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Accutane & Erectile Dysfunction (GUYS READ THIS!)


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#21 Evie Conrad

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Posted 28 May 2011 - 09:20 PM

Hi

1I am not aware of a study, which conclusively proved a link between isotretinoin use and erectile dysfunction of neurological origin.


However, there are known links between dysautonomia and erectile dysfunction

http://www.ncbi.nlm....pubmed/15574133

as well as between isotretinoin use and erectile dysfunction.

http://www.ncbi.nlm....pubmed/16447596


There is also evidence that isotretinoin can cause brain damage

http://www.pharmaceu...depression.html

http://ajp.psychiatr...t/162/5/983.pdf

and anecgotal evidence that it can cause dysautonomia.

http://www.thedysaut....com/search.php

Best Wishes
Evie

QUOTE (Babis @ May 27 2011, 07:39 PM) <{POST_SNAPBACK}>
QUOTE (Evie Conrad @ Jan 17 2010, 05:09 PM) <{POST_SNAPBACK}>
Erectile dysfunction was reported,as a side effect of Roaccutane, in a letter to The Lancet in 1994. The author, a dermatologist, suggested that it was likely that the problem was massively under-reported because it is too difficult for doctors and patients to discuss.

ED has been listed in Martindale [the standard, British, one-volume pharmacology reference book] as a potential side effect of Roaccutane, since that time. It was proposed that the drug damaged the seminal vesicles but I don't know what evidence there was to support this. The adverse reaction reports of the MCA [now the MHRA] show that around forty cases of ED, associated with isotretinoin, have been investigated and confirmed.

Isotretinoin was originally developed as a chemotherapy drug and has been used- experimentally- for the treatment of certain cancers. Those cancers were (and are) rare, compared to acne, from which 70% of teenagers suffer. You Americans can "do the math", as Roche's marketing department obviously did, back in the late 1970s.

Roche still claims that the method of action is unknown but very similar retinoids, which are used in the treatment of skin cancers and pancreatic cancer, work by destroying or limiting the ability of tumours to produce new cells. Unfortunately for those, who take retinoids, our own (healthy) cells are affected in the same way because they are governed by the same processes. This could be why Roaccutane's "side" effects are so numerous and so hard to predict.

Doctors and patients often fall into the trap of thinking that a particular side effect must have the same cause in every patient. We're all unique: even identical twins have some differences because of environmental factors. One drug will affect different patients in different ways. It will even affect the same patient in different ways at different times!

ED has many different causes. It's now estimated by urologists that 90% of cases are physical in origin. That's up from 70%, a few years ago. However, lots of GPs [family doctors], who haven't opened a medical journal for decades, are probably still telling patients that it's "all in the mind".

Some neurologists and physiologists have noted that Roaccutane recipients have abnormalities in their autonomic nervous systems. The brain stem, the "telephone exchange" at the base of the brain, controls functions, such as breathing, and reflex actions, of which having an erection [in the normal way] is one. If someone can achieve an erection [perhaps of poor quality and probably difficult to sustain] through manipulation but can't have a normal psychogenic erection [prompted by arousing thoughts, sights, sounds, smells], then autonomic damage [or "dysautonomia"] could well be the problem. Remember that ED is defined as the inability to maintain or sustain an erection of sufficient quality to enable intercourse [penetrative sex] to take place. If someone "gets a stiffy" and goes into action, as it were, but has to give up after only seconds or a couple of minutes because of loss of erection, that is still ED.

Isotretinoin is listed as a chemotherapy drug at http colon two forward slashes www dot chemocare dot com forward slash BIO forward slash accutane dot asp

The early history of the drug is mentioned in the following paper. http colon two forward slashes leda dot law dot harvard dot edu forward slash leda forward slash data forward slash 472 forward slash Green dot html

One of the best studies on neurological damage can be read at www.pnas.org/cgi/doi/10.1073/pnas.0306336101


Hi Evie,

Do you have any references linking Accutane specifically to dysautonomia?

I developed persistent ED and loss of libido while on Accutane of exactly the type you describe. I did not recover completely after stopping. A few weeks later, I was diagnosed with secondary hypogonadism. A few months later, I was also diagnosed with dysautonomia (postural orthostatic tachycardia syndrome, vasovagal syncope). Needless to say I never had any problems before Accutane.

Any info on Accutane and autonomic dysfunction would be appreciated.



