IndigoRush

Repairing the long-term damage from Accutane

11,029 posts in this topic

It's not true, if the body is in good/normal condition there is no disease, syphilis is not the main cause again, disease can only appear in congestioned & toxic tissue, the part of the body who is the most obtrued by toxins are the intestine, who poison the rest of the body. Just like the candida for example is here to help cleansing the intestine from the bad kind of food we ate. But of course the process can degenerate and get out of control if the body is in too bad condition.

Edited by anonyy
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Dubya - I think I took tane in 09 and my symptoms progressively got worse until maybe the half year mark. Other minor concerns bega to crop up as well. I think I finally started noticing in the mirror improvements 3 years after, and oddly enough, it was the in '12 that I saw most of my improvements. IIRC, I was feeling 50-60% better in 11/12 before it catapulted to 95% in the last year.

It's also why I'm not sure if it was simply a product of the waiting game or making so many lifestyle adjustments.

Edited by SClippers
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I still have a soul


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Hi all,

it took a little longer than expected but today the RSO arrived. I just started with the therapy and took 3 drops from the oil. If you guys are interested I can update you on the progress.

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Correct look into the fraudulent Germ Theory for starters..... it's not the germ but the terrain.

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Hi all,

it took a little longer than expected but today the RSO arrived. I just started with the therapy and took 3 drops from the oil. If you guys are interested I can update you on the progress.

Hi Roland, please do keep us updated. Although by the looks of it this could be a long progress (TA took it for 5 months). Also I presume you probably have mentioned your sides previously but could you give us a reminder please?


Do your part to raise awareness:

For new individuals PM'ing me, I will reply IF you report all your side effects to the links below and screenshot each one once you have completed it. PM me with your email and I will message you and you can send the screenshots over with whatever questions you like.

Report side effects to organisations here:

Rxisk
https://www.rxisk.org/Explore-Side-Effects/About.aspx
FDA
https://www.accessdata.fda.gov/scripts/medwatch/index.cfm?action=consumer.reporting1
NHS
http://yellowcard.mhra.gov.uk/
Roche
http://www.roche.co.uk/portal/uk/xxxcontactxxx

Report side effects to accutane sympathetic MP's here (UK):

mail@nickharveymp.com

vaizeye@parliament.uk

I encourage people to copy this signature into their own.


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Hi Mike...

i will point my son in this direction. Im not sure if he's aware thst i use these sites to compare notes so to speak. He cannot look at screens for long as he has permanent migraine. And to be honest i guess i tried to protect him by not telling him about other peoples experiences. He was really angry & depressed and i didnt want him feeling thst there was no hope & doing something terrible

mitch UK

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Hi all,

it took a little longer than expected but today the RSO arrived. I just started with the therapy and took 3 drops from the oil. If you guys are interested I can update you on the progress.

Hi Roland, please do keep us updated. Although by the looks of it this could be a long progress (TA took it for 5 months). Also I presume you probably have mentioned your sides previously but could you give us a reminder please?

I took accutane more than 10 years ago and I still suffer from:

* excessive dry skin (getting worse every year)

* thin skin

* super sensitive skin (especially against sunlight)

* dry eyes

* i react with migraine to any sun-blocker or moisturizer (headache + oversensitivity to noise, light)

* dry, strawy, thin hair

* permanently tired and nervous

It is especially the combination of super sensitive skin and intolerance of moisturizer/sunblocker, that makes my life to hell. In summer it is impossible for me to be outside for a longer time. I wear a baseball cap and sunglasses almost everyday to protect skin and eyes. I used to be a sports guy. Triathlon, windsurfing, skiing. Outdoor every day. This is all water under the bridge now. It haunts me every day, that I have taken this drug. It completely ruined my life. Angriness and desperation are awakening in me when I talk about those things.

Edited by Roland1968
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What was your dosage?

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A French petition against isotretinoin/Accutane:

http://www.avaaz.org/fr/petition/Reglementation_sur_les_medicaments_a_base_disotretinoine_Procuta_Curacnee_ContracneIsotretinoine_Teva/?copy

Translated

Today November 2, 2013, The Roaccutane is removed from the French market, but isotretinoin molecule is still sold as generic (Procuta, Curacnée, Contracné, Isotretinoin). Despite the information from May 2000 (modification on the package insert on side effects, depression, psychotic syndromes, suicidal ideation, suicide attempts), Medicine continues to wreak havoc. We seek from you particular interest to the dangers of this drug and the urgency of the need.

