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nate28

Possible Breakthrough in Acne Research

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@brian

good point about C&C sheets vs Sebutape. I live far and away from any distributor of Sebutape, and none I could find online export it to my country. So I had to make do.

30%+40%+30% = 100% (of one C&C oil absorbing strip).

unavoidably there was a large margin of error (10%?) in my guess-estimates. however it wasn't large enough to obscure actual positive results.

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good point about C&C sheets vs Sebutape. I live far and away from any distributor of Sebutape, and none I could find online export it to my country. So I had to make do.

Are you saying that CuDerm corporation (the makers of Sebutape test-strips) won't ship to other countries?? Did they actually tell you that? Call them up tomorrow and ask them that direct question. You can easily find their telephone number with a Google search. They are located in Dallas (central time zone).

30%+40%+30% = 100% (of one C&C oil absorbing strip).

unavoidably there was a large margin of error (10%?) in my guess-estimates. however it wasn't large enough to obscure actual positive results.

Surely you didn't re-apply a C&C strip to another part of your face AFTER having already applied it to your forehead, did you? :( I would have kept it as precise as possible by applying separate sheets to separate areas of my face.

But still, that is SOOO crude, compared to Sebutape.

.

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crude as it may have been it served its purpose. The blotted surface of one sheet had largely remained constant over the course of the experiment, while oxybutynin dose varied drastically, up to 20mg/day. Whatever variations I registered where either within the margin of measurement error or natural variations in my sebum excretion (I notice that for time to time, in the order of +/- 20%).

If there was a quantifiable improvement, my instrument was, well, too crude to register it. I was at no time even remotely close to the 90% reduction claimed in the patent application. OTOH side effects at doses north of 10mg/day are rather obnoxious, so it wouldn't be a viable long-term therapy even if it worked.

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SMT D002 is oxybutyn + another ingredient?

SMT D002 is oxybutyn, only effective on X diet.

SMT D002 is oxybutyn but in order to be effective must be taken with X

So many possibilities you don't consider.

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Has anyone gotten good results (for acne) with either oxybutyn or bromocriptine? Are they safe? Do people think SMT D002 is similar to either of these drugs?

interesting and hopeful but many years away.

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A couple of thoughts on this -

1. Regarding the issue of SMT D002 being tested on 'healthy volunteers', I am not sure this necessarily means those people had 'normal' skin. Without being an expert on the subject I tend to think that trial patients are routinely described this way in order to differentiate them from those with, say, a life-threatening medical condition, and that people with greasy skin or acne would still be described as healthy for the purposes of this research.

2. As I have said on a different thread, I think trying to get some answers from Summit might yield results if a lot of people do it. The information they have released appears to be misleading, and it caused the media to publish a lot of sensationalised stories which will have left many disappointed. I suggest that people demand some answers from Summit, first of all. (I have contacted them a couple of times without getting much of a response.) Failing that some negative media coverage to the effect of 'you said this, so what now??' would apply quite a lot of pressure on them to explain themselves.

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Aren't there a few issues with oxybutynin? Oxybutynin is an anti-cholinergic drug...so it would eventually make you quite dumb! Acetylcholine, an important neurotransmitter is one of many responsible for cognition and memory.

Frankly I'd rather have a shiny forehead than live life in a constant state of delirium!

I don't know why so many people discredit Accutane. I think its a wonderful drug that lives up to its claims. Yes....everyone is different, so they might react differently to the drug, but its definitely got the medical research to back up its use. At least Accutane can completely stop acne to a large degree (up to 90% in cases). If this new drug is in fact a Parkinson's drug, then you'll probaly have to take it for life to reap the benefits of dry skin. Any drug over a long term is bound to cause some kind of side effect especially one that interferes with brain and nerve signalling.

(:D I thought this was interesting!)

Despite Accutane causing night blindness, scientists have found it can actually help and even reverse visual loss in children with a recessive form of macular degeneration.

I think SMT D002 is definitely something else...they could have used an existing Parkinson's drug and added another molecule to it to change some of its biological properties for all we know.

Why not create a topical anti-DHT cream that locally exerts an anti-androgenic effect? Ketaconazole would be an ideal example! Its found in Nizoral but is far too drying to use on the face due to the use of harsh surfectants. There is also a cream available though I suspect it is highly emollient.

I'll be 25 by the time we even know what the drug is....(hopefully by then I won't have such oily skin)...though I do seriously hope some pharmaceutical company creates some kind of drug that slows down collagen breakdown (or generally stops skin ageing). Topical retinoids can only do so much!

As for now...I'll be sticking with my retinoid cocktail and a few skin bleachers:D

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I know this threat is kinda old, but i think it deserves more attention..

They have already done two trials and are now looking to put it into cream form.

The drug is already a common drug on the market that they wont name as im sure every acne sufferer including myself would run out and buy this product. I guess they are making it a cream form to make a profit on it, but if its claims of clearning acne are true with little side effects

I have more digging up to do to try to find out what this drug could possibly be, but in my opinion they make it into a topical just because they can't get the patent from the other company and making it into a topical is the only way to market it...btw what works as a pill may not work as a topical, just like accutane....

My hope is still out there tho, when 2011 comes..

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Roaccutane came in 1982. The lack of progress the last 28 years is just sad. This possible breakthrough seems implausible.


