Jump to content

Photo

Scarless Healing


5701 replies to this topic

#4701 no_hope

no_hope

    Member

  • Veteran Members
  • Posts & Likes
    Posts: 728
    Gallery Images: 1
    Likes: 56
About Me
  • Joined: 12-May 11

Posted 15 August 2013 - 07:02 PM

 

 

Forget hydrogel 3d printed skin graft is coming. The clinical trials have already started I think. There is a company in the europe named skinprint.

 

http://www.3dprinter...lls-burn-wounds

 

http://www.3dprinter...an-skin-horizon

 

http://www.betakit.c...-printing-skin/

 

Again.I have yet to see one single person in a forum be benefited by these so called revolutionary methods.

 

Forget about anything you read.

 

panos, I try to be respectful of your posts but this is just completely illogical. Any new and potentially groundbreaking pursuit in any field is going to take years to implement. Before its "discovery" in 1928, penicillin's potential uses in medicine was documented in 1877. Should people have just ignored it and forgotten what they'd read?

 

I get that you want things fast—faster than is possible—but using the fact that research takes time as an impetus to discount it entirely is just bogus. The dextran hydrogel or skin printing might not end up being the answer for scars, but that doesn't mean the entire study of regenerative medicine is meaningless.

 

BTW, a little girl did have a windpipe made from fibers and stem cells implanted successfully into her throat. She went on to die from lung complications but at the time of her death the new windpipe was working beautifully.

 

 

Forget hydrogel 3d printed skin graft is coming. The clinical trials have already started I think. There is a company in the europe named skinprint.

 

http://www.3dprinter...lls-burn-wounds

 

http://www.3dprinter...an-skin-horizon

 

http://www.betakit.c...-printing-skin/

 

Again.I have yet to see one single person in a forum be benefited by these so called revolutionary methods.

 

Forget about anything you read.

 

panos, I try to be respectful of your posts but this is just completely illogical. Any new and potentially groundbreaking pursuit in any field is going to take years to implement. Before its "discovery" in 1928, penicillin's potential uses in medicine was documented in 1877. Should people have just ignored it and forgotten what they'd read?

 

I get that you want things fast—faster than is possible—but using the fact that research takes time as an impetus to discount it entirely is just bogus. The dextran hydrogel or skin printing might not end up being the answer for scars, but that doesn't mean the entire study of regenerative medicine is meaningless.

 

BTW, a little girl did have a windpipe made from fibers and stem cells implanted successfully into her throat. She went on to die from lung complications but at the time of her death the new windpipe was working beautifully.

 

Yeah hopefully these revolutionary treatments will be indeed revolutionary.

 

Till then i know that the only cure to everything is red blood cells.Only the blood does the real job.

 

the cure to everything as in.....?



Forget hydrogel 3d printed skin graft is coming. The clinical trials have already started I think. There is a company in the europe named skinprint.

 

http://www.3dprinter...lls-burn-wounds

 

http://www.3dprinter...an-skin-horizon

 

http://www.betakit.c...-printing-skin/

wow the third article is groundbreaking. the fact that the research is being done in the city live in is extremely over whealming!



#4702 Binga

Binga

    Veteran Member

  • Veteran Members
  • Posts & Likes
    Posts: 1,046
    Likes: 92
About Me
  • Gender:Male
  • Location:New York
  • Joined: 05-June 12

Posted 15 August 2013 - 07:19 PM

Forget hydrogel 3d printed skin graft is coming. The clinical trials have already started I think. There is a company in the europe named skinprint.

 

http://www.3dprinter...lls-burn-wounds

 

http://www.3dprinter...an-skin-horizon

 

http://www.betakit.c...-printing-skin/

 

Again.I have yet to see one single person in a forum be benefited by these so called revolutionary methods.

 

Forget about anything you read.

There are no revolutionary treatment for scars. Everything out there only gives u improvement.



Forget hydrogel 3d printed skin graft is coming. The clinical trials have already started I think. There is a company in the europe named skinprint.

