Other reasons why Green Tea work is because of select antioxidants called catechins
that have DHT Inhibiting potential.EGCG
- if you were to take this pure it would only function to block Androgen Receptors so that DHT wouldn't bind.EGCG-gallate
- this has the added bonus of preventing DHT (Type 1) enzyme conversion of 5-alpha, however it will also prevent aromatase (some may not like that), but most people don't notice because the effects are still being inhibited.
"Growth suppression of hamster flank organs by topical application of catechins, alizarin, curcumin, and myristoleic acid.
Liao S, Lin J, Dang MT, Zhang H, Kao YH, Fukuchi J, Hiipakka RA.
Ben May Institute for Cancer Research, Department of Biochemistry and Molecular Biology, University of Chicago, IL 60637, USA. [email protected]
Hamster flank organ growth, as measured by an increase in the area of the pigmented macule, is androgen-dependent. When flank organs of a castrated hamster are treated topically with testosterone, the flank organ becomes larger and darker. Since this growth is known to be dependent on the intracellular active androgen, 5alpha-dihydrotestosterone (DHT), inhibitors of 5alpha-reductase which converts testosterone to DHT can inhibit the growth of the flank organ. Certain unsaturated aliphatic fatty acids, such as gamma-linolenic acid
and myristoleic acid, as well as other natural compounds, including alizarin and curcumin
, are 5alpha-reductase inhibitors and inhibited flank organ growth. Green tea catechins, including (-)-epicatechin-3-gallate, and (-)-epigallo-catechin-3-gallate (EGCG) are also 5alpha-reductase inhibitors and inhibited flank organ growth. However, (-)-epicatechin and (-)-epigallocatechin, which are not 5alpha-reductase inhibitors, also inhibited flank organ growth. EGCG also inhibited DHT-dependent growth of flank organs. These catechins, therefore, may act by a mechanism other than inhibition of 5alpha-reductase. The effect of EGCG and other compounds was localized at the site of application; they did not affect the growth of the contralateral flank organ in the same animal. Since these compounds do not appear to exhibit systemic effects, they may be potentially useful for treatment of androgen-dependent skin disorders."http://www.ncbi.nlm....t_uids=11380153
"Soy phytochemicals and tea bioactive components synergistically inhibit androgen-sensitive human prostate tumors in mice.
Zhou JR, Yu L, Zhong Y, Blackburn GL.
Nutrition/Metabolism Laboratory, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. [email protected]
Although high doses of single bioactive agents may have potent anticancer effects, the chemopreventive properties of the Asian diet may result from interactions among several components that potentiate the activities of any single constituent. In Asia, where intake of soy products and tea consumption are very high, aggressive prostate cancer is significantly less prevalent in Asian men. The objective of the present study was to identify possible synergistic effects between soy and tea components on prostate tumor progression in a mouse model of orthotopic androgen-sensitive human prostate cancer. Soy phytochemical concentrate (SPC), black tea and green tea were compared with respect to tumorigenicity rate, primary tumor growth, tumor proliferation index and microvessel density, serum androgen level and metastases to lymph nodes. SPC, black tea and green tea significantly reduced tumorigenicity. SPC and black tea also significantly reduced final tumor weights. Green tea did not reduce final tumor weight, although it tended to elevate (P = 0.14) the serum dihydrotestosterone (DHT) concentration. The combination of SPC and black tea synergistically inhibited prostate tumorigenicity, final tumor weight and metastases to lymph nodes in vivo. The combination of SPC and green tea
synergistically inhibited final tumor weight and metastasis and significantly reduced serum concentrations of both testosterone and DHT in vivo
. Inhibition of tumor progression was associated with reduced tumor cell proliferation and tumor angiogenesis. This study suggests that further research is warranted to study the role of soy and tea combination as effective nutritional regimens in prostate cancer prevention."http://www.ncbi.nlm....t_uids=12566493
One option is to try Green Tea patches from www.1800patches.com but they are more costly and you still have to use a fresh one daily.
To save money, you can purchase Pure Green Tea Extract powder (will have both substances) that will contain 80% catechins, and > 45% EGCG that is also "decaffeinated" ( <1% caffeine). So a dose of 400mg will contain 180mg of EGCG. If you can find EGCG in pure form you should be very lucky. You can use Stevion (non-bitter form of Stevia) or Xylitol (non cariogenic sweeter) as your safe & natural alternative sweeteners if you don't like the taste of this plain. If you take the powder, since there's no fillers
, it's really a very small amount (1/8 - 1/4 tsp) that you have to get down and half a cup of water should do it (not boiled).
I've got a bottle of this and it does help a bit with the inflammatory acne on the skin (supposed to be as effective as Benzoyl Peroxide) so if you find drinking it breaks you out maybe topically it won't. For those that still use BHA, Paula's Choice has a wonderful 2% BHA solution (liquid) that contain Green Tea and I used to use spot treat with that stuff to heal up acne wounds FAST.
As for the Soy, you want specific isoflavones:Equol
- most effective at reducing (Type II) DHT isoenzymes, and it also BINDS to DHT,
rendering it inactive (a first)!Diadzein
- Equol is derived from this, and reduces Type II DHT Isoenzymes.Genistein
- Reduces Type II DHT Isoenzymeshttp://www.ncbi.nlm....t_uids=14681200http://www.ncbi.nlm....t_uids=12566472