Jump to content

Photo

SMT D002 Drug - Clinical Trial

drug summit clinical

This topic has been archived. This means that you cannot reply to this topic.
40 replies to this topic

#1 RedMcIntosh

RedMcIntosh

    Member

  • Veteran Members
  • Posts & Likes
    Posts: 125
    Gallery Images: 24
    Likes: 0
About Me
  • Joined: 03-January 09

Posted 08 January 2009 - 12:31 PM

Hey! I know since this year Summit will test in people with acne this drug which can reduce 90% the sebum production.

Someone mainly from UK or Europe (the Lab is from UK) can contact them to join these clinical trials and share that amazing experience with us?

I also know the labs usually have a very confidential policy but maybe not only one of you can have success and try this drug but comment to us some results.

If you are from those countries I guess you don't lose anything to try.


From www.SummitPlc.com/Location.htm:


Summit plc
91 Milton Park
Abingdon
Oxfordshire
OX14 4RY
UK

Tel: +44 (0) 1235 44 39 39
Fax: +44 (0) 1235 44 39 99

info@summitplc.com


Summit (Wales)
Plas Gogerddan
Aberystwyth
Ceredigion
SY23 3EB
UK


Dextra Laboratories Ltd
Science and Technology Centre
Earley Gate
Whiteknights Road
Reading
RG6 6BZ
UK

Tel: +44 (0) 118 935 7000
Fax: +44 (0) 118 926 7917

dextra@dextra-labs.co.uk



E-mail:

* General Enquiries
info@summitplc.com

* Investor Information
investors@summitplc.com

* Commercial Information
busdev@summitplc.com

* Drug Discovery Information
research@summitplc.com




Thank you smile.gif

Ariel wink.gif

#2 followmesky

followmesky

    New Member

  • Members
  • Posts & Likes
    Posts: 3
    Likes: 0
About Me
  • Joined: 07-January 09

Posted 11 January 2009 - 11:52 PM

Thanks for the info. I never had heard of it.

hope it doesnt come with major side effects. Will definetely follow up .. or hopefully, by then I will no longer have acne.. haha .. hmmm let's pray!

#3 RedMcIntosh

RedMcIntosh

    Member

  • Veteran Members
  • Posts & Likes
    Posts: 125
    Gallery Images: 24
    Likes: 0
About Me
  • Joined: 03-January 09

Posted 12 January 2009 - 01:50 PM

Thank you. And yes... the only side effect is to have dry skin but I suppose at the level of a normal person with dry skin but of course without the lips trouble.

It's a pitty the UK citizens I've sent a PM with the link of this post never answered them. I don't know. If I'd live in UK and I'd know they will have clinical trials on acne patients since this year you can be sure I'll call the lab because I have all the contact information to do that and if I wouldn't I'd find it.


Bye.

#4 mfit

mfit

    gettinbig

  • Veteran Members
  • Posts & Likes
    Posts: 230
    Likes: 0
About Me
  • Joined: 06-February 08

Posted 20 January 2009 - 07:12 AM

So i did a little research and found:

http://www.webmd.com...disease#hw91089

1. Its a Parkinson Treatment
2. It says amantadine itself has very little side effects.
3. The Side effects being:
- Skin Rash (Due to the Sebum-Reduction/Dry Skin??)
- Dry Mouth (Sialorrhoea Treatment? See SMT D001 which is the basis for SMT D002!)
4. On the market for a few years
5. Is taken orally

What do you think? smile.gif

#5 RedMcIntosh

RedMcIntosh

    Member

  • Veteran Members
  • Posts & Likes
    Posts: 125
    Gallery Images: 24
    Likes: 0
About Me
  • Joined: 03-January 09

Posted 20 January 2009 - 08:10 AM

QUOTE (mfit @ Jan 20 2009, 11:12 AM) <{POST_SNAPBACK}>
So i did a little research and found:

http://www.webmd.com...disease#hw91089

1. Its a Parkinson Treatment
2. It says amantadine itself has very little side effects.
3. The Side effects being:
- Skin Rash (Due to the Sebum-Reduction/Dry Skin??)
- Dry Mouth (Sialorrhoea Treatment? See SMT D001 which is the basis for SMT D002!)
4. On the market for a few years
5. Is taken orally

What do you think? smile.gif



Yes, it can be. In my country it costs €8 x 30 pills but I'm not sure about a long-term use of the drug as 4 years could be. In the other side the brain systems tend to be dose-dependant of a drug. Because people with Parkinson as Alzheimer will die, if they get a dose-dependence, anyway they will die quite soon, unfortunately for them. We're young. It's a high risk without return. I'm afraid about that but SMT D002 comes from these technologies:

http://www.SummitPlc.com/Overview.htm


So we could say it's "natural" for our organisms. These technologies are a huge discovery for everyone.



