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Acne, dairy and cancer: The 5alpha-P link.

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#1 alternativista

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Posted 03 May 2011 - 10:00 AM

This is something I just came across in my Good Things thread that I'd completely forgot about. And thought the study title alone made it worth bringing to everyone's attention.

Study: Acne, dairy and cancer: The 5alpha-P link http://www.ncbi.nlm....pubmed/20046583

Also, I started gathering the reasons to avoid or limit dairy together in one place rather than only being scattered throughout under hormones, blood sugar, hyperkeratinization, etc.: http://www.acne.org/...p...t&p=3048157

So far I have:

-Contains IGF-1 that affects hyperkeratinization/hyperproliferation which is at the root of acne formation. Also affects the growth of cancers.  IgF-1 is reduced by fermentation. 

 

-Contains BTC, another hormone that affects hyperkeratinization/hyperproliferation of cells.

-It contains 5alpha-P a precursor to DHT. per the above study - Acne, dairy and cancer: The 5alpha-P link. also, per another study, it can make you more sensitive to estrogens.

-Low fat dairy (and sweetened products) has a high glycemic impact.

-It's insulinemic, being high in the amino acids that directly stimulate insulin. Whey is high in these aminos. And insulin stimulates IGF-1.

-It's very common to be allergic to the casein and other substances that will be in all dairy products regardless of processing. Dairy from goats, sheep, etc tend to be less problematic.

-It's very common to be lactose intolerant. Lactose is reduced in yogurts, kefir, cheese...

-There's the lectin content in dairy from grain fed animals. Lectins are anti-nutrients that cause various kinds/degrees of harm and may directly affect hyperkeratinization. Reduced by fermentation. (Goats are nearly always pastured)

-Omega 6 content in dairy from grain fed animals...

-They insist on processing it to death --pasteurization, homoginization, removing fat... Pasteurization reduces SigA an immunoglobulin that binds up harmful and/or inflammatory lectins which can increase allergic response. So the average gallon of milk or cheese product in an American supermarket has more harmful lectins due to the cows being fed grains they aren't meant to eat and then has less of at least one of the substances that binds up the harmful lectins.


Edited by alternativista, 15 July 2014 - 06:38 PM.


#2 rifkah6

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Posted 04 May 2011 - 12:52 PM

Yup, dairy sucks ass, although I couldn't live without my goats milk kefir. Since ditching the cows milk however, my sinusitis has completely cleared up.....

Edited by rifkah6, 04 May 2011 - 01:02 PM.


#3 Drizzler

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Posted 04 May 2011 - 06:08 PM

A huge thing to consider with dairy is that there is such a wide spanning gradient of source and quality, perhaps more so than any other food- grains/breads are a close second. You have everything from pasterurized, homogenized, defatted milk from a caged Holstein being fed GMO soymeal and antibiotics, all the way up to the fresh raw cheese produced that morning from your neighbor's goat that happily grazes on fresh pasture under the warm sun. And everything in between. There's "dairy", and there is "dairy". This is the mentality people all must adopt to get rid of acne and build health.

#4 rifkah6

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Posted 05 May 2011 - 02:06 AM

QUOTE (Drizzler @ May 4 2011, 06:08 PM) <{POST_SNAPBACK}>
A huge thing to consider with dairy is that there is such a wide spanning gradient of source and quality, perhaps more so than any other food- grains/breads are a close second. You have everything from pasterurized, homogenized, defatted milk from a caged Holstein being fed GMO soymeal and antibiotics, all the way up to the fresh raw cheese produced that morning from your neighbor's goat that happily grazes on fresh pasture under the warm sun. And everything in between. There's "dairy", and there is "dairy". This is the mentality people all must adopt to get rid of acne and build health.


For sure, I wouldn't know where to source raw goat or cows milk though, although I would love to try it as I have heard that it is a completely different ball game to the pasturised stuff they have to sell in the supermarkets, even the organic pasturised stuff.....

#5 alternativista

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Posted 05 May 2011 - 08:39 AM

QUOTE (Drizzler @ May 4 2011, 07:08 PM) <{POST_SNAPBACK}>
A huge thing to consider with dairy is that there is such a wide spanning gradient of source and quality, perhaps more so than any other food- grains/breads are a close second. You have everything from pasterurized, homogenized, defatted milk from a caged Holstein being fed GMO soymeal and antibiotics, all the way up to the fresh raw cheese produced that morning from your neighbor's goat that happily grazes on fresh pasture under the warm sun. And everything in between. There's "dairy", and there is "dairy". This is the mentality people all must adopt to get rid of acne and build health.


