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Scarless Healing


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#4521 Maldition

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Posted 20 May 2013 - 09:04 PM

This year test on animals, next year hydrogel is on sale in veterinary? you must asked that to this doctor.


Scars are like diseases, destroy the lives of people...

#4522 golfpanther

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Posted 20 May 2013 - 09:16 PM

I'll trying asking John Fini and Dr. Harmon again. Dr. Sun probably won't be able to update regularly because he's not there anymore and he'd be getting everything second hand. I don't really want to make him do that and I'd rather get it straight from the source anyway.

 

Dr. Sun didn't mention it moving into the veterinary world following tests on larger animals. He said (keep in mind he doesn't work there anymore) that if it worked on larger animals it would be moved to clinical testing soon after that. It's entirely possible that it would move into veterinary clinics but he didn't say anything about that.

 

I'd be curious to know if anyone has had success reaching out to Dr. Harmon. I sent him one last week and have not heard back. I know chuckstonchew used to talk to him but had said the responses ceased some time ago.



#4523 golfpanther

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Posted 20 May 2013 - 09:42 PM

Not about the hydrogel but interesting:

 

http://bodyodd.nbcne...t-revealed?lite

 

and a better link:

 

http://www.pnas.org/...60-06e9180b24dc


Edited by golfpanther, 20 May 2013 - 09:45 PM.


#4524 Maldition

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Posted 21 May 2013 - 01:13 AM

no one can explain how hydrogel works, this is my,fear.

 

anyway, this year if they test on animals, we have the pics of that test? i mean, if this is serious thing, they must upload the pictures of the test in animals.

 

All is very nasty to me.


Scars are like diseases, destroy the lives of people...

#4525 seabs135

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Posted 21 May 2013 - 06:51 AM

Maldition, it is really hard talking to you because of your English. But I'll attempt to answer you here.

In the paper they have explained how it works with detail. 

But as with almost everything discovered you don't need to know how it exactly works under the microscope, the 'scientific result' is what is important and that is the standard that has always been important.

Note, If you prove a result following a scientific method, then no one necessarily has to explain in more detail, how it works (It just works when you follow a scientific method). If that need for extreme detail/over result, was how it worked (say you needed to understand every moving adjusting matrix under a microscope alongside or over a result), then believe it or not you would not be sitting there with your computer typing away. You'd be stuck in the dark ages with people wondering how to explain how the apple falls to the ground, with extensive detail. You can keep magnifying or adding detail after detail, after detail forever on anything by increasing the focus. There comes a point, however, when enough detail is noted; and any detail should never shade a result.  What you have to worry about in life is people who talk detailed micro theory over scientific results, as in pseudo science.

 

 

no one can explain how hydrogel works, this is my,fear.


Edited by seabs135, 21 May 2013 - 08:19 AM.


#4526 panos

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Posted 21 May 2013 - 07:04 AM

Not about the hydrogel but interesting:

 

http://bodyodd.nbcne...t-revealed?lite

 

and a better link:

 

http://www.pnas.org/...60-06e9180b24dc

 

check Robert'O Becker's book ,''The body electric''...

 

It seems that everything begins from the electric current from th nervous system towards the injury.

 

Most of the limb regeneration studies today are too specific and complicated .This way ,we cant get the general idea.


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#4527 golfpanther

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Posted 21 May 2013 - 01:21 PM

no one can explain how hydrogel works, this is my,fear.

 

anyway, this year if they test on animals, we have the pics of that test? i mean, if this is serious thing, they must upload the pictures of the test in animals.

 

All is very nasty to me.

 

I asked Dr. Sun about whether or not anything would be published on the tests they currently have planned for larger animals and he said he didn't think so. Keep in mind he doesn't work there anymore so that may not be the case but also keep in mind that if it works on say, pigs, then they'd probably just rush it into clinical trails on humans given that it's just a device.

 

He did say I could try Fini, Gerecht or Harmon for more info so maybe they would release something directly once they've performed the tests.



Not about the hydrogel but interesting:

 

http://bodyodd.nbcne...t-revealed?lite

 

and a better link:

 

http://www.pnas.org/...60-06e9180b24dc

 

check Robert'O Becker's book ,''The body electric''...

 

It seems that everything begins from the electric current from th nervous system towards the injury.

 

Most of the limb regeneration studies today are too specific and complicated .This way ,we cant get the general idea.

 

Definitely will check out the book, thanks! I tend to agree about everything being too focused on one discipline in regards to limb regeneration and regeneration in general. It would be awesome if a more interdisciplinary approach was implemented; things would get solved much quicker I would imagine.

 

Alas, in my experience contacting researchers and asking them their thoughts on different approaches they are all too often myopic in their approach and haven't even heard of the things I've brought to their attention. I guess that's how it goes. If you alone find all the cures, then you alone get all the glory. I'm probably being too hard on them though. I'm sure there's more cross-talk than I'm aware of.



