268 replies to this topic

[alternativista]

About FoxO1

Paper by researchers that theorize that FoxO1

FoxO1 plays a pivotal role in the regulation of androgen receptor (ARs), cell proliferation, cell survival, apoptosis, lipid
and glucose metabolism, oxidative stress and innate immunity– all important factors in acne pathogenesis (Fig. 1).
2
Nuclear FoxO1 is predominantly regulated by the activity of the phosphoinositol-3 kinase ⁄Akt pathway. Increased growth factor
signalling in puberty (insulin-like growth factor-1, IGF-1) and an insulinotropic Western diet, especially by high-glycaemic load diets (insulin) and increased consumption of insulinotropic dairy products (insulin ⁄IGF-1), may play a fundamental role in the reduction of the nuclear content of FoxO1.

Oxidative stress is AKA inflammation.

But elsewhere there's this statement:

If a substantial body of evidence accumulates showing that FoxO1 levels are different in patients with acne compared with
patients without acne, then the discussion can be elevated to that of a theory.

So as of 2010 when this was written, it hasn't been demonstrated that acne prone patients are any more deficient in FoxO1 than anyone else. However, I've found some info on the use of linoleic acid

This site is a data mining site for 'for previously unknown relations between genes and phenotypes, and improved gene prioritisation catching non-obvious disease causing genes.'
http://biograph.be/project/project And apparently there is a known relationship between the FoxO1 gene and linoleic acid. There's an interactive chart that 'provides putative functional links between FOXO1 gene (context) and trans-10,cis-12-conjugated linoleic acid (target)'

And here's a paper on the 'Role of FoxO1 in FFA-induced oxidative stress in adipocytes' FFA = free fatty acids, but as far as I can tell, they don't say which FFAs.
http://ajpendo.physi...1/E159.full.pdf

And here's one on resveraterol. I don't know if it's already in the resveraterol or linoleic acid thread:

Conjugated linoleic acid-mediated inflammation and insulin resistance in human adipocytes are attenuated by resveratrol^*

---------------
Several studies on the benefits of topical green tea:

Skin photoprotection by green tea: antioxidant and immunomodulatory effects
Green tea polyphenolic antioxidants and skin photoprotection (Review)
Polyphenolic antioxidant (-)-epigallocatechin-3-gallate from green tea reduces UVB-induced inflammatory responses and infiltration of leukocytes in human skin
And some on topical lotions. Some of these may be duplicates.
Topical therapy of acne vulgaris using 2% tea lotion in comparison with 5% zinc sulphate solution
The efficacy of topical 2% green tea lotion in mild-to-moderate acne vulgaris
Treatment of acne vulgaris with 2% topical tea lotion
Outcomes of 3% green tea emulsion on skin sebum production in male volunteers

Edited by alternativista, 19 June 2012 - 03:03 PM.

[Perspective77]

I will most definately be following your blog. All this information really makes you think about how wrong we all have it. I feel like we could be living forever if it was possible to do everything in this thread.

[CherrySoda08]

About FoxO1

Paper by researchers that theorize that FoxO1

FoxO1 plays a pivotal role in the regulation of androgen receptor (ARs), cell proliferation, cell survival, apoptosis, lipid
and glucose metabolism, oxidative stress and innate immunity– all important factors in acne pathogenesis (Fig. 1).
2
Nuclear FoxO1 is predominantly regulated by the activity of the phosphoinositol-3 kinase ⁄Akt pathway. Increased growth factor
signalling in puberty (insulin-like growth factor-1, IGF-1) and an insulinotropic Western diet, especially by high-glycaemic load diets (insulin) and increased consumption of insulinotropic dairy products (insulin ⁄IGF-1), may play a fundamental role in the reduction of the nuclear content of FoxO1.

Oxidative stress is AKA inflammation.

But elsewhere there's this statement:

If a substantial body of evidence accumulates showing that FoxO1 levels are different in patients with acne compared with
patients without acne, then the discussion can be elevated to that of a theory.

So as of 2010 when this was written, it hasn't been demonstrated that acne prone patients are any more deficient in FoxO1 than anyone else. However, I've found some info on the use of linoleic acid

This site is a data mining site for 'for previously unknown relations between genes and phenotypes, and improved gene prioritisation catching non-obvious disease causing genes.'
http://biograph.be/project/project And apparently there is a known relationship between the FoxO1 gene and linoleic acid. There's an interactive chart that 'provides putative functional links between FOXO1 gene (context) and trans-10,cis-12-conjugated linoleic acid (target)'

And here's a paper on the 'Role of FoxO1 in FFA-induced oxidative stress in adipocytes' FFA = free fatty acids, but as far as I can tell, they don't say which FFAs.
http://ajpendo.physi...1/E159.full.pdf

