra.gov.uk/
Roche
http://www.roche.co.uk/portal/uk/xxxcontactxxx

Report side effects to accutane sympathetic MP's here (UK):

mail@nickharveymp.com

vaizeye@parliament.uk

I encourage people to copy this signature into their own.


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Dubya B of course a study NOT funded by Roche found a high correlation between isotretinoin and IBD because there is one , lot's of people have crohn's disease now due to this POISON one of many illnesses it produces , but what should one expect from a company that makes a date rape drug , no doubt a very EVIL company. There are so many law suits against this drug and Roche that they took it off the market , yet they handed it out like CANDY to teenagers and young adults even though they knew the serious risk involved but in the end $$$$ is more important and they down play the risks , someone should have told them that pimples are not a life threatening condition that needs toxic CHEMO

to treat lol... CHEMO stands for Chemical Holocaust Either by Murder or Overdose , sounds about right.

Edited by Gladiatoro

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If you guys want to learn something go to NATURAL NEWS.com there are lots of articles about Hemp oil and anything else concerning health. (=

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All rightey people I'm back from holiday,

I'm going to tentatively put forth that I have good news. I actually think this cannabis stuff is really really legit, I've tried to control for all other confounding factors e.g placebo effect (I had a smashing hangover, generally not a feel good thing) amongst others.

I'm going to do a full write up once the girl friend is off home (tomorrow or Monday). But I think AccutaneIsPoison really was onto something.

Muchos Love

Crank

Great to hear !

You did the RSO ?

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Vape Report I

So just a heads up, I'm going to be a bit graphic in regards to talking about my relationship between my D & I. If you don't fancy reading about my dick I would skip this post.

Post-'tane and Pre-vape state of D

As I've mentioned before my libido and dick erecting skills disappeared after taking 'tane. At its worst I could not summon a much sought after hard-on even with the filth that litters the internet, nor the best efforts of my left hand or the gf. At it's best I could bring forth some sort of semi-hard entity, to detail the extent I could achieve I would say if I was lying down my D would not raise off my abdomen. However, the amount of stimulation it took to get to this stage where I could put the D in the V meant I would be gone in 60 seconds. Also had the very real possibility of losing wood within this 60 second window. On top of this I didn't really have any lust for sex, just a feeling that I should continue on doing what I did before 'tane with an insatiable lust. So with this said, at best I could usually manage was once a day or if I was lucky twice a day. However, if I managed twice in a day I would usually be done for about 48 hours.

Even more fun was that 'tane had completely robbed me of sensation. The kind of proprioceptive sense you have that you know your fingers are there without moving them, I don't have that with my D. I feel like a ken doll. To put it in perspective, If I'm getting a cheeky handsfree BJ and I close my eyes I don't know if someones on my D or not unless some serious tonsil smashing is going on.

Post Vape

Upon finishing exams on the 21st of Jan I vaped on the 21st/22nd/23rd for most of each of those days. I didn't really notice much difference. For me that rules out any acute effect i.e being high is not the time that the benefits are realised. I then went skiing for a week on the 25th for a week with the gf. I first noticed something different on the 12 hour drive down. I had at least a semi for about 2-3 hours without any stimulation, this was defo new although I had previously been able to crack a semi for a roughly 20-30 minutes so decided to rule it out as just a really really good day. However, for the whole week I was seemingly able to conjure spontaneous erections outta nowhere. Sat in the jacuzzi at the public pool next to the gf and suddenly I was sat there going "nope, can't stand up now give me a minute". Then there was the fact I had sex 2 x everyday sometimes even 3 and without prior stimulation. I even out horned the gf on two of the nights. I have never been hornier than the gf since taking 'tane.

However, before it goes sounding like I'm cured. I'm still a way from 100%. It still took longer to get hard than usual and I wasn't always 100% but the fact I was close to 100% without much stimulation as opposed to the 60-70% that takes an age of stimulation is a HUGE improvement. Also the fact I had a libido almost felt alien. It's still not the heart pumping, ball tingling experience that naked females usually provoke but it's a lot better than having the same level of arousal as a lamp post would provoke (none, just in case you're thinking I'm into that kinda thing). Also the numbness was still there. I got to say I think there was a marginal improvement, but I think that was to do with being harder more than an improvement in sensitivity.

Things of note:

Possible confounding factors include;

i) I was at altitude
ii) Was snowboarding daily for 4-6 hours per day (aerobic exercise)
iii) Drinking a bit of red wine most nights (alcohol = vasodilator, disinhibition)

I can discount altitude and the red wine as I managed to have sex at home without the sauce just fine too. The gf even on the first night said "are you better?" after some sexy time. The exercise one I'm going to discount because after Thailand of training for 4+ hours per day in a far more intense manner than snowboarding I could only have sex once over a 4 day period. The only way is if exercise has some very acute effects i.e in the 6 hour period afterwards before returning to baseline. But to be honest the fact I managed to have sex hungover, dehydrated and the like which I would have prior considered an impossibility is something worth noting.