Yes, many issues are due to/worsened by being from grain fed cows. Many issues are reduced/eliminated with fermentation into cheese, yogurt, kefir, etc.

Above all, don't drink the ordinary cows milk in your supermarket. And in general, don't drink a lot of cows milk.

But I don't know if anything reduces the 5alpha-P in milk, if there's any less in milk from goats, sheep, pastured animals, etc. So you don't want dairy to be a big part of your diet. And the way it's a big part of anyone's diet is usually by drinking it.

And as it takes a lot of milk to make small amounts of cheese, is the 5alpha-P concentrated in the cheese?, drained away with the whey? Or is it concentrated in the whey?

Edited by alternativista, 05 May 2011 - 08:40 AM.


#6 alternativista

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Posted 05 May 2011 - 08:50 AM

More on IGF-1 and dairy. Remember in addition to being in dairy, IGF-1 is stimulated by insulin so in other words, high glycemic and insulinemic meals.

This info below, from a PCOS organization, claims that also IGF-1 stimulates insulin so it's a cycle. Also that 5alpha-P makes you more sensitive to estrogens.


QUOTE
IGF-1 is a "growth factor" that regulates cell growth and development. There is lots of IGF-1 in cow's milk because cow's milk is intended to make baby cows grow fast into mature cows.

But you are not a baby cow. You are an adult human being. So what do you think all this IGF-1 is going to do inside your body? No one knows for sure, but the evidence so far is troubling.

1) IGF-1 stimulates cell division and retards cell death. Therefore, it is a supporter of cancer growth. And acne.

2) IGF-1 in milk appears to increase your insulin levels and possibly increases IGF-1 production inside your body. Excessively high insulin levels are a huge problem for women with PCOS, resulting in a condition called "insulin resistance." Insulin resistance in turn is a driving force behind infertility, weight gain, and all the other symptoms of polycystic ovarian syndrome.

3) IGF-1 stimulates an enzyme called 5alpha-reductase. 5alpha-reductase in turn stimulates the production of DHT (dihydrotestosterone). DHT is thought to be the #1 cause of acne, hirsutism, and hair loss.

4) IGF-1 stimulates production of male hormones by your ovaries and adrenal glands. This is exactly what you don't want to happen. Your male hormone levels are already too high.

5) Increased IGF-1 levels during pregnancy may unfavorably affect the "fetal programming" of the baby that is developing in your uterus. There may be future health consequences for your child.

Enough about IGF-1.

Milk has another problematic compound called 5alpha-P. 5alpha-P is converted into DHT, which in turn worsens acne, hirsutism and hair loss.

5alpha-P also appears to make you more sensitive to estrogen. Many women who have PCOS also have a condition called "estrogen dominance", where they have too much estrogen in relation to progesterone. So, if you have too much "unopposed" estrogen and if 5alpa-P makes you more sensitive to estrogen, you open yourself up to increased risk of estrogen-related disorders such as endometriosis, endometrial cancer, and breast cancer.

Folks, this is only the tip of the iceberg regarding milk. Please review chapter 5.2 "The Problem with Milk" in the diet ebook for more information.

Milk and dairy products are a mixed bag. Dairy has some good things and some bad things. If you consume a lot of dairy products, we suggest you think about cutting back. If you're worried about getting enough calcium, simply take a high-quality multi-vitamin/mineral supplement.

Sources: Melnik B et al, Role of insulin, insulin-like growth factor-1, hyperglycaemic food and milk consumption in the pathogenesis of acne vulgaris, Exp Dermatol. 2009 Oct;18(10):833-41
Danby FW, Acne, dairy and cancer: The 5alpha-P link, Dermatoendocrinol. 2009 Jan;1(1):12-6
Melnik B, Milk consumption: aggravating factor of acne and promoter of chronic diseases of Western societies, J Dtsch Dermatol Ges. 2009 Apr;7(4):364-70
Melnik B, Milk--the promoter of chronic Western diseases, Med Hypotheses. 2009 Jun;72(6):631-9

Has links to the studies and the ebook. See it here if you want to follow them:
http://www.ovarian-c...ws109.html#sec1


Edited by alternativista, 15 July 2014 - 06:35 PM.


