Posted 19 August 2007 - 04:18 AM
heres a random abstract about nutrigenomics
: Acta Vet Hung. 2007 Jun;55(2):229-39.Links
Veterinary aspects and perspectives of nutrigenomics: a critical review.Fekete SG, Brown DL.
Institute of Animal Breeding, Nutrition and Laboratory Animal Science, Faculty of Veterinary Science, Szent István University, H-1400 Budapest, P.O. Box 2, Hungary. Fekete.Sandor@aotk.szie.hu
Nutrigenomics examines nutrient-gene interactions on a genome-wide scale. Increased dietary fat or higher non-esterified fatty acids (NEFA) from starvation-induced mobilisation may enhance hepatic oxidation and decrease esterification of fatty acids by reducing the expression of the fatty acid synthase gene. The key factors are the peroxisome proliferator-activated receptors (PPARs). Dietary carbohydrates--both independently and through insulin effect--influence the transcription of the fatty acid synthase gene. Oleic acid or n-3 fatty acids downregulate the expression of leptin, fatty acid synthase and lipoprotein lipase in retroperitoneal adipose tissue. Protein-rich diets entail a shortage of mRNA necessary for expression of the fatty acid synthase gene in the adipocytes. Conjugated linoleic acids (CLAs) are activators of PPAR and also induce apoptosis in adipocytes. Altered rumen microflora produces CLAs that are efficient inhibitors of milk fat synthesis in the mammary gland ('biohydrogenation theory'). Oral zinc or cadmium application enhances transcription rate in the metallothionein gene. Supplemental CLA in pig diets was found to decrease feed intake and body fat by activating PPARgamma-responsive genes in the adipose tissue. To prevent obesity and type II diabetes, the direct modulation of gene expression by nutrients is also possible. Nutrigenomics may help in the early diagnosis of genetically determined metabolic disorders and in designing individualised diets for companion animals.
I just found out that apolipoprotein a- I gene expression could be regulated by ppar alpha.
: Eur J Pharmacol. 2006 Dec 3;551(1-3):80-6. Epub 2006 Sep 6. Links
Anti-hyperlipidemic properties of CM108 (a flavone derivative) in vitro and in vivo.Guo L, Hu WR, Lian JH, Ji W, Deng T, Qian M, Gong BQ.
State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China. firstname.lastname@example.org
Peroxisome proliferator-activated receptors (PPARs) and liver X receptor alpha are ligand-activated transcription factors that belong to nuclear receptors superfamily and are involved in the regulation of lipid metabolism. PPAR, especially PPAR-alpha, PPAR-gamma agonists and liver X receptor alpha agonists can regulate the expression or biosynthesis of some factors involved in the formation and function of HDL, such as apolipoprotein (apo) A-I and ATP binding cassette transporter A1 (ABCA1). It is well known that HDL plays an important role in the treatment of hyperlipidemia as the carrier of reverse cholesterol transport. In the present study, the anti-hyperlipidemic properties of CM108, a derivative of flavone, 9-Hydroxy-2-mercapto-6-phenyl-2-thioxo-1,3,5-trioxa-2lambda(5)-phospha-cyclopenta[b]naphthalen-8-one, were studied. Through the transactivation assays of in vitro study, it was discovered that CM108 could activate PPAR-alpha PPAR-gamma and liver X receptor alpha at 40-150 microg/ml, which subsequently resulted in activating ABCA1 promoter and enhancing apoA-I and apoA-II production, whereas reducing apoC-III production significantly. Furthermore, after in vivo study that the hyperlipidemic rats were treated with CM108 for 4 weeks, a significant increase was found in HDL cholesterol levels (26.7%, P<0.05) and a significant decrease was also noticed in triglyceride levels (26.3%, P<0.01) at 100 mg/kg CM108 group compared with that of control animals. Meanwhile, the atherogenicity index, represented by total cholesterol/HDL ratio, was significantly reduced (P<0.01). In conclusion, CM108 can effectively elevate HDL levels and lower triglyceride levels in hyperlipidemic rats maybe by regulating a series of genes, receptors and proteins related to HDL.
since it is known that people with acne have low levels of apolipoprotein a-I sseing now its relationship to ppar alpha is also a good thing. so far ppar alpha could possibly improve two big opponents in acne, sebum production and apolipoprotein a-I or so it seems.
#1.critical nutritional issues- b12(three forms exist), Calcium(yogurt, cheese or calcium phosphate supps) and vitamin d(sun or supps not to exceed 1000 iu). heme iron-most absorbable from meat only, clams are high. these are the most difficult vitamins to get and absorb. All others or about the same in difficulty in absorption. MAgnesium in our food supply is generally low as well, try natural calm supps.
#2 Fats- monounsaturated should dominate(olives), followed by polyunsaturated plant sources(nuts) but not if you have acne. the health benefits of fish oil and fish are controversial and i dont consume them due to mercury contamination and immune supression avoid processed fats if possible.
#3 Protein/amino acids- dairy and eggs best sources for tryptophan and methionine which convert to powerful antioxidants melatonin and glutathione.
#4 Carotenoids- alpha- beta carotene, beta cryptoxanthin, lutein zeaxanthin, astaxanthin. these are vital to human nutrition, carrots, butternut squash, pumpkin, chili pepper and cayenne pepper are the best sources.
#5 Regularity-BM at least once a day, Moist, large stools, 1 piece ideal, no maldigestion, no floating stools indicative of maldigested fat. HOW- insoluble fiber- wheat and cooked vegetables. soluble fiber-oats/ good bacteria ferment soluble fiber making short chain fatty acids that inhibit pathogens.
#6 Circadian cycles-Light, get up with the sun, and expose your entire body to it. darkness-melatonin is released upon the sensing of absolute darkness. sleep in a pitch black room, try to ensure 10 hours total darkness, wear sunglasses before bed. do not eat too late at night.
#7 Desirable physiological states(positive moods/emotions) do precisely what you like and what feels good to you, but not regardless of consequences, just from a perspective that, you own your life, and can determine precisely what you do with it and need not answer or ask of permission from anyone,achieving maximum autonomy and self government.