Paper by researchers that theorize that FoxO1
FoxO1 plays a pivotal role in the regulation of androgen receptor (ARs), cell proliferation, cell survival, apoptosis, lipid
and glucose metabolism, oxidative stress and innate immunity– all important factors in acne pathogenesis (Fig. 1).
Nuclear FoxO1 is predominantly regulated by the activity of the phosphoinositol-3 kinase ⁄Akt pathway. Increased growth factor
signalling in puberty (insulin-like growth factor-1, IGF-1) and an insulinotropic Western diet, especially by high-glycaemic load diets (insulin) and increased consumption of insulinotropic dairy products (insulin ⁄IGF-1), may play a fundamental role in the reduction of the nuclear content of FoxO1.
Oxidative stress is AKA inflammation.
But elsewhere there's this statement:
If a substantial body of evidence accumulates showing that FoxO1 levels are different in patients with acne compared with
patients without acne, then the discussion can be elevated to that of a theory.
So as of 2010 when this was written, it hasn't been demonstrated that acne prone patients are any more deficient in FoxO1 than anyone else. However, I've found some info on the use of linoleic acid
This site is a data mining site for 'for previously unknown relations between genes and phenotypes, and improved gene prioritisation catching non-obvious disease causing genes.'
http://biograph.be/project/project And apparently there is a known relationship between the FoxO1 gene and linoleic acid. There's an interactive chart that 'provides putative functional links between FOXO1 gene (context) and trans-10,cis-12-conjugated linoleic acid (target)'
And here's a paper on the 'Role of FoxO1 in FFA-induced oxidative stress in adipocytes' FFA = free fatty acids, but as far as I can tell, they don't say which FFAs.
And here's one on resveraterol. I don't know if it's already in the resveraterol or linoleic acid thread:
Conjugated linoleic acid-mediated inflammation and insulin resistance in human adipocytes are attenuated by resveratrol*
Several studies on the benefits of topical green tea:
Skin photoprotection by green tea: antioxidant and immunomodulatory effects
Green tea polyphenolic antioxidants and skin photoprotection (Review)
Polyphenolic antioxidant (-)-epigallocatechin-3-gallate from green tea reduces UVB-induced inflammatory responses and infiltration of leukocytes in human skin
And some on topical lotions. Some of these may be duplicates.
Topical therapy of acne vulgaris using 2% tea lotion in comparison with 5% zinc sulphate solution
The efficacy of topical 2% green tea lotion in mild-to-moderate acne vulgaris
Treatment of acne vulgaris with 2% topical tea lotion
Outcomes of 3% green tea emulsion on skin sebum production in male volunteers
Edited by alternativista, 19 June 2012 - 03:03 PM.