#22 DariusFiat

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Posted 22 June 2011 - 11:28 AM

[quote name='mikeye' date='Jun 8 2008, 03:38 AM' post='2320054']

Hey Guys,

I have the same issue and its freaking me out. I am on my second dose of accutane and just doing 20mg a day, cause I cant tolerate more, very tired here, I need lots of sleep and water to function. I am a runer, and I eat very heatlhy and beside dealing with acne I had perfect hepealth.
First time around I did not have erection issues, but the second round did it. I can get hard but it does not stay up for long. I thought it was my girfriend, but had a fling with another chick, that was totally my type and the same problem.... It is so freaking me out. I never had an issue with that. Also couple more things I am very senstive to light, and my eyes are always tired, had to get a filter for my computer screen.
Accutane works for my skin but fucks up everything else,

Any comments or ideas

thanks for readin

#23 Brad1972

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Posted 23 June 2011 - 07:28 AM

I'm on my 3rd course and never had problems in that area. I don't doubt though that something like that could happen. Accutane can cause some freaky things.

#24 Babis

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Posted 24 June 2011 - 09:27 AM

QUOTE (DariusFiat @ Jun 22 2011, 12:28 PM) <{POST_SNAPBACK}>
Hey Guys,

I have the same issue and its freaking me out. I am on my second dose of accutane and just doing 20mg a day, cause I cant tolerate more, very tired here, I need lots of sleep and water to function. I am a runer, and I eat very heatlhy and beside dealing with acne I had perfect hepealth.
First time around I did not have erection issues, but the second round did it. I can get hard but it does not stay up for long. I thought it was my girfriend, but had a fling with another chick, that was totally my type and the same problem.... It is so freaking me out. I never had an issue with that. Also couple more things I am very senstive to light, and my eyes are always tired, had to get a filter for my computer screen.
Accutane works for my skin but fucks up everything else,

Any comments or ideas

thanks for readin


Hey,

I've been through the exact same thing and more. I've seen 6 neurologists, 3 endocrinologists, 2 neuro-endocrinologists, 1 ophthalmologist, 1 neuro-ophthalmologist etc. They generally disagree with each other... But some of them get some things partly right rolleyes.gif

First of all, have you stopped accutane?
Where you drinking any alcohol while on accutane?
Did you notice any other symptoms such as muscles not responding to weightlifting, changes in @@ size or anything like that?
What is your blood pressure & heart rate when laying and when standing?

Obviously I would stop accutane asap and never take it again. The problem often goes away 2-4 weeks after you stop. If it does not, you could see a good endocrinologist specializing in male hypogonadism. In the mean time, I would completely avoid alcohol for at least a month after stopping accutane, as it significantly increases retinoid toxicity.

With accutane stored in the liver, brain, fatty tissues and even your @@, you don't want to be drinking. But I did not know that. In my case, the problem started when I had one drink while on accutane. I stopped the next day and things started to improve gradually 2 weeks later. Funny thing is, it started to improve when I smoked a big cigar. Maybe it has to do with dopamine receptors. But 6 weeks later I had one drink and the problem returned (loss of libido, nocturnal erections, etc).

Since I was traveling to Europe, I saw a very good endocrinologist there, who ordered thorough labwork. This included complete blood count, vitamin levels, liver panel and hormone panel.
Hormone panel included androgens, estrogens, pituitary hormones, thyroid hormones and antibodies. Btw the levels must be checked after fasting at 08:00 am, otherwise they are useless.

My vitamin D was low and testosterone was borderline low. The endo said that is why a little bit of alcohol or accutane was causing problems. He put me on a testosterone gel which improved things immediately. I stopped the gel and I was fine for 10 weeks. Then I had another drink, and the problem returned persistently. I now have to avoid alcohol completely.

Have you seen an ophtalmologist for photosensitivity? You can mention accutane, which is known to affect the retina. If the reason for photosensitivity is in the retina of your eye, then Lutein and Zeaxanthin supplements may help. If the problem is in the brain, they will not. My ophtalmologist checked the back of my eye and also did an ERG (electroretinogram), which were more or less normal. So we know the problem is in the brain. Some of my neurologists think the photosensitivity is because I am predisposed to migraine, but I don't have headaches so I doubt it.

If you are tired and need to drink water all the time, be sure to mention it to your endocrinologist. You may be dehydrated and/or have low blood volume. I had to drink water mixed with salt and sugar to increase my blood volume/pressure. My bloodwork showed an elevated BUN:Cr ratio, which meant I was dehydrated. I asked them if low Aldosterone could be the reason when they checked it it was low indeed. Vasopressin is equally important.