 

http://www.3dprinter...lls-burn-wounds

 

http://www.3dprinter...an-skin-horizon

 

http://www.betakit.c...-printing-skin/

 

Yeah, they're doing something similar at Wake Forest University with Dr. Anthony Atala's team. However, it's important to note that this method would likely still lead to scarring around the edges of where the transplant took place. Atala's team was working on printing the skin directly onto the patient. But in both cases, these treatments are probably years away—much longer than the 5 years van Hengel was quoted as saying—because the safety standards and testing phase would be much more rigorous since it wouldn't be defined as a medical device (at least not in the USA).

 

I'd also be curious to see if it could print all the skin's appendages (hair, sebaceous and sweat glands etc.) or if it would be void of those features like current skin grafts. Still, this is another promising line of research, no doubt about that. I'm still more interested in the dextran hydrogel for now because it has pre-clinical proof of concept and could get to the market much faster.

 

Yeah you are probably right. Once it works for burn patients only then we can see cosmetic applications. I am also interested in ATP (adenosine triphospate) . There is already a cream called CULT 51 in the UK  for anti ageing.

 

http://dermatologyti...eds-light-scars



#4703 Maldition

Maldition

    Member

  • Banned
  • Posts & Likes
    Posts: 804
    Likes: 17
About Me
  • Gender:Male
  • Joined: 03-October 09

Posted 17 August 2013 - 03:33 AM

it's hydrogel dextran really revolutionary? nobody tolk no more about this, nothing comment non about pigs tests.


Scars are like diseases, destroy the lives of people...

#4704 Vladislav

Vladislav

    Member

  • Veteran Members
  • Posts & Likes
    Posts: 230
    Gallery Images: 3
    Likes: 36
About Me
  • Gender:Male
  • Location:Novi Sad
  • Interests:regenerative medicine
  • Joined: 14-April 12

Posted 18 August 2013 - 07:45 AM

3D Bioprinting:
 


#4705 no_hope

no_hope

    Member

  • Veteran Members
  • Posts & Likes
    Posts: 728
    Gallery Images: 1
    Likes: 56
About Me
  • Joined: 12-May 11

Posted 18 August 2013 - 07:23 PM

the whole face printing seems so far from now. -__-



#4706 golfpanther

golfpanther

    Member

  • Veteran Members
  • Posts & Likes
    Posts: 167
    Likes: 64
About Me
  • Gender:Male
  • Joined: 04-May 11

Posted 19 August 2013 - 02:43 PM

it's hydrogel dextran really revolutionary? nobody tolk no more about this, nothing comment non about pigs tests.

 

Actually, several very recent posts have discussed it. They're conducting the test with larger animals right now. When I talked to Dr. Sun he said he didn't expect them to publish those results, but he doesn't work at JHU so he could be wrong. A few pages ago I posted a link to an article that quoted Gerecht as saying that they hoped it would be being used on humans in 18-24 months.



the whole face printing seems so far from now. -__-

 

Yeah, most of the stuff in the video is a good bit away. But who knows, we could be wrong about that.



#4707 Lapis lazuli

Lapis lazuli

    Veteran Member

  • Veteran Members
  • Posts & Likes
    Posts: 1,740
    Likes: 185
About Me
  • Gender:Male
  • Location:The Netherlands
  • Joined: 25-February 08

Posted 19 August 2013 - 03:52 PM

it's hydrogel dextran really revolutionary? nobody tolk no more about this, nothing comment non about pigs tests.

 

Actually, several very recent posts have discussed it. They're conducting the test with larger animals right now. When I talked to Dr. Sun he said he didn't expect them to publish those results, but he doesn't work at JHU so he could be wrong.

 

Hi golfpanther.

 

Why do you think it is that they won't publish the results of the tests on larger animals in the case Sun is right? Just wondering.


Edited by Lapis lazuli, 19 August 2013 - 03:53 PM.


#4708 golfpanther

golfpanther

    Member

  • Veteran Members
  • Posts & Likes
    Posts: 167
    Likes: 64
About Me
  • Gender:Male
  • Joined: 04-May 11

Posted 19 August 2013 - 04:05 PM

 

it's hydrogel dextran really revolutionary? nobody tolk no more about this, nothing comment non about pigs tests.

 

Actually, several very recent posts have discussed it. They're conducting the test with larger animals right now. When I talked to Dr. Sun he said he didn't expect them to publish those results, but he doesn't work at JHU so he could be wrong.

