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Possible Breakthrough in Acne Research

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#1 nate28

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Posted 27 August 2007 - 11:25 AM

cure?

Edited by Wynne, 21 April 2008 - 10:09 PM.
merged four threads, changed title.


#2 come back clear skin

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Posted 27 August 2007 - 12:10 PM

this sounds promising thanks for posting it

#3 Listener

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Posted 27 August 2007 - 03:54 PM

omg, we NEED a way of finding out which drug they are testing. It might be sitting right there on the shelf!

Lol, i hope it isn't something the orgers have already tried out, like omega 3 or ACV.

I really think we should try and formulate a plan to find out. Maybe something to do with pretending to be inquiring about volunteering to be a test subject.


#4 Listener

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Posted 27 August 2007 - 04:02 PM

After a few minutes of digging i found this page http://64.233.183.10...Z...;cd=2&gl=uk

Slightly more informative, i figure the treatment is one that was originally used for Parkinson's disease.

EDIT:
'L-dopa and dopamine agonists ' are used by Vastox (old name for their company, Summit) to treat Parkinson's.

EDIT:

In general, treatment of early Parkinson's starts with:

* Levodopa and carbidopa.
* Dopamine agonists (bromocriptine, pergolide, pramipexole, ropinirole).
* COMT inhibitors (entacapone, tolcapone).
* MAO-B inhibitors (rasagiline, selegiline).
* Amantadine.
* Anticholinergic agents (benztropine, trihexyphenidyl).

Hmm, any of those things reduce sebum.... i wonder.

#5 Listener

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Posted 27 August 2007 - 04:07 PM

I used to take anticholinergic nasal spray and that was intended to dry up all secretions... probably no connection tho.


#6 DeAntonio

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Posted 27 August 2007 - 04:08 PM

sounds interesting

#7 Listener

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Posted 27 August 2007 - 04:11 PM

Only thing i can link to dry skin thus far: http://64.233.183.10...f...;cd=3&gl=uk


#8 DeAntonio

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Posted 27 August 2007 - 04:17 PM

well whatever bromocriptine is....

http://www.ncbi.nlm....pt=AbstractPlus

#9 Listener

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Posted 28 August 2007 - 04:12 AM

Nice find dude,
http://en.wikipedia....i/Bromocriptine

It appears it also has a connection with insulin sensitivity.


#10 un4tunate

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Posted 28 August 2007 - 02:29 PM

http://www.newsrx.co...112007188W.html

ok someone try vastox..
Done with accutane 20mgs for 7 months

22 years old, 180lbs

no side effects, bye.

#11 un4tunate

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Posted 28 August 2007 - 02:33 PM

GENERIC NAME: BROMOCRIPTINE - ORAL

SIDE EFFECTS: May cause drowsiness. Avoid tasks requiring alertness. Other side effects may include stomach cramps, nausea, vomiting, indigestion, constipation, diarrhea, headache, fatigue, lightheadedness, insomnia, nasal congestion. These should subside as your body adjusts to the medication. If any of these effects persist or worsen, notify your doctor promptly. Notify your doctor if you develop: bloody vomit, confusion, fainting, depression, irregular pulse, shortness of breath, rash, tingling of hands or feet, involuntary movements, nightmares, vision changes. If you notice other effects not listed above, contact your doctor or pharmacist.
Done with accutane 20mgs for 7 months

22 years old, 180lbs

no side effects, bye.

#12 tricky1

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Posted 28 August 2007 - 09:03 PM

yah i was just about to post this in a new thread, good thing i came into this thread.....

some interesting news, God I wish it was available now... i mean it is, but i wish we knew more about dosage, etc...

#13 nate28

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Posted 28 August 2007 - 09:03 PM

side effects do not seem to bad, anyone finding anything new. I can't wait until next year.

#14 tricky1

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Posted 28 August 2007 - 09:06 PM

QUOTE(Listener @ Aug 27 2007, 05:02 PM) View Post
After a few minutes of digging i found this page http://64.233.183.10...Z...;cd=2&gl=uk


QUOTE
In a Phase I study in nine patients, sebum production was reduced by up to 70% with a single oral dose, and a second Phase I study in 18 patients is now under way. β€˜The Phase I results are startlingly good,’ he said.


with one dose? that would be unreal biggrin.gif

hopefully phase 2 goes well biggrin.gif

the most promising news on this site for some time in my mind.... hopefully this thread isnt lost over the coming months.....

#15 un4tunate

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Posted 29 August 2007 - 09:22 AM

somewhere in the article it said it's going to be a topical cream not pill...in that case it's probably going to suck.
Done with accutane 20mgs for 7 months

22 years old, 180lbs

no side effects, bye.

#16 tricky1

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Posted 29 August 2007 - 11:51 AM

QUOTE(un4tunate @ Aug 29 2007, 10:22 AM) View Post
somewhere in the article it said it's going to be a topical cream not pill...in that case it's probably going to suck.


in the quote i have in the post above yours, it says oral, but that is from a different article on the same subject that someone posted a bit lower down....but i read the part about topical too. i think you are referring to this:

QUOTE
The company hopes to begin critical Phase 2 trials to assess the efficacy of the drug in acne sufferers next year. Depending on the results, the drug could either be formulated as a stand-alone topical treatment or more likely in combination with other existing treatments. The company has already been in talks with several interested companies, who are waiting to see whether the initial results can be repeated in a larger study group.


maybe they are trying to milk it you know? it already seems to be ready in oral form, since the drug pretty much exists...but for not serious enough acne they can also make a topical treatment.....most people that have acne its pretty mild, so in this respect a topical solution would also be beneficial to have if you are talking about a business standpoint..... kind of like how there are topical (retin-a) and oral (accutane) retinoids available....

-------------------------------------

also the article which was initially posted to start this thread is this one:
http://www.news-medical.net/?id=28774

then someone else posted this one:
http://64.233.183.10...Z...;cd=2&gl=uk

there are differences in the articles on specific details.....

#17 chrisaus

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Posted 29 August 2007 - 08:40 PM

so who is brave enough to be the guinea pig for us all? The people need a hero. Order some of this stuff and start off with a tiny dosage or something.
The 2nd poster to jump on the pgx bandwagon. User Blessthefall being my superior.

#18 Listener

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Posted 30 August 2007 - 05:15 AM

QUOTE(chrisaus @ Aug 29 2007, 08:40 PM) View Post
so who is brave enough to be the guinea pig for us all? The people need a hero. Order some of this stuff and start off with a tiny dosage or something.



Some of what stuff!?

#19 un4tunate

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Posted 30 August 2007 - 08:20 AM

QUOTE(Listener @ Aug 30 2007, 07:15 AM) View Post
QUOTE(chrisaus @ Aug 29 2007, 08:40 PM) View Post
so who is brave enough to be the guinea pig for us all? The people need a hero. Order some of this stuff and start off with a tiny dosage or something.



Some of what stuff!?


vastox
Done with accutane 20mgs for 7 months

22 years old, 180lbs

no side effects, bye.

#20 nate28

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Posted 30 August 2007 - 10:06 AM

I think Vastox is the name of the company, what you would need to take is Bromocriptine.