Something like the below do wentworth? Or is it to detailed?
When will this be available?
We can’t say. This is down to John Hopkins and their lawyers. There is however an article in late December 2011 that states it could be available within a few years as this is a device. There is information on the internet of devices being approved after months. So we guess as soon as this is funded this will be approved within months???
BTW this page was created to hopefully create social awareness and maybe push funding along consequentially. Will this pushing along work? We do not know but we think the getting information on here is proactive, benevolent and can only help; so who knows. We want this information out there so this can be funded sooner. We hope you take notice of the page.
What is this?
This is a degradable scaffold. This is a degradable hydrogel that degrades rapidly when inserted in mammal wounds.
Degradable scaffolds like the comparison control in the test, equally treated have been tested thousands of time on most mammals, their properties and behaviours are well established.
This particular scaffold is a rapidly degrading dextran hydrogel in a 80:20 ratio. It is cited in the paper as a dextran-allyl isocyanate-ethylamine (Dex-AE)/polyethylene glycol diacrylate (PEGDA) in ratio of 80/20, with a loose interior architecture.
And this ratio of scaffold was chosen over the lower ratio 60:40 dextran hydrogel because of the better cell infiltration, lower crosslinking density properties of the 80/20. Cited in the paper.
This is a degradable scaffold that achieved complete regeneration of tissue, when tested against an established reliable standardised control scaffold. The control scaffold this was tested against is a state of the art scaffold called Integra which has been used thousands of times on all mammal wounds. This control scaffold is currently used in many hospitals in standardised burn treatments. In the test the state of the art control behaved typically and regenerated incompletely. Cited in the paper.
The dextran also degrades rapidly (7 to 10 days), is easily ate by the neutrophils, is very soft and also has a smaller porosity than the control, enabling rapid neutrophil and cell infiltration. Cited in the paper.
What has it achieved? Or what makes it stand out?
The rapidly degrading dextran hydrogel was inserted into a fresh wound from a 3rd degree burn, the wound completely regenerated with appendages, and the wound treated by the control behaved typically. Scar free healing, rapid neovascularization and complete skin regeneration was achieved by dextran hydrogel treated wounds.
Neovascularization and angiogenesis determine what the outcome will be in wounds and deep burn injuries. Tredget. New blood vessels participate by providing nutrition and oxygen to growing tissues. Li.
It is known first degree burns heal with no scarring and deep second degree burns heal with scarring and are slow healing, they take more than a month to heal.
It is known that generally if a wound takes over 3 weeks to re-epithelize the end point will result in scarring. Also this knowledge with regards to healing time for scarring has been shown scientifically, Cubison et al.
It is also established that when a scaffold degrades via neutrophils cells are created and when a scaffold does not degrade scarring occurs. Khetan S, Kloxin AM et al
It is known skin appendages do not grow is scar tissue.
Further facts from the paper:
A 3rd degree burn was cut out completely with a full thickness excision; leaving a rim of burned tissue. This standard protocol was following the standard treatment in hospitals with regards to 3rd degree burns using the control scaffold. Following this standard protocol enabled a comparison with the established control.
The wounds were checked at various intervals over 5 weeks to compare the dextran and the controls:
At 5 and 7 days the dextran hydrogel treated wounds vascular networks had expanded and developed even more. The dextran hydrogel had rapid neovascularisation and angiogenesis when compared to the controls.
The dextran hydrogel degraded rapidly in 7 to 10 days and cells were created. The scaffold control did not degrade in that time. The neutrophils where stuck in the peripheral of the control scaffold after day 7.
When the wounds were checked at day 14 the dextran hydrogel had demonstrated epithelial repair. Way before day 21. The scaffold control had not as typical.
When the wounds were checked at day 21, the dextran treated wounds had complete regeneration with appendages. The control behaved typically with incomplete regeneration.
After 5 weeks the wound areas were checked one last time, the hydrogel treated wounds had complete regeneration with appendages and the skin width was found to be normal.
The information for these three above FAQs is creative commons, you are free to share. This information is referenced to the best of human ability. Errors may be in this information, please check the references used.
What are the recuring questions you get?
i think its a good idea, does anyone want to do it?
I pointed out via pm that the facebook might need a faq, if the page has faqs.
Seabs is pointing out the possibility to make a FAQ ,so people can understand what is this better.
We need to change the page a bit.What do you think.
lol! as you can see by the facebook page i dont get any. You would have to create them out of questions we have all asked and think others might or would like to know
Edited by seabs135, 30 April 2013 - 04:47 AM.