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nate28

Possible Breakthrough in Acne Research

54 posts in this topic

omg, we NEED a way of finding out which drug they are testing. It might be sitting right there on the shelf!

Lol, i hope it isn't something the orgers have already tried out, like omega 3 or ACV.

I really think we should try and formulate a plan to find out. Maybe something to do with pretending to be inquiring about volunteering to be a test subject.

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After a few minutes of digging i found this page http://64.233.183.104/search?q=cache:IHRrZ...;cd=2&gl=uk

Slightly more informative, i figure the treatment is one that was originally used for Parkinson's disease.

EDIT:

'L-dopa and dopamine agonists ' are used by Vastox (old name for their company, Summit) to treat Parkinson's.

EDIT:

In general, treatment of early Parkinson's starts with:

* Levodopa and carbidopa.

* Dopamine agonists (bromocriptine, pergolide, pramipexole, ropinirole).

* COMT inhibitors (entacapone, tolcapone).

* MAO-B inhibitors (rasagiline, selegiline).

* Amantadine.

* Anticholinergic agents (benztropine, trihexyphenidyl).

Hmm, any of those things reduce sebum.... i wonder.

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I used to take anticholinergic nasal spray and that was intended to dry up all secretions... probably no connection tho.

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GENERIC NAME: BROMOCRIPTINE - ORAL

SIDE EFFECTS: May cause drowsiness. Avoid tasks requiring alertness. Other side effects may include stomach cramps, nausea, vomiting, indigestion, constipation, diarrhea, headache, fatigue, lightheadedness, insomnia, nasal congestion. These should subside as your body adjusts to the medication. If any of these effects persist or worsen, notify your doctor promptly. Notify your doctor if you develop: bloody vomit, confusion, fainting, depression, irregular pulse, shortness of breath, rash, tingling of hands or feet, involuntary movements, nightmares, vision changes. If you notice other effects not listed above, contact your doctor or pharmacist.


Done with accutane 20mgs for 7 months

22 years old, 180lbs

no side effects, bye.


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yah i was just about to post this in a new thread, good thing i came into this thread.....

some interesting news, God I wish it was available now... i mean it is, but i wish we knew more about dosage, etc...

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After a few minutes of digging i found this page http://64.233.183.104/search?q=cache:IHRrZ...;cd=2&gl=uk

In a Phase I study in nine patients, sebum production was reduced by up to 70% with a single oral dose, and a second Phase I study in 18 patients is now under way. ‘The Phase I results are startlingly good,’ he said.

with one dose? that would be unreal :D

hopefully phase 2 goes well :D

the most promising news on this site for some time in my mind.... hopefully this thread isnt lost over the coming months.....

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somewhere in the article it said it's going to be a topical cream not pill...in that case it's probably going to suck.


Done with accutane 20mgs for 7 months

22 years old, 180lbs

no side effects, bye.


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somewhere in the article it said it's going to be a topical cream not pill...in that case it's probably going to suck.

in the quote i have in the post above yours, it says oral, but that is from a different article on the same subject that someone posted a bit lower down....but i read the part about topical too. i think you are referring to this:

The company hopes to begin critical Phase 2 trials to assess the efficacy of the drug in acne sufferers next year. Depending on the results, the drug could either be formulated as a stand-alone topical treatment or more likely in combination with other existing treatments. The company has already been in talks with several interested companies, who are waiting to see whether the initial results can be repeated in a larger study group.

maybe they are trying to milk it you know? it already seems to be ready in oral form, since the drug pretty much exists...but for not serious enough acne they can also make a topical treatment.....most people that have acne its pretty mild, so in this respect a topical solution would also be beneficial to have if you are talking about a business standpoint..... kind of like how there are topical (retin-a) and oral (accutane) retinoids available....

-------------------------------------

also the article which was initially posted to start this thread is this one:

http://www.news-medical.net/?id=28774

then someone else posted this one:

http://64.233.183.104/search?q=cache:IHRrZ...;cd=2&gl=uk

there are differences in the articles on specific details.....

