Well, I am not sure about this for 3 reasons:
1) Inflammation Comes First in Acne -
http://www.nature.co...l/5601829a.html,
2) P. Acnes is meant to be in the follicles.
http://jcm.asm.org/c...ourcetype=HWCIT, and;
3) Comedones form independently of P. Acnes activity - see this about P. Acnes:
http://www3.intersci...388382/PDFSTART (note the part of this document where it is stated "By depleting P. acnes through antibiotic use, the host could theoretically increase susceptibility to infection by pathogens" - a possible "side" effect of this proposed Anti-Acne vaccine?).
For these reasons, I doubt that there can be an anti-Acne vaccine, unless you turn the body into being anti-inflammatory somehow; and especially not one that will
actually work for acne through somehow modifying P. Acnes activity.
Apparently antibiotics work for Acne because of the seemingly little known fact that antibiotics are anti-inflammatory.