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Scarless Healing


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#4721 panos

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Posted 10 September 2013 - 02:00 AM

Here on page 22 and 23 you can see the result of phase 1 clinical trials of the drug RXI-109:
This drug will probably be the next Juvista, I used to think this drug is something because it is based on RNAi (which is discovered by Dr. Graig Mello for what he was awarded with the Nobel Prize in 2006 and he is the founder of the company that is developing that drug) and because it is often mentioned (and overhyped) by Ray Kurzweil, so that's why I now understand that biotechnology/genomic medicine will stay primitive for a long time to come, it is simply the wrong approach, Seabs is right when he says that the mechanism of the scar formation is too complex for us to understand it in details, so regenerative medicine is the only approach that can result in scar free healing in the foreseeable future.

 

I suggest you begin again from the basics.In adults scars are results of lime/bad inorganic calcium that is being accumulated.

So the blood after the first days of scar forming cant break this hard calcium.Its all about this hard collagen that CAN BE manipulated back to liquid again.

 

For scar free healing in most cases use cayenne to close the cut and then put aloe vera and slippery elm paste and cover with bandaid.

For burns there are various soothing herbs .



#4722 skinregenerator

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Posted 10 September 2013 - 07:24 PM

This hydrogel is devoid of growth factor and cell, totally biomaterial. Do you guys think JHU can do this after Dr Sun left the team?Maybe that's why no progress made yet?



#4723 2001

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Posted 10 September 2013 - 07:46 PM

http://www.google.co...tents/US3622668

 

This was posted here before many years back. All of the drugs used to make the it are easy to find and buy on the net. I can't seem to understand the mixing ratio, and there is one other issue. The "88% phenol" at it's full 88% concentration can kill you in 90 seconds if you apply it to a 10inch x 10 inch area of skin. I'm hoping someone around here can read through this and explain the mixing ratios more clearly.



It has been found that when appropriate portions of Vitamin A" Vitamin D," olive oil, and a suitable aromatic hydroxyl derivative (PHENOL) are mixed together to form a homogeneous lotion, that the lotion compounded therefrom will provide the following synergistic effect. First, the skin laceration is disinfected, Second, regenerative healing of the endodermal layer is accelerated while the healing process of the epidermal layer is temporarily suspended. Third, the keratoid or comified tissue, but not the soft nonnal tissue, of the endodermal layer is dissolved or otherwise prevented from accumulating. The synergistic result of certain homogeneous mixtures of these four ingredients is to promote a rapid healing of a skin laceration, commencing at the cross-sectional periphery thereof, so as to provide scar-free characteristics in the ultimately healed skin laceration.

---------------------

Again, discovered in 1969! I would like to understand how to make this stuff. I do not understand the mix ratios or how one might consider altering them for human testing.  It was used on larger heavier animals than man.I can get my hands on all the ingredients used to make this stuff.



#4724 seabs135

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Posted 10 September 2013 - 08:22 PM

This hydrogel is devoid of growth factor and cell, totally biomaterial. Do you guys think JHU can do this after Dr Sun left the team?Maybe that's why no progress made yet?

 

It doesn't need anything added. In the objective data, inside the scientific document, the material degraded rapidly and got complete regeneration.



#4725 panos

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Posted 10 September 2013 - 10:19 PM

http://www.google.co...tents/US3622668

 

This was posted here before many years back. All of the drugs used to make the it are easy to find and buy on the net. I can't seem to understand the mixing ratio, and there is one other issue. The "88% phenol" at it's full 88% concentration can kill you in 90 seconds if you apply it to a 10inch x 10 inch area of skin. I'm hoping someone around here can read through this and explain the mixing ratios more clearly.



It has been found that when appropriate portions of Vitamin A" Vitamin D," olive oil, and a suitable aromatic hydroxyl derivative (PHENOL) are mixed together to form a homogeneous lotion, that the lotion compounded therefrom will provide the following synergistic effect. First, the skin laceration is disinfected, Second, regenerative healing of the endodermal layer is accelerated while the healing process of the epidermal layer is temporarily suspended. Third, the keratoid or comified tissue, but not the soft nonnal tissue, of the endodermal layer is dissolved or otherwise prevented from accumulating. The synergistic result of certain homogeneous mixtures of these four ingredients is to promote a rapid healing of a skin laceration, commencing at the cross-sectional periphery thereof, so as to provide scar-free characteristics in the ultimately healed skin laceration.

