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PPAR stimulator GW1514 (topical) for repairing accutane damage?

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http://www.ncbi.nlm.nih.gov/pubmed/15102088

I took accutane 5 years ago and have permanent damage: Now my face has skin fragility and thinness, extreme dryness and wrinkling, inflammation and irritation, dyshesion and diminished waterproofing, as the skin barrier homeostasis has been disrupted, etc. etc.

about 1 year ago i started taking adderall for adhd. and this has made my skin condition worse.

i'm wondering if anyone knows anything about PPAR stimulators ...which stimulate seb glands and other relevant mechanisms. i did not realize that there are TOPICAL ppar stims. i have posted about internal treatments for diabetes, but a topical option seems more pragmatic and less risky, especially since my damage is mostly localized in the face.

the specific one i read about is called GW1514....

Peroxisome proliferator-activated receptor (PPAR)-beta/delta stimulates differentiation and lipid accumulation in keratinocytes.

Schmuth M, Haqq CM, Cairns WJ, Holder JC, Dorsam S, Chang S, Lau P, Fowler AJ, Chuang G, Moser AH, Brown BE, Mao-Qiang M, Uchida Y, Schoonjans K, Auwerx J, Chambon P, Willson TM, Elias PM, Feingold KR.

Department of Medicine, University of California, San Francisco, California, USA.

Erratum in:

J Invest Dermatol. 2004 Oct;123(4):806.

Peroxisome proliferator-activated receptor (PPAR) are nuclear hormone receptors that are activated by endogenous lipid metabolites. Previous studies have demonstrated that PPAR-alpha activation stimulates keratinocyte differentiation in vitro and in vivo, is anti-inflammatory, and improves barrier homeostasis. Recent studies have shown that PPAR-beta/delta activation induces keratinocyte differentiation in vitro. This study demonstrated that topical treatment of mice with a selective PPAR-beta/delta agonist (GW1514) in vivo had pro-differentiating effects, was anti-inflammatory, improved barrier homeostasis, and stimulated differentiation in a disease model of epidermal hyperproliferation [corrected]. In contrast to PPAR-alpha activation, PPAR-beta/deltain vivo did not display anti-proliferative or pro-apoptotic effects. The pro-differentiating effects persisted in mice lacking PPAR-alpha, but were decreased in mice deficient in retinoid X receptor-alpha, the major heterodimerization partner of PPAR. Furthermore, in vitro PPAR-beta/delta activation, aside from stimulating differentiation-related genes, additionally induced adipose differentiation-related protein (ADRP) and fasting induced adipose factor (FIAF) mRNA in cultures keratinocytes, which was paralleled by increased oil red O staining indicative of lipid accumulation, the bulk of which were triglycerides (TG). Comparison of differentially expressed genes between PPAR-beta/delta and PPAR-alpha activation revealed distinct profiles. Together, these studies indicate that PPAR-beta/delta activation stimulates keratinocyte differentiation, is anti-inflammatory, improves barrier homeostasis, and stimulates TG accumulation in keratinocytes.

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So its just your facial skin thats very dry after accutane?

how is the rest of your skin on your body?

What did the derm that prescribed the Accutane say about this severe dryness?

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So its just your facial skin thats very dry after accutane?

how is the rest of your skin on your body?

What did the derm that prescribed the Accutane say about this severe dryness?

yes just my face. however i have dry, coarse hair around my hair near the ear line and neck line. but the difference between my face and the rest of my body is so stark -- I actually really like the rest of my skin.

about my former dermatologist...i dont know what to say...it was 5+ years ago, i was a dumb teenageer seeing the random private practice derm in my neighborhood. now im seeing dermatologists at a major university hosptial....some of them with MD/PHD credentials. don't really know what that has to do with moving forward and trying to find treatment for my current ailments....

one other thing.....even within my face the damage seems to exclude my chin and even nose. my nose still has oil production and my chin also looks and feels like "normal"...but the rest of my face (cheeks, forhead, etc.) are very clearly damaged.

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Just read your post. Lad I'm Irish too and going through the exact same problem as you. Post accutane damage is horrible. Hope your still active on this as I'd really appreciate someone to talk to about this.

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I took accutane 5 years ago and have permanent damage: Now my face has skin fragility and thinness, extreme dryness and wrinkling, inflammation and irritation, dyshesion and diminished waterproofing, as the skin barrier homeostasis has been disrupted, etc. etc.

What dose did you take? And for how long?


MtF Transgenered, 18 years old, oily skin, acne, and non-Rosacea redness.

Recently diagnosed as having hyperthyroidism...this explains my skin.

*Daily Regimen*

Wake up

Cleanse with First-Aid Beauty Face Wash

Apply SkinCeuticals Phyto Corrective Gel

Apply First-Aid Beauty Daily Face Cream

Repeat

Go to sleep

*Shaving* (every other day)

Apply First-Aid Beauty Daily Face Cream; lather

Shave with disposable razor

*Makeup*

Laura Mercier Mineral Pressed Powder SPF 15


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I really want to get this thred going again because this is EXACTLY the problem I have and from reading the article this is the SOLUTION. I know im not the only person with extremely dry skin even after 1 year post Accutane. I know it's a damaged lipid barrier and Does anyone know how to obtain these PPAR stimulators, is there a brand ? a different name for them ? If there is an answer to repairing this problem then its this !!

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I really want to get this thred going again because this is EXACTLY the problem I have and from reading the article this is the SOLUTION. I know im not the only person with extremely dry skin even after 1 year post Accutane. I know it's a damaged lipid barrier and Does anyone know how to obtain these PPAR stimulators, is there a brand ? a different name for them ? If there is an answer to repairing this problem then its this !!

Niacin is one of them. That should be easy to find. Lots of people here have had some nice results with Niacin supplementation.

Another is Orlistat. If you don't know what that is, maybe you've heard of the pill Alli. Unless you're willing to change your underwear twice a day, I wouldn't recommend getting it lol.


After suffering with acne since age 11, finally found my triggers 11 years later.

Clear for almost 1 year & in control of my acne, although due to some hyperpigmentation, I believed I was still breaking out. In fact, I thought I had just cleared up a few months ago, but after realizing my "breakouts" were simply scarring I also realized I was technically clear for much longer than I thought. Rare breakouts only whenever I get lazy with my diet.

The Cure for Acne:

-Avoid the Acne Trifecta: Soy, Gluten, and Dairy like the plague.

-Eat a Low-GI diet and avoid Sugar.

-Eat lots of protein and healthy fats (ANTIBIOTIC FREE/NO HORMONES ADDED/FREE RANGE/HUMANELY SLAUGHTERED)

-Get lots of green vegetables and sunshine.

-Supplement whenever possible. Due to how much we've ruined food in the past 60 years, the amount of nutrients found in food nowadays is lower than it was decades ago.

-Exercise, get sunshine, and avoid stressful situations.

-Don't fear food. Go out & eat. It's not good for the skin, but it's good for the soul.


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Sorry it took me awhile to get back to this thread. Thank you very kindly for your reply. Been looking everywhere for a solution to this. I read afew articles and medical info on niacin. Looks promising. I'll look into the other one you mentioned too. This is definately something that needs more attention.

Cheers

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By the way. There are several products out there that are Barrier Repaire. Do these actually work?

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Thanks for posting that article flem.

The article is great and seems to address the problem, and offers a solution for it.

But what frustrates me is looking at the patent its dated year 2000, and yet there's no updates on whether this patent has been turned into a product or something consumers can use.

I know the science is available fix accutane damage and repair the lipid barrier, but there is nothing available to consumers that I know of, if anyone has anything, please share !!!!

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