#4528 trendycat

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Posted 22 May 2013 - 12:06 AM

Recent developments in limb regeneration and scar-less healing:

http://www.abc.net.a...tm#.UZw067VzLzw

 

Here's hoping for a cure within 20 years.



#4529 panos

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Posted 22 May 2013 - 10:28 AM

Info from JHU from the fb page.

 

"The dextran hydrogel for wound healing is to enter large animal trials this summer. If the trials are successful – we will be entering the veterinary market within a year after that. Human trials will start shortly after we have entered the veterinary market."


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#4530 skinregenerator

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Posted 22 May 2013 - 12:30 PM

nothing is gonna happen!



#4531 panos

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Posted 22 May 2013 - 02:28 PM

Seems to me like they are rushing to prove that hydrogel is useless .


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#4532 Maldition

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Posted 22 May 2013 - 11:45 PM

Seems to me like they are rushing to prove that hydrogel is useless .

 

 

 

You're right, we will never heal our scars, we're screwed.


Scars are like diseases, destroy the lives of people...

#4533 Lapis lazuli

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Posted 23 May 2013 - 10:50 AM

He says the work has implications not just for entire limb regrowth, but for "smaller, less ambitious" goals such as scar-less healing.

 

Finding a way to prevent scarring isn't exactly moderately ambitious plus aren't the two connected? If you can't stop scarring you won't be able to regenerate limbs.

 

Anyway, it's a nice article. Thanks for sharing, trendycat. The axolotyl looked very funny too, by the way.

 

Recent developments in limb regeneration and scar-less healing:

http://www.abc.net.a...tm#.UZw067VzLzw

 

Here's hoping for a cure within 20 years.


Edited by Lapis lazuli, 23 May 2013 - 10:51 AM.


#4534 panos

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Posted 23 May 2013 - 11:11 AM

Speaking about scarring and limb regeneration ,Methyl Rose used a hypertonic NaCl solution

on stumps of frog's amputated limbs.

The scarring on the stumps began to fade and more regeneration achieved!!!

 

How no one continue those guys experiments...

This is why i believe this specific limb regeneration  studies are crap,since the people

behind them are just dudes that chase a carreer .

Its really difficult to go the independent way 

 

And hell yeah,if this solution could fade scarrig and produce partial regeneration

in frogs(animals that lack the ability to regenerate) then why it wouldnt fade scarring

in humans?

Oh l forgot,its just a Nacl solution.No one is going to run studies on a Nacl

to prove its effectiveness.


Edited by panos, 23 May 2013 - 11:14 AM.

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#4535 Vladislav

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Posted 24 May 2013 - 09:15 PM

human embryonic stem cells have finally been made using cloning techniques
http://www.nature.co...cloning-1.12983



#4536 Maldition

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Posted 24 May 2013 - 11:30 PM

yes, and we need '20 years', '40 years', '50 years' to see a fine result.


Scars are like diseases, destroy the lives of people...

#4537 Vladislav

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Posted 25 May 2013 - 01:51 AM

I would say 5 to 20 years, I mean regeneration of existing organs shouldn't be such a big deal, the real challenge for regenerative medicine and tissue engineering is to create new lab grown organs, especially complex ones such as the kidneys. And without some non-controversial source of embryonic stem cells forget about all of it.
http://en.wikipedia....ell_controversy



#4538 panos

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Posted 25 May 2013 - 03:34 AM

When you hear things like cure withing 5-20 years= scam


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#4539 seabs135

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Posted 25 May 2013 - 06:40 AM

I would say stick to the facts, a lesser digestible material digests slower and scars, a faster digestible material digests fast and regenerates.



#4540 Vladislav

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Posted 26 May 2013 - 04:27 AM

Well OK, I just want to say that the number of publications related to regenerative medicine and stem cells research doubles approximately every 5 years, it is a clear trend, it is something like 'Moore's law for biomedicine' so to speak, so that means in 5 years there will be 2 times more publications than today, in 10 years 4 times more, in 15 years 8 times more, in 20 years 16 times more,... and so on, and now the whole world is involved in the research related to tissue engineering and stem cells - developed counties (USA, EU, Japan, Canada) and developing countries (BRIC) even small countries like Serbia, our government has decided to put 400 million euros in the scientific infrastructure and according to the new 'Stategy of scientific and technological development' the goal is to raise expednitures for science to 1% of GDP by 2015 and I can see that the first among seven listed priorities is biomedicine, so they decided to build the 'Center for stem cells research', it should be the most modern such facility in Southeastern Europe, so they said scientists will there do resarch with induced pluripotent stem cells, umbilical cord blood stem cells and with some new scaffolds, lab-grown organs, on new possible treatments for spinal cord injuries, neurodegenerative diseases and so on.
http://www.ekapija.c...ung-researchers
So I guess there are (or there will be) dozens of such centers in developing countries around the world, which is good.






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