Also I can't tell you if this is a new baseline for me or if I will slowly slip back to before or maybe even continue to improve. Time will tell. To be honest I'm not really enjoying the vaping, being stoned is debilitating and a bit of a pain in the A in my opinion when I've got sh*t to do. Obviously though I will continue because I'd rather be stoned than not have a working D. Furthermore, I can't entirely rule out a 'natural recovery' but the fact this week was such a dramatic difference and coincided with the vaping gives me reason to believe there may be a causal association between the two.

Finally, apologies if the graphic nature of the report offends you. I've spent the last 2 months writing in objective scientific jargon BS for my exams. I thought I'd relish in a bit of the 50 shades style for a change.

Any questions just shoot.




Also I thought it worth noting - everyone of note currently who has recovered has been smoking the reefer or ingesting cannabis in one form or another;

i) AccutaneIsPoison
ii) TaneAbomination
iii) Anonny
iv) ManitobaMountain
v) SClippers

Sure iii and iv don't put it directly down to cannabis but that being said, I didn't notice any difference post vaping until I saw the gf. Interesting that cannabis is the common link between all those recovered on this thread.

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Do your part to raise awareness:

For new individuals PM'ing me, I will reply IF you report all your side effects to the links below and screenshot each one once you have completed it. PM me with your email and I will message you and you can send the screenshots over with whatever questions you like.

Report side effects to organisations here:

Rxisk
https://www.rxisk.org/Explore-Side-Effects/About.aspx
FDA
https://www.accessdata.fda.gov/scripts/medwatch/index.cfm?action=consumer.reporting1
NHS
http://yellowcard.mhra.gov.uk/
Roche
http://www.roche.co.uk/portal/uk/xxxcontactxxx

Report side effects to accutane sympathetic MP's here (UK):

mail@nickharveymp.com

vaizeye@parliament.uk

I encourage people to copy this signature into their own.


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Cannabis didn't cured me, it helped at first to get my mind "clearer" and the strength to start my research trying and finding things who actually work.

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Thirst of all I would love to thank you for this report! I'm so happy for you. My case is almost exactly the same as yours in terms of side effects so I can't help enough for sharing your experience.

First quick questions (I know almost nothing about smoking/vaping MJ, especially that I've been trying to live as healthy as possible for many years...) Could you tell me how did you vape? What eqipment did you use? And what exactly did you vape? Was it liquid (oil??) or dried mj? Do you know what strain was it?

Thank you so much again!

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Thirst of all I would love to thank you for this report! I'm so happy for you. My case is almost exactly the same as yours in terms of side effects so I can't help enough for sharing your experience.

First quick questions (I know almost nothing about smoking/vaping MJ, especially that I've been trying to live as healthy as possible for many years...) Could you tell me how did you vape? What eqipment did you use? And what exactly did you vape? Was it liquid (oil??) or dried mj? Do you know what strain was it?

Thank you so much again!

No problem, exactly how I'd want it if I was suffering from something and wanted someone to relate to!

I used the Da Buddha vapouriser, I would have got the volcano but as a student I don't have much cash currently. I literally have gone for the most crude option and just found a dealer and am vaping whatever their strain is. Reliable source? No. But it'll have to do till Summer when I can grow my own and then make the oil.

Cannabis didn't cured me, it helped at first to get my mind "clearer" and the strength to start my research trying and finding things who actually work.

I'm not saying it cured you. Simply it was 'the common link' between all 5 of you. Simply an observation.


Do your part to raise awareness:

For new individuals PM'ing me, I will reply IF you report all your side effects to the links below and screenshot each one once you have completed it. PM me with your email and I will message you and you can send the screenshots over with whatever questions you like.

Report side effects to organisations here:

Rxisk
https://www.rxisk.org/Explore-Side-Effects/About.aspx
FDA
https://www.accessdata.fda.gov/scripts/medwatch/index.cfm?action=consumer.reporting1
NHS
http://yellowcard.mhra.gov.uk/
Roche
http://www.roche.co.uk/portal/uk/xxxcontactxxx

Report side effects to accutane sympathetic MP's here (UK):

mail@nickharveymp.com

vaizeye@parliament.uk

I encourage people to copy this signature into their own.


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Yeah Crank. Thanks for reporting in. Sounds as if your 'D' problems are very similar to mine. Can't really be detailed enough about this topic without getting explicit. It is what it is. It's interesting that you tried a recreational variety, which means it likely wasn't high in CBD.

I didn't realize there were so many who weed helped either. I think the member "Maynerd" mentioned something about it helping him too.

Pab, good to see you here. Hope all is well.