Edited by Dubya_B
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I don't really know much about epigenetics but i know DNA methylation plays a part in it. If you look at the propecia site a lot of people are claiming to feel better after trying methylating agents. Just read that CBD "increases global DNA methylation levels."

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I don't really know much about epigenetics but i know DNA methylation plays a part in it. If you look at the propecia site a lot of people are claiming to feel better after trying methylating agents. Just read that CBD "increases global DNA methylation levels."

Nice find! Looks as if CBD is an epigenetically active substance.

Not sure where you read that, but I came across this article in Scholar in the strangest format I've seen. All the author's sources check-out though:

http://www.isbp.org.il/upfiles/Raphael%20Mechoulam.pdf

Treatment of differentiated human keratinocytes cells with CBD led to increased DNA methylation of keratin 10 gene and reduced its expression. CBD increased global DNA methylation levels by selectively enhancing DNA methyltransferase (DNMT1) expression,without affecting DNMT 3a, 3b or 3L

The author also states that he suspects the epigenetic effects of CBD might explain its efficacy in treating other ailments.

So, there's a good chance CBD drastically and selectively upregulates expression of DNMT1. I think that's kind of a good sign since it means its effects aren't "sloppy" like many epigenetic drugs.

The strange thing is that in the past, people have associated our condition with gene silencing, which usually involves hypermethylation

Hypomethylation often leads to a gene being strongly over-expressed. (opposite of silenced)

Since we don't really know what's going on it is difficult to say one way or the other.

I think the supplements some of the guys on the Propecia site are taking help increase the amount of raw material (methyl groups) available for the DMNT enzymes to do their job. I'm not sure of that though. They don't seem to be having huge benefits from their treatment protocol either, just a few guys saying it helps a little.

Here is the study showing increased DMNT1 activity if you're interested, although it may be the article you were talking about:

http://onlinelibrary...enticated=false

Thanks for pointing this out 1776.

Is anyone here in contact with Scott from the Medschat thread? I want to speak with him, but their damn site won't let me post messages because I tried sending a link.

Edited by Dubya_B
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Guys you realize that even if this theory of permanent "epigenetic" modification was true (its 100% false), it is not with adding things that it will be "fixed", if the body doesnt do it by its own it will never be done by anything else. Temporarly genetic expression change are naturals, it get back to normal as soon as what cause the change go away and if the body have the possibility to do so.

Edited by anonyy

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Yes, there is also a France RAGFOURM for Victims. So anyone who knows French or are from France, you can seek help there also. http://avrg.unblog.fr/

It won't let me paste links here so you can type it in. There is also a victim forum for those in Swiss countries.

Great it finally came off the market in France! cheer.gif It will be a harder battle for Generics. There was a petition on change.org that posted all over the place for generics, yet we couldn't get enough signatures to do anything :(

Hope all is well



I hate to tell you epigenetics is a real plausible explanation, especially since if you get pregnant on Accutane it causes epigenetics of the fetus. I believe in some maybe they are not damaged to the extreme and so they may get away with diet and life style changes, however that is not the case with every victim. We are all different yet suffer some of the same things, I believe this poison changes DNA in some.

Diet worked for you, doesn't mean for everyone!

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The secret of health for both mind & body

is not to mourn for the past, not to worry about the future, or not anticipate troubles, but to live the present moment wisely and earnestly.

The Buddha


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No, epigenetic theory is 100% false. Everything that get in contact of the body cells act on dna expression, accutane included, it is not abnormal. You again focus on symptoms, epigenetic is one of them (in the case of accutane), the source of the problem is the accutane molecule and its induced toxicity as it cause a global toxicity by destroying the third kidney (the skin), the intestine & liver, and affect the adrenals who build and control the most important hormone & neurotransmitters of the body.

And again, you don't get cured with diet, i never said that, i already said 10000000 times, diet is about "do no more arm".

And like i said, even if the permanent epigenetic change was true, if the body doesnt restore it back by himself, nothing else will do, how do you want that something precisely target precise cells who have been modified and precisely reverse back the precise dna expression mechanism of 13-cis retinoic and all-trans-retinoic acid, it is 10000% impossible.

Edited by anonyy

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I've been taking the CBD oil for 3 weeks now.

There are some surprises which I didnt expected.

Biggest suprise is I feel good, great actually.