And here's one on resveraterol. I don't know if it's already in the resveraterol or linoleic acid thread:

Conjugated linoleic acid-mediated inflammation and insulin resistance in human adipocytes are attenuated by resveratrol^*

---------------
Several studies on the benefits of topical green tea:

Skin photoprotection by green tea: antioxidant and immunomodulatory effects
Green tea polyphenolic antioxidants and skin photoprotection (Review)
Polyphenolic antioxidant (-)-epigallocatechin-3-gallate from green tea reduces UVB-induced inflammatory responses and infiltration of leukocytes in human skin
And some on topical lotions. Some of these may be duplicates.
Topical therapy of acne vulgaris using 2% tea lotion in comparison with 5% zinc sulphate solution
The efficacy of topical 2% green tea lotion in mild-to-moderate acne vulgaris
Treatment of acne vulgaris with 2% topical tea lotion
Outcomes of 3% green tea emulsion on skin sebum production in male volunteers

Hey there Alternativista,

Firstly, I just would like to tell you how much I admire your contributions to this board. They have taught me alot, and I will most certainly be checking out your blog. Your posts have inspired me to make quite a few changes to my diet. I was on a low-glycemic diet to shed the "puff" I carry on the sides of my waist and hips for a few months before even coming across your posts, but the research that some of your posts contain has inspired me to try a Paleo diet, and abstain from gluten and most dairy to see if it helps me not to have the little pustules I get once in a while.

But I have a question for you; how exactly could changing my diet make a real impact on my hormonal acne? I know my cystic acne that I got beginning around 21, and lasting until 24 was linked to my hormones. The lifestyle choices I made at the time were of no help, either. I am nearly convinced they made my acne worse. I guess what I'm saying to you is that I don't quite understand the connection between diet and hormones. Of course I get that humans should not eat any junk they want, because it can affect the internal organs (my mom quit drinking diet Dr. Pepper, because she realized that it was causing pains to her liver for nearly a year), but what I want to know is how can eating a Paleo-type diet clear one's skin if the problems with one's skin are related to the hormones?

I am trying to do a Paleo-diet because I think it's worth a shot. Also, I just plain feel better when I eat low-glyemic, or Paleo-type foods. My body looks healthier. It's not bloated anymore, and that's always a plus! But I would just absolutely love it if you would take the time to explain the correlation between a healthier diet and hormonal acne.

Thanks so much,

Cherry

[alternativista]

Page listing the diet makeup of the various primates include those in the genus homo: http://tolweb.org/tr...eehouse_id=4446. Thought it would be handy to refer to next time we argue about how much we are adapted to eating meat.

Tree of Life
The Tree of Life Web Project (ToL) is a collaborative effort of biologists and nature enthusiasts from around the world. On more than 10,000 World Wide Web pages, the project provides information about biodiversity, the characteristics of different groups of organisms, and their evolutionary history (phylogeny).

[Max-]

It would be best if you could "Long story cut short".

[Max-]

alternativista, do you think that having white rice on a daily basis is bad? Rice is a staple in my country so it is hard for me not to have it since I am already on gluten, diary, wheat-free diet. Can't stop drinking coffee though because I am kinda "slow" without it. I also think that it is bad to consume meat everyday.

Edited by Max-, 18 July 2012 - 03:06 AM.

[alternativista]

It would be best if you could "Long story cut short".

I did. It's there in the first post.

alternativista, do you think that having white rice on a daily basis is bad? Rice is a staple in my country so it is hard for me not to have it since I am already on gluten, diary, wheat-free diet. Can't stop drinking coffee though because I am kinda "slow" without it. I also think that it is bad to consume meat everyday.

It's individual how bad consuming that empty carb is for you because it depends on what else you do, your lean muscle mass, insulin sensitivity that may vary due to genetics, etc. . But regardless, white rice is an empty carb that could be taking the place of much more nutrient dense foods. And have you tried drinking teas for a lower dose of caffeine?

[Max-]

Hi alternativista, I drank green tea for a while but it caused me lower back pain which of course, was unusual for most people. I stopped drinking coffee for more than a year but it did not make a difference so I was back on a few months ago since I figure that it helps my memory.

I was cleared for a while when I stopped eating meat (mainly pork), but my acne began to metastasizing after I reintroduced it back into my diet. I am unsure if it is a coincidence or that meat really gives me acne.

If you do not mind, could you tell me what you eat and drink everyday?

Edited by Max-, 19 July 2012 - 06:14 PM.

[ManFeelings]

This is a great thread but how am I supposed to manage to avoid high GI foods and high GL meals when I'm trying to bulk and put on weight?

[alternativista]

This is a great thread but how am I supposed to manage to avoid high GI foods and high GL meals when I'm trying to bulk and put on weight?