Thank you smile.gif

#6 mfit

mfit

    gettinbig

  • Veteran Members
  • Posts & Likes
    Posts: 230
    Likes: 0
About Me
  • Joined: 06-February 08

Posted 20 January 2009 - 08:21 AM

We have no choice but to wait... but i want that drug! smile.gif



#7 RedMcIntosh

RedMcIntosh

    Member

  • Veteran Members
  • Posts & Likes
    Posts: 125
    Gallery Images: 24
    Likes: 0
About Me
  • Joined: 03-January 09

Posted 20 January 2009 - 01:45 PM

Summit says the drug could be realeased in the end of 2011 or beginnings of 2012. It's the best hope since the use of isotretinoin 30 years ago. The only thing would be necessary is a good price, of course better than isotretinoin.

The side effect is to suffer a dry skin but I suposse at a similar level of a normal person with with dry skin has. Maybe with a lower dose than the trials you could have the skin not so dry so everything is resolved.


Bye smile.gif

#8 Wotever

Wotever

    Junior Member

  • Members
  • Posts & Likes
    Posts: 28
    Likes: 0
About Me
  • Joined: 25-January 09

Posted 25 January 2009 - 03:13 PM

I would also be interested in further information about SMT D002. The trial results released by Summit sound very impressive. However, I am also a bit dubious. Although I can't find the quote at this moment, Summit said they would be developing a topical formulation (rather than the pill used in the trials) because it would be faster-acting, or words to that effect. This justification sounds very weak.

Based on what Summit have said or implied (i.e. something like 90% sebum reduction without significant side effects) SMT D002 would be clearly better than Accutane and would have a big market immediately. Why not release it in pill form now? Why create a topical version at all?

I can only think of a few possibilities -

1. SMT D002 is not as effective as has been suggested, or
2. The side effects are not as negligible as has been suggested, or
3. Other business/legal reasons i.e. patents, contracts, licences, agreements, etc.



#9 spacetravler

spacetravler

    Member

  • Veteran Members
  • Posts & Likes
    Posts: 101
    Likes: 0
About Me
  • Joined: 04-November 08

Posted 25 January 2009 - 09:31 PM

many mails, which one?

and what to write...? smile.gif
"Hey I heard you had an awesome medication for Acne in the making. Mind if I try??"

#10 RedMcIntosh

RedMcIntosh

    Member

  • Veteran Members
  • Posts & Likes
    Posts: 125
    Gallery Images: 24
    Likes: 0
About Me
  • Joined: 03-January 09

Posted 26 January 2009 - 05:51 PM

QUOTE (Wotever @ Jan 25 2009, 07:13 PM) <{POST_SNAPBACK}>
I would also be interested in further information about SMT D002. The trial results released by Summit sound very impressive. However, I am also a bit dubious. Although I can't find the quote at this moment, Summit said they would be developing a topical formulation (rather than the pill used in the trials) because it would be faster-acting, or words to that effect. This justification sounds very weak.

Based on what Summit have said or implied (i.e. something like 90% sebum reduction without significant side effects) SMT D002 would be clearly better than Accutane and would have a big market immediately. Why not release it in pill form now? Why create a topical version at all?

I can only think of a few possibilities -

1. SMT D002 is not as effective as has been suggested, or
2. The side effects are not as negligible as has been suggested, or
3. Other business/legal reasons i.e. patents, contracts, licences, agreements, etc.


Approving a drug has many steps: it's discovery and registration, the animal testing, the human testing, the sent of the scientific and clinical safety informs of the drug to the official drug organism of the country, the possible approving and finally the bureaucrat steps to release it to the market. Normally these steps are 5 years since its discover.



QUOTE (spacetravler @ Jan 26 2009, 01:31 AM) <{POST_SNAPBACK}>
many mails, which one?

and what to write...? smile.gif
"Hey I heard you had an awesome medication for Acne in the making. Mind if I try??"


Forget the mails. They don't answer them. The best and direct thing it's to call them but anyway you can try the e-mail way.


- General Enquiries: info@summitplc.com

- Drug Discovery Information: research@summitplc.com

#11 Wotever

Wotever

    Junior Member

  • Members
  • Posts & Likes
    Posts: 28
    Likes: 0
About Me
  • Joined: 25-January 09

Posted 27 January 2009 - 03:51 PM

QUOTE
Approving a drug has many steps: it's discovery and registration, the animal testing, the human testing, the sent of the scientific and clinical safety informs of the drug to the official drug organism of the country, the possible approving and finally the bureaucrat steps to release it to the market. Normally these steps are 5 years since its discover.