---------------------

Again, discovered in 1969! I would like to understand how to make this stuff. I do not understand the mix ratios or how one might consider altering them for human testing.  It was used on larger heavier animals than man.I can get my hands on all the ingredients used to make this stuff.

 

I suggest to stop looking for the difficult way and next time use aloe vera and slippery elm paste on wound.

If it heals incomplete then try b,f&c ointment from dr christopher.



#4726 2001

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Posted 10 September 2013 - 10:48 PM

 

http://www.google.co...tents/US3622668

 

This was posted here before many years back. All of the drugs used to make the it are easy to find and buy on the net. I can't seem to understand the mixing ratio, and there is one other issue. The "88% phenol" at it's full 88% concentration can kill you in 90 seconds if you apply it to a 10inch x 10 inch area of skin. I'm hoping someone around here can read through this and explain the mixing ratios more clearly.



It has been found that when appropriate portions of Vitamin A" Vitamin D," olive oil, and a suitable aromatic hydroxyl derivative (PHENOL) are mixed together to form a homogeneous lotion, that the lotion compounded therefrom will provide the following synergistic effect. First, the skin laceration is disinfected, Second, regenerative healing of the endodermal layer is accelerated while the healing process of the epidermal layer is temporarily suspended. Third, the keratoid or comified tissue, but not the soft nonnal tissue, of the endodermal layer is dissolved or otherwise prevented from accumulating. The synergistic result of certain homogeneous mixtures of these four ingredients is to promote a rapid healing of a skin laceration, commencing at the cross-sectional periphery thereof, so as to provide scar-free characteristics in the ultimately healed skin laceration.

---------------------

Again, discovered in 1969! I would like to understand how to make this stuff. I do not understand the mix ratios or how one might consider altering them for human testing.  It was used on larger heavier animals than man.I can get my hands on all the ingredients used to make this stuff.

 

I suggest to stop looking for the difficult way and next time use aloe vera and slippery elm paste on wound.

If it heals incomplete then try b,f&c ointment from dr christopher.

Panos you're promoting snake oil. I run right through your posts here because they defame hydrogel and defend thieves and con-artist. I don't know why you do it, but it's ruining the credability and direction of this "Scarless Healing" thread. I've been here for a long time now and I've had my ear to the ground for a solution for a lot longer. I use to talk to Mark Furgeson when he was trying to find investors for Renovo before it was even an ipo. I believe in 3 things for "Scar free" wound healing right now.

 

Egg oil (with intact proteins)

Hydrogel

The Phenol Vit A Vit D lotion combo

 

You are talking to deaf ears. The guy who filed for this patent paid thousands of dollars to secure it. Can someone else here please help me concerning the mixing ratios.
 



#4727 panos

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Posted 11 September 2013 - 06:24 AM

Stop with your toxic solutions!!!!
How is it going with the castor oil and wrap thingy?Still results?

Aloe vera and slippery elm is NOT A SCAM.Also b,f&c is a mix of herbs .Whats wrong with it?



#4728 skinregenerator

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Posted 11 September 2013 - 07:35 AM

This hydrogel is devoid of growth factor and cell, totally biomaterial. Do you guys think JHU can do this after Dr Sun left the team?Maybe that's why no progress made yet?

 

It doesn't need anything added. In the objective data, inside the scientific document, the material degraded rapidly and got complete regeneration.

That's true!

But it looks like that Dr Sun started this during his PhD study and carried on at JHU. As for me, it's just weird that he is not working on this any more...



#4729 golfpanther

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Posted 11 September 2013 - 02:17 PM

 

This hydrogel is devoid of growth factor and cell, totally biomaterial. Do you guys think JHU can do this after Dr Sun left the team?Maybe that's why no progress made yet?

 

It doesn't need anything added. In the objective data, inside the scientific document, the material degraded rapidly and got complete regeneration.

That's true!

But it looks like that Dr Sun started this during his PhD study and carried on at JHU. As for me, it's just weird that he is not working on this any more...

 

Well, he's not working on that exact hydrogel because I don't think he owns the patent. Some time ago a poster on this board was talking to Dr. Harmon and said that they were working out the patent issues.