By eating plenty of real, nutrient dense low to moderate GI food.

[TheSavyBanana]

You are absolutely incredible! This is the most helpful thread I think on this entire site, and I can't believe I didn't start reading this until a couple of days ago. Everything is really straight-forward and informative, and it has really helped guide me through changing my lifestyle. I will definitely check out your blog. Thanks for all the help!

[strauss12]

Very informative list regarding health. Came across such an informative post for the first time. I was craving to find information like these on the internet but in vain. Anyways, thank you for sharing these online. Would love to see more like these.

Edited by strauss12, 09 August 2012 - 11:10 PM.

[alternativista]

Natural alternatives that do the same thing as side effect causing drugs. Nutrients that cause cancer cell suicide by inhibiting an enzyme used for Glycolysis -- anerobic energy production from sugar perferred by cancer cells:

What if there were natural agents that induced cancer cell suicide, without the side effects of DCA? As it turns out, these agents DO exist—and you may already have some in your kitchen pantry or supplement cabinet. Here are a few²¹:

• Co-Q10/Ubiquinol
• Curcumin (the active agent in the spice turmeric)
• Capsaicin (the compound that makes hot peppers hot)
• Se-methylselenocysteine aka methylselenocysteine (found in garlic and broccoli)
• Ellagic acid (from pomegranates and other fruits)

There are many all-natural cancer-prevention strategies, and research shows they may cut your risk in half. Consequently, by implementing multiple strategies, you can radically lower your risk of cancer as well as other chronic diseases.

[oilskinchile]

First of all i want to thanks you alternativista, about your spectacular outstanding and good information to help the people with this illness call acne, you are amazing!!
My question is! How can i get rid or control my oily skin with some tiny spots but horrible oily skin! Like things to eat! Vitamins and suplements only focusing in the oily skin! ?!
And a particular question is good vitamin A for oil control?! Is like accutane?!
And what you know about lactoferrin?!
Thanks!! Alternativista!! Good luck!
I am a male! 20 years old!

[oilskinchile]

Alternavista i think you need to write a book! With all the contributions that you made!
Congratulations!!

[YoursTruly*Ashleigh]

Wow, this is awesome information!

[alternativista]

Mercola article about why/how media reports on nutrition and medical studies are usually wrong/stupid. And the inherent flaws in medical research.

http://articles.merc...nformation.aspx

Also, I would add that the media just tends to focus on the stupid, trivial or simple studies such as those that evaluate when a drug or nutrient helps such and such when it's already well known the various reasons why such things would benefit whatever condition. Because that research has already been done by the real scientists.

Such as today's announcement that the Diabetes II drug Metformin has been shown to help recovery outcome from ovarian cancer. Someone, I'm sure the drug company, surveyed ovarian cancer sufferers and found that those with diabetes on metformin had a better outcome. But they claim they don't know why because they didn't study that. But it's fairly obvious why--it improves blood sugar/insulin which promotes cancer growth. But now they can sell metformin to cancer patients and they don't have to bother improving their diets.

A couple of days ago there was an announcement of a study on the negative effects of soft drinks on some kind of knee pain. They claimed not to know why. Hello! Try the phosphoric acid that weakens your bones.

Edited by alternativista, 03 December 2012 - 11:06 AM.

[oilskinchile]

Saw buckthorn slashes sebum production by 45%
The first study was done by researchers at the Islamia University of Bahawalpur, Pakistan. They studied the effect of 1% sea buckthorn cream extract cream on sebum production. In this study they used 10 male volunteers aged between 20 and 35 years, and gave each participant either the treatment cream or a placebo cream that didn’t contain the plant extract.

Basically they made the treatment cream by first making a ‘vehicle base’ (that takes the active ingredients into the skin) and mixing the plant extract into the base. The placebo cream was just the base.

They asked the participants to apply the treatment cream to one side of the face and the placebo cream to the other side. This is known as split-face study design.

This chart shows the results, % reduction in sebum production over 8 weeks.



 Source: Formulation and evaluation of antisebum secretion effects of sea buckthorn w/o emulsion
 

There was a steady decline in sebum production in the side treated with sea buckthorn cream. After 8 weeks sebum production had dropped by 45%. This is more or less in line with results from green tea and saw palmetto/sesame seed/argan oil studies.

Interestingly the side treated with base-only cream showed increase in sebum production. The researchers note that this change was not statistically significant, so it’s possible it was just due to the inherent randomness of measurements like these.

Capparis decidua extract reduces sebum production by about 20%
The other study also comes from the same university. This time they studied fruits from a desert plant Capparis decidua, commonly known as kerda or kair.

They made a cream with 5% extract of kair plant, I presume with plant they mean the fruit this bush produces. This study was very similar with the above study, a split-face design with treatment cream applied to one side of the face and base cream on the other side.

