From my logic, to build a tissue you’d need collagen and cell proliferation, otherwise you’d have a gaping hole in the tissue.
They said that roughly, I was paraphrasing on memory heh heh... It should be within a 2.5 years though IMO saying it is a device and that article was a couple of month ago. It doesn't need much approval.
Let's hope they achieve the desired results in tests in humans. *crosses fingers*
Btw, Gerecht is Dutch for dish. A dish as in a plate of food. How do you non-Dutch guys pronounce Gerecht? Guhrect? In Dutch it sounds sort of like this: ggguhrrregggt.
Sun and Gerecht stated that the hydrogel will be easily mass produced and as it is made of non biological components, it will be approved inside three years
U sure? Did they say that in the original article you posted?
Here's what she said in the article:
"It could be approved for clinical use after just a few years of testing."
That doesn't sound like it's going to take forever if succesful to me. Now let's just hope it works! If it does, that would mean this hydrogel is history in the making though. I would be a bit surprised if it does end up being a genuine way to prevent scarring but hey you never know.
BTW if it can reepithalize a full thickness wound in a 21 day time frame, then that is scar free healing. Scars form way over 21 days. Which was cited in a post above.
BTW regarding Gerecht's name, it sounds German to me 'to be fair.' And I dont know how you'd pronounce it.
Seabs answer this:
then the hydrogel does is prevent cell proliferation? or what it really does is accelerate the proliferation?
if making hydrogel is to inhibit cell proliferation, then what you said to stop fibrosis using decorin is correct.
but what makes hydrogel is to accelerate the proliferation of cells, then the theory of stopping fibrosis for not made scar, is incorrect.
so... what's the answer, inhibit cell proliferation or accelerate it? What makes hydrogel?
However the problem is when you build to much of the collagen. E.g. when fibroblasts continue to proliferate and lay down collagen over many months, which builds a lumpy white scar tissue.
Regarding the the 21days time frame, if anything reepithilizes tissue inside 21 days, then by logical default it has to stop continuous ‘fibroblast proliferation’ which is how scarring is produced. The end of reepithelization means the key structural remodelling is finished. Also on the same token, hair follicles can then grow in the tissue that means there is no scar, saying that hair follicles do not grow in white scar tissue.
Seperately, regarding decorin, from the logic I have, scars come about because of over intense fibroblast proliferation over many months, and in that time decorin is absent. Where the fibroblasts continue to lay down collagen and build a lumpy mass.
Edited by seabs135, 10 February 2012 - 12:32 AM.