I have energy and my mood is on the positive side.

I dont blame Accutane on my mood because this was pre-accutane.

Maybe its placebo I dont know. Yet it catches me on suprise every day.

y lips are still dried out yet it comes and goes these days.

Can someone explain the Irritatable Bowel Syndrome symptons ?

I know its too early to conclude something, but I feel this CBD is helping me, the CBD is on my side.

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I've been taking the CBD oil for 3 weeks now.

There are some surprises which I didnt expected.

Biggest suprise is I feel good, great actually.

I have energy and my mood is on the positive side.

I dont blame Accutane on my mood because this was pre-accutane.

Maybe its placebo I dont know. Yet it catches me on suprise every day.

y lips are still dried out yet it comes and goes these days.

Can someone explain the Irritatable Bowel Syndrome symptons ?

I know its too early to conclude something, but I feel this CBD is helping me, the CBD is on my side.

Great to hear CBD is helping! What kind of CBD oil are you taking? Is it Rick Simpson Oil (which has THC in it), Real Scientific Hemp Oil, etc?

Edited by acne1776

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I've been taking the CBD oil for 3 weeks now.

There are some surprises which I didnt expected.

Biggest suprise is I feel good, great actually.

I have energy and my mood is on the positive side.

I dont blame Accutane on my mood because this was pre-accutane.

Maybe its placebo I dont know. Yet it catches me on suprise every day.

y lips are still dried out yet it comes and goes these days.

Can someone explain the Irritatable Bowel Syndrome symptons ?

I know its too early to conclude something, but I feel this CBD is helping me, the CBD is on my side.

Great to hear CBD is helping! What kind of CBD oil are you taking? Is it Rick Simpson Oil (which has THC in it), Real Scientific Hemp Oil, etc?

CBD oil diluted 15x (Golyoli)
A major benefit of CBD oil, also known as Golyoli, is that it does not cause a high or stoned feeling because of its very low THC content. But, because Golyoli oil contains a fairly high amount of CBD, this oil is suitable for medicinal purposes. This oil contains 10 to 20 times more CBD than there is in the oil made from commercial weed that is available at coffee shops.
Since the CBD content of this oil is below the required limit, it can be pruchased legally at Apollyon Headshop. For the treatment of cancer and other serious diseases, we recommend you to contact the Medical Weed Foundation support center. For all other ailments, treatment with CBD oil can give positive results.

Medical CBD Oil - 15x diluted 0.173% + 2.6% THC CBD var. diseases, ailments and discomforts

Medical Cannabis Oil - 5x diluted 7.15% + 2:34% THC CBD var. diseases, ailments and discomforts

Medical Cannabis Oil - 3x diluted 11.9% + 3.9% THC CBD

for cancer and other serious diseases

I ordered from this website:

http://www.apollyon.nl/cbd-olie/

It's Dutch and from the Netherlands, so I dont know anything about international restrictions.

Edited by Ottovisual
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Submitted for your approval anonyy:

DNA Methylation Does Not Stably Lock Gene Expression but Instead Serves as a Molecular Mark for Gene Silencing Memory

http://europepmc.org/articles/PMC3294136/reload=0;jsessionid=h0MHdLaXjcUMHlkWv9pB.0

This directly contradicts that all persistent DNA methylation is impossible to reverse. Sometimes you just have to nudge things in the right direction to reverse it.

Pretty sure the study referenced in my previous post was pertaining to "permanent" downregulation of a keratin-producing gene involved in causing psoriasis. This was achieved by increasing DNMT1 with CBD. Pretty precise from the sounds of it.

So, long-term epigenetic marks are able to be removed. The question is how. Sometimes one's own body will not do this by itself.

Otto, thanks for sharing this with us. Please keep us updated on how things are going for you.

Can I ask you to list the symptoms you had after tane, and how long ago you first noticed them?

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Submitted for your approval anonyy:

DNA Methylation Does Not Stably Lock Gene Expression but Instead Serves as a Molecular Mark for Gene Silencing Memory

http://europepmc.org/articles/PMC3294136/reload=0;jsessionid=h0MHdLaXjcUMHlkWv9pB.0

This directly contradicts that all persistent DNA methylation is impossible to reverse. Sometimes you just have to nudge things in the right direction to reverse it.

Pretty sure the study referenced in my previous post was pertaining to "permanent" downregulation of a keratin-producing gene involved in causing psoriasis. This was achieved by increasing DNMT1 with CBD. Pretty precise from the sounds of it.