 

Hi golfpanther.

 

Why do you think it is that they won't publish the results of the tests on larger animals in the case Sun is right? Just wondering.

 

I'm not really sure. I went back and looked at the e-mail he sent me and this is what he said, verbatim:

 

I am not sure if there will be papers out from jhu on this project. You may try to talk to dr Harmon , dr Gerecht or even John fini.

 

So really, he's just speculating and not sure because he's no longer there. I've reached out to Harmon, Gerecht and Fini but haven't heard back from any of them as of yet. chuckstonchew was talking to Dr. Harmon a while ago though and the Facebook moderator has talked to Fini.

 

BTW, Sun is an extremely nice and responsive guy. I wish more people involved in this field were as forthcoming as him. He did say that he's continuing his work into scar free healing at Columbia University—where he now works.



#4709 Maldition

Maldition

    Member

  • Banned
  • Posts & Likes
    Posts: 804
    Likes: 17
About Me
  • Gender:Male
  • Joined: 03-October 09

Posted 20 August 2013 - 07:29 AM

rocky balboa boxing is back


Edited by Maldition, 23 August 2013 - 03:44 AM.

Scars are like diseases, destroy the lives of people...

#4710 Lapis lazuli

Lapis lazuli

    Veteran Member

  • Veteran Members
  • Posts & Likes
    Posts: 1,740
    Likes: 185
About Me
  • Gender:Male
  • Location:The Netherlands
  • Joined: 25-February 08

Posted 21 August 2013 - 04:33 AM

 

 

it's hydrogel dextran really revolutionary? nobody tolk no more about this, nothing comment non about pigs tests.

 

Actually, several very recent posts have discussed it. They're conducting the test with larger animals right now. When I talked to Dr. Sun he said he didn't expect them to publish those results, but he doesn't work at JHU so he could be wrong.

 

Hi golfpanther.

 

Why do you think it is that they won't publish the results of the tests on larger animals in the case Sun is right? Just wondering.

 

I'm not really sure. I went back and looked at the e-mail he sent me and this is what he said, verbatim:

 

I am not sure if there will be papers out from jhu on this project. You may try to talk to dr Harmon , dr Gerecht or even John fini.

 

So really, he's just speculating and not sure because he's no longer there. I've reached out to Harmon, Gerecht and Fini but haven't heard back from any of them as of yet. chuckstonchew was talking to Dr. Harmon a while ago though and the Facebook moderator has talked to Fini.

 

BTW, Sun is an extremely nice and responsive guy. I wish more people involved in this field were as forthcoming as him. He did say that he's continuing his work into scar free healing at Columbia University—where he now works.

 

It seems kind of strange to me if they didn't publish the results. Publishing them only seems to be in everyone's interest? But hey I'm just a layman.

 

I should check out Columbia university's website to see what they're working on.



#4711 golfpanther

golfpanther

    Member

  • Veteran Members
  • Posts & Likes
    Posts: 167
    Likes: 64
About Me
  • Gender:Male
  • Joined: 04-May 11

Posted 21 August 2013 - 11:52 AM

 

 

 

it's hydrogel dextran really revolutionary? nobody tolk no more about this, nothing comment non about pigs tests.

 

Actually, several very recent posts have discussed it. They're conducting the test with larger animals right now. When I talked to Dr. Sun he said he didn't expect them to publish those results, but he doesn't work at JHU so he could be wrong.

 

Hi golfpanther.

 

Why do you think it is that they won't publish the results of the tests on larger animals in the case Sun is right? Just wondering.

 

I'm not really sure. I went back and looked at the e-mail he sent me and this is what he said, verbatim:

 

I am not sure if there will be papers out from jhu on this project. You may try to talk to dr Harmon , dr Gerecht or even John fini.

 

So really, he's just speculating and not sure because he's no longer there. I've reached out to Harmon, Gerecht and Fini but haven't heard back from any of them as of yet. chuckstonchew was talking to Dr. Harmon a while ago though and the Facebook moderator has talked to Fini.

