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Possible Breakthrough in Acne Research

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#181 just another1

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Posted 11 December 2008 - 05:54 PM

interesting and hopeful but many years away.

#182 truckg

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Posted 17 December 2008 - 05:34 PM

Has anyone gotten good results (for acne) with either oxybutyn or bromocriptine? Are they safe? Do people think SMT D002 is similar to either of these drugs?

QUOTE (just another1 @ Dec 11 2008, 04:54 PM) <{POST_SNAPBACK}>
interesting and hopeful but many years away.



#183 lilakroses

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Posted 23 December 2008 - 11:11 AM

sucks that we have to wait so long cry.gif cry.gif cry.gif

i need to reduce all this dam oil on my face evil.gif

#184 timmoore

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Posted 09 January 2009 - 01:38 PM

radikal tried it , doesnt work

#185 Wotever

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Posted 27 March 2009 - 12:04 PM

A couple of thoughts on this -

1. Regarding the issue of SMT D002 being tested on 'healthy volunteers', I am not sure this necessarily means those people had 'normal' skin. Without being an expert on the subject I tend to think that trial patients are routinely described this way in order to differentiate them from those with, say, a life-threatening medical condition, and that people with greasy skin or acne would still be described as healthy for the purposes of this research.

2. As I have said on a different thread, I think trying to get some answers from Summit might yield results if a lot of people do it. The information they have released appears to be misleading, and it caused the media to publish a lot of sensationalised stories which will have left many disappointed. I suggest that people demand some answers from Summit, first of all. (I have contacted them a couple of times without getting much of a response.) Failing that some negative media coverage to the effect of 'you said this, so what now??' would apply quite a lot of pressure on them to explain themselves.


#186 umbrae

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Posted 31 March 2009 - 03:29 AM

Aren't there a few issues with oxybutynin? Oxybutynin is an anti-cholinergic drug...so it would eventually make you quite dumb! Acetylcholine, an important neurotransmitter is one of many responsible for cognition and memory.

Frankly I'd rather have a shiny forehead than live life in a constant state of delirium!

I don't know why so many people discredit Accutane. I think its a wonderful drug that lives up to its claims. Yes....everyone is different, so they might react differently to the drug, but its definitely got the medical research to back up its use. At least Accutane can completely stop acne to a large degree (up to 90% in cases). If this new drug is in fact a Parkinson's drug, then you'll probaly have to take it for life to reap the benefits of dry skin. Any drug over a long term is bound to cause some kind of side effect especially one that interferes with brain and nerve signalling.

(:D I thought this was interesting!)
Despite Accutane causing night blindness, scientists have found it can actually help and even reverse visual loss in children with a recessive form of macular degeneration.

I think SMT D002 is definitely something else...they could have used an existing Parkinson's drug and added another molecule to it to change some of its biological properties for all we know.

Why not create a topical anti-DHT cream that locally exerts an anti-androgenic effect? Ketaconazole would be an ideal example! Its found in Nizoral but is far too drying to use on the face due to the use of harsh surfectants. There is also a cream available though I suspect it is highly emollient.

I'll be 25 by the time we even know what the drug is....(hopefully by then I won't have such oily skin)...though I do seriously hope some pharmaceutical company creates some kind of drug that slows down collagen breakdown (or generally stops skin ageing). Topical retinoids can only do so much!

As for now...I'll be sticking with my retinoid cocktail and a few skin bleachers:D


#187 ShirleyB

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Posted 01 October 2009 - 03:57 PM

I know this threat is kinda old, but i think it deserves more attention..

QUOTE
They have already done two trials and are now looking to put it into cream form.

The drug is already a common drug on the market that they wont name as im sure every acne sufferer including myself would run out and buy this product. I guess they are making it a cream form to make a profit on it, but if its claims of clearning acne are true with little side effects


I have more digging up to do to try to find out what this drug could possibly be, but in my opinion they make it into a topical just because they can't get the patent from the other company and making it into a topical is the only way to market it...btw what works as a pill may not work as a topical, just like accutane....

My hope is still out there tho, when 2011 comes..

#188 Wotever

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Posted 25 March 2010 - 01:47 PM

See these two items for background:

http://en.wikipedia.org/wiki/SMT_D002
http://www.acne.org/...ea-t168119.html


#189 MrSebastian

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Posted 07 April 2010 - 09:48 AM

Roaccutane came in 1982. The lack of progress the last 28 years is just sad. This possible breakthrough seems implausible.