English is not my native language :)


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Hey guys, I have been reading this post for a long time and have delayed responding because I wasnt for sure that this Bromocriptine was helping my acne. I ordered some over the internet and its fairly cheap, but I finally got it for my doctor to prescribe it to me. Its already being used off-labely to help women ovulate, so if any of you are worried about having trouble having your doctors prescribe this to you can : if your a woman this is easy because you just have to say that you are trying to conceive and are having trouble or you are having irregular menstrual cycles. alot of doctors will prescribe things if you mention that you have used it before and it worked but stopped for whatever reason (ex. yea, the bromocriptine worked for me awhile back but I stopped because I switched to a different birth control pill and i felt nauteous while taking it. but now that im back on the old birth control pill...) you get the idea. but anyways, I have personally tried the bromocriptine and it has worked amazingly on my acne. I think others should try it and I cant say it will work for you but it did for me. I am taking 5 mg ever night which is a moderate dose. you can get it from 2.5 mg-i think like 10? mg. it does cause nausea, so thats why i take it at night *right before * i pass out. the first few days you will feel like you want to vomit a few times a day, i only vomited once. that will pass, but im just letting you know. I also want to let you know that i am taking other acne meds at this point, i started the bromocriptine because i wasnt completely clear. but now I am 100% clear and have been for months. so i wanted to share this with you all. the things i have tried before from researching these boards are so many. i tried spironolactone, that didnt work but i hear its good for alot of gals out there. anyways YOU HAVE TO TRY THIS STUFF. Ill post my routine below:

am

wash with dove sens. bar

apply dans bp (use 1/2 a pump)

any lotion around (right now i use cerave)

sunscreen

pm

wash with dove

use a face scrub or loofah

apply 0.05% tretinoin gel

cetaphil cream

meds: I take Ortho Tri cyclen in am and bromocriptine in pm

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Oh wow I hope it works!! I just read an article on this, it says it reduces sebum by 90%....

I'm hopeful!!!!!!! :D

Seborrhoea

SMT D002

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Anyone heard anything new regarding the release of this drug? Google yielded little results for me.



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Last year Summit announced that SMT D002, along with two other drugs, had been licensed to Orient Pharma in return for an investment 500,000 pounds:

"Orient gains exclusive development and commercialisation rights in Asia Pacific and Australasia and will be responsible for all development, manufacturing and distribution costs associated with the products within its territories."

They have also said:

"Summit retains valuable rights to the products in North America, Europe and the rest of the world and has rights to access data generated by Orient. Our intention is to use these data, which will include clinical trial results, to secure future commercial agreements within our territories"

which I would interpret to mean that they intend to sell off the rights elsewhere in due course.

And:

"Although Summit's future research and development activities are now primarily focused on the SeglinTM technology, these programmes remain a potential source of future value upside that requires no investment from the Company"

I understand this to mean they are not concentrating on SMT D002 at the moment.

Neither Summit nor Orient Pharma show much if any evidence of rushing to bring it to market. All in all it doesn't appear to be living up to the hype from spring 2008.

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Since Orient Pharma have now entered into an agreement with Summit for SMT D002, I have sent them a question, asking what their plans are for trials/release. I don't really expect to get a response, but you never know.

As with Summit, I would urge anyone who wants information about this to contact Orient Pharma in order to make the point that some people outside their organisation want to know WTF is going on. Messages can be sent via their website at http://www.orientpharma.net/contactus.html.

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So if you have excessive clogged pores, Oily skin, and are beggining to notice twitching in your fingers, you have parkinsons ?

haha. Wheres my gun........ Going to shoot myself in the face now, so i can meet my maker and give him the shit kickin of his life.

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I'm assuming the bromocriptine works because it reduces prolactin levels and in turn raises dopamine levels. In my case, I'm 90% sure my acne is caused by low progesterone levels after ovulation and high prolactin causes reduced progesterone levels. As long as you reduce prolactin levels does it matter how you do it? Why not try natural progesterone cream? If does the same thing to prolactin levels as bromocriptine does and has less side effects.


Morning

Paula's choice 1 step cleanser

Paula's choice 2%BHA liquid (leave for 3 mins and wash off)

Paula's choice 8%AHA gel (leave for 3 mins and wash off)

paula's choice HydraLight Moisture-Infusing Lotion

lily lolo mineral make up

Evening

Paula's choice 1 step cleanser

Paula's choice 2%BHA liquid (leave for 3 mins and wash off)

0.30 retinol cream (Neova) (on forehead cheeks and chin)

paula's choice HydraLight Moisture-Infusing Lotion (on nose around lips and eyes)


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Probably B.S. to keep some stuggling pharma company from going belly-up. Happens all the time for acne and hairloss treatments.


Low dose oral antibiotics for the long-term. Hibiclens morning and night in the shower. Occassional max strength triple-antibiotic white petroleum jelly all over the face (rarely, now). And occassionally salicylic acid wipes prep followed by 10% benzoyl peroxide PanOxyl (deactivates the Hibiclens, though). If you can afford oral or topical retinoids, you should try them.


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Is bromocriptine safe and effective for men?

Should be.

If you want to know more about Bromocriptine (unrelated to acne) you can check out Lyle Mcdonald's book

"Bromocriptine. An Old Drug with New Uses"

Turns out it also helps dieting.

misscruella16:

It's better to take it in the morning.

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