 

BTW, Sun is an extremely nice and responsive guy. I wish more people involved in this field were as forthcoming as him. He did say that he's continuing his work into scar free healing at Columbia University—where he now works.

 

It seems kind of strange to me if they didn't publish the results. Publishing them only seems to be in everyone's interest? But hey I'm just a layman.

 

I should check out Columbia university's website to see what they're working on.

 

Pretty sure he's working on the exact same kind of thing; hydrogels to promote scar free healing. He said as much in his e-mail and his little bio (which for some reason is listed on the dentistry page along with a bunch of other people that don't seem to belong there) indicates that as well:

 

 

Sun, Guoming Ph.D., gsun@columbia.edu
Assoc Research Scientist
Dr. Guoming Sun received his M.S. and Ph.D. degrees from Cornell University. His research interests are primarily directed toward the development of novel and translational biomaterials for tissue engineering and regenerative medicine. His current research focuses on wound healing and scarless skin regeneration.
 
As for why they might not publish the results, your guess is as good as mine. The only thing I can think of is that it might be considered an intermediate step to provide more pre-clinical proof. But that's really just a guess. And again, Sun might not be right about that.


#4712 Maldition

Maldition

    Member

  • Banned
  • Posts & Likes
    Posts: 804
    Likes: 17
About Me
  • Gender:Male
  • Joined: 03-October 09

Posted 22 August 2013 - 02:32 PM

Call columbia and the other drs keep pushing people


Edited by Maldition, 23 August 2013 - 03:48 AM.

Scars are like diseases, destroy the lives of people...

#4713 golfpanther

golfpanther

    Member

  • Veteran Members
  • Posts & Likes
    Posts: 167
    Likes: 64
About Me
  • Gender:Male
  • Joined: 04-May 11

Posted 26 August 2013 - 01:35 PM

I'll do what I can. I'm going to follow up with them in September (trials in larger mammals were supposed to be this summer). Hopefully, there are positive things to report.


Edited by golfpanther, 27 August 2013 - 02:59 PM.


#4714 REPOLA

REPOLA

    Junior Member

  • Members
  • Posts & Likes
    Posts: 53
    Likes: 9
About Me
  • Joined: 30-August 13

Posted 30 August 2013 - 04:29 AM

Thank you guys, please keep us in informed about the progress.



#4715 srammer

srammer

    New Member

  • Members
  • Posts & Likes
    Posts: 4
    Likes: 0
About Me
  • Joined: 02-September 13

Posted 04 September 2013 - 12:09 PM

Please keep us informed !! I was this thread alive and popin!! 



#4716 Maldition

Maldition

    Member

  • Banned
  • Posts & Likes
    Posts: 804
    Likes: 17
About Me
  • Gender:Male
  • Joined: 03-October 09

Posted 05 September 2013 - 02:48 PM

I'm just falling again ... be with this kind of problem is very screwed. I try to be positive but it's really really fucked up we were born into a caveman stage in regard to medicine. the genetic cures will answer within far future

 

the medical doctors say  ''in medicine nothing is deterministic'' hydrogel that means a lottery would work and if it works will not in all cases, there are people with problems of disease and unknown things that probably will make it possible for hydrogel not work .

 

sorry for the bad vibe but you be the only ones who can understand this feeling but not like reading some this.

 

i have to say

 

I'm sure many here are in psychiatric treatment with anxiety antidepressant and much more medication because it produces them


Edited by Maldition, 05 September 2013 - 02:49 PM.

Scars are like diseases, destroy the lives of people...

#4717 Vladislav

Vladislav

    Member

  • Veteran Members
  • Posts & Likes
    Posts: 230
    Gallery Images: 3
    Likes: 36
About Me
  • Gender:Male
  • Location:Novi Sad
  • Interests:regenerative medicine
  • Joined: 14-April 12