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so who is brave enough to be the guinea pig for us all? The people need a hero. Order some of this stuff and start off with a tiny dosage or something.


The 2nd poster to jump on the pgx bandwagon. User Blessthefall being my superior.


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so who is brave enough to be the guinea pig for us all? The people need a hero. Order some of this stuff and start off with a tiny dosage or something.

Some of what stuff!?

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so who is brave enough to be the guinea pig for us all? The people need a hero. Order some of this stuff and start off with a tiny dosage or something.

Some of what stuff!?

vastox


Done with accutane 20mgs for 7 months

22 years old, 180lbs

no side effects, bye.


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someone try and email vastox for any updates. I tried but you need sometype of login and my brother has that info.

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Let me re-phrase. The people of acne org need a leader. Who is willing to be the choosen one to sample a small dosage of bromocriptine?


The 2nd poster to jump on the pgx bandwagon. User Blessthefall being my superior.


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somewhere in the article it said it's going to be a topical cream not pill...in that case it's probably going to suck.

if there is a topical that will reduce sebum, thats better then destroying your body or dealing with crazy side effects like accutane.

whos to say that there is a cure in pill form in existence? is that asking too much of god?

Lets just be glad the even found this in our lifetime.


#1.critical nutritional issues- b12(three forms exist), Calcium(yogurt, cheese or calcium phosphate supps) and vitamin d(sun or supps not to exceed 1000 iu). heme iron-most absorbable from meat only, clams are high. these are the most difficult vitamins to get and absorb. All others or about the same in difficulty in absorption. MAgnesium in our food supply is generally low as well, try natural calm supps.

#2 Fats- monounsaturated should dominate(olives), followed by polyunsaturated plant sources(nuts) but not if you have acne. the health benefits of fish oil and fish are controversial and i dont consume them due to mercury contamination and immune supression avoid processed fats if possible.

#3 Protein/amino acids- dairy and eggs best sources for tryptophan and methionine which convert to powerful antioxidants melatonin and glutathione.

#4 Carotenoids- alpha- beta carotene, beta cryptoxanthin, lutein zeaxanthin, astaxanthin. these are vital to human nutrition, carrots, butternut squash, pumpkin, chili pepper and cayenne pepper are the best sources.

#5 Regularity-BM at least once a day, Moist, large stools, 1 piece ideal, no maldigestion, no floating stools indicative of maldigested fat. HOW- insoluble fiber- wheat and cooked vegetables. soluble fiber-oats/ good bacteria ferment soluble fiber making short chain fatty acids that inhibit pathogens.

#6 Circadian cycles-Light, get up with the sun, and expose your entire body to it. darkness-melatonin is released upon the sensing of absolute darkness. sleep in a pitch black room, try to ensure 10 hours total darkness, wear sunglasses before bed. do not eat too late at night.

#7 Desirable physiological states(positive moods/emotions) do precisely what you like and what feels good to you, but not regardless of consequences, just from a perspective that, you own your life, and can determine precisely what you do with it and need not answer or ask of permission from anyone,achieving maximum autonomy and self government.


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somewhere in the article it said it's going to be a topical cream not pill...in that case it's probably going to suck.

if there is a topical that will reduce sebum, thats better then destroying your body or dealing with crazy side effects like accutane.

whos to say that there is a cure in pill form in existence? is that asking too much of god?

Lets just be glad the even found this in our lifetime.

Conversely you could argue that if it was truly a cure then it wouldn't be having negative effects on your body, moreover it would be correcting the initial fault when taken systemically.

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Well it is official that the drug has to be what was prescribed for parkinson patients with over-production of sebum, it seems that they have done studies with anticholinergic agents (Biperiden), L-dopa plus AAID, and Bromocriptone. While The anticholineric agents did not show any effect. Both L-dopa +AAID , and Bromocriptone did. here are some articles.

article 1

article 2

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