SMT D002 is an existing drug, already on the market for another purpose, and would therefore not require the normal lengthy approval process. I believe Summit (or their licencee / partner) could release it as a sebosuppressive pill fairly quickly if they wanted to, and if the information they have released is accurate.

However, they have apparently decided not to commercialise the pill. Instead they have opted to spend four years developing a topical version. As well as the time, this will cost a lot of money and there is presumably nothing to say that it will be effective in topical form.

Something about this does not make sense, so I think the information currently available does not tell the whole story.

#12 RedMcIntosh

RedMcIntosh

    Member

  • Veteran Members
  • Posts & Likes
    Posts: 125
    Gallery Images: 24
    Likes: 0
About Me
  • Joined: 03-January 09

Posted 27 January 2009 - 07:55 PM

I'm not so sure the drug actually exists. I want to see the documents says that drug already exists but everything can happend in this twisted world.

In the other side, I've an oily skin not only in my face so I prefer a pill that suppresses all the oil excess my body is producing. I want a deep effect from inside of my body.

#13 Wotever

Wotever

    Junior Member

  • Members
  • Posts & Likes
    Posts: 28
    Likes: 0
About Me
  • Joined: 25-January 09

Posted 28 January 2009 - 01:44 PM

Just about all the reports concerning SMT D002 state that it is an existing drug, for instance "At present, the drug is in pill form and is used to treat a condition other than acne".

The reason given by Summit for developing a topical version is "to improve the way this
treatment is administered" (http://www.summitplc...ts2008final.pdf) which, as I said, sounds like a very weak explanation and probably a way of avoiding some other issue.

As far as I can see there is nothing to suggest that there are any plans to make the pill available to the public. I asked Summit about this once but they weren't talking.


#14 RedMcIntosh

RedMcIntosh

    Member

  • Veteran Members
  • Posts & Likes
    Posts: 125
    Gallery Images: 24
    Likes: 0
About Me
  • Joined: 03-January 09

Posted 28 January 2009 - 03:02 PM

QUOTE (Wotever @ Jan 28 2009, 05:44 PM) <{POST_SNAPBACK}>
Just about all the reports concerning SMT D002 state that it is an existing drug, for instance "At present, the drug is in pill form and is used to treat a condition other than acne".

The reason given by Summit for developing a topical version is "to improve the way this
treatment is administered" (http://www.summitplc.com/uploads/interimresults2008final.pdf) which, as I said, sounds like a very weak explanation and probably a way of avoiding some other issue.

As far as I can see there is nothing to suggest that there are any plans to make the pill available to the public. I asked Summit about this once but they weren't talking.


Originally, the drug is for Parkinson's disease. They've hyper-seborrhoea. That's the "other condition" I think.

Read here:

http://www.SummitPlc...om/SMT D002.htm


Bye smile.gif

Ariel

#15 Wotever

Wotever

    Junior Member

  • Members
  • Posts & Likes
    Posts: 28
    Likes: 0
About Me
  • Joined: 25-January 09

Posted 04 February 2009 - 02:39 PM

To anyone interested in SMT D002, I would suggest pushing Summit for more information. For instance -

a. Are there any plans to commercialise the pill form of SMT D002?
b. If not, why not?

The more people ask, the more likely they will be to release information.

#16 midtudorcrisis

midtudorcrisis

    New Member

  • Members
  • Posts & Likes
    Posts: 3
    Likes: 0
About Me
  • Joined: 20-February 09

Posted 20 February 2009 - 06:07 AM

I hate to be bring bad news, but this was posted on Summit's website today.

http://www.summitplc...updatefinal.pdf
Translated from the corporate waffle it means: "we're broke".

The kind of cash-flow problems which are suggested by this do not augur well for the rapid release of SMT D-002 on to the open market.

Anyone have a couple of million to spare to finance the bringing of this drug to market? (If indeed it is as effective as has sometimes been suggested).

#17 spacetravler

spacetravler

    Member

  • Veteran Members
  • Posts & Likes
    Posts: 101
    Likes: 0
About Me
  • Joined: 04-November 08

Posted 24 February 2009 - 08:51 PM

I got this reply after asking,

"Dear xxx

Thank you for your enquiry and your interest in Summit.
Please be advised that your enquiry has been passed on to the relevant
person for reply.