 

In terms of progress being made, there has been. JHU, through their technology transfer, is working with Gerecht to create a start-up company for her. Trials on larger animals started this summer and are probably still going on right now. Their timeline in the article posted a bit ago on here and on the JHU technology transfer site said that they anticipate human applications would be possible in 18-24 months. The article was written some time ago so we're probably looking at 14-20 months now if not less as long as they're on schedule. These things take time and money, but that's not a bad estimate at all!



#4730 skinregenerator

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Posted 11 September 2013 - 07:33 PM

 

 

This hydrogel is devoid of growth factor and cell, totally biomaterial. Do you guys think JHU can do this after Dr Sun left the team?Maybe that's why no progress made yet?

 

It doesn't need anything added. In the objective data, inside the scientific document, the material degraded rapidly and got complete regeneration.

That's true!

But it looks like that Dr Sun started this during his PhD study and carried on at JHU. As for me, it's just weird that he is not working on this any more...

 

Well, he's not working on that exact hydrogel because I don't think he owns the patent. Some time ago a poster on this board was talking to Dr. Harmon and said that they were working out the patent issues.

 

In terms of progress being made, there has been. JHU, through their technology transfer, is working with Gerecht to create a start-up company for her. Trials on larger animals started this summer and are probably still going on right now. Their timeline in the article posted a bit ago on here and on the JHU technology transfer site said that they anticipate human applications would be possible in 18-24 months. The article was written some time ago so we're probably looking at 14-20 months now if not less as long as they're on schedule. These things take time and money, but that's not a bad estimate at all!

I talked to some researchers, they told me those who conducted the research, in most cases, not the professors, can do better



#4731 seabs135

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Posted 11 September 2013 - 08:19 PM

 

This hydrogel is devoid of growth factor and cell, totally biomaterial. Do you guys think JHU can do this after Dr Sun left the team?Maybe that's why no progress made yet?

 

It doesn't need anything added. In the objective data, inside the scientific document, the material degraded rapidly and got complete regeneration.

That's true!

But it looks like that Dr Sun started this during his PhD study and carried on at JHU. As for me, it's just weird that he is not working on this any more...

 

I personally don't know if it is different or not. Golfpanthers post seems reasonably explained imo.


Edited by seabs135, 11 September 2013 - 08:39 PM.


#4732 golfpanther

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Posted 13 September 2013 - 01:53 PM

 

This hydrogel is devoid of growth factor and cell, totally biomaterial. Do you guys think JHU can do this after Dr Sun left the team?Maybe that's why no progress made yet?

 

It doesn't need anything added. In the objective data, inside the scientific document, the material degraded rapidly and got complete regeneration.

That's true!

But it looks like that Dr Sun started this during his PhD study and carried on at JHU. As for me, it's just weird that he is not working on this any more...

 

Dr. Sun isn't at JHU anymore because funding ran out for his position. They likely wanted to give the funds to a new post-doctoral fellow.

 

He is still working on hydrogels and scar free healing though (he told me an email response I got from him). But as I said before, I don't think he owns the patent, at least not outright, so he probably can't continue working on the exact same idea. I might be wrong about that though. It might just be that he doesn't want to work on the same thing because JHU is still researching it and even if he did succeed with the Dextran Hydrogel he'd likely have to pay the patent holder for the right to use it, which would make commercialization less feasible.



#4733 2001

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Posted 14 September 2013 - 09:20 AM

Castor oil will eliminate scars in fresh  and recently healed wounds, but it takes a long time and if the wound/scar is really big it will be difficult to keep the castor oil wrap in place. It isnt easy or enjoyable to keep a large wounds/scar covered 24-7 like this. i have large scars I want to remove, and I need something different to do it.

 

Cayenne pepper will cauterize a wound but it wont heal it scarfree- so throw that theory away.


Slipper elm does not work- toss that one out as well. It's as effective as aloe oil. Aloe doesn't remove scars. Show me one case were it did.


Iodine will flatten scars but it will also make the scar tissue thicker- toss that theory away.


Castor oil works but it also take up to a year to remove old scars and at least 4 months or more in new wounds. I know I got rid of all my cutter scars on my arm using it. Castor oil is not effective for my needs. I cant keep a wrap on that large of an area for that long. I can do 30 days easy with something else, but theres no way in hell I can do 1 year under the oil for my situation

.



#4734 panos

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Posted 14 September 2013 - 09:44 AM

Which wrap are you using?Plastic or cotton?