Btw, when I ask my doctors "can we test this?" they typically refuse. They hate being told what to do. So I have to say "what tests can we do to find out what is causing this"? or "oh, I think this and this, I don't know, do you think this test could be helpful?" or and they are more cooperative.

Anyway, hope you do not have to go through all this. If you stop accutane and try not to over-worry, the problem may go away on its own...

Edited by Babis, 24 June 2011 - 09:40 AM.


#25 acnesucks1988

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Posted 20 August 2011 - 08:49 PM

QUOTE (mikeye @ Jun 8 2008, 03:38 AM) <{POST_SNAPBACK}>
Alrite,

I just finished 5 months on Accutane and around the 4th month I noticed that I was slowly losing my sex drive (libido). Obviously no sex drive means no erection, unless your on Viagra!

So my derm tells me that ED and loss of libido are both documented as very rare side effects of Accutane. I was wondering why he didn't tell me this before? In any case, its already too late. Apparently, he says it shouldn't be permanent but I've been reading other guys posts on this issue and none really get back to 100%.

So just beware.

For the guys that have experience with this...your feedback would be greatly appreciated.


hello mate, i see its been 3 years since you created this thread and i was wondering if you could provide us with an update? ive been on the treatment for 7 months and ive too not been able to get the full erection i once was able to get, also it doesnt last very long too. my tip (i believe its called urethra) of the penis also looks red and looks unusual. it irritates me upon any kind of contact, even from the inner material from the boxers i wear. im getting extremely worried and depressed.
redface.gif
hope you see this post and reply. much appreciated

#26 sverd

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Posted 21 August 2011 - 08:05 AM

Take L-arginine to increase your sex drive. Its a natural supplement that can be bought in any drug store and carries a huge host of other benefits.

Edited by sverd, 21 August 2011 - 08:05 AM.


#27 DaveK

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Posted 19 October 2011 - 04:15 PM

All-

For those of us to be unfortunate enough to be victim to persistant (possible permanent) sexual dysfunction from isotrentinoin, PLEASE REPORT THIS TO THE FDA MEDWATCH. Here is the link:
http://www.accessdat...atch-online.htm

Ref:
http://www.google.co...&rlz=1I7_____en

#28 Conde de Montecristo

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Posted 11 November 2011 - 08:02 PM

Sorry, I can't find any relation between Accutane/Roaccutane and ED. I've used Accutane/Roaccutane a couple of times, full treatment.
It may be a psychological effect.

#29 darkstar42

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Posted 13 November 2011 - 02:09 PM

Not on your own at all bro's!

3rd course of isotretinoin now and this time it's had serious implications on my sexual health. Gone down the gutter. Was quite a.. Ravenous young man before I started, now I've got no desire at all. For a day I thought I was turning gay or something, then realised my love for breasts can never be diminished.

But still. ED persists. As well as many other factors, it's enough to stop me taking the medication. It's just not worth it for the removal of acne. I'd rather be fully health and have some acne than have to deal with this for the next however many years of my life.

Pretty livid I wasn't warned of this before, but hey ho, so it goes.

#30 Mickyemouse

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Posted 13 November 2011 - 04:50 PM

I too suffered from this, 2-3 weeks in on a 20mg dose daily. I stopped taking this medication and started doing some weights which have helped. Things are no way like they where, but 3 weeks after not taking I can sustain a weakish erection, and decided to try this out to make sure everything else was okay, and my semen was like water, though white really runny. My doctor told me to give it more time and to try again, which I did and it was back to normality, although my erections arent perfect they sure do feel better!
I'd recommend you guys try some weights and see how it goes, usually shortly after I can feel the difference.
Also, after stopping Accutane I've been sleeping 14 hours when theres nothing to wake me up, I sure do feel better after sleeping, maybe its the body trying to repair itself?
I'm 17, and was really upset about this, I wish you guys all the best! I to was not warned about this, phoned my derm and he didnt sound interested at the least, but told me to stop taking and wait, theres no way I'm going back on this!

#31 LMo1503

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Posted 10 January 2012 - 07:32 AM

Hey guys!

My boyfriend of 14months has recently finished his course of roaccutane. He was on it for 5 months on the highest dose (cant remember how much). He had common side effects like really red dry skin, conjunctivitis, sore joints etc but about month 3/4 his libido has vanished and he cant maintain an erection for long. It's been about a month and a half since being off the medication and things are still the same.

To be honest I think it's more than just the medication. He says his confidence is shattered and he always worrys about it which really gets me down. And since being a lass I do get really paranoid that he just doesn't find me atrractive anymore but I try and not say since that will only make it worse! He's too embarrased to get help since he's only 22.

