no VEGF added? from the patent http://patentscope.w...&tab=PCT Biblio
 In exemplary embodiments, the delivery of VEGF promotes tissue ingrowth and functional vascularization. In the examples that follow, five- week-long study first revealed significantly more tissue ingrowth, primarily by macrophages, into the VEGF-encapsulated hydrogel than into blank hydrogel. This result may suggest that VEGF attracts circulating cells into the hydrogel, thus promoting tissue penetration. Phelps et al. also found that matrices lacking VEGF showed less tissue invasion than VEGF-incorporating matrices (Phelps et al., Proc Natl Acad Sci U S A, vol. 107, no. 8, pp. 3323-8, 2010). The tissue ingrowth might further expedite scaffold biodegradation, which in return could facilitate further ingrowth. This result was further confirmed by a three-week-long multiple GF delivery study; without the VEGF encapsulation, in which neither the blank hydrogel nor the hydrogel loaded with SDF-1 and IGF showed any significant tissue ingrowth. Although Cohen et al. (Dvir et al., Proc Natl Acad Sci U S A vol. 106, no. 35, pp. 14990-5, 2009) demonstrated that a scaffold encapsulated with SDF-1 and IGF promoted prevascularization when implanted onto a rat omentum, these hydrogels revealed neither significant tissue ingrowth nor vascular structures with the encapsulation of SDF-1 and IGF. Overall, these results suggest that VEGF delivery is required to initiate sufficient tissue ingrowth, which eventually leads to functional vascular development within the hydrogel implants.
That is from a patent, and patents are full of claims and abstract claims, some tested, some theorised, the claims in a patent is all about trying to protect property.
The paper on the other hand has a 'factual basis,' It is not abstract. The paper observes something tested in method, using a control. And can be tested again. It states nothing was added. And it states it got rapid neovascularization and angiogenesis in 7 days. VEGF is 'theorised' to be involved in angiogenesis and neovascularization. VEGF and angiogenisis was stimulated by the digestion of the hydrogel, proven by the rapid neovascularization and the fact that the hydrogel had 714 blood vessels per mm squared and the control had 182 vessels per mm squared. The whole paper is about neovascularization and regeneration.
Edited by seabs135, 28 February 2013 - 03:29 PM.