#190 misscruella16

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Posted 02 May 2010 - 02:57 AM

Hey guys, I have been reading this post for a long time and have delayed responding because I wasnt for sure that this Bromocriptine was helping my acne. I ordered some over the internet and its fairly cheap, but I finally got it for my doctor to prescribe it to me. Its already being used off-labely to help women ovulate, so if any of you are worried about having trouble having your doctors prescribe this to you can : if your a woman this is easy because you just have to say that you are trying to conceive and are having trouble or you are having irregular menstrual cycles. alot of doctors will prescribe things if you mention that you have used it before and it worked but stopped for whatever reason (ex. yea, the bromocriptine worked for me awhile back but I stopped because I switched to a different birth control pill and i felt nauteous while taking it. but now that im back on the old birth control pill...) you get the idea. but anyways, I have personally tried the bromocriptine and it has worked amazingly on my acne. I think others should try it and I cant say it will work for you but it did for me. I am taking 5 mg ever night which is a moderate dose. you can get it from 2.5 mg-i think like 10? mg. it does cause nausea, so thats why i take it at night *right before * i pass out. the first few days you will feel like you want to vomit a few times a day, i only vomited once. that will pass, but im just letting you know. I also want to let you know that i am taking other acne meds at this point, i started the bromocriptine because i wasnt completely clear. but now I am 100% clear and have been for months. so i wanted to share this with you all. the things i have tried before from researching these boards are so many. i tried spironolactone, that didnt work but i hear its good for alot of gals out there. anyways YOU HAVE TO TRY THIS STUFF. Ill post my routine below:

am
wash with dove sens. bar
apply dans bp (use 1/2 a pump)
any lotion around (right now i use cerave)
sunscreen

pm
wash with dove
use a face scrub or loofah
apply 0.05% tretinoin gel
cetaphil cream

meds: I take Ortho Tri cyclen in am and bromocriptine in pm

Edited by misscruella16, 02 May 2010 - 03:14 AM.


#191 Maya94

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Posted 02 May 2010 - 09:58 AM

Oh wow I hope it works!! I just read an article on this, it says it reduces sebum by 90%....
I'm hopeful!!!!!!! biggrin.gif

Seborrhoea

SMT D002



#192 wishfulthinkin

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Posted 03 May 2010 - 11:57 AM

Anyone heard anything new regarding the release of this drug? Google yielded little results for me.

#193 Wotever

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Posted 16 May 2010 - 08:36 PM

Last year Summit announced that SMT D002, along with two other drugs, had been licensed to Orient Pharma in return for an investment 500,000 pounds:

"Orient gains exclusive development and commercialisation rights in Asia Pacific and Australasia and will be responsible for all development, manufacturing and distribution costs associated with the products within its territories."

They have also said:

"Summit retains valuable rights to the products in North America, Europe and the rest of the world and has rights to access data generated by Orient. Our intention is to use these data, which will include clinical trial results, to secure future commercial agreements within our territories"

which I would interpret to mean that they intend to sell off the rights elsewhere in due course.

And:

"Although Summit's future research and development activities are now primarily focused on the SeglinTM technology, these programmes remain a potential source of future value upside that requires no investment from the Company"

I understand this to mean they are not concentrating on SMT D002 at the moment.

Neither Summit nor Orient Pharma show much if any evidence of rushing to bring it to market. All in all it doesn't appear to be living up to the hype from spring 2008.


#194 Wotever

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Posted 08 June 2010 - 12:36 PM

Since Orient Pharma have now entered into an agreement with Summit for SMT D002, I have sent them a question, asking what their plans are for trials/release. I don't really expect to get a response, but you never know.

As with Summit, I would urge anyone who wants information about this to contact Orient Pharma in order to make the point that some people outside their organisation want to know WTF is going on. Messages can be sent via their website at http://www.orientpha.../contactus.html.


#195 epcortek

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Posted 26 September 2010 - 06:39 AM

So if you have excessive clogged pores, Oily skin, and are beggining to notice twitching in your fingers, you have parkinsons ?

haha. Wheres my gun........ Going to shoot myself in the face now, so i can meet my maker and give him the shit kickin of his life.

#196 Enlightened

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Posted 06 December 2010 - 03:24 AM

I'm assuming the bromocriptine works because it reduces prolactin levels and in turn raises dopamine levels. In my case, I'm 90% sure my acne is caused by low progesterone levels after ovulation and high prolactin causes reduced progesterone levels. As long as you reduce prolactin levels does it matter how you do it? Why not try natural progesterone cream? If does the same thing to prolactin levels as bromocriptine does and has less side effects.

#197 Agouti

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Posted 30 January 2011 - 12:15 PM

Is bromocriptine safe and effective for men?

#198 Empty Inside

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Posted 13 April 2011 - 07:57 PM

so wtf is going on with this? it didnt turn out to be the miracle cure it was hyped up to be in the beggining?

#199 Reti

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Posted 14 April 2011 - 06:28 PM

Probably B.S. to keep some stuggling pharma company from going belly-up. Happens all the time for acne and hairloss treatments.

#200 av1sp33k

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Posted 07 May 2011 - 11:27 AM

QUOTE (Agouti @ Jan 30 2011, 09:15 PM) <{POST_SNAPBACK}>
Is bromocriptine safe and effective for men?

Should be.

If you want to know more about Bromocriptine (unrelated to acne) you can check out Lyle Mcdonald's book
"Bromocriptine. An Old Drug with New Uses"
Turns out it also helps dieting.


misscruella16:
It's better to take it in the morning.