Posted 05 September 2013 - 04:52 PM

I can see that you suffer a lot, I recommend you to read the book 'Physics of the Future' (author: Michio Kaku), an entire chapter in that book is devoted to the future of medicine and the whole book content is based on Kaku's interviews with 300 of the world's leading scientists (such as for example Anthony Atala, so that means it is not some SF or pseudo-scientific bullshit), I believe it has been translated into Spanish and you can find it in any bookstore, so I agree with you that genomic medicine will not bear any fruit in the near future, it is over-hyped, however I believe that regenerative medicine is more promising than genomic medicine and it will start bearing fruit in the not too distant future and that the promise of regenerative medicine goes far beyond scarless skin wound healing. And I generally agree with you that if we talk about technology we can conclude that we live in a 'caveman era' (just a few facts: 85% of the produced global energy comes from fossil fuels, that is from dead plants, we still have no cure for cancer, heart disease, Alzheimer's, multiple sclerosis,... instead of that we have alternative medicine and homeopathy, gadgets, smartphones, tablets, broadband Internet, GPS, Web 2.0, trash pop culture, MTV, Gangdam Style, Lady Gaga, consumerism, advertising, brands, unhealthy fast food, skyscrapers, multinational companies,...), generally speaking our post-industrial society in which we live is archaic, human relationships and values in the western society are such that somehow everything always comes down to the question who is more physically attractive, who has more successful career, etc. So in that book you can find a lot of info about different experimental technologies that are currently under research and their prospects, the most interesting chapter is about medicine, but other chapters are interesting too, maybe you will feel better if you read it. rolleyes.gif


Edited by Vladislav, 05 September 2013 - 04:55 PM.


#4718 Maldition

Maldition

    Member

  • Banned
  • Posts & Likes
    Posts: 804
    Likes: 17
About Me
  • Gender:Male
  • Joined: 03-October 09

Posted 05 September 2013 - 05:15 PM

Scars are like diseases destroy the lives of people


Edited by Maldition, 06 September 2013 - 04:14 PM.

Scars are like diseases, destroy the lives of people...

#4719 2001

2001

    Junior Member

  • Members
  • Posts & Likes
    Posts: 73
    Likes: 7
About Me
  • Joined: 02-October 10

Posted 09 September 2013 - 09:46 AM

http://www.google.co...tents/US3622668

 

This was posted here before many years back. All of the drugs used to make the it are easy to find and buy on the net. I can't seem to understand the mixing ratio, and there is one other issue. The "88% phenol" at it's full 88% concentration can kill you in 90 seconds if you apply it to a 10inch x 10 inch area of skin. I'm hoping someone around here can read through this and explain the mixing ratios more clearly.



It has been found that when appropriate portions of Vitamin A" Vitamin D," olive oil, and a suitable aromatic hydroxyl derivative (PHENOL) are mixed together to form a homogeneous lotion, that the lotion compounded therefrom will provide the following synergistic effect. First, the skin laceration is disinfected, Second, regenerative healing of the endodermal layer is accelerated while the healing process of the epidermal layer is temporarily suspended. Third, the keratoid or comified tissue, but not the soft nonnal tissue, of the endodermal layer is dissolved or otherwise prevented from accumulating. The synergistic result of certain homogeneous mixtures of these four ingredients is to promote a rapid healing of a skin laceration, commencing at the cross-sectional periphery thereof, so as to provide scar-free characteristics in the ultimately healed skin laceration.



#4720 Vladislav

Vladislav

    Member

  • Veteran Members
  • Posts & Likes
    Posts: 230
    Gallery Images: 3
    Likes: 36
About Me
  • Gender:Male
  • Location:Novi Sad
  • Interests:regenerative medicine
  • Joined: 14-April 12

Posted 09 September 2013 - 01:51 PM

Here on page 22 and 23 you can see the result of phase 1 clinical trials of the drug RXI-109:
This drug will probably be the next Juvista, I used to think this drug is something because it is based on RNAi (which is discovered by Dr. Graig Mello for what he was awarded with the Nobel Prize in 2006 and he is the founder of the company that is developing that drug) and because it is often mentioned (and overhyped) by Ray Kurzweil, so that's why I now understand that biotechnology/genomic medicine will stay primitive for a long time to come, it is simply the wrong approach, Seabs is right when he says that the mechanism of the scar formation is too complex for us to understand it in details, so regenerative medicine is the only approach that can result in scar free healing in the foreseeable future.

Edited by Vladislav, 09 September 2013 - 04:30 PM.



1 user(s) are reading this topic

0 members, 0 guests, 0 anonymous users


    Google (1)