#7 alternativista

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Posted 09 May 2011 - 11:02 AM

I just came across this:

QUOTE
Dairy may be potentially more harmful in pasteurized, processed milk because of the reduction of SIgA, an immunoglobulin that binds dangerous lectins , Biol Neonate 1991;59(3):121-5 Davin JC et al The high lectin-binding capacity of human secretory IgA protects nonspecifically mucosae against environmental antigens.),
http://www.krispin.com/lectin.html

So not only does pasteurized dairy from grain fed cows have more lectins, it has less of what binds them up and protects us from them.

And on the same page:

QUOTE
GM (genetically modified foods) are modified by splicing 'lectins' from one plant family to another. This is extremely problematic. If you know you react to a particular plant family but that lectin has been put in a plant not of that family you may consume the 'toxic to you' lectin, have the reaction/response and not know the cause.

Edited by alternativista, 09 May 2011 - 06:48 PM.


#8 spectacled_owl

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Posted 09 May 2011 - 02:54 PM

QUOTE (rifkah6 @ May 5 2011, 04:06 AM) <{POST_SNAPBACK}>
QUOTE (Drizzler @ May 4 2011, 06:08 PM) <{POST_SNAPBACK}>
A huge thing to consider with dairy is that there is such a wide spanning gradient of source and quality, perhaps more so than any other food- grains/breads are a close second. You have everything from pasterurized, homogenized, defatted milk from a caged Holstein being fed GMO soymeal and antibiotics, all the way up to the fresh raw cheese produced that morning from your neighbor's goat that happily grazes on fresh pasture under the warm sun. And everything in between. There's "dairy", and there is "dairy". This is the mentality people all must adopt to get rid of acne and build health.


For sure, I wouldn't know where to source raw goat or cows milk though, although I would love to try it as I have heard that it is a completely different ball game to the pasturised stuff they have to sell in the supermarkets, even the organic pasturised stuff.....


Rifkah, have you ever been to eatwild.com? I found a local farm (kinda local, the closest one to me is still about 30miles) that sells raw milk and cheese, grass fed/pasture raised beef and eggs and seasonal fruits and veggies. I never thought there was anything like that close to me until I looked smile.gif


#9 alternativista

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Posted 24 May 2011 - 05:20 PM

Role of insulin, insulin-like growth factor-1, hyperglycaemic food and milk consumption in the pathogenesis of acne vulgaris

http://www.canibaise...a-milk-acne.pdf

This is about cow's milk:

QUOTE
Differential induction of insulin and IGF-1 by
milk protein fractions

The major protein fraction of cow€™s milk is casein (80%),
and the remaining 20% are whey proteins. The effect of
whey and casein fractions of milk on fasting concentrations
of IGF-1 and insulin has been examined in fifty-seven
8-year-old boys who received over 7 days either casein or
whey proteins in amounts similar to that found in 1.5 l of
skim milk. In the casein group, serum IGF-1 increased by
15%, whereas there was no change in fasting insulin. In the
whey group, fasting insulin increased by 21%, with no
change in IGF-1 (89). The insulin response to a whey meal
has been reported to be higher than that of a milk meal.
This differential response suggests that the insulinotropic
component of milk resides predominantly within the whey
fraction, whereas casein has a stronger IGF-1 stimulating
effect than does whey (89).


But whey contains the very proteins that are needed to produce Growth Hormone. I wish I could find more research on adult acne and some advice on how to balance an older person's desire to keep the HGH going for its anti-aging effects without the detrimental effects of stimulating excess IGF-1 and acne and other related skin conditions.

BTW, mentioned in the same paper:
QUOTE
There is evidence that smokers are insulin resistant and
hyperinsulinaemic compared with non-smokers (92).
Hyperinsulinaemia, dyslipidaemia and exaggerated adrenal
androgen response to ACTH have been observed in male
smokers (93).

Edited by alternativista, 02 August 2011 - 06:36 AM.


#10 alternativista

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Posted 01 August 2011 - 01:14 PM

QUOTE
One scientist referred to milk as a "complex aqueous, suspended fat, liposomal, suspended protein emulsion". What we do know is that milk is designed to grow things--namely, babies--and in the case of cow's milk, calves. It is naturally full of what we call anabolic hormones (the same ones that body builders and A Rod use to grow big muscles, and which cause bad acne). These are mostly androgens (like testosterone) and growth hormones including insulin like growth factor 1 (IGF-1). There is no such thing as hormone-free milk.