 

I cut the toe skin from a fridge,closed it with cayenne(it closed in 1 minute) and then applied honey.

Now after almost 3-4 weeks a can barely see wound where it was and i assume in a couple of months it will be vanished.



#4735 trendycat

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Posted 15 September 2013 - 02:05 AM

Which wrap are you using?Plastic or cotton?

 

I cut the toe skin from a fridge,closed it with cayenne(it closed in 1 minute) and then applied honey.

Now after almost 3-4 weeks a can barely see wound where it was and i assume in a couple of months it will be vanished.

Without a control wound, that doesn't mean anything. It could be that it would have healed normally anyways. It depends on the severity of the cut, location, and a number of other environmental features. 



#4736 panos

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Posted 15 September 2013 - 03:00 AM

Which wrap are you using?Plastic or cotton?

 

I cut the toe skin from a fridge,closed it with cayenne(it closed in 1 minute) and then applied honey.

Now after almost 3-4 weeks a can barely see wound where it was and i assume in a couple of months it will be vanished.

Without a control wound, that doesn't mean anything. It could be that it would have healed normally anyways. It depends on the severity of the cut, location, and a number of other environmental features. 

 

I also hae removed some flat moles without even been able to seen it now with a toothpick and close it with chilli powder.Now i really cant see it ;)

So dont toss that theory so fast ;)



#4737 2001

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Posted 16 September 2013 - 04:33 AM

Which wrap are you using?Plastic or cotton?

 

I cut the toe skin from a fridge,closed it with cayenne(it closed in 1 minute) and then applied honey.

Now after almost 3-4 weeks a can barely see wound where it was and i assume in a couple of months it will be vanished.

 

sterile cotton gauze soaked in castor oil held in place with sewing thread wrapped around it. but this was on the arms and it took over a year to remove the scars, and i didn't take pictures. i have a scar on my face i want to get rid of, but it's hard to keep a swatch of cotton in place on this area for long periods of time. It works but you have to keep it on the scar 24/7 for a long long time. I dont trust plastic wrap with castor oil. only use dye free natural fabrics that dont have plastics in them. I avoid skin care products with Parabens and Hexanes as well.



 

Which wrap are you using?Plastic or cotton?

 

I cut the toe skin from a fridge,closed it with cayenne(it closed in 1 minute) and then applied honey.

Now after almost 3-4 weeks a can barely see wound where it was and i assume in a couple of months it will be vanished.

Without a control wound, that doesn't mean anything. It could be that it would have healed normally anyways. It depends on the severity of the cut, location, and a number of other environmental features. 

 

I also hae removed some flat moles without even been able to seen it now with a toothpick and close it with chilli powder.Now i really cant see it wink.png

So dont toss that theory so fast wink.png

I removed these from my arms and legs using a pair of flat fingernail clippers. Neosporin. No scars



#4738 golfpanther

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Posted 16 September 2013 - 01:07 PM

Alright, so they've definitely started testing on pigs. Check this out:

 

https://aiche.confex...aper337043.html

 

And we now have a date that will reveal more information (one would think anyway) about how things are going; November 6th.

 

It's only going to be an 18 minute presentation (per the itinerary for the conference) so it might not be thorough but I'm sure we'll learn something about how it's progressing. 



#4739 AghhNe

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Posted 16 September 2013 - 01:50 PM

Alright, so they've definitely started testing on pigs. Check this out:

 

https://aiche.confex...aper337043.html

 

And we now have a date that will reveal more information (one would think anyway) about how things are going; November 6th.

 

It's only going to be an 18 minute presentation (per the itinerary for the conference) so it might not be thorough but I'm sure we'll learn something about how it's progressing. 


thank you for the updates.
I really hope this will be the answer to the mystery of scars.



#4740 golfpanther

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Posted 16 September 2013 - 05:16 PM

Alright, so they've definitely started testing on pigs. Check this out:

 

https://aiche.confex...aper337043.html

 

And we now have a date that will reveal more information (one would think anyway) about how things are going; November 6th.

 

It's only going to be an 18 minute presentation (per the itinerary for the conference) so it might not be thorough but I'm sure we'll learn something about how it's progressing. 


thank you for the updates.
I really hope this will be the answer to the mystery of scars.

 

No worries! It's nice to have a date too. I feel like I can stop bugging the researchers at least until that conference takes place.






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