I just really need some advice! Does the effects get better or are we needing to tackle it with other means than just waiting?

Thanks so much for reading!
Lou :) x

#32 IndigoRush

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Posted 10 January 2012 - 11:37 AM

Hey guys!

My boyfriend of 14months has recently finished his course of roaccutane. He was on it for 5 months on the highest dose (cant remember how much). He had common side effects like really red dry skin, conjunctivitis, sore joints etc but about month 3/4 his libido has vanished and he cant maintain an erection for long. It's been about a month and a half since being off the medication and things are still the same.

To be honest I think it's more than just the medication. He says his confidence is shattered and he always worrys about it which really gets me down. And since being a lass I do get really paranoid that he just doesn't find me atrractive anymore but I try and not say since that will only make it worse! He's too embarrased to get help since he's only 22.

I just really need some advice! Does the effects get better or are we needing to tackle it with other means than just waiting?

Thanks so much for reading!
Lou Posted Image x


Trust me - He still finds you attractive.
Unfortunately we're all suffering.
It's not just down to 'the mind'.
Something is wrong on a physical level, and until we find out what - this is permanent.
This drug is the worst thing that happened to me.

#33 darkstar42

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Posted 02 February 2012 - 06:30 PM

Hey guys!

My boyfriend of 14months has recently finished his course of roaccutane. He was on it for 5 months on the highest dose (cant remember how much). He had common side effects like really red dry skin, conjunctivitis, sore joints etc but about month 3/4 his libido has vanished and he cant maintain an erection for long. It's been about a month and a half since being off the medication and things are still the same.

To be honest I think it's more than just the medication. He says his confidence is shattered and he always worrys about it which really gets me down. And since being a lass I do get really paranoid that he just doesn't find me atrractive anymore but I try and not say since that will only make it worse! He's too embarrased to get help since he's only 22.

I just really need some advice! Does the effects get better or are we needing to tackle it with other means than just waiting?

Thanks so much for reading!
Lou Posted Image x


You sound just like my missus; she was in tears about it to me yesterday thinking she was the cause of the problem!

Honestly, it isn't our other halves that are doing us over at all.

I've been to my doctor at university and he kinda shrugged/laughed it off when I suggested it may be isotretinoin; especially when I said I'd been reading stuff on here! He said it was something psychological and got me to tell him about my relationship history. What he said made sense, I have had 2 strange relationships recently but it's not something I think about at all. I had a blood test too, and they came back absolutely fine. No low testosterone, nothing.. It WAS my birthday the day before and I'm pretty sure the alcohol didn't help the test? Haha!

Either way, I'm pretty convinced by now it's the medication. My acne's come back with a nice bite to it, as it always has whenever I've stopped treatment. I'm gonna wait it out till the end of the year I think, and if nothing's improved by then, then it's obvious there's a much more serious/permanent issue to be dealt with.

Just hope it isn't permanent, words can't describe how much I despise that drug.

#34 thefloydfan

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Posted 02 February 2012 - 07:16 PM

Hey guys!

My boyfriend of 14months has recently finished his course of roaccutane. He was on it for 5 months on the highest dose (cant remember how much). He had common side effects like really red dry skin, conjunctivitis, sore joints etc but about month 3/4 his libido has vanished and he cant maintain an erection for long. It's been about a month and a half since being off the medication and things are still the same.

To be honest I think it's more than just the medication. He says his confidence is shattered and he always worrys about it which really gets me down. And since being a lass I do get really paranoid that he just doesn't find me atrractive anymore but I try and not say since that will only make it worse! He's too embarrased to get help since he's only 22.

I just really need some advice! Does the effects get better or are we needing to tackle it with other means than just waiting?

Thanks so much for reading!
Lou Posted Image x


I think it may be in his head. Read all the roacutane horror stories swimming around the net and perhaps in some people it could invoke the opposite of the placebo effect.

Has he ever seen Return of the Jedi? Try dressing up as princess Leia in that gold metal bikini, it will definatly have the desired effect. You could also try dressing as Jabba the hut just to surprise him and spice things up. Learn how to speak Huttese for additional bonus points.

#35 darkstar42

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Posted 26 February 2012 - 09:24 PM

Just thought I'd pop back and explain the current situation a bit more.

I stopped taking iso. in the 2nd week of November I think? For the last 2 weeks (so 3 months between when I stopped and now) I've seen a major improvement; not as functional as it used to be, but definitely on the road to recovery it seems!