Here's a short list of the 60-some hormones in your average glass of milk--even the organic, raw, and bovine growth hormone free milk:

20α-dihydropregnenolone
progesterone (from pregnenolone)
5α-pregnanedione
5α-pregnan-3β-ol-20-one, 20α- and 20β-dihydroprogesterone (from progesterone)
5α-androstene-3β17β-diol
5α-androstanedione
5α-androstan-3β-ol-17-one
androstenedione
testosterone
dehydroepiandrosterone sulphate acyl ester
insulin like growth factors 1 and 2 (IGF-1 and IGF-2)
insulin


Some of those are precursors to DHT which is implicated in oily skin, hirsutism and male pattern baldness. And some are major factors in hyperkeratinization which is at the root of clogged pores and acne and other skin issues.

From this article on diet and acne: http://www.huffingto...a_b_822163.html

Edited by alternativista, 01 August 2011 - 01:17 PM.


#11 Thehoper

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Posted 01 August 2011 - 05:26 PM

In today's world people should just simply know that you should not drink cow milk. The molecules are meant for a huge species, to get bigger. Our digestive systems cannot handle it and half of it ends up not even being digestive, only to cause further problems. Now that I have been drinking raw goat milk kefir though, I'm not against all dairy. I did a bunch of searches through this forum for goat milk, and I didn't see one negative comment. So it's crazy that everyone just writes off dairy, even though goat and sheep milk seem to be just fine.

IGF-1 is suppose to make acne terrible, right? Yet many people have had no breakouts from goat milk like myself, so is it the IGF-1 or something else? Pastuerization is also huge like I said in my goat milk kefir thread, it becomes a totally different substance. None the less Raw Organic Goat/Sheep milk seems to be great for acne sufferers, and making kefir/yogurt out of them is best. I have only drank about a cup of the goat milk straight, the rest in kefir. I'm on my 2nd gallon now and just loving the stuff, seeing a bunch of improvements in health.

#12 alternativista

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Posted 02 August 2011 - 06:41 AM

QUOTE (Thehoper @ Aug 1 2011, 06:26 PM) <{POST_SNAPBACK}>
IGF-1 is suppose to make acne terrible, right? Yet many people have had no breakouts from goat milk like myself, so is it the IGF-1 or something else?


IGF1 is a major factor in hyperkeratinization which is the reason our pores clog. It is made in our bodies stimulated by insulin and is in dairy. But the consumption of dairy does not automatically lead to a pimple unless you are intolerant. But it has a negative impact on many of the processes involved in the formation of acne such as containing IGF-1 and precursors to DHT.

Dairy doesn't noticeably break me out either. Not even cow dairy. But I only have limited amounts. I would bet if I went back to the kind of consumption I used to with drinking big glasses of milk with half my meals, plus eating lots of cheese and ice cream, it would. But I don't plan on ever doing that.

#13 bɭesstheʄẚɭɭ

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Posted 02 August 2011 - 06:43 AM

I've had about two gallons of 2% milk in the last four days, and my skin is A-OK!

#14 XC60

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Posted 02 August 2011 - 06:44 AM

FUCK dairy products, and the farmers can go to hell as well for animal cruelty!!!

EOM

#15 Thehoper

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Posted 02 August 2011 - 09:16 AM

^^a lot of dairy farms are like luxury palaces to their animals.. the organic farm near me for sure. It is an old couple in their 70's, they have over 115 goats. They are incredibly healthy, very friendly, playful, it was really cool to see. They took me through a whole detour of the place lol. Everything was clean as hell and they took their farm VERY serious.

The goats have a great home, plenty of food, SECURITY, constant attention/care, free to do whatever the hell they want, they had plenty of room to roam. Those goats wouldn't want their lives any other way lol, there's no way they would choose to be out in the wild scrambling for food, having half their family killed every other day, no one to watch over them etc..



#16 alternativista

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Posted 13 January 2012 - 10:30 AM

About Calcium- deficiency is rare, even in those that don't consume it.

You don't need as much as you think and that dairy and calcium supplement vendors try to tell you. Calcium deficiency is rare and the planet is filled with people that eat little dairy yet have strong bones. What you need is the other nutrients the body needs to use the calcium and to make bones such as D, Magnesium, Vitamin C, vitamin K, zinc and boron.

C is need to make new cells. Any new cell including bone cells. And you need much, much more than the RDA to make all these cells. And because it is water soluble, you need it all day long. This is why you eat fresh fruits and vegetables several times per day.

Magnesium is the fourth most abundant mineral in the body. About 50% of total body magnesium is found in bone.