With best regards"


Nothing really happend after that... I guess the above poster is right about the financial problems.

#18 Wotever

Wotever

    Junior Member

  • Members
  • Posts & Likes
    Posts: 28
    Likes: 0
About Me
  • Joined: 25-January 09

Posted 23 March 2009 - 02:39 PM

I just sent this email to Summit:

"[I am sending this email] to express concern about the information that has been released about SMT D002. Approximately one year ago it was hailed by the press as 'the cure for acne' following your company's reporting of successful trials. Since then there has been no indication that the pill form of the drug is to be brought to market, and the only further information from Summit has been that it is to be developed as a topical preparation (which will take years, and presumably there is nothing to say that it will even be effective in that form).

I appreciate that it was the press that sensationalised the story, but the fact remains that your company has reported that SMT D002 is effective and at least reasonably safe, without giving any explanation as to why it may not be suitable for release. The fact that it is not apparently being commercialised does not make sense given the information that has been made available, therefore it seems reasonable to assume that information has been witheld. Under the circumstances, raising false hopes seems somewhat cruel.

I would urge you to provide further information in a public statement."


#19 acneis2unfair

acneis2unfair

    New Member

  • Members
  • Posts & Likes
    Posts: 15
    Likes: 0
About Me
  • Joined: 04-November 08

Posted 29 March 2009 - 05:20 AM

This is going to put a huge dent in Benzoyl Peroxide's use of Acne. I hope anyway, because I really dislike that stuff. It's harsh, and it's not a decent method of helping your skin in my opinion *looks at the huge jars of benzoyl peroxide he ordered sitting on his shelf* damn.. anyone want these? lol.. wasted my money.. well that's ok. I also wasted £120 on a thermaclear acne removing device (similar to Zeno) and guess what... waste of money. I hope this drug actually does that it claims to and we get closer to controlling Acne more quickly and efficiently. Now.... how about some FAST or instant treatments for hyperpigmentation marks? I am surprised that this SMT D002 cream won't be available for another few years though sad.gif that's not much use to me as I am 20, almost 21. But goodluck all with your quest to get back the skin that is rightfully yours.

QUOTE (Wotever @ Mar 23 2009, 09:39 PM) <{POST_SNAPBACK}>
I just sent this email to Summit:

"[I am sending this email] to express concern about the information that has been released about SMT D002. Approximately one year ago it was hailed by the press as 'the cure for acne' following your company's reporting of successful trials. Since then there has been no indication that the pill form of the drug is to be brought to market, and the only further information from Summit has been that it is to be developed as a topical preparation (which will take years, and presumably there is nothing to say that it will even be effective in that form).

I appreciate that it was the press that sensationalised the story, but the fact remains that your company has reported that SMT D002 is effective and at least reasonably safe, without giving any explanation as to why it may not be suitable for release. The fact that it is not apparently being commercialised does not make sense given the information that has been made available, therefore it seems reasonable to assume that information has been witheld. Under the circumstances, raising false hopes seems somewhat cruel.

I would urge you to provide further information in a public statement."


Let us know if they answer you. You're right. The press hailing it as the "Acne Cure" is so misleading. I'll tell you what an acne cure REALLY is. An injection in your arm or something. And your skin problems just fade before your eyes. lol.. That's a cure. This seems like just a more effective treatment and prevention.

#20 wavv

wavv

    New Member

  • Members
  • Posts & Likes
    Posts: 2
    Likes: 0
About Me
  • Joined: 13-March 07

Posted 05 April 2009 - 08:51 PM

I work in a pharmacy, and I'm quite sure that the medication is currently in a cheap and affordable generic form that wouldn't be as profitable as one would think the "cure" for acne would be, hence the creation of the cream that they can then label as a "brand name drug" and charge you RIDICULOUS amounts of money for.

Actually, I'm quite sure this is the case, as most everything in the pharmaceutical world is absolutely and utterly controlled and dictated by money.

Also, these medications that are used for Parkinson's treatment have much potential and are quite interesting drugs when looked at for their many other benefits.

Just remember that pharmaceutical companies don't care whether or not they actually help people (Phentermine), they want to create a blockbuster drug that will sell itself with premonitions and indications of miraculous properties. God forbid if they do create something that does what they intend (probably with a myriad of side effects) because one pill will cost you your life savings (Lipitor, Plavix, Viagra).

Oh, what's that? You just want to stay alive? Two thousand dollars for you AIDS medication (literally, a bottle of 30 pills). Two hundred dollars for your regulatory maintenance INSULIN because you CHOSE to be a diabetic, right?

I'm disgusted with this business.