Edited by Dubya_B

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So just been the doc's today who specialises in sexual dysfunction and ED. It seems a pretty easy specialism as his verdict was - "we'll do your hormones, if you're they come back normal it's probably all in your head". He did seem genuinely intrigued in what I'd been reading and requested I send him all the details. I will get around to that as soon as I can.

If anyone has any info on studies on accutane and its possible effects on sexual dysfunction and ED can you please PM them to me and I will collate and organise a report to send off to him.

Cheers.

Also, I think I might have sounded too positive in my post-vape report which is very uncharacteristic for me in general. So I'll note that I still can't raise the sheets with a thought like before and even with the help of redtube it's still a bit of a mission to keep it harder than a semi for the entirety of Lisa Ann's exploits. I think AccutaneIsPoison had a point with vaping is good but simply isn't a large enough dose to illicit the kind of results we're after.

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Do your part to raise awareness:

For new individuals PM'ing me, I will reply IF you report all your side effects to the links below and screenshot each one once you have completed it. PM me with your email and I will message you and you can send the screenshots over with whatever questions you like.

Report side effects to organisations here:

Rxisk
https://www.rxisk.org/Explore-Side-Effects/About.aspx
FDA
https://www.accessdata.fda.gov/scripts/medwatch/index.cfm?action=consumer.reporting1
NHS
http://yellowcard.mhra.gov.uk/
Roche
http://www.roche.co.uk/portal/uk/xxxcontactxxx

Report side effects to accutane sympathetic MP's here (UK):

mail@nickharveymp.com

vaizeye@parliament.uk

I encourage people to copy this signature into their own.


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Cannabis didn't cured me, it helped at first to get my mind "clearer" and the strength to start my research trying and finding things who actually work.

Were you smoking or vaping anony? How soon did you notice improvements in mental clarity - first time or gradual over time?

I suffer from brain fog and there's no doubt that exacerbates the sexual sides. I find it fairly hard to concentrate and feel quite detached all the time, especially if it's dark and warm - cold and bright conditions sharpen my senses obviously, but not completely.

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I eated it heated with fat (yogurt + oil). It was benefic but it came with a side effect too, some panic attack for 6+ month, i didn't took it the right way.. Vaped, smoked or eated heated with fat will always be with some nefast effects, the only medicinal way is vaped without the THC (vape off the THC first, then take only the CBD) or eated raw or heated with absolutely 0 fat to not make the THC bypass the liver. Even if you don't realize it at first, THC took in the wrong way will wreak havoc the nervous system and it's really bad if you are looking for beneficial effects.

Anyway cannabis can only be an help, it will not fix anything.

Edited by anonyy
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Crank, here's a good question for your doctor in the event he cannot find a hormonal imbalance:

If this is "all in the head", why is morning wood so negatively affected since it is thought to be an autonomic function?


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I went out and purchased a highly concentrated CBD oil that I have taken daily for about a month now.

The concentration is significantly higher than what the studies showed was necessary to achieve beneficial effects.

I can honestly tell you that it, so far, does not cure everything, but it sure as hell helps: 1) My mind feels more unified and not anxious/depressed/self-critical 2) My face and skin are completely restored, but it appears the best effects are only when you first start the treatment, and kind of plateau as you continue/unless you take it off and on (this makes me think that no matter what at first, treatments will have positive effects, but it depends on your diet whether they persist at the highest level) 3) I have a LOT of energy and feel like myself, as well as brain fog dissipating... I feel like I was when I was a kid/pre-accutane. The restorative effects of the medicine on the brain/liver are absolutely phenomenal in my experience.

I took no THC with this oil, except occasionally smoking. It appears that CBD will be most noticeable (cognitively) if you take some other supplement while you are taking it. This could be caffeine, THC, Omegas, whatever you prefer will be more pronounced and will feel like you're actually experiencing it instead of compensating for your brain fog/energy depletion.

I also have regular bowel movements, but that was only an issue with me when I ate large portions/a lot of carbs/meat. I am still early in the treatment I suppose, but I would have to stay this stuff really works. ****However, it is like anything else that helps- you will have to keep up with your diet/not continue to dehydrate and poison yourself with other foods/drugs. Add CBD to your diet and I believe you will notice the difference absolutely. Tweak it to where you want from there.

Cheers

Edited by Nick Ryan
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What has worked for me in order of safety/effectiveness: Eating small portions of food (no more than 2 fistfuls at any given sitting) *and/or* Low calorie/low fat/low-to-no grain diet while minimizing all dehydrating substances.

What helps: Manganese! Molybdenum, Methyl-B12, Exercise+Water and a Humidifier in your room.

What hasn't: Everything else (so far).

What makes it worse: Multivitamins** for whatever reason. If you need to take supplements, get the single supplement as needed- multivitamins can make your symptoms worse. Do your research on each vitamin! Eating large meals, and eating highly processed/fatty foods.


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Nick that is absolutely great to hear it is working. Very exciting that you feel like you did pre accutane.

What side effects did you have?

Edited by acne1776

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