So, long-term epigenetic marks are able to be removed. The question is how. Sometimes one's own body will not do this by itself.

Otto, thanks for sharing this with us. Please keep us updated on how things are going for you.

Can I ask you to list the symptoms you had after tane, and how long ago you first noticed them?

List of post accutane symptons.

To be clear. After 3 years I started noticing it.

Wasnt aware of any post side effects until i noticed my nails didn't grow.

So I thought I was lacking some vitamins, bought some general multi vits and after that my hair started falling out.

It felt like it activated something inside my. It activated the Male Baldness Pattern.

I also noticed my lips dried out ( or burnt up ) when it was sunny instead of the usual cold cracked lips.

I also noticed my hands have extra wrinkles ( old man hands ) but that starts to look better now.

Some minor joint pains now and then, but I want to link that to my lack of exercise.

Symptons I have

  • Dry lips
  • Hair shedding ( MBP )
  • Hand Wrinkles ( I dont care if I have hands looking like a old man, yet the underlying cause I care about )
  • Sensitive skin
  • Slow Nail growth

I do NOT have

  • Sexual Dysfunction
  • Irritatable Bowel Syndrome

I will check this site now and then and keep you posted.

Edited by Ottovisual

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Submitted for your approval anonyy:

DNA Methylation Does Not Stably Lock Gene Expression but Instead Serves as a Molecular Mark for Gene Silencing Memory

http://europepmc.org/articles/PMC3294136/reload=0;jsessionid=h0MHdLaXjcUMHlkWv9pB.0

This directly contradicts that all persistent DNA methylation is impossible to reverse. Sometimes you just have to nudge things in the right direction to reverse it.

Pretty sure the study referenced in my previous post was pertaining to "permanent" downregulation of a keratin-producing gene involved in causing psoriasis. This was achieved by increasing DNMT1 with CBD. Pretty precise from the sounds of it.

So, long-term epigenetic marks are able to be removed. The question is how. Sometimes one's own body will not do this by itself.

Otto, thanks for sharing this with us. Please keep us updated on how things are going for you.

Can I ask you to list the symptoms you had after tane, and how long ago you first noticed them?

Like i said, dna expression induced by something exterior are only temporary, and only the body can reverse it back by himself. Psoriasis as nothing to do with dna.. you just pointed a symptom again.

This article mean nothing as it is intentional with an exterior substance and on cancerous cells, nothing is reversed back as those cells was already naturally like they was. And those cancerous cells are not really considered as a part of the body, they will be eliminated if the body as the possibility to do so, it is a really bad example.

Edited by anonyy

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A fairly large amount then depending on your weight anywhere from 5000 mg to 9000... thanks for the info.

Edited by Gladiatoro
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I've been taking the CBD oil for 3 weeks now.

There are some surprises which I didnt expected.

Biggest suprise is I feel good, great actually.

I have energy and my mood is on the positive side.

I dont blame Accutane on my mood because this was pre-accutane.

Maybe its placebo I dont know. Yet it catches me on suprise every day.

y lips are still dried out yet it comes and goes these days.

Can someone explain the Irritatable Bowel Syndrome symptons ?

I know its too early to conclude something, but I feel this CBD is helping me, the CBD is on my side.

Glad you've had positive results from this oil so far Otto. I've been using a CBD oil for about 4 weeks now which is the Cibdex brand. I've not noticed any benefits so far, but my sides are different to yours. I've also been taking RSHO (see what they've done there?!..) for the past week or so as well.

I think I'll order some of the stuff from that side you got yours from an see how it compares!

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Something interesting I noted lately. I was looking through the drug product monographs for isotretinoin products; Accutane, Clavus and Epuris, and I noticed that while they all have the same active ingredient, only Epuris mentioned erectile dysfunction as a side effect. This was interesting as health professionals have to let patients know of any potential side effects listed in the monograph, I might have not taken accutane if I knew this was a risk, even a rare one...

So I contacted Epuris to see why it was included, and they told me it was "inappropriately included", and thanked me for bringing it to their attention so they can remove it. there was one case of ED out of 464 patients on isotretinoin in the drug's clinical trial, which is less than the 2% incidence rate required by Health Canada

Anyway, seems shady...especially if they don't remove it after my response...like they know there will be a shitstorm of lawsuits against isotretinoin coming and they want to cover their asses

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