Calcium sources:
There's calcium in broccoli, spinach, almonds, and other greens and seeds, stock made by boiling bones. Fish bones as in canned sardines. all kinds of foods. Most calcium supplements come from rocks. The calcium in animal bones, shells and plants is much more usable by the body. A little acid (vinegar or lemon juice) added to veggies, egg shells and when boiling bones extracts more calcium. Make your own 'supplements.'

Your body takes minerals from your bones when it needs them.

Don't consume things that impairs the body's ability to use calcium or causes the body to take calcium from the bones. Like the phosphoric acid in sodas and other carbonated drinks, excessive amounts of caffeine, salt, sugar, alcohol, protein. Cigarette smoking. drugs like aspirin, antacids, cortisone and corticosteroids, antibiotics, Stress and depression.

Edited by alternativista, 13 April 2012 - 08:00 AM.


#17 maistro

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Posted 14 January 2012 - 11:55 PM

I've had a bit of a breakthrough regarding dairy, calcium and all that.

I've come to realise, dairy is not evil.

Raw dairy, in moderation is great. Even better is fermented dairy. Also as you point out alteravista, it should not be a main staple in your diet, to get your calcium needs and whatnot.

Balance is the key with all diets. I only have raw milk kefir a couple days a week and use ghee in my cooking which is techincally not dairy as it has milk solids removed. I don't have cheese or use it in my foods. I think it's a great addition to your diet, but in moderation and according to how you tolerate it and react to it.

#18 alternativista

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Posted 13 April 2012 - 07:58 AM

Some of these might already be posted above, but a search for something I just did turned them up.



High intakes of skimmed milk, but not meat, increase serum IGF-I and IGFBP-3 in eight-year-old boys.
http://www.ncbi.nlm....3?dopt=Abstract



D i e t a r y I m p l i c a t i o n s f o r t h e D e v e l o p m e n t o f A c n e : A S h i f t i n g P a r a d i g m by Cordain
http://www.touchbrie...163/Cordain.pdf There's quite a bit about the BTC in dairy.

This Paleo blog article on dairy is pretty good with the info on the hormones in dairy, what might survive digestion/pasteurization/fermentation, etc. With a lot of good sources sited for more info on dairy's impact on factors that affect acne, diabetes and prostate cancer and many other conditions: http://thepaleodiet....-2010-milk.html


High school dietary dairy intake and teenage acne.
http://www.ncbi.nlm....pubmed/15692464




Milk consumption and acne in teenaged boys.http://missclasses.c... dairy zits.pdf

The same people did another on adolescent girls. http://www.ncbi.nlm....pubmed/17083856



Acne: Are Milk and Sugar the Causes?

http://www.huffingto...a_b_822163.html article

#19 Michaelangelo

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Posted 14 April 2012 - 01:02 AM

You might be interested in watching Forks Over Knives. I watched in on Netflix for free, not sure if it's still on there. Might be able to find it online somehwere but part of it basically explains how our bodies weren't meant to consume animal protein. Wheather through milk or meat.

When they increased levels of casein given to lab rats they actually found evidence of cancer growth. It's been awhile since I've watched it but there was some scary stuff in it and lots of evidence and science to back it up.

Also talks about how bad the American diet is and how it is causing the alarming amount of diseases we suffer from. Interesting watch even if you don't buy into it all.

Not trying to advertise but a trailer is on the site
http://www.forksoverknives.com/

I'd look for it on Netflix if you got it.

Edited by Michaelangelo, 14 April 2012 - 01:04 AM.


#20 alternativista

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Posted 16 July 2012 - 01:04 PM

I had this posted elsewhere. Apparently probiotics involved in the fermentation of dairy in yogurt and cheese making reduce the IGF1 content:

And this little tidbit on the IGF1 in dairy being reduced in fermented dairy:
Quote


We also find it noteworthy that of three large population studies linking dairy consumption (most notably milk) and acne, none made a positive correlation between fermented dairy (e.g. yogurt) and acne . It has been postulated that milk is associated with acne because it contains growth hormones (both synthetically added and naturally occurring) . Acne is certainly driven by insulin-like growth factor I (IGF-I) , and IGF-I can be absorbed across colonic tissue. Therefore, it is interesting to note that probiotic bacteria (Lactobacilli in particular) utilize IGF-I during the fermentation process when added to milk, with a resultant 4-fold lower level of IGF-I in fermented vs. skim milk .


From this post: http://www.acne.org/...20#entry3242187




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