This graph shows the results, change in sebum production over time.



Source: Development of a sebum control cream from a local desert plant Capparis decidua. (PDF)
 

As you can see the treatment cream reduced sebum production by 18% after 12 weeks. This graph also shows what I’ve been saying over and over. It takes time for these creams to work. Notice the big drop in sebum production from week 4 to week 6, from about 5% to 12%.

As with the previous study the side treated with placebo cream showed an increase in sebum production (not statistically significant). Researchers speculate this could be because of the oils used in the base cream. Though I’m not sure how applying oil on the skin could increase sebum production.

Information from acneeinstein

[alternativista]

Blog many might like by a Med student with an interest in evolution. In other words how things we are supposed to do/eat help maintain health while all these unnatural lifestyle and diet habits cause disease. It's called Principle Into Practice.

This article is about how Saturated fat benefits both leaky gut and liver health: http://principleinto...saturated-fats/

Cells from the small intestine of mice maintained on a diet high in SAFA, in comparison to those maintained on a diet high in PUFA, have significantly higher levels of mRNA coding for a number of the proteins that are important for intestinal integrity such as Tight Junction Protein ZO-1, Intestine Claudin 1, and Intestine Occludin. Furthermore, alcohol consumption further decreases the mRNA levels of most of these genes in animals fed a high-PUFA containing diet, while alcohol has no effect on levels in SAFA-fed animals. Changes in mRNA level do not necessarily mean changes in protein levels, however the same study showed an increase in intestinal permeability in mice fed PUFA and ethanol in comparison to control when measured by an ex-vivo fluorescent assay. This shows that PUFA alone can disturb the expression of proteins that maintain gut integrity, and that alcohol further diminishes integrity. In combination with a SAFA diet, however, alcohol does not affect intestinal permeability [4].

Cells from the small intestine of mice maintained on a diet high in SAFA, in comparison to those maintained on a diet high in PUFA, have significantly higher levels of mRNA coding for a number of the proteins that are important for intestinal integrity such as Tight Junction Protein ZO-1, Intestine Claudin 1, and Intestine Occludin. Furthermore, alcohol consumption further decreases the mRNA levels of most of these genes in animals fed a high-PUFA containing diet, while alcohol has no effect on levels in SAFA-fed animals. Changes in mRNA level do not necessarily mean changes in protein levels, however the same study showed an increase in intestinal permeability in mice fed PUFA and ethanol in comparison to control when measured by an ex-vivo fluorescent assay. This shows that PUFA alone can disturb the expression of proteins that maintain gut integrity, and that alcohol further diminishes integrity. In combination with a SAFA diet, however, alcohol does not affect intestinal permeability [4].
Improved gut integrity is no doubt a key aspect of the protective effects of SAFA. Increased gut integrity leads to decreased inflammatory compounds in the blood, which in turn means there will be decreased inflammatory interactions in the liver. Indeed, in comparison to animals fed alcohol and PUFA, animals fed alcohol with a SAFA diet had significantly lower levels of the inflammatory cytokine TNF-a and the marker of macrophage infiltration MCP-1 [4]. Decreased inflammation, both systemically and in the liver, is undoubtedly a key element of the protective effects of dietary SAFA.

4. Kirpich, I.A., W. Feng, Y. Wang, Y. Liu, D.F. Barker, S.S. Barve, and C.J. McClain, The type of dietary fat modulates intestinal tight junction integrity, gut permeability, and hepatic toll-like receptor expression in a mouse model of alcoholic liver disease. Alcohol Clin Exp Res, 2012. 36(5): p. 835-46.

Edited by alternativista, 03 December 2012 - 11:12 AM.

[alternativista]

The famous Cordain Kitavaan Islander study:
http://archderm.jama...rticleid=479093

Excerpt about the other acne free group studied in Paraguay:

The Aché diet contains wild, foraged foods, locally cultivated foods, and Western foods obtained from external sources. By energy, their diet consists of 69% cultigens, 17% wild game, 8% Western foods, 3% domestic meat, and 3% collected forest products.^{25- 26}The cultigens consist mainly of sweet manioc, followed by peanuts, maize, and rice, whereas the Western goods are mainly pasta, flour, sugar, yerba tea, and bread.²³

Note how a large part of their diet is made up of problematic foods such as maize and peanuts, plus some wheat products. Cordain doesn't want any of us to eat any grains really, but sites studies on a few being particularly gut penetrating and that includes peanuts. Yet he uses this study as support for his recommendations. When obviously it's all about the combination of things you do to yourself. And their active lifestyle with natural circadian rhythms and lack of exposure to antibiotics clearly counter the high glycemic grain and tuber based diet that also includes damaging foods.