Acne came back terribly about a month ago, so I had the worst of both worlds. But both aspects are on the up I guess (pun not intended).

Just thought it'd be helpful for some people to know it does improve over time for some people and not all is lost!

#36 Vince Is A Stud Muffin

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Posted 28 February 2012 - 11:54 AM

I will say this I was a virgin at the time I was on Accutane, i've done other stuff with women just not sliding into home if you catch my drift. To be honest with you I was hornier than ever while on Accutane and when my skin was clear I finally had the confidence to go up to girls for the last 4 months on the drug. After i was done I suffered zero side effects in regards to sexual stamina and effectively felt better than ever.

If I was to say anything I think you are suffering from what I call *shooting pool with a rope because you can't stop thinking about it syndrome*. Essentially you are worried about not being able to perform so therefore you cannot. Relax brotha and just let the good times roll. Wish you the best

#37 thefrenchguy

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Posted 04 March 2012 - 12:04 PM

Hi guys,

Do you think such problems could happend after having taken a little cumulative dose like 100 or 200 mg ?

#38 Dubya_B

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Posted 08 March 2012 - 07:52 PM

There's a guy on another forum who has been suffering from ED for a year since taking a low (20mg) dose for half a month. Around 300mg

#39 =art=is=life=

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Posted 05 April 2013 - 11:47 PM

I had massive erections throughout middle school that literally raised my desk at times, then I took Accutane in 9th grade and began having trouble keeping it up. I have to really work at it, and then race to the finish if I want to cum at all, which has made me learn other skills in bed to compensate for the lack of swordplay. I've never had the guts to tell a doctor because I didn't think they'd believe me, plus guys are taking Viagra for fun nowdays. But since I've seen other Accutane patients report this effect, and I've got terrible joint pain all over my body that no one can diagnose either, I'm starting to pin things on the drug out of a lack of reasonable explanations.


Edited by =art=is=life=, 05 April 2013 - 11:48 PM.


#40 aussie1213

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Posted 21 August 2013 - 03:08 AM

Hi, I've read through these pages and a lot on other sites and am hoping there's help to be found. I'm 22 and I started taking a version of roaccutane in November 2011 and was on it for about 8 months as far as I remember. I was single while I was on it so I never really noticed anything different as far as my libido/erections went. However just after I stopped taking it I met a girl and when we finally got around to IT (despite her being amazing to look at and everything I want in a girl) I couldn't get a decent erection. At the time I put it down to alcohol and exhaustion as I had spent the night before drinking heavily and not got much sleep then drinking again that night - and maybe a little anxiety over the situation. But then I started to wonder, I started to notice that even when I was well rested and by myself I couldn't get a decent erection or sustain it.

After trying a number of over the counter supplements (not wanting to put my name to anything) I finally bit the bullet and went to a GP who told me it was probably psychological, took some blood and gave me a scrip for Cialis. The blood test showed everything within normal ranges - it even said my testosterone was on the higher end of normal. The Cialis did nothing so the GP sent me to a urologist, who again said it was probably psychological and gave me a scrip for Levitra which also did nothing. The specialist sent me for a penile ultrasound which showed no abnormalities. The urologist then gave me a scrip for Caverject which did nothing. After that it was a medication even stronger and I assume not often required as it isn't available in normal pharmacies and I had to go to a compounding pharmacy to have it made specially. Again nothing. The concentration of the medication was then doubled. This had some minor results but nowhere near where it should be. (and I certainly did not enjoy sticking a needle into my penis)

Tomorrow I am having some other sort of imaging done. I'm not exactly sure what as the appointment was made in a bit of a hurry.

It has become VERY frustrating. I haven't been with my girlfriend for months and I'm getting no results from medications that are powerful enough to give a dead man wood. When the urologist asked if I knew what might be causing it, at first I didn't know but when I thought about it the only thing different in my life from around that time was roaccutane. When I mentioned it he didn't seem to take any notice. Possibly because it had been so long since I had stopped the roaccutane or maybe just because he thought it irrelevant.

Is anyone out there having success with anything? This problem is slowly killing me. I know it will eventually destroy my relationship. Once the pleasure of life is gone you end up just being a drone - work, eat, sleep, work, etc. but what's the point of any of that if u can't enjoy yourself?

This has dragged on a little more than I originally intended so I'll wrap it up now.

Please, if anyone out there has any progress, anything to offer let it be known because its obvious this is a problem that is going to persist for a lot of people.






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